From af414deea28d53f6a377dd19e00348e199a92838 Mon Sep 17 00:00:00 2001 From: Jakob Vanhoefer <38346459+jvanhoefer@users.noreply.github.com> Date: Thu, 23 Feb 2023 11:27:04 +0100 Subject: [PATCH] add getting started notebook (#1023) * initial commit nb * fix minor issues * update pre-commit deps * Updated changelog * Updated changelog --------- Co-authored-by: Yannik Schaelte Co-authored-by: Paul Jonas Jost <70631928+PaulJonasJost@users.noreply.github.com> Co-authored-by: PaulJonasJost --- .pre-commit-config.yaml | 6 +- CHANGELOG.rst | 6 +- doc/example.rst | 1 + .../Boehm_JProteomeRes2014.yaml | 13 + ...mentalCondition_Boehm_JProteomeRes2014.tsv | 2 + ...measurementData_Boehm_JProteomeRes2014.tsv | 49 + .../model_Boehm_JProteomeRes2014.xml | 290 + .../observables_Boehm_JProteomeRes2014.tsv | 4 + .../parameters_Boehm_JProteomeRes2014.tsv | 12 + .../simulatedData_Boehm_JProteomeRes2014.tsv | 49 + ...onSpecification_Boehm_JProteomeRes2014.tsv | 4 + doc/example/getting_started.ipynb | 9328 +++++++++++++++++ doc/example/rosenbrock.ipynb | 1 + 13 files changed, 9761 insertions(+), 4 deletions(-) create mode 100644 doc/example/boehm_JProteomeRes2014/Boehm_JProteomeRes2014.yaml create mode 100644 doc/example/boehm_JProteomeRes2014/experimentalCondition_Boehm_JProteomeRes2014.tsv create mode 100644 doc/example/boehm_JProteomeRes2014/measurementData_Boehm_JProteomeRes2014.tsv create mode 100644 doc/example/boehm_JProteomeRes2014/model_Boehm_JProteomeRes2014.xml create mode 100644 doc/example/boehm_JProteomeRes2014/observables_Boehm_JProteomeRes2014.tsv create mode 100644 doc/example/boehm_JProteomeRes2014/parameters_Boehm_JProteomeRes2014.tsv create mode 100644 doc/example/boehm_JProteomeRes2014/simulatedData_Boehm_JProteomeRes2014.tsv create mode 100644 doc/example/boehm_JProteomeRes2014/visualizationSpecification_Boehm_JProteomeRes2014.tsv create mode 100644 doc/example/getting_started.ipynb diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml index 32e3466fc..1730fde8f 100644 --- a/.pre-commit-config.yaml +++ b/.pre-commit-config.yaml @@ -11,12 +11,12 @@ repos: - repo: https://github.com/psf/black - rev: 22.12.0 + rev: 23.1.0 hooks: - id: black description: The uncompromising code formatter - repo: https://github.com/pycqa/isort - rev: 5.11.1 + rev: 5.12.0 hooks: - id: isort name: isort (python) @@ -27,7 +27,7 @@ repos: name: isort (pyi) types: [pyi] - repo: https://github.com/nbQA-dev/nbQA - rev: 1.5.3 + rev: 1.6.3 hooks: - id: nbqa-black - id: nbqa-pyupgrade diff --git a/CHANGELOG.rst b/CHANGELOG.rst index f4b74914b..288b2ac43 100644 --- a/CHANGELOG.rst +++ b/CHANGELOG.rst @@ -6,7 +6,7 @@ Release notes .......... -0.2.16 (2023-02-14) +0.2.16 (2023-02-23) ------------------- * Optimize: @@ -14,6 +14,8 @@ Release notes * Warn only once if using ineffiecient objective settings (#996) * Hierarchical Optimization (#1006) * Fix cma documentation (#987) +* Petab + * Improvement to create_startpoint_method() (#1018) * Sampling: * Dynesty sampler (#1002) * Fix test/sample/test_sample.py::test_samples_cis failures (#1004) @@ -32,6 +34,8 @@ Release notes * black update (#1010) * Doc typo fixes (#995) * Doc: Install amici on RTD (#1016) + * Add getting_started notebook (#1023) + * remove alernative formats build (#1022) 0.2.15 (2022-12-21) diff --git a/doc/example.rst b/doc/example.rst index 84ecb4812..91f5bb232 100644 --- a/doc/example.rst +++ b/doc/example.rst @@ -23,6 +23,7 @@ Getting started .. toctree:: :maxdepth: 2 + example/getting_started.ipynb example/rosenbrock.ipynb PEtab and AMICI diff --git a/doc/example/boehm_JProteomeRes2014/Boehm_JProteomeRes2014.yaml b/doc/example/boehm_JProteomeRes2014/Boehm_JProteomeRes2014.yaml new file mode 100644 index 000000000..887aaa7eb --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/Boehm_JProteomeRes2014.yaml @@ -0,0 +1,13 @@ +format_version: 1 +parameter_file: parameters_Boehm_JProteomeRes2014.tsv +problems: +- condition_files: + - experimentalCondition_Boehm_JProteomeRes2014.tsv + measurement_files: + - measurementData_Boehm_JProteomeRes2014.tsv + observable_files: + - observables_Boehm_JProteomeRes2014.tsv + sbml_files: + - boehm_JProteomeRes2014.xml + visualization_files: + - visualizationSpecification_Boehm_JProteomeRes2014.tsv diff --git a/doc/example/boehm_JProteomeRes2014/experimentalCondition_Boehm_JProteomeRes2014.tsv b/doc/example/boehm_JProteomeRes2014/experimentalCondition_Boehm_JProteomeRes2014.tsv new file mode 100644 index 000000000..d6a622a67 --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/experimentalCondition_Boehm_JProteomeRes2014.tsv @@ -0,0 +1,2 @@ +conditionId conditionName +model1_data1 condition1 diff --git a/doc/example/boehm_JProteomeRes2014/measurementData_Boehm_JProteomeRes2014.tsv b/doc/example/boehm_JProteomeRes2014/measurementData_Boehm_JProteomeRes2014.tsv new file mode 100644 index 000000000..b75b086c6 --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/measurementData_Boehm_JProteomeRes2014.tsv @@ -0,0 +1,49 @@ +observableId preequilibrationConditionId simulationConditionId measurement time observableParameters noiseParameters datasetId +pSTAT5A_rel model1_data1 7.901072999 0.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 66.36349397 2.5 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 81.17132392 5.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 94.73030806 10.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 95.11648305 15.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 91.44171655 20.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 91.25709923 30.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 93.67229784 40.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 88.75423282 50.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 85.26970322 60.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 81.13239534 80.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 76.13592848 100.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 65.24805913 120.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 42.59965871 160.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 25.15779754 200.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 15.4301824 240.0 sd_pSTAT5A_rel model1_data1_pSTAT5A_rel +pSTAT5B_rel model1_data1 4.596533343 0.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 29.63454599 2.5 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 46.04380647 5.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 81.97473362 10.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 80.5716093 15.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 79.03571964 20.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 75.67238037 30.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 71.62471986 40.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 69.06286328 50.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 67.14738432 60.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 60.89947629 80.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 54.80925777 100.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 43.98128998 120.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 29.77145816 160.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 20.08901656 200.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 10.96184517 240.0 sd_pSTAT5B_rel model1_data1_pSTAT5B_rel +rSTAT5A_rel model1_data1 14.72316822 0.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 33.76234229 2.5 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 36.79985129 5.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 49.71760229 10.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 46.9281201 15.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 47.83657456 20.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 46.92872725 30.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 40.59775294 40.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 43.78366389 50.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 44.45738765 60.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 41.32715926 80.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 41.06273321 100.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 39.23583003 120.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 36.61946054 160.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 34.8937144 200.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 32.21107716 240.0 sd_rSTAT5A_rel model1_data1_rSTAT5A_rel diff --git a/doc/example/boehm_JProteomeRes2014/model_Boehm_JProteomeRes2014.xml b/doc/example/boehm_JProteomeRes2014/model_Boehm_JProteomeRes2014.xml new file mode 100644 index 000000000..b3df1b446 --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/model_Boehm_JProteomeRes2014.xml @@ -0,0 +1,290 @@ + + + + + + 
PEtab implementation of the model from Boehm et al. (2014), J. Proteome Res., 13, 12, 5685-5694
+ + + + + + + + + + Boehm + Martin + + + + + + 2019-11-29T09:41:48Z + + + 2019-11-29T09:41:48Z + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 207.6 + ratio + + + + + + + + 207.6 + + + 207.6 + ratio + + + + + + + + + + + 1.25 -7 + + + + + -1 + Epo_degradation_BaF3 + t + + + + + + + + + + + + + + + + + + + cyt + BaF3_Epo + + + STAT5A + 2 + + k_phos + + + + + + + + + + + + + + + + + cyt + BaF3_Epo + STAT5A + STAT5B + k_phos + + + + + + + + + + + + + + + + cyt + BaF3_Epo + + + STAT5B + 2 + + k_phos + + + + + + + + + + + + + + + + cyt + k_imp_homo + pApA + + + + + + + + + + + + + + + + cyt + k_imp_hetero + pApB + + + + + + + + + + + + + + + + cyt + k_imp_homo + pBpB + + + + + + + + + + + + + + + + nuc + k_exp_homo + nucpApA + + + + + + + + + + + + + + + + + nuc + k_exp_hetero + nucpApB + + + + + + + + + + + + + + + + nuc + k_exp_homo + nucpBpB + + + + + + + diff --git a/doc/example/boehm_JProteomeRes2014/observables_Boehm_JProteomeRes2014.tsv b/doc/example/boehm_JProteomeRes2014/observables_Boehm_JProteomeRes2014.tsv new file mode 100644 index 000000000..8f756e8e3 --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/observables_Boehm_JProteomeRes2014.tsv @@ -0,0 +1,4 @@ +observableId observableName observableFormula noiseFormula observableTransformation noiseDistribution +pSTAT5A_rel (100 * pApB + 200 * pApA * specC17) / (pApB + STAT5A * specC17 + 2 * pApA * specC17) noiseParameter1_pSTAT5A_rel lin normal +pSTAT5B_rel -(100 * pApB - 200 * pBpB * (specC17 - 1)) / ((STAT5B * (specC17 - 1) - pApB) + 2 * pBpB * (specC17 - 1)) noiseParameter1_pSTAT5B_rel lin normal +rSTAT5A_rel (100 * pApB + 100 * STAT5A * specC17 + 200 * pApA * specC17) / (2 * pApB + STAT5A * specC17 + 2 * pApA * specC17 - STAT5B * (specC17 - 1) - 2 * pBpB * (specC17 - 1)) noiseParameter1_rSTAT5A_rel lin normal diff --git a/doc/example/boehm_JProteomeRes2014/parameters_Boehm_JProteomeRes2014.tsv b/doc/example/boehm_JProteomeRes2014/parameters_Boehm_JProteomeRes2014.tsv new file mode 100644 index 000000000..c80b3cd93 --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/parameters_Boehm_JProteomeRes2014.tsv @@ -0,0 +1,12 @@ +parameterId parameterName parameterScale lowerBound upperBound nominalValue estimate +Epo_degradation_BaF3 EPO_{degradation,BaF3} log10 1E-05 100000 0.026982514033029 1 +k_exp_hetero k_{exp,hetero} log10 1E-05 100000 1.00067973851508E-05 1 +k_exp_homo k_{exp,homo} log10 1E-05 100000 0.006170228086381 1 +k_imp_hetero k_{imp,hetero} log10 1E-05 100000 0.0163679184468 1 +k_imp_homo k_{imp,homo} log10 1E-05 100000 97749.3794024716 1 +k_phos k_{phos} log10 1E-05 100000 15766.5070195731 1 +ratio ratio lin -5 5 0.693 0 +sd_pSTAT5A_rel \sigma_{pSTAT5A,rel} log10 1E-05 100000 3.85261197844677 1 +sd_pSTAT5B_rel \sigma_{pSTAT5B,rel} log10 1E-05 100000 6.59147818673419 1 +sd_rSTAT5A_rel \sigma_{rSTAT5A,rel} log10 1E-05 100000 3.15271275648527 1 +specC17 specC17 lin -5 5 0.107 0 diff --git a/doc/example/boehm_JProteomeRes2014/simulatedData_Boehm_JProteomeRes2014.tsv b/doc/example/boehm_JProteomeRes2014/simulatedData_Boehm_JProteomeRes2014.tsv new file mode 100644 index 000000000..87107539e --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/simulatedData_Boehm_JProteomeRes2014.tsv @@ -0,0 +1,49 @@ +observableId preequilibrationConditionId simulationConditionId simulation time observableParameters noiseParameters observableTransformation datasetId +pSTAT5A_rel model1_data1 0 0 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 75.1549671358 2.5 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 85.2163816535 5 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 90.6694732203 10 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 92.1422837775 15 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 92.5018522474 20 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 91.9628925517 30 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 90.625262994 40 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 88.7858308028 50 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 86.5228969273 60 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 80.8019280011 80 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 73.5772935097 100 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 65.1055254027 120 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 46.4623038404 160 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 29.5144935856 200 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5A_rel model1_data1 17.1453510648 240 3.8526119788 lin model1_data1_pSTAT5A_rel +pSTAT5B_rel model1_data1 0 0 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 40.1654621871 2.5 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 54.5032976736 5 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 66.2879117046 10 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 70.9429990469 15 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 72.9589968453 20 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 73.5974399901 30 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 72.082995757 40 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 69.4358397665 50 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 66.0720835416 60 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 58.0459969685 80 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 49.2225279021 100 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 40.4540966361 120 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 25.2906981147 160 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 14.6584042019 200 6.5914781874 lin model1_data1_pSTAT5B_rel +pSTAT5B_rel model1_data1 8.0932190893 240 6.5914781874 lin model1_data1_pSTAT5B_rel +rSTAT5A_rel model1_data1 21.2892834379 0 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 34.8294204521 2.5 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 39.0090255401 5 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 42.2330600419 10 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 43.5005507095 15 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 44.09441589 20 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 44.4535462193 30 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 44.3019891288 40 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 43.885163825 50 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 43.2989886397 60 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 41.8054478544 80 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 40.0835500781 100 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 38.3234573256 120 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 35.2468851779 160 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 33.1841581699 200 3.1527127566 lin model1_data1_rSTAT5A_rel +rSTAT5A_rel model1_data1 32.0668685917 240 3.1527127566 lin model1_data1_rSTAT5A_rel diff --git a/doc/example/boehm_JProteomeRes2014/visualizationSpecification_Boehm_JProteomeRes2014.tsv b/doc/example/boehm_JProteomeRes2014/visualizationSpecification_Boehm_JProteomeRes2014.tsv new file mode 100644 index 000000000..12f594b48 --- /dev/null +++ b/doc/example/boehm_JProteomeRes2014/visualizationSpecification_Boehm_JProteomeRes2014.tsv @@ -0,0 +1,4 @@ +plotId plotName plotTypeSimulation plotTypeData datasetId xValues xOffset xLabel yValues yOffset yLabel legendEntry xScale yScale +plot1 pSTAT5A_rel LinePlot MeanAndSD model1_data1_pSTAT5A_rel time 0 Time [min] pSTAT5A_rel 0 frac. [%] pSTAT5A lin lin +plot2 pSTAT5B_rel LinePlot MeanAndSD model1_data1_pSTAT5B_rel time 0 Time [min] pSTAT5B_rel 0 frac. [%] pSTAT5B lin lin +plot3 rSTAT5A_rel LinePlot MeanAndSD model1_data1_rSTAT5A_rel time 0 Time [min] rSTAT5A_rel 0 relative STAT5A abundance [%] rSTAT5A lin lin diff --git a/doc/example/getting_started.ipynb b/doc/example/getting_started.ipynb new file mode 100644 index 000000000..06a7e0b12 --- /dev/null +++ b/doc/example/getting_started.ipynb @@ -0,0 +1,9328 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# pyPESTO: Getting started\n", + "\n", + "This notebook takes you through the first steps to get started with [pyPESTO](https://github.com/ICB-DCM/pyPESTO).\n", + "\n", + "\"pyPESTO\n", + "\n", + "pyPESTO is a python package for parameter inference, offering a unified interface to various optimization and sampling methods. \n", + "pyPESTO is highly modular and customizable, e.g. with respect to objective function definition and employed inference algorithms." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "metadata": {}, + "outputs": [], + "source": [ + "import os.path\n", + "\n", + "import amici\n", + "\n", + "# import matplotlib and increase image resolution\n", + "import matplotlib as mpl\n", + "import numpy as np\n", + "import petab\n", + "\n", + "import pypesto\n", + "import pypesto.optimize as optimize\n", + "import pypesto.petab\n", + "import pypesto.visualize as visualize\n", + "\n", + "mpl.rcParams['figure.dpi'] = 300" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Objective Definition\n", + "\n", + "PyPESTO allows the definition of a custom objectives, as well as offers support for objectives defined in the [PEtab](https://github.com/PEtab-dev/PEtab) format.\n", + "\n", + "## Custom Objective Definition\n", + "\n", + "You can define an objective via a python function. Also providing an analytical gradient (and potentiall also a hessian) improves the performance of Gradient/Hessian-based optimizers. When acessing parameter uncertainties via profile-likelihoods/sampling, pyPESTO interprets the objective function as the negative-log-likelihood/negative-log-posterior." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "metadata": {}, + "outputs": [], + "source": [ + "# define objective function\n", + "def f(x: np.array):\n", + " return x[0] ** 2 + x[1] ** 2\n", + "\n", + "\n", + "# define gradient\n", + "def grad(x: np.array):\n", + " return 2 * x\n", + "\n", + "\n", + "# define objective\n", + "custom_objective = pypesto.Objective(fun=f, grad=grad)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Define lower and upper parameter bounds and create an optimization problem. " + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "metadata": {}, + "outputs": [], + "source": [ + "# define optimization bounds\n", + "lb = np.array([-10, -10])\n", + "ub = np.array([10, 10])\n", + "\n", + "# create problem\n", + "custom_problem = pypesto.Problem(objective=custom_objective, lb=lb, ub=ub)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Now choose an optimizer to perform the optimization. `minimize` uses multi-start optimization, meaning that the optimzation is run `n_start` times from different initial values, in case the problem contians multiple local optima (which of course is not the case for this toy problem)." + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "100%|██████████████████████████████████████████| 10/10 [00:00<00:00, 496.47it/s]\n" + ] + } + ], + "source": [ + "# choose optimizer\n", + "optimizer = optimize.ScipyOptimizer()\n", + "\n", + "# do the optimization\n", + "result_custom_problem = optimize.minimize(\n", + " problem=custom_problem, optimizer=optimizer, n_starts=10\n", + ")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "`result_custom_problem.optimize_result` now stores a list, that contains the results and meta data of the individual optimizer runs (ordered by function value)." + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'id': '0',\n", + " 'x': array([0., 0.]),\n", + " 'fval': 0.0,\n", + " 'grad': array([0., 0.]),\n", + " 'hess': None,\n", + " 'res': None,\n", + " 'sres': None,\n", + " 'n_fval': 4,\n", + " 'n_grad': 4,\n", + " 'n_hess': 0,\n", + " 'n_res': 0,\n", + " 'n_sres': 0,\n", + " 'x0': array([0.6901338 , 7.17776654]),\n", + " 'fval0': 51.996617134691896,\n", + " 'history': ,\n", + " 'exitflag': 0,\n", + " 'time': 0.007859945297241211,\n", + " 'message': 'CONVERGENCE: NORM_OF_PROJECTED_GRADIENT_<=_PGTOL',\n", + " 'optimizer': \"\"}" + ] + }, + "execution_count": 5, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# E.g. The best model fit was obtained by the following optimization run:\n", + "result_custom_problem.optimize_result.list[0]" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "[0.0,\n", + " 0.0,\n", + " 0.0,\n", + " 0.0,\n", + " 0.0,\n", + " 7.523163845262637e-37,\n", + " 1.504632769052528e-36,\n", + " 1.5046327690525307e-36,\n", + " 3.0562853121379475e-36,\n", + " 3.1973446342366133e-36]" + ] + }, + "execution_count": 6, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# Objective function values of the different optimizer runs:\n", + "result_custom_problem.optimize_result.get_for_key('fval')" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Problem Definition via PEtab\n", + "\n", + "### Background on PEtab\n", + "\n", + "\"pyPESTO\n", + "\n", + "PyPESTO supports the [PEtab](https://github.com/PEtab-dev/PEtab) standard. PEtab is a data format for specifying parameter estimation problems in systems biology. \n", + "\n", + "A PEtab problem consist of an [SBML](https://sbml.org) file, defining the model topology and a set of `.tsv` files, defining experimental conditions, observables, measurements and parameters (and their optimization bounds, scale, priors...). All files, that make up a PEtab problem, can be structured in a `.yaml` file. The `pypesto.Objective` comming from a PEtab problem corresponds to the negative-log-likelihood/negative-log-posterior disrtibution of the parameters. \n", + "\n", + "For more details on PEtab, the interested reader is refered to [PEtab's format definition](https://petab.readthedocs.io/en/latest/documentation_data_format.html), for examples, the reader is refered to the [PEtab benchmark collection](https://github.com/Benchmarking-Initiative/Benchmark-Models-PEtab). The Model from _[Böhm et al. JProteomRes 2014](https://pubs.acs.org/doi/abs/10.1021/pr5006923)_ is part of the benchmark collection and will be used as the running example throughout this notebook.\n", + "\n", + "PyPESTO provides an interface to the model simulation tool [AMICI](https://github.com/AMICI-dev/AMICI) for the simulation of Ordinary Differential Equation (ODE) models specified in the SBML format." + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Basic Model Import and Optimization \n", + "\n", + "The first step is to import a PEtab problem and create a `pypesto.problem` object:" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [], + "source": [ + "%%capture\n", + "# directory of the PEtab problem\n", + "petab_yaml = './boehm_JProteomeRes2014/Boehm_JProteomeRes2014.yaml'\n", + "\n", + "importer = pypesto.petab.PetabImporter.from_yaml(petab_yaml)\n", + "problem = importer.create_problem()" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Next, we choose an `optimizer` to perform the multi start optimization." + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "2023-02-17 16:01:22.984 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 158.494 and h = 1.34133e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:22.986 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 158.494: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:23.022 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 158.494 and h = 1.34133e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:23.023 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 158.494: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:23.045 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 158.494 and h = 1.34133e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:23.046 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 158.494: AMICI failed to integrate the forward problem\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 15 s, sys: 476 ms, total: 15.5 s\n", + "Wall time: 15.4 s\n" + ] + } + ], + "source": [ + "%%time\n", + "%%capture\n", + "\n", + "# choose optimizer\n", + "optimizer = optimize.ScipyOptimizer()\n", + "\n", + "# do the optimization\n", + "result = optimize.minimize(problem=problem, \n", + " optimizer=optimizer,\n", + " n_starts=10)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "`result.optimize_result` contains a list with the ordered optimization results." + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'id': '3',\n", + " 'x': array([-1.56904695, -5. , -2.20985861, -1.78591646, 5. ,\n", + " 4.19769784, 0.693 , 0.58567634, 0.81886181, 0.49859024,\n", + " 0.107 ]),\n", + " 'fval': 138.2219738778035,\n", + " 'grad': array([ 1.02808139e-02, 5.53588489e-02, 2.03115656e-04, 1.00993749e-02,\n", + " -4.41596715e-05, -9.26213990e-03, nan, 2.11437217e-03,\n", + " 2.50708689e-03, -3.97887714e-04, nan]),\n", + " 'hess': None,\n", + " 'res': None,\n", + " 'sres': None,\n", + " 'n_fval': 191,\n", + " 'n_grad': 191,\n", + " 'n_hess': 0,\n", + " 'n_res': 0,\n", + " 'n_sres': 0,\n", + " 'x0': array([ 2.1608791 , -2.88363288, -4.61132422, 1.82016484, -1.49529658,\n", + " -1.08670354, 0.693 , -3.8208997 , 2.23962013, 0.32443793,\n", + " 0.107 ]),\n", + " 'fval0': 1950794339021.3562,\n", + " 'history': ,\n", + " 'exitflag': 0,\n", + " 'time': 2.9797539710998535,\n", + " 'message': 'CONVERGENCE: REL_REDUCTION_OF_F_<=_FACTR*EPSMCH',\n", + " 'optimizer': \"\"}" + ] + }, + "execution_count": 9, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# E.g. best model fit was obtained by the following optimization run:\n", + "result.optimize_result.list[0]" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "[138.2219738778035,\n", + " 149.58788363739558,\n", + " 149.58968254433313,\n", + " 150.06701061933796,\n", + " 158.809924925096,\n", + " 171.13435267913164,\n", + " 233.09982603500364,\n", + " 249.74596437461332,\n", + " 249.74599739701642,\n", + " 249.74599747333608]" + ] + }, + "execution_count": 10, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# Objective function values of the different optimizer runs:\n", + "result.optimize_result.get_for_key('fval')" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Optimizer Choice\n", + "\n", + "PyPESTO provides a unified interface to a variety of optimizers of different types:\n", + "\n", + "* All [scipy optimizer](https://docs.scipy.org/doc/scipy/reference/generated/scipy.optimize.minimize.html#scipy.optimize.minimize) (`optimize.ScipyOptimizer(method=)`)\n", + " * _function-value_ or _least-squares_-based optimizers\n", + " * _gradient_ or _hessian_-based optimizers\n", + "* [IpOpt](https://pypi.org/project/ipopt/) (`optimize.IpoptOptimizer()`)\n", + " * Interior point method\n", + "* [Dlib](http://dlib.net) (`optimize.DlibOptimizer(options={'maxiter': })`)\n", + " * Global optimizer\n", + " * Gradient free\n", + "* [FIDES](https://github.com/fides-dev/fides/) (`optimize.FidesOptimizer()`)\n", + " * Interior Trust Region optimizer \n", + "* [Particle Swarm](https://github.com/tisimst/pyswarm) (`optimize.PyswarmOptimizer()`)\n", + " * Particle swarm algorithm\n", + " * Gradient free\n", + "* [CMA-ES](https://pypi.org/project/cma-es/) (`optimize.CmaesOptimizer()`)\n", + " * Covariance Matrix Adaptation Evolution Strategy\n", + " * Evolutionary Algorithm" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "metadata": {}, + "outputs": [], + "source": [ + "optimizer_scipy_lbfgsb = optimize.ScipyOptimizer(method='L-BFGS-B')\n", + "optimizer_scipy_powell = optimize.ScipyOptimizer(method='Powell')\n", + "\n", + "optimizer_fides = optimize.FidesOptimizer()\n", + "optimizer_pyswarm = optimize.PyswarmOptimizer()" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "The following performs 100 multi-start runs with different optimizers in order to compare their performance. \n", + "\n", + "_Note_: `dlib` and `pyswarm` need to be installed for this section to run. Furthermore the computation time is in the order of minutes, so you might want to skip the excecution and jump to the section on large scale models. " + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Engine set up to use up to 8 processes in total. The number was automatically determined and might not be appropriate on some systems.\n", + "Performing parallel task execution on 8 processes.\n", + "2023-02-17 16:01:41.379 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 98.8572 and h = 1.56563e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:41.379 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 98.8572: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:41.408 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 98.8572 and h = 1.56563e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:41.408 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 98.8572: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:42.689 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.945 and h = 2.71313e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:42.690 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.945: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:42.903 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.945 and h = 2.71313e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:42.904 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.945: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:43.010 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.945 and h = 2.71313e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:43.010 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.945: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:43.595 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 51.0716 and h = 3.63082e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:43.595 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 51.0716: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:43.628 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 51.0716 and h = 3.63082e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:43.628 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 51.0716: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:50.278 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:TOO_MUCH_WORK] AMICI ERROR: in module CVODES in function CVode : At t = 76.964, mxstep steps taken before reaching tout. \n", + "2023-02-17 16:01:50.278 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 76.964: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:50.564 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 140.591 and h = 1.97937e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:50.565 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 140.591: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:51.675 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 167.379 and h = 7.66589e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:51.676 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 167.379: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:51.735 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 167.379 and h = 7.66589e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:51.736 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 167.379: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:01:55.008 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 188.834 and h = 3.15716e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:01:55.009 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 188.834: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:00.240 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.6972 and h = 1.45985e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:00.240 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.6972: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:00.294 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.6972 and h = 1.45985e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:00.294 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.6972: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:07.377 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 169.229 and h = 1.90001e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:07.378 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 169.229: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:07.511 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 169.229 and h = 1.90001e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:07.512 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 169.229: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:08.616 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 92.2863 and h = 1.84593e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:08.616 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 92.2863: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:08.718 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.037 and h = 2.126e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:08.718 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.037: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:08.830 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.037 and h = 2.126e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:08.831 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.037: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:08.900 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.037 and h = 2.126e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:08.900 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.037: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:12.500 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 138.745 and h = 1.31331e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:12.500 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 138.745: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:12.732 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 138.745 and h = 1.31331e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:12.732 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 138.745: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:12.830 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 138.745 and h = 1.31331e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:12.830 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 138.745: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:13.480 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.825 and h = 1.87415e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:13.480 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.825: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:13.674 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.825 and h = 1.87415e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:13.674 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.825: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:13.761 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.825 and h = 1.87415e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:13.761 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.825: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:15.776 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 168.782 and h = 3.21943e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:15.776 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 168.782: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:16.578 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 168.806 and h = 2.98398e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:16.578 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 168.806: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:18.407 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.788 and h = 1.37128e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:18.407 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.788: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:18.474 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.788 and h = 1.37128e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:18.474 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.788: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:18.529 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.788 and h = 1.37128e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:18.530 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.788: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:20.019 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 150.727 and h = 1.41441e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:20.020 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 150.727: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:20.112 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 150.727 and h = 1.41441e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:20.113 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 150.727: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:22.871 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 66.7204 and h = 1.90309e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:22.871 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 66.7204: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:27.514 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 13.8788 and h = 2.73008e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:27.514 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 13.8788: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:27.582 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 13.8788 and h = 2.73008e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:27.583 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 13.8788: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:27.608 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 13.8788 and h = 2.73008e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:27.608 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 13.8788: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:27.889 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 221.347 and h = 4.88446e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:27.889 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 221.347: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:28.730 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 97.978 and h = 2.09287e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:28.730 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 97.978: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:28.807 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 97.978 and h = 2.09287e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:28.807 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 97.978: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:02:28.886 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 97.978 and h = 2.09287e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:02:28.886 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 97.978: AMICI failed to integrate the forward problem\n", + "Performing parallel task execution on 8 processes.\n", + "Performing parallel task execution on 8 processes.\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +2.27E+04 | NaN | NaN | 1.0E+00 | 9.5E+04 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +9.53E+12 | NaN | NaN | 1.0E+00 | 4.4E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +7.39E+13 | NaN | NaN | 1.0E+00 | 3.4E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +3.54E+08 | NaN | NaN | 1.0E+00 | 1.6E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +4.33E+02 | NaN | NaN | 1.0E+00 | 6.4E+01 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +3.21E+11 | NaN | NaN | 1.0E+00 | 1.4E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +4.32E+02 | NaN | NaN | 1.0E+00 | 6.4E+01 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 0| +8.98E+11 | NaN | NaN | 1.0E+00 | 4.1E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +9.31E+02 | -2.2E+04 | +1.3E-01 | 1.0E+00 | 9.5E+04 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +9.41E+06 | -9.5E+12 | +8.5E-02 | 1.0E+00 | 4.4E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +4.70E+04 | -3.5E+08 | +1.0E-01 | 1.0E+00 | 1.6E+09 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +3.88E+02 | -5.4E+02 | +9.0E-01 | 2.5E-01 | 3.0E+03 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +3.05E+02 | -1.3E+02 | +5.0E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +1.79E+06 | -7.6E+06 | +8.9E-01 | 2.5E-01 | 3.6E+07 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 3| +3.04E+02 | -8.4E+01 | +8.9E-01 | 5.0E-01 | 4.8E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +2.34E+11 | -7.4E+13 | +8.4E-02 | 1.0E+00 | 3.4E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +8.13E+03 | -3.9E+04 | +9.0E-01 | 2.5E-01 | 2.1E+05 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +7.96E+09 | -3.1E+11 | +9.3E-02 | 1.0E+00 | 1.4E+12 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +3.05E+02 | -1.3E+02 | +5.4E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 3| +2.78E+05 | -1.5E+06 | +9.0E-01 | 5.0E-01 | 6.2E+06 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +2.73E+02 | -3.2E+01 | +5.6E-01 | 1.0E+00 | 7.5E+01 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +3.48E+10 | -2.0E+11 | +8.9E-01 | 2.5E-01 | 1.1E+12 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 3| +1.52E+03 | -6.6E+03 | +9.0E-01 | 5.0E-01 | 3.3E+04 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +4.37E+04 | -2.3E+05 | +9.0E-01 | 1.0E+00 | 9.6E+05 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +2.58E+02 | -4.7E+01 | +8.8E-01 | 1.0E+00 | 2.3E+02 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 5| +2.51E+02 | -2.2E+01 | +7.0E-01 | 1.0E+00 | 9.4E+01 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +1.20E+09 | -6.8E+09 | +8.9E-01 | 2.5E-01 | 3.7E+10 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 1| +2.58E+08 | -9.0E+11 | +8.9E-02 | 1.0E+00 | 4.1E+12 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +2.68E+02 | -3.7E+01 | +8.8E-01 | 1.0E+00 | 1.9E+02 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 6| +2.51E+02 | +3.1E+00 | -1.3E+00 | 1.0E+00 | 1.7E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 3| +5.19E+09 | -3.0E+10 | +8.9E-01 | 5.0E-01 | 1.6E+11 | 7.6E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +4.18E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 5.3E+03 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 5| +7.03E+03 | -3.7E+04 | +9.0E-01 | 1.0E+00 | 1.5E+05 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 7| +2.51E+02 | +3.2E+00 | -1.3E+00 | 2.5E-01 | 1.7E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 3| +2.58E+02 | +1.6E+02 | -1.0E+01 | 2.0E+00 | 3.8E+01 | 4.1E+00 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 6| +1.28E+03 | -5.8E+03 | +9.0E-01 | 1.0E+00 | 2.4E+04 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 8| +2.50E+02 | -1.1E+00 | +5.2E-01 | 6.2E-02 | 1.7E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 5| +2.63E+02 | -1.5E+02 | +8.8E-01 | 1.0E+00 | 8.2E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +7.78E+08 | -4.4E+09 | +8.9E-01 | 5.0E-01 | 2.4E+10 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 3| +1.81E+08 | -1.0E+09 | +8.9E-01 | 5.0E-01 | 5.5E+09 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 3| +2.68E+02 | +2.9E+06 | -2.2E+05 | 2.0E+00 | 3.7E+01 | 5.2E+00 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 5| +1.17E+08 | -6.6E+08 | +8.9E-01 | 5.0E-01 | 3.6E+09 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 9| +2.50E+02 | -4.6E-02 | +2.0E-01 | 6.2E-02 | 6.5E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 7| +3.80E+02 | -9.0E+02 | +9.0E-01 | 1.0E+00 | 3.8E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 2| +3.93E+07 | -2.2E+08 | +8.9E-01 | 2.5E-01 | 1.2E+09 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 6| +2.32E+02 | -3.1E+01 | +1.4E+00 | 2.0E+00 | 1.1E+02 | 4.0E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +2.58E+02 | +1.6E+02 | -9.3E+00 | 5.0E-01 | 3.8E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 6| +1.77E+07 | -9.9E+07 | +8.9E-01 | 5.0E-01 | 5.4E+08 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 10| +2.50E+02 | -5.6E-02 | +4.5E-01 | 1.6E-02 | 4.6E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +2.76E+07 | -1.5E+08 | +8.9E-01 | 1.0E+00 | 8.3E+08 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 8| +2.56E+02 | -1.2E+02 | +8.7E-01 | 1.0E+00 | 5.9E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 11| +2.50E+02 | -2.1E-03 | +8.3E-02 | 1.6E-02 | 2.1E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 4| +2.68E+02 | +8.2E+01 | -3.8E+00 | 5.0E-01 | 3.7E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 5| +2.50E+02 | -8.2E+00 | +7.7E-01 | 1.2E-01 | 3.8E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 7| +2.32E+02 | +2.8E+03 | -8.1E+01 | 4.0E+00 | 4.5E+01 | 1.1E+01 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 7| +2.70E+06 | -1.5E+07 | +8.9E-01 | 5.0E-01 | 8.2E+07 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 12| +2.50E+02 | -9.9E-03 | +7.0E-01 | 3.9E-03 | 1.8E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 9| +2.32E+02 | -2.4E+01 | +1.6E+00 | 2.0E+00 | 7.0E+01 | 3.8E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 5| +4.23E+06 | -2.3E+07 | +8.9E-01 | 1.0E+00 | 1.3E+08 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 8| +4.12E+05 | -2.3E+06 | +8.9E-01 | 5.0E-01 | 1.2E+07 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 13| +2.50E+02 | -3.6E-05 | +2.6E-01 | 3.9E-03 | 1.3E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 8| +2.32E+02 | +2.5E+02 | -9.6E+00 | 1.0E+00 | 4.5E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 5| +2.57E+02 | -1.1E+01 | +9.5E-01 | 1.2E-01 | 3.7E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 14| +2.50E+02 | -3.8E-05 | +2.8E-01 | 3.9E-03 | 1.3E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 6| +2.50E+02 | +3.5E-01 | -5.0E-01 | 2.5E-01 | 1.0E+01 | 5.8E-01 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 9| +6.25E+04 | -3.5E+05 | +9.0E-01 | 5.0E-01 | 1.9E+06 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 3| +5.97E+06 | -3.3E+07 | +8.9E-01 | 5.0E-01 | 1.8E+08 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 15| +2.50E+02 | -3.7E-05 | +2.8E-01 | 3.9E-03 | 1.3E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 10| +2.32E+02 | +1.0E+03 | -3.9E+01 | 4.0E+00 | 4.2E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 9| +2.22E+02 | -9.9E+00 | +4.0E-01 | 2.5E-01 | 4.5E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 6| +6.50E+05 | -3.6E+06 | +9.0E-01 | 1.0E+00 | 1.9E+07 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 6| +2.57E+02 | +3.5E+00 | -4.3E-01 | 2.5E-01 | 3.0E+01 | 6.5E-01 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) 7| +2.50E+02 | +3.5E-01 | -5.0E-01 | 6.2E-02 | 1.0E+01 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:05 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:05 fides(INFO) 10| +9.71E+03 | -5.3E+04 | +9.0E-01 | 5.0E-01 | 2.9E+05 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:05 fides(INFO) 16| +2.50E+02 | -3.9E-05 | +2.9E-01 | 3.9E-03 | 1.3E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 7| +9.99E+04 | -5.5E+05 | +9.0E-01 | 1.0E+00 | 3.0E+06 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +2.50E+02 | -3.8E-05 | +2.9E-01 | 3.9E-03 | 1.3E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 10| +2.18E+02 | -4.7E+00 | +6.3E-01 | 2.5E-01 | 4.8E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 11| +2.32E+02 | +1.1E+02 | -5.5E+00 | 1.0E+00 | 4.2E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 11| +1.61E+03 | -8.1E+03 | +9.1E-01 | 1.0E+00 | 4.4E+04 | 5.1E-01 | trr |1\n", + "2023-02-17 16:05:06 fides(INFO) 8| +2.50E+02 | -2.9E-01 | +8.4E-01 | 1.6E-02 | 1.0E+01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 7| +2.53E+02 | -4.3E+00 | +9.3E-01 | 6.2E-02 | 3.0E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +2.50E+02 | -4.0E-05 | +3.0E-01 | 3.9E-03 | 1.3E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +2.28E+02 | -4.3E+00 | +1.7E-01 | 2.5E-01 | 4.2E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +2.50E+02 | -3.9E-05 | +3.0E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +4.30E+02 | -1.2E+03 | +9.0E-01 | 1.0E+00 | 6.6E+03 | 2.7E+00 | trr |1\n", + "2023-02-17 16:05:06 fides(INFO) 11| +2.17E+02 | -6.0E-01 | +6.6E-02 | 2.5E-01 | 2.1E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +2.23E+02 | -5.2E+00 | +8.6E-01 | 6.2E-02 | 6.5E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 8| +2.51E+02 | -1.4E+00 | +2.2E-01 | 1.2E-01 | 2.3E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 9| +2.50E+02 | +2.2E-02 | -1.7E-01 | 3.1E-02 | 4.7E+00 | 7.6E-02 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +2.50E+02 | -4.1E-05 | +3.1E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 4| +9.12E+05 | -5.1E+06 | +8.9E-01 | 5.0E-01 | 2.7E+07 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +2.50E+02 | -4.0E-05 | +3.1E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +2.35E+02 | -1.9E+02 | +9.3E-01 | 1.0E+00 | 1.0E+03 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 14| +2.20E+02 | -2.3E+00 | +5.9E-01 | 1.2E-01 | 3.3E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 8| +1.53E+04 | -8.5E+04 | +9.0E-01 | 1.0E+00 | 4.6E+05 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +2.14E+02 | -3.4E+00 | +8.3E-01 | 6.2E-02 | 4.6E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +2.50E+02 | -4.2E-05 | +3.3E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 10| +2.50E+02 | -6.0E-02 | +8.0E-01 | 7.8E-03 | 4.7E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 9| +2.50E+02 | -1.0E+00 | +8.3E-01 | 3.1E-02 | 2.5E+01 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 15| +2.20E+02 | +3.1E-01 | -1.7E-01 | 1.2E-01 | 1.9E+01 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 23| +2.50E+02 | -4.1E-05 | +3.3E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +2.12E+02 | -2.0E+00 | +7.7E-01 | 1.2E-01 | 2.1E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 11| +2.50E+02 | +4.3E-04 | -2.9E-02 | 1.6E-02 | 1.7E+00 | 3.7E-02 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 24| +2.50E+02 | -4.3E-05 | +3.4E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 10| +2.50E+02 | -1.5E-01 | +3.2E-01 | 6.2E-02 | 9.9E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 14| +2.14E+02 | -2.1E+01 | +7.7E-01 | 2.0E+00 | 1.4E+02 | 5.9E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 16| +2.19E+02 | -9.2E-01 | +8.5E-01 | 3.1E-02 | 1.9E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 25| +2.50E+02 | -4.2E-05 | +3.4E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 14| +2.09E+02 | -2.5E+00 | +6.5E-01 | 2.5E-01 | 1.6E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 5| +1.41E+05 | -7.7E+05 | +9.0E-01 | 5.0E-01 | 4.2E+06 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +2.50E+02 | -8.0E-03 | +6.8E-01 | 3.9E-03 | 1.7E+00 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 26| +2.50E+02 | -4.4E-05 | +3.5E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 9| +2.47E+03 | -1.3E+04 | +9.1E-01 | 1.0E+00 | 7.0E+04 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +2.18E+02 | -1.1E+00 | +9.1E-01 | 6.2E-02 | 1.5E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 11| +2.50E+02 | +2.9E-02 | -1.4E-01 | 6.2E-02 | 5.7E+00 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 27| +2.50E+02 | -4.3E-05 | +3.5E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 15| +2.14E+02 | +1.2E+04 | -3.9E+02 | 4.0E+00 | 5.8E+01 | 9.7E+00 | trr |0\n", + "2023-02-17 16:05:06 fides(INFO) 15| +2.02E+02 | -7.4E+00 | +1.0E+00 | 2.5E-01 | 2.9E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 28| +2.50E+02 | -4.5E-05 | +3.7E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +2.17E+02 | -1.3E+00 | +7.6E-01 | 1.2E-01 | 1.7E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 29| +2.50E+02 | -4.5E-05 | +3.7E-01 | 3.9E-03 | 1.1E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +2.50E+02 | -1.0E-04 | +1.0E-01 | 3.9E-03 | 4.0E-01 | 8.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +2.50E+02 | -1.1E-01 | +6.3E-01 | 1.6E-02 | 5.7E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 30| +2.50E+02 | -4.6E-05 | +3.8E-01 | 3.9E-03 | 1.1E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +2.17E+02 | +3.8E-01 | -2.1E-01 | 2.5E-01 | 1.7E+01 | 7.0E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 6| +2.19E+04 | -1.2E+05 | +9.0E-01 | 5.0E-01 | 6.4E+05 | 9.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 16| +1.88E+02 | -1.3E+01 | +1.8E-01 | 5.0E-01 | 2.3E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 16| +2.14E+02 | +3.6E+01 | -2.8E+00 | 9.1E-01 | 5.8E+01 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 14| +2.50E+02 | -4.0E-04 | +5.9E-01 | 9.8E-04 | 3.7E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 31| +2.50E+02 | -4.6E-05 | +3.8E-01 | 3.9E-03 | 1.1E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +2.50E+02 | -5.0E-03 | +7.3E-01 | 1.6E-02 | 5.3E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +2.16E+02 | -9.1E-01 | +5.2E-01 | 6.2E-02 | 1.7E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 10| +5.65E+02 | -1.9E+03 | +9.0E-01 | 1.0E+00 | 1.1E+04 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 32| +2.50E+02 | -4.8E-05 | +3.9E-01 | 3.9E-03 | 1.1E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +1.62E+02 | -2.6E+01 | +9.5E-01 | 1.2E-01 | 2.4E+02 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +2.15E+02 | -7.3E-01 | +7.1E-01 | 6.2E-02 | 1.6E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 15| +2.50E+02 | -1.8E-05 | +4.9E-01 | 9.8E-04 | 6.0E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 33| +2.50E+02 | -8.5E-05 | +1.0E+00 | 3.9E-03 | 1.1E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 14| +2.50E+02 | -4.5E-03 | +6.8E-01 | 1.6E-02 | 5.8E-01 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 34| +2.50E+02 | +3.0E-03 | -1.3E+01 | 7.8E-03 | 3.4E-02 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 7| +3.57E+03 | -1.8E+04 | +9.0E-01 | 5.0E-01 | 9.9E+04 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +2.15E+02 | -2.4E-01 | +2.6E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 35| +2.50E+02 | +1.1E-03 | -1.0E+01 | 2.0E-03 | 3.4E-02 | 5.0E-03 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 16| +2.50E+02 | -1.7E-05 | +5.1E-01 | 9.8E-04 | 5.5E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +1.51E+02 | -1.2E+01 | +7.1E-01 | 2.5E-01 | 5.4E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 36| +2.50E+02 | +7.4E-05 | -2.0E+00 | 4.9E-04 | 3.4E-02 | 1.2E-03 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 11| +2.58E+02 | -3.1E+02 | +9.3E-01 | 2.0E+00 | 1.7E+03 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +2.02E+02 | -1.2E+01 | +9.9E-01 | 2.3E-01 | 5.8E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 15| +2.50E+02 | -4.3E-03 | +6.5E-01 | 1.6E-02 | 6.2E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 8| +7.19E+02 | -2.9E+03 | +8.9E-01 | 1.0E+00 | 1.5E+04 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 23| +2.14E+02 | -7.2E-01 | +6.0E-01 | 6.2E-02 | 1.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 37| +2.50E+02 | -3.1E-06 | +3.0E-01 | 1.2E-04 | 3.4E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +2.50E+02 | -1.8E-05 | +5.4E-01 | 9.8E-04 | 5.4E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +2.04E+02 | -5.3E+01 | +9.2E-01 | 2.0E+00 | 2.4E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +1.49E+02 | -1.5E+00 | +8.9E-01 | 2.5E-01 | 2.9E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 38| +2.50E+02 | -2.7E-06 | +1.0E+00 | 1.2E-04 | 1.9E-02 | 3.0E-04 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 24| +2.14E+02 | -1.0E-01 | +1.3E-01 | 6.2E-02 | 1.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 39| +2.50E+02 | -5.2E-06 | +1.0E+00 | 2.4E-04 | 8.2E-03 | 6.3E-04 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 16| +2.50E+02 | -3.8E-03 | +6.2E-01 | 1.6E-02 | 6.2E-01 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +2.50E+02 | -1.7E-05 | +5.6E-01 | 9.8E-04 | 5.0E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 25| +2.14E+02 | -3.8E-01 | +9.0E-01 | 1.6E-02 | 1.8E+01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 9| +3.47E+02 | -3.7E+02 | +6.6E-01 | 2.0E+00 | 2.4E+03 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 40| +2.50E+02 | -9.1E-06 | +1.0E+00 | 4.9E-04 | 8.8E-03 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +1.48E+02 | -1.0E+00 | +6.6E-01 | 5.0E-01 | 3.8E+01 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 41| +2.50E+02 | -1.9E-05 | +1.0E+00 | 9.8E-04 | 8.3E-03 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +1.89E+02 | -1.2E+01 | +7.6E-02 | 4.6E-01 | 3.2E+01 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +2.50E+02 | -3.6E-03 | +6.1E-01 | 1.6E-02 | 6.4E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +2.04E+02 | +7.8E+03 | -4.7E+02 | 2.0E+00 | 5.1E+01 | 4.2E+00 | trr |0\n", + "2023-02-17 16:05:06 fides(INFO) 19| +2.50E+02 | -1.8E-05 | +5.8E-01 | 9.8E-04 | 4.9E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 42| +2.50E+02 | -3.8E-05 | +1.0E+00 | 2.0E-03 | 1.1E-02 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 26| +2.14E+02 | -3.5E-01 | +7.6E-01 | 3.1E-02 | 1.3E+01 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 43| +2.50E+02 | -7.6E-05 | +1.0E+00 | 3.9E-03 | 1.0E-02 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +1.48E+02 | +3.6E+01 | -1.4E+01 | 5.0E-01 | 2.5E+01 | 7.9E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 14| +1.72E+02 | -3.2E+01 | +8.5E-01 | 5.0E-01 | 5.1E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 10| +2.01E+02 | -1.5E+02 | +9.0E-01 | 2.0E+00 | 5.2E+02 | 1.8E+00 | trr |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +2.50E+02 | -3.2E-03 | +5.8E-01 | 1.6E-02 | 6.2E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +2.50E+02 | -1.7E-05 | +5.9E-01 | 9.8E-04 | 4.7E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 44| +2.50E+02 | -1.6E-04 | +1.0E+00 | 7.8E-03 | 1.4E-02 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 27| +2.13E+02 | -3.5E-01 | +6.8E-01 | 6.2E-02 | 8.4E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 45| +2.50E+02 | -3.3E-04 | +1.0E+00 | 1.6E-02 | 2.7E-02 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 15| +1.72E+02 | +4.5E+03 | -2.0E+02 | 1.0E+00 | 1.3E+02 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 28| +2.13E+02 | -2.6E-01 | +4.4E-01 | 6.2E-02 | 1.3E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +1.48E+02 | +4.0E-01 | -4.6E-01 | 1.2E-01 | 2.5E+01 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 46| +2.50E+02 | -7.3E-04 | +1.1E+00 | 3.1E-02 | 5.6E-02 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +2.50E+02 | -1.8E-05 | +6.2E-01 | 9.8E-04 | 4.6E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +2.50E+02 | -3.1E-03 | +5.7E-01 | 1.6E-02 | 6.4E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +1.68E+02 | -2.1E+01 | +9.8E-01 | 1.1E-01 | 2.5E+02 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 47| +2.50E+02 | -1.8E-03 | +1.2E+00 | 6.2E-02 | 1.1E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 16| +1.60E+02 | -1.3E+01 | +5.5E-01 | 2.4E-01 | 1.3E+02 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 29| +2.13E+02 | +1.7E-02 | -5.8E-02 | 6.2E-02 | 8.9E+00 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 23| +1.48E+02 | -2.2E-01 | +7.3E-01 | 3.1E-02 | 2.5E+01 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 48| +2.50E+02 | -6.0E-03 | +1.5E+00 | 1.2E-01 | 2.2E-01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 11| +2.01E+02 | +7.6E+02 | -3.3E+01 | 2.0E+00 | 1.3E+02 | 2.0E+00 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +2.50E+02 | -2.7E-03 | +5.5E-01 | 1.6E-02 | 6.1E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +2.50E+02 | -1.8E-05 | +6.2E-01 | 9.8E-04 | 4.4E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 49| +2.50E+02 | -3.3E-02 | +2.1E+00 | 2.5E-01 | 4.4E-01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 30| +2.13E+02 | -2.1E-01 | +8.2E-01 | 1.6E-02 | 8.9E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +1.53E+02 | -6.8E+00 | +9.6E-01 | 2.4E-01 | 1.9E+02 | 8.8E-02 | trr |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06.633 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.235 and h = 2.73909e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:06.633 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.235: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:06 fides(INFO) 50| +2.49E+02 | -5.0E-01 | +3.7E+00 | 5.0E-01 | 8.0E-01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 24| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 1.1E+01 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 23| +2.50E+02 | -1.8E-05 | +6.4E-01 | 9.8E-04 | 4.4E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 31| +2.13E+02 | -1.5E-01 | +7.0E-01 | 3.1E-02 | 6.6E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +2.50E+02 | -2.6E-03 | +5.4E-01 | 1.6E-02 | 6.2E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +1.50E+02 | -3.2E+00 | +7.8E-01 | 2.4E-01 | 5.5E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 12| +1.89E+02 | -1.2E+01 | +5.5E-01 | 3.2E-01 | 1.3E+02 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 51| +2.37E+02 | -1.2E+01 | +4.4E+00 | 1.0E+00 | 1.3E+00 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 32| +2.13E+02 | -1.4E-01 | +5.8E-01 | 3.1E-02 | 8.4E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 25| +1.48E+02 | -5.5E-02 | +9.5E-01 | 7.8E-03 | 1.1E+01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 24| +2.50E+02 | -1.8E-05 | +6.4E-01 | 9.8E-04 | 4.3E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +1.50E+02 | +5.4E+01 | -1.2E+01 | 4.7E-01 | 6.5E+01 | 7.7E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +1.59E+02 | -8.8E+00 | +8.0E-01 | 2.3E-01 | 4.5E+01 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +2.50E+02 | -2.3E-03 | +5.2E-01 | 1.6E-02 | 5.9E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 13| +1.82E+02 | -6.7E+00 | +9.3E-01 | 3.2E-01 | 1.2E+02 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 33| +2.12E+02 | -6.5E-02 | +3.0E-01 | 3.1E-02 | 6.3E+00 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 52| +2.28E+02 | -9.6E+00 | +5.7E-01 | 2.0E+00 | 3.1E+01 | 2.9E+00 | trr |1\n", + "2023-02-17 16:05:06 fides(INFO) 25| +2.50E+02 | -1.8E-05 | +6.5E-01 | 9.8E-04 | 4.3E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 26| +1.48E+02 | -4.0E-02 | +9.3E-01 | 1.6E-02 | 1.3E+01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +1.49E+02 | -3.2E-01 | +1.4E-01 | 1.2E-01 | 6.5E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 53| +2.28E+02 | +4.7E+03 | -1.9E+02 | 2.0E+00 | 4.1E+01 | 3.2E+00 | trr |0\n", + "2023-02-17 16:05:06 fides(INFO) 34| +2.12E+02 | -1.4E-01 | +5.3E-01 | 3.1E-02 | 8.8E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 14| +1.82E+02 | -8.6E-01 | -1.3E-01 | 6.4E-01 | 3.2E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 23| +2.50E+02 | -2.2E-03 | +5.2E-01 | 1.6E-02 | 6.0E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 26| +2.50E+02 | -1.8E-05 | +6.5E-01 | 9.8E-04 | 4.2E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 27| +1.48E+02 | -4.3E-02 | +9.2E-01 | 3.1E-02 | 7.4E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 35| +2.12E+02 | -4.9E-02 | +2.7E-01 | 3.1E-02 | 5.7E+00 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +1.49E+02 | -5.4E-01 | +9.3E-01 | 2.9E-02 | 3.9E+01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 27| +2.50E+02 | -1.8E-05 | +6.6E-01 | 9.8E-04 | 4.2E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 24| +2.50E+02 | -2.0E-03 | +4.9E-01 | 1.6E-02 | 5.7E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 54| +2.21E+02 | -6.9E+00 | +2.5E-01 | 3.2E-01 | 4.1E+01 | 8.2E-01 | trr |1\n", + "2023-02-17 16:05:06 fides(INFO) 15| +1.79E+02 | -2.9E+00 | +9.5E-01 | 1.6E-01 | 3.2E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 36| +2.12E+02 | -1.2E-01 | +5.0E-01 | 3.1E-02 | 8.1E+00 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 28| +1.48E+02 | -5.0E-02 | +9.3E-01 | 6.2E-02 | 8.9E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +1.48E+02 | -4.9E-01 | +6.7E-01 | 5.9E-02 | 3.5E+01 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 28| +2.50E+02 | -1.8E-05 | +6.6E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 25| +2.50E+02 | -1.9E-03 | +5.0E-01 | 1.6E-02 | 5.8E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 55| +2.14E+02 | -6.7E+00 | +8.1E-01 | 8.0E-02 | 7.1E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:06.818 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.0543 and h = 1.00881e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:06.818 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.0543: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:06 fides(INFO) 37| +2.12E+02 | -4.5E-02 | +2.6E-01 | 3.1E-02 | 5.3E+00 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 23| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.9E-02 | 2.9E+01 | 5.4E-02 | 2d |0\n", + "2023-02-17 16:05:06.820 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.802 and h = 3.01856e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:06.820 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.802: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:06 fides(INFO) 29| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 5.5E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 16| +1.76E+02 | -2.8E+00 | +1.0E+00 | 3.2E-01 | 5.7E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 21| +1.55E+02 | -4.4E+00 | +1.1E+00 | 4.6E-01 | 1.3E+02 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 29| +2.50E+02 | -1.9E-05 | +6.7E-01 | 9.8E-04 | 4.2E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 38| +2.12E+02 | -1.0E-01 | +4.8E-01 | 3.1E-02 | 7.4E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 56| +2.13E+02 | -1.4E+00 | +8.9E-01 | 1.6E-01 | 2.1E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 26| +2.50E+02 | -1.7E-03 | +4.7E-01 | 1.6E-02 | 5.5E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 30| +1.48E+02 | -3.0E-02 | +9.2E-01 | 3.1E-02 | 5.5E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 24| +1.48E+02 | -1.3E-01 | +9.5E-01 | 1.5E-02 | 2.9E+01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 17| +1.76E+02 | +5.8E+00 | -1.0E+00 | 6.4E-01 | 3.4E+01 | 9.5E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 39| +2.12E+02 | -4.6E-02 | +2.9E-01 | 3.1E-02 | 4.9E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 30| +2.50E+02 | -1.8E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 25| +1.48E+02 | -1.4E-01 | +9.7E-01 | 2.9E-02 | 2.0E+01 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 57| +2.13E+02 | -1.6E-01 | +8.3E-02 | 3.2E-01 | 9.5E+00 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 27| +2.50E+02 | -1.6E-03 | +4.7E-01 | 1.6E-02 | 5.6E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 31| +1.48E+02 | -4.1E-02 | +9.4E-01 | 6.2E-02 | 8.6E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 18| +1.72E+02 | -4.7E+00 | +1.0E+00 | 1.6E-01 | 3.4E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 40| +2.12E+02 | -9.2E-02 | +4.9E-01 | 3.1E-02 | 6.6E+00 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 31| +2.50E+02 | -1.9E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 26| +1.48E+02 | -1.3E-01 | +9.2E-01 | 5.9E-02 | 2.0E+01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 58| +2.12E+02 | -1.1E+00 | +9.4E-01 | 8.0E-02 | 1.6E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 32| +1.48E+02 | -6.2E-02 | +9.3E-01 | 1.2E-01 | 3.4E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 28| +2.50E+02 | -1.4E-03 | +4.4E-01 | 1.6E-02 | 5.3E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 19| +1.69E+02 | -3.0E+00 | +9.6E-01 | 3.2E-01 | 7.8E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 41| +2.12E+02 | -5.1E-02 | +3.6E-01 | 3.1E-02 | 4.5E+00 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 32| +2.50E+02 | -1.8E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 22| +1.55E+02 | -6.0E-02 | +2.0E-01 | 4.6E-01 | 1.6E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 59| +2.11E+02 | -8.6E-02 | +4.5E-01 | 1.6E-01 | 3.0E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 33| +1.48E+02 | -5.6E-02 | +5.5E-01 | 2.5E-01 | 7.0E+00 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 27| +1.48E+02 | -1.5E-01 | +8.3E-01 | 1.2E-01 | 1.2E+01 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 42| +2.12E+02 | -8.7E-02 | +5.3E-01 | 3.1E-02 | 5.9E+00 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:06.973 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.433 and h = 1.57281e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:06.973 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.433: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:06 fides(INFO) 29| +2.50E+02 | -1.3E-03 | +4.5E-01 | 1.6E-02 | 5.4E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:06 fides(INFO) 20| +1.69E+02 | +0.0E+00 | +0.0E+00 | 6.4E-01 | 3.8E+01 | 9.4E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 33| +2.50E+02 | -1.9E-05 | +6.8E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:06 fides(INFO) 34| +1.48E+02 | +1.4E-01 | -7.5E-01 | 2.5E-01 | 3.6E+00 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:06 fides(INFO) 43| +2.12E+02 | -6.0E-02 | +4.7E-01 | 3.1E-02 | 4.0E+00 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 60| +2.11E+02 | -4.1E-01 | +1.6E+00 | 1.6E-01 | 4.8E+00 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 28| +1.48E+02 | +1.2E+00 | -3.6E+00 | 2.4E-01 | 1.1E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 21| +1.64E+02 | -4.6E+00 | +8.6E-01 | 1.6E-01 | 3.8E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 30| +2.50E+02 | -1.2E-03 | +4.2E-01 | 1.6E-02 | 5.1E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 34| +2.50E+02 | -1.9E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 44| +2.12E+02 | -8.8E-02 | +6.1E-01 | 3.1E-02 | 5.1E+00 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 35| +1.48E+02 | -5.7E-03 | +4.7E-02 | 6.2E-02 | 3.6E+00 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 22| +1.62E+02 | -2.0E+00 | +9.1E-01 | 3.2E-01 | 9.0E+01 | 8.9E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 29| +1.48E+02 | -2.4E-02 | +2.0E-01 | 5.9E-02 | 1.1E+01 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 61| +2.10E+02 | -1.3E+00 | +1.6E+00 | 3.2E-01 | 4.7E+00 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 31| +2.50E+02 | -1.1E-03 | +4.2E-01 | 1.6E-02 | 5.2E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 35| +2.50E+02 | -2.6E-05 | +1.0E+00 | 9.8E-04 | 4.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 45| +2.12E+02 | -7.4E-02 | +6.0E-01 | 3.1E-02 | 3.6E+00 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 36| +1.48E+02 | -3.6E-02 | +9.2E-01 | 1.6E-02 | 1.2E+01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 30| +1.48E+02 | -5.9E-02 | +6.2E-01 | 1.5E-02 | 7.1E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 23| +1.62E+02 | +6.4E+01 | -1.0E+01 | 6.4E-01 | 2.8E+01 | 7.8E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 62| +2.10E+02 | +3.8E+01 | -2.7E+01 | 6.4E-01 | 8.3E+00 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 46| +2.11E+02 | -9.7E-02 | +7.2E-01 | 3.1E-02 | 4.4E+00 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 36| +2.50E+02 | -4.4E-05 | +1.0E+00 | 2.0E-03 | 1.3E-02 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 32| +2.50E+02 | -9.9E-04 | +3.9E-01 | 1.6E-02 | 5.0E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 23| +1.55E+02 | -1.6E-01 | +9.6E-01 | 1.1E-01 | 3.5E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 37| +1.48E+02 | -1.9E-02 | +6.6E-01 | 3.1E-02 | 2.4E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 31| +1.48E+02 | -2.2E-02 | +9.5E-01 | 1.5E-02 | 1.2E+01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 47| +2.11E+02 | -9.3E-02 | +7.4E-01 | 3.1E-02 | 3.2E+00 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 24| +1.60E+02 | -1.6E+00 | +4.6E-01 | 1.6E-01 | 2.8E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 37| +2.50E+02 | -5.0E-05 | +5.4E-01 | 3.9E-03 | 3.3E-02 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 38| +1.48E+02 | -6.6E-03 | +9.5E-01 | 3.1E-02 | 2.7E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 63| +2.10E+02 | -1.7E-02 | -1.9E-02 | 1.6E-01 | 8.3E+00 | 4.2E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 48| +2.11E+02 | -1.2E-01 | +8.2E-01 | 3.1E-02 | 3.8E+00 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 33| +2.50E+02 | -9.9E-05 | +5.5E-02 | 1.6E-02 | 5.1E-01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 32| +1.48E+02 | -1.0E-02 | +8.3E-01 | 2.9E-02 | 1.9E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 25| +1.59E+02 | -8.2E-01 | +9.2E-01 | 1.6E-01 | 7.7E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 49| +2.11E+02 | -2.5E-01 | +9.9E-01 | 6.2E-02 | 2.9E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 38| +2.50E+02 | -1.4E-04 | +1.0E+00 | 3.9E-03 | 1.3E-01 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 39| +1.48E+02 | -9.5E-03 | +9.5E-01 | 6.2E-02 | 9.8E-01 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 64| +2.09E+02 | -2.9E-01 | +1.1E+00 | 4.0E-02 | 8.3E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 33| +1.48E+02 | -1.6E-02 | +9.3E-01 | 5.9E-02 | 3.7E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 26| +1.59E+02 | +1.4E+00 | -9.1E-01 | 3.2E-01 | 1.4E+01 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 34| +2.50E+02 | -1.6E-03 | +5.5E-01 | 3.9E-03 | 7.6E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 39| +2.50E+02 | -1.9E-04 | +1.0E+00 | 7.8E-03 | 3.9E-02 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 50| +2.10E+02 | -8.2E-01 | +1.3E+00 | 1.2E-01 | 4.2E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 40| +1.48E+02 | -1.5E-02 | +9.6E-01 | 1.2E-01 | 1.4E+00 | 9.6E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 65| +2.09E+02 | -2.2E-03 | -4.0E-03 | 8.0E-02 | 2.7E+00 | 2.1E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 34| +1.48E+02 | -8.3E-03 | +3.8E-01 | 1.2E-01 | 1.5E+00 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 40| +2.50E+02 | -4.0E-04 | +1.0E+00 | 1.6E-02 | 3.2E-02 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 51| +2.06E+02 | -4.2E+00 | +1.9E+00 | 2.5E-01 | 5.5E+00 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 27| +1.59E+02 | -2.9E-01 | +3.6E-01 | 8.0E-02 | 1.4E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 35| +2.50E+02 | -5.5E-04 | +1.0E+00 | 3.9E-03 | 3.4E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 24| +1.55E+02 | -5.3E-02 | +8.6E-01 | 2.3E-01 | 9.3E+00 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 41| +1.48E+02 | -1.7E-02 | +8.2E-01 | 2.5E-01 | 7.1E-01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 66| +2.09E+02 | -6.0E-02 | +9.2E-01 | 2.0E-02 | 2.7E+00 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 35| +1.48E+02 | +1.5E-01 | -2.0E+00 | 1.2E-01 | 2.4E+00 | 8.4E-02 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 28| +1.59E+02 | -2.9E-01 | +9.1E-01 | 8.0E-02 | 4.7E+01 | 1.3E-01 | trr |1\n", + "2023-02-17 16:05:07 fides(INFO) 41| +2.50E+02 | -9.0E-04 | +1.1E+00 | 3.1E-02 | 7.0E-02 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 42| +1.48E+02 | +1.8E-01 | -6.0E+00 | 5.0E-01 | 1.3E+00 | 2.7E-01 | trr |0\n", + "2023-02-17 16:05:07 fides(INFO) 52| +1.82E+02 | -2.4E+01 | +1.6E+00 | 5.0E-01 | 1.7E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 36| +2.50E+02 | -4.2E-04 | +9.5E-01 | 7.8E-03 | 3.5E-02 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 36| +1.48E+02 | -7.1E-03 | +2.8E-01 | 2.9E-02 | 2.4E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 42| +2.50E+02 | -2.3E-03 | +1.2E+00 | 6.2E-02 | 1.4E-01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 29| +1.59E+02 | -5.4E-02 | +6.6E-01 | 8.0E-02 | 7.8E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:07.368 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.2556 and h = 1.10609e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:07.368 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.2556: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:07 fides(INFO) 43| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 1.3E+00 | 6.7E-02 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 67| +2.09E+02 | +1.3E-02 | -3.3E-01 | 4.0E-02 | 8.9E-01 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 53| +1.82E+02 | +4.1E+01 | -3.7E+00 | 1.0E+00 | 4.0E+01 | 2.1E+00 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 37| +2.50E+02 | -7.0E-04 | +7.1E-01 | 1.6E-02 | 1.1E-01 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 37| +1.48E+02 | -5.7E-03 | +5.0E-01 | 2.9E-02 | 4.8E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 30| +1.59E+02 | -1.4E-02 | +6.0E-01 | 8.0E-02 | 6.5E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 43| +2.50E+02 | -8.0E-03 | +1.6E+00 | 1.2E-01 | 2.9E-01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 25| +1.55E+02 | -5.3E-02 | +1.1E+00 | 4.6E-01 | 1.1E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 44| +1.48E+02 | -2.9E-03 | +7.2E-01 | 3.1E-02 | 1.3E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 54| +1.75E+02 | -7.0E+00 | +3.9E-01 | 2.5E-01 | 4.0E+01 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 68| +2.09E+02 | -1.2E-02 | +8.8E-01 | 1.0E-02 | 8.9E-01 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 38| +1.48E+02 | -1.7E-03 | +3.0E-01 | 2.9E-02 | 1.1E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 38| +2.50E+02 | -9.7E-04 | +1.0E+00 | 1.6E-02 | 2.7E-01 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 31| +1.59E+02 | -2.1E-03 | +1.1E-01 | 8.0E-02 | 4.2E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 44| +2.50E+02 | -5.1E-02 | +2.4E+00 | 2.5E-01 | 5.9E-01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 45| +1.48E+02 | -1.6E-03 | +9.8E-01 | 3.1E-02 | 1.4E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 55| +1.65E+02 | -9.7E+00 | +1.1E+00 | 2.5E-01 | 9.5E+01 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 39| +1.48E+02 | -2.7E-03 | +3.8E-01 | 2.9E-02 | 3.2E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 26| +1.55E+02 | +2.1E+01 | -4.1E+02 | 9.1E-01 | 5.1E+00 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 45| +2.49E+02 | -1.0E+00 | +4.7E+00 | 5.0E-01 | 1.3E+00 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 32| +1.59E+02 | -7.8E-03 | +7.2E-01 | 2.0E-02 | 4.0E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 39| +2.50E+02 | -1.3E-03 | +1.0E+00 | 3.1E-02 | 4.4E-02 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 69| +2.09E+02 | -7.3E-03 | +9.6E-01 | 2.0E-02 | 6.9E-01 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 46| +1.48E+02 | -2.4E-03 | +9.7E-01 | 6.2E-02 | 4.0E-01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 40| +1.48E+02 | +4.8E-04 | -1.0E-01 | 2.9E-02 | 8.6E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 56| +1.51E+02 | -1.4E+01 | +1.1E+00 | 5.0E-01 | 5.4E+01 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 33| +1.59E+02 | -2.3E-03 | +8.5E-01 | 2.0E-02 | 2.5E+00 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 70| +2.09E+02 | +9.4E-03 | -7.8E-01 | 4.0E-02 | 4.6E-01 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 47| +1.48E+02 | -3.0E-03 | +8.2E-01 | 1.2E-01 | 7.2E-01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 40| +2.50E+02 | -1.9E-03 | +9.5E-01 | 6.2E-02 | 4.8E-02 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 41| +1.48E+02 | -8.9E-04 | +4.3E-01 | 7.4E-03 | 8.6E-01 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 57| +1.51E+02 | +6.8E+00 | -1.5E+00 | 1.0E+00 | 6.2E+01 | 1.0E+00 | trr |0\n", + "2023-02-17 16:05:07 fides(INFO) 27| +1.55E+02 | -5.3E-02 | +1.4E+00 | 2.3E-01 | 5.1E+00 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 34| +1.59E+02 | -1.0E-03 | +7.6E-01 | 4.0E-02 | 1.4E+00 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 48| +1.48E+02 | +1.4E-02 | -2.2E+00 | 2.5E-01 | 5.3E-01 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 71| +2.09E+02 | -1.4E-03 | +3.6E-01 | 1.0E-02 | 4.6E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 41| +2.50E+02 | -2.2E-03 | +1.1E+00 | 1.2E-01 | 1.9E-01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 42| +1.48E+02 | -1.1E-03 | +9.4E-01 | 7.4E-03 | 2.7E+00 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 58| +1.49E+02 | -2.4E+00 | +9.7E-01 | 1.5E-01 | 6.2E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 35| +1.59E+02 | -7.6E-04 | +5.0E-01 | 8.0E-02 | 1.5E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 59| +1.49E+02 | +1.9E+00 | -1.2E+00 | 3.1E-01 | 1.5E+01 | 4.2E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 46| +2.30E+02 | -1.9E+01 | +3.6E+00 | 1.0E+00 | 6.0E+00 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 28| +1.55E+02 | +9.0E-01 | -9.7E+00 | 4.6E-01 | 8.2E+00 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 49| +1.48E+02 | -5.8E-04 | +2.4E-01 | 6.2E-02 | 5.3E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 43| +1.48E+02 | -5.3E-04 | +9.8E-01 | 1.5E-02 | 3.1E-01 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 36| +1.59E+02 | +3.0E-03 | -1.1E+00 | 8.0E-02 | 9.1E-01 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 72| +2.09E+02 | -3.3E-03 | +1.0E+00 | 1.0E-02 | 6.9E-01 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 42| +2.50E+02 | -8.4E-04 | +1.4E+00 | 2.5E-01 | 1.8E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 50| +1.48E+02 | -1.0E-03 | +7.4E-01 | 1.6E-02 | 1.3E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 44| +1.48E+02 | -7.2E-04 | +9.3E-01 | 2.9E-02 | 7.2E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 60| +1.48E+02 | -4.6E-01 | +4.5E-01 | 7.7E-02 | 1.5E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 43| +2.50E+02 | -3.8E-04 | +1.3E+00 | 2.5E-01 | 4.7E-02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 37| +1.59E+02 | -5.2E-04 | +5.3E-01 | 2.0E-02 | 9.1E-01 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 73| +2.09E+02 | -3.0E-03 | +6.9E-01 | 2.0E-02 | 2.2E-01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 51| +1.48E+02 | -2.7E-04 | +8.9E-01 | 1.6E-02 | 2.4E-01 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 45| +1.48E+02 | -7.6E-04 | +7.2E-01 | 5.9E-02 | 2.6E-01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 29| +1.55E+02 | -6.0E-02 | +1.2E+00 | 1.1E-01 | 8.2E+00 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 61| +1.48E+02 | -2.5E-01 | +4.8E-01 | 7.7E-02 | 4.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 44| +2.50E+02 | -2.1E-04 | +1.2E+00 | 2.5E-01 | 8.0E-02 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 38| +1.59E+02 | -1.2E-04 | +8.9E-01 | 2.0E-02 | 7.5E-01 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 46| +1.48E+02 | +3.8E-03 | -1.7E+00 | 5.9E-02 | 5.2E-01 | 4.3E-02 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 74| +2.09E+02 | -6.2E-03 | +1.2E+00 | 2.0E-02 | 6.9E-01 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 52| +1.48E+02 | -3.5E-04 | +9.2E-01 | 3.1E-02 | 1.1E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 47| +2.24E+02 | -6.0E+00 | +5.9E-01 | 2.0E+00 | 5.6E+01 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 62| +1.48E+02 | +6.5E-02 | -1.4E-01 | 7.7E-02 | 1.1E+01 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 39| +1.59E+02 | -8.4E-05 | +7.5E-01 | 4.0E-02 | 3.7E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 45| +2.50E+02 | -8.4E-05 | +1.4E+00 | 2.5E-01 | 5.6E-02 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 47| +1.48E+02 | -2.8E-04 | +4.1E-01 | 1.5E-02 | 5.2E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 53| +1.48E+02 | -5.6E-04 | +9.9E-01 | 6.2E-02 | 3.4E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 63| +1.48E+02 | -1.3E-01 | +7.3E-01 | 1.9E-02 | 1.1E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 75| +2.09E+02 | -1.1E-02 | +1.0E+00 | 4.0E-02 | 2.8E-01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 30| +1.54E+02 | -9.4E-02 | +5.4E-01 | 2.3E-01 | 4.2E+00 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 46| +2.50E+02 | -4.5E-05 | +1.4E+00 | 2.5E-01 | 1.1E-02 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 48| +1.48E+02 | -1.2E-04 | +4.9E-01 | 1.5E-02 | 2.5E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 40| +1.59E+02 | +1.3E-04 | -9.4E-01 | 8.0E-02 | 3.1E-01 | 6.6E-03 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 54| +1.48E+02 | -6.1E-04 | +9.0E-01 | 1.2E-01 | 1.0E-01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 64| +1.48E+02 | -4.6E-02 | +9.2E-01 | 1.9E-02 | 1.4E+01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 76| +2.09E+02 | -2.8E-02 | +1.2E+00 | 8.0E-02 | 4.1E-01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 41| +1.59E+02 | -3.6E-05 | +6.4E-01 | 2.0E-02 | 3.1E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 31| +1.54E+02 | -8.5E-02 | +1.3E-01 | 2.3E-01 | 2.8E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 49| +1.48E+02 | -9.6E-05 | +5.4E-01 | 1.5E-02 | 3.0E-01 | 7.1E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 47| +2.50E+02 | -2.1E-05 | +1.4E+00 | 2.5E-01 | 5.0E-03 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 55| +1.48E+02 | +2.3E-03 | -4.7E+00 | 2.5E-01 | 2.3E-01 | 5.3E-02 | trr |0\n", + "2023-02-17 16:05:07 fides(INFO) 65| +1.48E+02 | -3.8E-02 | +9.3E-01 | 3.8E-02 | 5.5E+00 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 77| +2.09E+02 | -9.8E-02 | +1.6E+00 | 1.6E-01 | 8.6E-01 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 42| +1.59E+02 | -2.2E-05 | +6.9E-01 | 2.0E-02 | 2.2E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 50| +1.48E+02 | -4.4E-05 | +3.1E-01 | 1.5E-02 | 1.5E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 48| +2.50E+02 | -1.0E-05 | +1.4E+00 | 2.5E-01 | 2.5E-03 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 56| +1.48E+02 | -3.8E-05 | +1.7E-01 | 5.7E-02 | 2.3E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 78| +2.08E+02 | -7.3E-01 | +2.7E+00 | 3.2E-01 | 1.7E+00 | 8.5E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 66| +1.48E+02 | -5.2E-02 | +8.7E-01 | 7.7E-02 | 5.7E+00 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 43| +1.59E+02 | -9.7E-06 | +4.7E-01 | 2.0E-02 | 1.7E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:07.915 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.426 and h = 1.34871e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:07.915 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.426: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:07 fides(INFO) 32| +1.54E+02 | -1.2E-01 | +9.6E-01 | 5.7E-02 | 2.8E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 51| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.5E-02 | 4.5E-01 | 7.8E-03 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 49| +2.50E+02 | -4.6E-06 | +1.4E+00 | 2.5E-01 | 2.9E-04 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 79| +2.05E+02 | -3.5E+00 | +9.6E-01 | 6.4E-01 | 3.7E+00 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 67| +1.48E+02 | +1.3E-01 | -2.0E+00 | 1.5E-01 | 2.4E+00 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:07 fides(INFO) 57| +1.48E+02 | -1.2E-04 | +4.9E-01 | 1.4E-02 | 1.8E-01 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 44| +1.59E+02 | -6.2E-06 | +3.7E-01 | 2.0E-02 | 1.3E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 52| +1.48E+02 | -6.5E-05 | +8.6E-01 | 3.7E-03 | 4.5E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 50| +2.50E+02 | -2.0E-06 | +1.4E+00 | 2.5E-01 | 2.6E-04 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(WARNING) Stopping as function difference 2.03E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:07 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:07 fides(INFO) 80| +2.02E+02 | -2.6E+00 | +6.2E-01 | 1.3E+00 | 4.4E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 68| +1.48E+02 | -8.2E-03 | +3.9E-01 | 3.8E-02 | 2.4E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 58| +1.48E+02 | -2.3E-05 | +9.1E-01 | 1.4E-02 | 1.8E-01 | 2.9E-03 | 2d |1\n", + "2023-02-17 16:05:07 fides(INFO) 45| +1.59E+02 | +7.7E-08 | -4.1E-03 | 2.0E-02 | 1.1E-01 | 1.1E-03 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 33| +1.54E+02 | -4.6E-02 | +8.8E-01 | 1.1E-01 | 1.0E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 48| +2.24E+02 | +2.3E+02 | -8.9E+00 | 2.0E+00 | 5.0E+01 | 1.9E+00 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 53| +1.48E+02 | -3.0E-05 | +7.3E-01 | 7.4E-03 | 6.1E-02 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 69| +1.48E+02 | +2.3E-02 | -5.4E-01 | 3.8E-02 | 2.7E+00 | 3.7E-02 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 59| +1.48E+02 | -2.8E-05 | +8.9E-01 | 2.8E-02 | 5.1E-02 | 6.1E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 81| +2.02E+02 | +6.9E+01 | -1.0E+01 | 1.3E+00 | 2.2E+01 | 3.0E+00 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) 46| +1.59E+02 | -3.8E-06 | +5.6E-01 | 5.0E-03 | 1.1E-01 | 2.9E-04 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 54| +1.48E+02 | -2.2E-05 | +1.0E+00 | 7.4E-03 | 5.7E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 70| +1.48E+02 | -6.9E-03 | +3.8E-01 | 9.6E-03 | 2.7E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 60| +1.48E+02 | -3.5E-05 | +8.4E-01 | 5.7E-02 | 6.1E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 55| +1.48E+02 | -3.6E-05 | +1.0E+00 | 1.5E-02 | 7.9E-02 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 47| +1.59E+02 | -4.3E-07 | +2.7E-01 | 5.0E-03 | 7.0E-02 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:08 fides(WARNING) Stopping as function difference 4.32E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:08 fides(INFO) 82| +1.96E+02 | -6.6E+00 | +1.8E+00 | 2.7E-01 | 2.2E+01 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 34| +1.54E+02 | -4.9E-02 | +8.7E-01 | 2.3E-01 | 1.1E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 61| +1.48E+02 | +5.0E-04 | -5.9E+00 | 1.1E-01 | 3.8E-02 | 2.3E-02 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 0| +2.03E+13 | NaN | NaN | 1.0E+00 | 6.9E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:08 fides(INFO) 71| +1.48E+02 | -6.8E-03 | +8.7E-01 | 9.6E-03 | 6.0E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 56| +1.48E+02 | -4.2E-05 | +8.9E-01 | 2.9E-02 | 4.2E-02 | 6.0E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 1| +1.32E+10 | -2.0E+13 | +1.1E-01 | 1.0E+00 | 6.9E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 83| +1.96E+02 | +5.1E+00 | -6.2E-01 | 5.3E-01 | 2.9E+01 | 1.5E+00 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) 62| +1.48E+02 | +3.7E-06 | -1.1E-01 | 2.8E-02 | 3.8E-02 | 5.8E-03 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 72| +1.48E+02 | -3.8E-03 | +8.6E-01 | 1.9E-02 | 6.6E-01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 57| +1.48E+02 | -2.8E-05 | +8.4E-01 | 5.9E-02 | 5.8E-02 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 84| +1.89E+02 | -6.6E+00 | +1.5E+00 | 1.3E-01 | 2.9E+01 | 3.6E-01 | trr |1\n", + "2023-02-17 16:05:08 fides(INFO) 49| +2.01E+02 | -2.3E+01 | +1.1E+00 | 2.3E-01 | 5.0E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 63| +1.48E+02 | -8.8E-06 | +9.8E-01 | 7.1E-03 | 3.8E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 2| +2.14E+09 | -1.1E+10 | +8.8E-01 | 2.5E-01 | 6.1E+10 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 35| +1.54E+02 | -2.3E-02 | +7.8E-01 | 4.6E-01 | 4.4E+00 | 7.8E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 73| +1.48E+02 | -6.8E-03 | +8.8E-01 | 3.8E-02 | 6.9E-01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 58| +1.48E+02 | +4.4E-04 | -1.3E+01 | 1.2E-01 | 3.7E-02 | 7.8E-03 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) 64| +1.48E+02 | -3.3E-06 | +6.2E-01 | 1.4E-02 | 3.8E-02 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 85| +1.82E+02 | -7.5E+00 | +7.6E-01 | 2.7E-01 | 3.2E+01 | 7.2E-01 | trr |1\n", + "2023-02-17 16:05:08 fides(INFO) 3| +3.18E+08 | -1.8E+09 | +8.9E-01 | 5.0E-01 | 9.3E+09 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 74| +1.48E+02 | +3.8E-03 | -4.3E-01 | 7.7E-02 | 7.3E-01 | 8.7E-02 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 36| +1.54E+02 | -1.3E-02 | +9.2E-01 | 9.1E-01 | 4.6E+00 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 0| +3.89E+02 | NaN | NaN | 1.0E+00 | 6.4E+01 | NaN | NaN |1\n", + "2023-02-17 16:05:08 fides(INFO) 59| +1.48E+02 | +1.6E-05 | -1.0E+00 | 9.9E-03 | 3.7E-02 | 2.0E-03 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 65| +1.48E+02 | -4.5E-06 | +1.1E+00 | 1.4E-02 | 2.3E-02 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 4| +4.57E+07 | -2.7E+08 | +9.0E-01 | 5.0E-01 | 1.4E+09 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 75| +1.48E+02 | -2.0E-03 | +7.1E-01 | 1.9E-02 | 7.3E-01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 37| +1.54E+02 | +6.1E-02 | -6.0E+00 | 1.8E+00 | 5.8E-01 | 7.5E-01 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 60| +1.48E+02 | -1.4E-06 | +3.2E-01 | 2.5E-03 | 3.7E-02 | 4.9E-04 | 2d |1\n", + "2023-02-17 16:05:08 fides(WARNING) Stopping as function difference 1.44E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:08 fides(INFO) 86| +1.82E+02 | +1.8E+02 | -8.8E+00 | 5.3E-01 | 4.6E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 1| +2.62E+02 | -1.3E+02 | +6.5E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 5| +6.32E+06 | -3.9E+07 | +9.0E-01 | 5.0E-01 | 2.0E+08 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 76| +1.48E+02 | +7.0E-04 | -1.9E-01 | 1.9E-02 | 4.9E-01 | 1.7E-02 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 66| +1.48E+02 | -7.6E-06 | +1.3E+00 | 2.8E-02 | 3.3E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 2| +2.38E+02 | -2.4E+01 | +6.8E-01 | 1.0E+00 | 8.7E+01 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 38| +1.54E+02 | -2.1E-03 | +5.7E-01 | 2.0E-01 | 5.8E-01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 6| +9.04E+05 | -5.4E+06 | +9.0E-01 | 5.0E-01 | 2.9E+07 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 67| +1.48E+02 | +3.6E-06 | -4.7E-01 | 5.7E-02 | 1.7E-02 | 6.1E-03 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 77| +1.48E+02 | +4.7E-04 | -2.3E-01 | 4.8E-03 | 4.9E-01 | 7.5E-03 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 87| +1.73E+02 | -8.4E+00 | +7.9E-01 | 1.3E-01 | 4.6E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 3| +2.38E+02 | -1.7E+01 | -3.4E-01 | 1.0E+00 | 5.5E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 7| +1.32E+05 | -7.7E+05 | +8.9E-01 | 5.0E-01 | 4.4E+06 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 78| +1.48E+02 | -5.8E-04 | +5.9E-01 | 1.2E-03 | 4.9E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 68| +1.48E+02 | -2.4E-08 | +8.8E-03 | 1.4E-02 | 1.7E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 39| +1.54E+02 | -5.8E-04 | +8.9E-01 | 2.0E-01 | 5.2E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 88| +1.66E+02 | -7.4E+00 | +7.2E-01 | 2.7E-01 | 2.7E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 69| +1.48E+02 | +4.0E-07 | -4.9E-01 | 3.5E-03 | 3.4E-02 | 4.3E-04 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 4| +2.19E+02 | -1.9E+01 | +9.9E-01 | 2.5E-01 | 5.5E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 8| +1.97E+04 | -1.1E+05 | +8.9E-01 | 5.0E-01 | 6.9E+05 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 50| +2.01E+02 | +1.3E+02 | -4.8E+00 | 4.5E-01 | 5.6E+01 | 9.4E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 40| +1.54E+02 | -8.3E-04 | +1.0E+00 | 3.9E-01 | 2.3E-01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 79| +1.48E+02 | -2.7E-04 | +9.7E-01 | 1.2E-03 | 1.1E+00 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 0| +1.94E+12 | NaN | NaN | 1.0E+00 | 8.9E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:08 fides(INFO) 89| +1.66E+02 | +8.5E+01 | -5.9E+00 | 2.7E-01 | 5.0E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 5| +2.19E+02 | +1.6E+02 | -7.7E+00 | 5.0E-01 | 4.4E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 70| +1.48E+02 | -4.4E-06 | +1.4E+01 | 8.9E-04 | 3.4E-02 | 1.1E-04 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 80| +1.48E+02 | -2.5E-04 | +9.9E-01 | 2.4E-03 | 2.0E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 9| +3.04E+03 | -1.7E+04 | +8.9E-01 | 5.0E-01 | 1.1E+05 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 41| +1.54E+02 | +1.7E-03 | -1.6E+00 | 7.9E-01 | 3.7E-01 | 2.5E-01 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 90| +1.66E+02 | +5.9E+00 | -1.0E+00 | 6.7E-02 | 5.0E+01 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 6| +2.09E+02 | -1.0E+01 | +9.3E-01 | 1.2E-01 | 4.4E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 81| +1.48E+02 | -4.5E-04 | +9.7E-01 | 4.8E-03 | 2.9E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 1| +2.04E+06 | -1.9E+12 | +8.7E-02 | 1.0E+00 | 8.9E+12 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 71| +1.48E+02 | +4.6E-06 | -1.4E+01 | 1.8E-03 | 8.1E-03 | 2.1E-04 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 10| +5.75E+02 | -2.5E+03 | +8.8E-01 | 5.0E-01 | 1.7E+04 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 7| +2.06E+02 | -2.8E+00 | +2.6E-01 | 2.5E-01 | 3.2E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 82| +1.48E+02 | -8.1E-04 | +9.6E-01 | 9.6E-03 | 2.3E-01 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 2| +3.17E+05 | -1.7E+06 | +9.0E-01 | 2.5E-01 | 9.4E+06 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 42| +1.54E+02 | -3.0E-04 | +6.2E-01 | 1.2E-01 | 3.7E-01 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 72| +1.48E+02 | +5.3E-06 | -4.8E+01 | 4.4E-04 | 8.1E-03 | 5.4E-05 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 91| +1.65E+02 | -1.1E+00 | +5.7E-01 | 1.7E-02 | 5.0E+01 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 11| +2.11E+02 | -3.6E+02 | +8.6E-01 | 5.0E-01 | 2.9E+03 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 8| +1.96E+02 | -1.0E+01 | +9.7E-01 | 2.5E-01 | 7.1E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 3| +4.97E+04 | -2.7E+05 | +9.0E-01 | 5.0E-01 | 1.5E+06 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 43| +1.54E+02 | -2.9E-04 | +8.4E-01 | 1.2E-01 | 1.3E-01 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 83| +1.48E+02 | -1.4E-03 | +9.8E-01 | 1.9E-02 | 3.5E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 73| +1.48E+02 | +2.9E-06 | -5.4E+01 | 1.1E-04 | 8.1E-03 | 1.6E-05 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 12| +1.67E+02 | -4.4E+01 | +6.4E-01 | 1.0E+00 | 5.1E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 4| +8.02E+03 | -4.2E+04 | +9.0E-01 | 1.0E+00 | 2.3E+05 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 51| +1.95E+02 | -6.1E+00 | +6.2E-01 | 1.1E-01 | 5.6E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 9| +1.84E+02 | -1.1E+01 | +1.1E+00 | 5.0E-01 | 4.1E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 92| +1.64E+02 | -7.7E-01 | +9.9E-01 | 1.7E-02 | 3.9E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 74| +1.48E+02 | +3.8E-06 | -9.6E+01 | 2.8E-05 | 8.1E-03 | 9.6E-06 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 84| +1.48E+02 | -1.8E-03 | +9.3E-01 | 3.8E-02 | 2.1E-01 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 44| +1.54E+02 | -1.1E-04 | +2.8E-01 | 2.4E-01 | 5.9E-01 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 5| +1.46E+03 | -6.6E+03 | +9.0E-01 | 1.0E+00 | 3.6E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 10| +1.76E+02 | -8.0E+00 | +3.6E-01 | 1.0E+00 | 2.6E+01 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 13| +1.50E+02 | -1.6E+01 | +9.1E-01 | 1.0E+00 | 2.6E+02 | 2.7E+00 | trr |1\n", + "2023-02-17 16:05:08 fides(INFO) 75| +1.48E+02 | +5.2E-06 | -1.4E+02 | 6.9E-06 | 8.1E-03 | 8.9E-06 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 85| +1.48E+02 | +6.0E-04 | -4.5E-01 | 7.7E-02 | 3.3E-01 | 4.5E-02 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) 93| +1.63E+02 | -1.2E+00 | +9.0E-01 | 3.3E-02 | 3.3E+01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 6| +4.22E+02 | -1.0E+03 | +9.0E-01 | 1.0E+00 | 5.7E+03 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 45| +1.54E+02 | +7.4E-03 | -4.7E+00 | 2.4E-01 | 1.0E-01 | 7.6E-02 | trr |0\n", + "2023-02-17 16:05:08 fides(INFO) 14| +1.49E+02 | -1.1E+00 | +2.7E-01 | 1.0E+00 | 9.6E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 86| +1.48E+02 | -4.6E-04 | +7.7E-01 | 1.8E-02 | 3.3E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 7| +2.66E+02 | -1.6E+02 | +8.9E-01 | 2.0E+00 | 9.1E+02 | 4.8E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 11| +1.72E+02 | -4.6E+00 | +7.7E-01 | 1.0E+00 | 6.3E+01 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 46| +1.54E+02 | -2.6E-04 | +4.0E-01 | 5.1E-02 | 1.0E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 76| +1.48E+02 | +5.5E-06 | -2.1E+02 | 1.7E-06 | 8.1E-03 | 4.5E-06 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 15| +1.49E+02 | +1.4E+02 | -2.4E+01 | 1.0E+00 | 6.2E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 8| +2.37E+02 | -2.8E+01 | +1.0E+00 | 4.0E+00 | 1.3E+02 | 4.8E+00 | trr |1\n", + "2023-02-17 16:05:08 fides(INFO) 94| +1.62E+02 | -1.2E+00 | +8.0E-01 | 6.7E-02 | 3.7E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 87| +1.48E+02 | +1.7E-03 | -1.5E+00 | 3.6E-02 | 1.5E-01 | 3.7E-02 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 52| +1.93E+02 | -1.5E+00 | +8.0E-01 | 1.1E-01 | 2.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 16| +1.49E+02 | -4.9E-01 | +1.1E-01 | 2.5E-01 | 6.2E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 12| +1.71E+02 | -4.6E-01 | +7.5E-01 | 2.0E+00 | 1.8E+01 | 2.8E+00 | trr |1\n", + "2023-02-17 16:05:08 fides(INFO) 77| +1.48E+02 | +1.5E-06 | -1.9E+02 | 4.3E-07 | 8.1E-03 | 1.1E-06 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 9| +2.37E+02 | +2.0E+02 | -1.2E+01 | 4.0E+00 | 3.2E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 47| +1.54E+02 | -9.5E-05 | +4.3E-01 | 5.1E-02 | 4.2E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 88| +1.48E+02 | -1.6E-04 | +4.8E-01 | 9.0E-03 | 1.5E-01 | 9.1E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 95| +1.62E+02 | +4.1E-01 | -4.3E-01 | 1.3E-01 | 2.2E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 10| +2.37E+02 | +3.3E+01 | -3.9E+00 | 1.0E+00 | 3.2E+01 | 2.9E+00 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 78| +1.48E+02 | +4.2E-06 | -2.0E+03 | 1.1E-07 | 8.1E-03 | 2.8E-07 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 89| +1.48E+02 | -1.0E-04 | +3.4E-01 | 9.0E-03 | 2.2E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 17| +1.48E+02 | -5.8E-01 | +9.5E-01 | 6.2E-02 | 6.4E+01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 13| +1.71E+02 | -1.2E-02 | +9.5E-02 | 2.0E+00 | 7.1E+00 | 3.1E-01 | trr |1\n", + "2023-02-17 16:05:08 fides(INFO) 11| +2.37E+02 | +9.4E+00 | -9.6E-01 | 2.5E-01 | 3.2E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 48| +1.54E+02 | -4.6E-05 | +3.6E-01 | 5.1E-02 | 7.2E-02 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 96| +1.61E+02 | -5.5E-01 | +1.0E+00 | 3.3E-02 | 2.2E+01 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 12| +2.34E+02 | -3.9E+00 | +8.6E-01 | 6.2E-02 | 3.2E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 79| +1.48E+02 | +2.5E-06 | -4.6E+03 | 2.7E-08 | 8.1E-03 | 7.0E-08 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 90| +1.48E+02 | -9.1E-05 | +2.6E-01 | 9.0E-03 | 2.6E-01 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 18| +1.48E+02 | -3.9E-01 | +6.1E-01 | 1.2E-01 | 3.1E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 13| +2.33E+02 | -5.2E-01 | +1.1E-01 | 1.2E-01 | 2.0E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 49| +1.54E+02 | -1.1E-05 | +7.9E-02 | 5.1E-02 | 1.5E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 14| +1.71E+02 | -4.8E-02 | +5.8E-01 | 1.4E-01 | 4.7E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 97| +1.60E+02 | -1.0E+00 | +7.6E-01 | 6.7E-02 | 1.9E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 80| +1.48E+02 | +4.0E-07 | -3.0E+03 | 6.8E-09 | 8.1E-03 | 1.7E-08 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 19| +1.48E+02 | -2.0E-01 | +9.2E-01 | 1.2E-01 | 3.9E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 91| +1.48E+02 | +1.0E-04 | -2.6E-01 | 9.0E-03 | 2.1E-01 | 3.6E-03 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 14| +2.31E+02 | -1.8E+00 | +9.2E-01 | 3.1E-02 | 4.1E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 53| +1.91E+02 | -2.0E+00 | +1.2E+00 | 2.3E-01 | 1.0E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 50| +1.54E+02 | -6.4E-05 | +7.1E-01 | 1.3E-02 | 5.9E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 81| +1.48E+02 | -4.6E-07 | +1.4E+04 | 1.7E-09 | 8.1E-03 | 4.4E-09 | 2d |1\n", + "2023-02-17 16:05:08 fides(WARNING) Stopping as function difference 4.61E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:08 fides(INFO) 92| +1.48E+02 | -7.7E-05 | +6.3E-01 | 2.3E-03 | 2.1E-01 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 15| +2.29E+02 | -2.0E+00 | +8.6E-01 | 6.2E-02 | 2.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 15| +1.71E+02 | -8.8E-03 | +8.3E-01 | 1.4E-01 | 5.9E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:08 fides(INFO) 20| +1.48E+02 | -6.9E-02 | +8.0E-01 | 2.5E-01 | 1.2E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 98| +1.60E+02 | +2.9E+00 | -9.3E-01 | 1.3E-01 | 4.1E+01 | 3.4E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 16| +2.26E+02 | -3.5E+00 | +1.2E+00 | 1.2E-01 | 1.8E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 51| +1.54E+02 | -1.5E-05 | +9.4E-01 | 1.3E-02 | 1.8E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 93| +1.48E+02 | -3.0E-05 | +8.5E-01 | 2.3E-03 | 3.7E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:08 fides(INFO) 21| +1.48E+02 | +2.4E-01 | -2.3E+00 | 4.9E-01 | 1.1E+01 | 5.1E-01 | 2d |0\n", + "2023-02-17 16:05:08 fides(INFO) 17| +2.21E+02 | -4.4E+00 | +1.1E+00 | 2.5E-01 | 1.8E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 99| +1.60E+02 | -4.3E-01 | +3.8E-01 | 3.3E-02 | 4.1E+01 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 16| +1.71E+02 | -2.1E-03 | +9.9E-01 | 2.8E-01 | 1.2E+00 | 7.2E-02 | trr |1\n", + "2023-02-17 16:05:09 fides(INFO) 94| +1.48E+02 | -3.9E-05 | +9.9E-01 | 4.5E-03 | 6.3E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 18| +2.18E+02 | -3.2E+00 | +5.1E-01 | 5.0E-01 | 2.6E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 52| +1.54E+02 | -1.8E-05 | +1.1E+00 | 2.5E-02 | 3.4E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 22| +1.48E+02 | -1.8E-02 | +4.4E-01 | 1.2E-01 | 1.1E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 100| +1.59E+02 | -4.9E-01 | +1.0E+00 | 3.3E-02 | 2.8E+01 | 6.9E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 95| +1.48E+02 | -4.2E-05 | +6.7E-01 | 9.0E-03 | 1.9E-01 | 5.7E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 19| +1.98E+02 | -2.0E+01 | +1.5E+00 | 5.0E-01 | 4.0E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 17| +1.71E+02 | -4.8E-05 | +3.4E-01 | 5.6E-01 | 4.9E-01 | 5.5E-03 | trr |1\n", + "2023-02-17 16:05:09 fides(INFO) 53| +1.54E+02 | -2.5E-05 | +1.2E+00 | 5.1E-02 | 9.4E-02 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 0| +5.85E+12 | NaN | NaN | 1.0E+00 | 2.7E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:09 fides(INFO) 54| +1.91E+02 | -4.2E+00 | -3.0E-01 | 4.5E-01 | 2.5E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 23| +1.48E+02 | -7.8E-03 | +1.9E-01 | 1.2E-01 | 5.9E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 101| +1.59E+02 | -2.4E-01 | +4.7E-01 | 6.7E-02 | 8.2E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 96| +1.48E+02 | +5.6E-05 | -5.8E-01 | 9.0E-03 | 8.7E-02 | 1.7E-03 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 18| +1.71E+02 | -3.1E-06 | +3.2E-02 | 5.6E-01 | 1.8E-01 | 6.7E-03 | trr |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 20| +1.98E+02 | +1.9E+03 | -4.7E+01 | 1.0E+00 | 3.7E+01 | 2.1E+00 | trr |0\n", + "2023-02-17 16:05:09 fides(INFO) 1| +1.05E+07 | -5.9E+12 | +8.3E-02 | 1.0E+00 | 2.7E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 24| +1.48E+02 | -1.7E-02 | +8.1E-01 | 3.1E-02 | 9.3E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 54| +1.54E+02 | -9.9E-07 | +5.9E-02 | 1.0E-01 | 2.7E-02 | 4.2E-03 | trr |1\n", + "2023-02-17 16:05:09 fides(INFO) 97| +1.48E+02 | -1.2E-05 | +3.4E-01 | 2.3E-03 | 8.7E-02 | 6.5E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 2| +2.00E+06 | -8.5E+06 | +9.1E-01 | 2.5E-01 | 3.6E+07 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 21| +1.79E+02 | -1.9E+01 | +9.5E-01 | 2.5E-01 | 3.7E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 25| +1.48E+02 | -3.3E-03 | +5.9E-01 | 6.2E-02 | 2.4E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 102| +1.59E+02 | +7.1E-01 | -1.5E+00 | 6.7E-02 | 6.6E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 19| +1.71E+02 | -3.2E-05 | +3.8E-01 | 1.9E-03 | 1.9E-01 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 55| +1.54E+02 | +5.1E-04 | -4.1E+00 | 1.2E-02 | 3.0E-02 | 1.8E-02 | trr |0\n", + "2023-02-17 16:05:09 fides(INFO) 22| +1.79E+02 | -1.4E+01 | -3.3E-02 | 5.0E-01 | 8.4E+01 | 9.2E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 98| +1.48E+02 | -2.4E-05 | +9.6E-01 | 2.3E-03 | 3.0E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:09.201 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 117.386 and h = 3.00881e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:09.202 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 117.386: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:09 fides(INFO) 103| +1.59E+02 | +0.0E+00 | +0.0E+00 | 1.7E-02 | 6.6E+00 | 3.7E-02 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 26| +1.48E+02 | -1.6E-03 | +9.3E-01 | 6.2E-02 | 2.6E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 20| +1.71E+02 | -8.8E-06 | +3.9E-01 | 1.9E-03 | 1.4E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 3| +3.31E+05 | -1.7E+06 | +9.0E-01 | 5.0E-01 | 6.6E+06 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 99| +1.48E+02 | -7.5E-06 | +5.8E-01 | 4.5E-03 | 3.6E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 23| +1.68E+02 | -1.2E+01 | +1.0E+00 | 1.2E-01 | 8.4E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 56| +1.54E+02 | -1.4E-05 | +2.6E-01 | 2.1E-03 | 3.0E-02 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 4| +5.18E+04 | -2.8E+05 | +9.0E-01 | 1.0E+00 | 1.1E+06 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 27| +1.48E+02 | -1.6E-03 | +9.7E-01 | 1.2E-01 | 1.6E+00 | 9.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 104| +1.59E+02 | -3.3E-02 | +6.8E-01 | 4.2E-03 | 6.6E+00 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 21| +1.71E+02 | -2.4E-07 | +2.8E-02 | 1.9E-03 | 7.6E-02 | 1.8E-03 | trr |1\n", + "2023-02-17 16:05:09 fides(INFO) 5| +8.31E+03 | -4.4E+04 | +9.0E-01 | 1.0E+00 | 1.7E+05 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 24| +1.61E+02 | -7.0E+00 | +6.1E-01 | 2.5E-01 | 6.1E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 100| +1.48E+02 | -1.2E-05 | +1.2E+00 | 4.5E-03 | 3.0E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 55| +1.89E+02 | -2.8E+00 | +9.3E-01 | 1.1E-01 | 2.5E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 57| +1.54E+02 | +6.2E-06 | -2.1E-01 | 2.1E-03 | 2.9E-02 | 4.2E-03 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 6| +1.47E+03 | -6.8E+03 | +9.0E-01 | 1.0E+00 | 2.7E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 25| +1.53E+02 | -7.2E+00 | +4.6E-01 | 2.5E-01 | 1.7E+02 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 28| +1.48E+02 | -1.2E-03 | +8.4E-01 | 2.5E-01 | 1.8E+00 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 105| +1.59E+02 | -3.4E-02 | +8.9E-01 | 4.2E-03 | 9.4E+00 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 101| +1.48E+02 | -1.4E-05 | +9.8E-01 | 9.0E-03 | 3.3E-02 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 22| +1.71E+02 | -3.9E-07 | +1.5E-01 | 1.7E-04 | 5.9E-02 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 7| +4.09E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 4.3E+03 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 58| +1.54E+02 | -6.8E-06 | +7.5E-01 | 5.4E-04 | 2.9E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 29| +1.48E+02 | +1.7E-02 | -6.6E+00 | 4.9E-01 | 7.7E-01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 26| +1.49E+02 | -4.5E+00 | +9.6E-01 | 2.5E-01 | 2.1E+02 | 7.9E-01 | trr |1\n", + "2023-02-17 16:05:09 fides(INFO) 102| +1.48E+02 | +7.9E-06 | -5.8E-01 | 1.8E-02 | 2.0E-02 | 3.0E-03 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 8| +2.59E+02 | -1.5E+02 | +8.7E-01 | 1.0E+00 | 6.6E+02 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 23| +1.71E+02 | -1.8E-06 | +3.0E+00 | 4.2E-05 | 2.8E-02 | 6.1E-05 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 106| +1.59E+02 | -4.6E-02 | +8.4E-01 | 8.3E-03 | 4.3E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 9| +2.39E+02 | -2.0E+01 | +1.1E+00 | 2.0E+00 | 8.1E+01 | 4.0E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 59| +1.54E+02 | -2.1E-06 | +6.9E-01 | 5.4E-04 | 1.7E-02 | 7.1E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 30| +1.48E+02 | +3.6E-04 | -3.1E-01 | 1.2E-01 | 7.7E-01 | 7.3E-02 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 27| +1.48E+02 | -9.4E-01 | +6.7E-01 | 5.0E-01 | 3.8E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 103| +1.48E+02 | -7.8E-06 | +1.5E+00 | 4.5E-03 | 2.0E-02 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 107| +1.59E+02 | -1.9E-02 | +7.9E-01 | 1.7E-02 | 5.2E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 31| +1.48E+02 | -3.0E-04 | +6.1E-01 | 3.1E-02 | 7.7E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 24| +1.71E+02 | -6.3E-07 | +1.2E+00 | 8.3E-05 | 1.9E-02 | 1.1E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 6.33E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 60| +1.54E+02 | -2.3E-06 | +1.2E+00 | 5.4E-04 | 1.2E-02 | 3.3E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 10| +2.39E+02 | +2.5E+02 | -1.2E+01 | 4.0E+00 | 3.4E+01 | 1.1E+01 | trr |0\n", + "2023-02-17 16:05:09 fides(INFO) 104| +1.48E+02 | +1.9E-05 | -1.6E+00 | 9.0E-03 | 4.3E-02 | 3.8E-03 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 28| +1.48E+02 | -1.4E-02 | -3.5E-01 | 5.0E-01 | 2.5E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 11| +2.39E+02 | +6.1E+01 | -5.4E+00 | 1.0E+00 | 3.4E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 32| +1.48E+02 | -2.0E-04 | +9.4E-01 | 3.1E-02 | 1.1E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 56| +1.77E+02 | -1.2E+01 | +1.8E+00 | 2.3E-01 | 3.2E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 108| +1.59E+02 | +3.5E-02 | -1.2E+00 | 3.3E-02 | 2.7E+00 | 3.5E-02 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 105| +1.48E+02 | +7.4E-06 | -2.0E+00 | 2.3E-03 | 4.3E-02 | 9.6E-04 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 29| +1.48E+02 | -1.7E-01 | +9.4E-01 | 1.2E-01 | 2.5E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 12| +2.39E+02 | +6.7E+00 | -6.1E-01 | 2.5E-01 | 3.4E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 61| +1.54E+02 | -2.1E-06 | +1.1E+00 | 1.1E-03 | 4.2E-02 | 3.3E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 33| +1.48E+02 | -1.4E-04 | +9.7E-01 | 6.2E-02 | 4.4E-01 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 13| +2.35E+02 | -4.3E+00 | +8.8E-01 | 6.2E-02 | 3.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 106| +1.48E+02 | +4.3E-06 | -3.8E+00 | 5.6E-04 | 4.3E-02 | 2.4E-04 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 30| +1.48E+02 | -9.7E-02 | +3.7E-01 | 2.5E-01 | 9.0E+00 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 62| +1.54E+02 | -7.0E-07 | +4.7E-01 | 2.1E-03 | 6.9E-03 | 9.2E-04 | trr |1\n", + "2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 6.97E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:09 fides(INFO) 109| +1.59E+02 | -9.5E-03 | +7.2E-01 | 8.3E-03 | 2.7E+00 | 8.9E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 34| +1.48E+02 | -1.1E-04 | +8.6E-01 | 1.2E-01 | 6.1E-01 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 14| +2.34E+02 | -8.2E-01 | +1.7E-01 | 1.2E-01 | 2.2E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 107| +1.48E+02 | +4.4E-06 | -9.6E+00 | 1.4E-04 | 4.3E-02 | 6.1E-05 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 31| +1.48E+02 | +7.1E-02 | -5.0E-01 | 2.5E-01 | 1.9E+01 | 2.3E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 0| +9.19E+02 | NaN | NaN | 1.0E+00 | 3.1E+03 | NaN | NaN |1\n", + "2023-02-17 16:05:09 fides(INFO) 15| +2.32E+02 | -1.8E+00 | +9.2E-01 | 3.1E-02 | 3.8E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 110| +1.59E+02 | -2.8E-03 | +6.2E-01 | 8.3E-03 | 1.0E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 35| +1.48E+02 | +3.6E-04 | -2.0E+00 | 2.5E-01 | 2.4E-01 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 32| +1.48E+02 | -5.4E-02 | +7.6E-01 | 6.2E-02 | 1.9E+01 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 108| +1.48E+02 | +4.9E-06 | -1.7E+01 | 3.5E-05 | 4.3E-02 | 1.9E-05 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 1| +2.87E+02 | -6.3E+02 | +1.3E-01 | 1.0E+00 | 3.1E+03 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 16| +2.30E+02 | -2.0E+00 | +8.7E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 36| +1.48E+02 | -2.7E-05 | +3.7E-01 | 6.2E-02 | 2.4E-01 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 111| +1.59E+02 | -1.7E-03 | +8.1E-01 | 8.3E-03 | 2.8E+00 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 2| +2.61E+02 | -2.7E+01 | +8.9E-01 | 2.5E-01 | 7.8E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 109| +1.48E+02 | +6.0E-06 | -2.5E+01 | 8.8E-06 | 4.3E-02 | 1.1E-05 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 17| +2.27E+02 | -3.5E+00 | +1.2E+00 | 1.2E-01 | 1.8E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 33| +1.48E+02 | -2.7E-02 | +7.8E-01 | 1.2E-01 | 4.4E+00 | 9.6E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 37| +1.48E+02 | -1.3E-05 | +1.2E-01 | 6.2E-02 | 3.6E-01 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 18| +2.22E+02 | -4.9E+00 | +1.2E+00 | 2.5E-01 | 1.9E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 3| +2.61E+02 | +3.7E+02 | -1.9E+01 | 5.0E-01 | 3.3E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 0| +6.60E+12 | NaN | NaN | 1.0E+00 | 2.2E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 110| +1.48E+02 | +6.7E-06 | -4.9E+01 | 2.2E-06 | 4.3E-02 | 4.0E-06 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 112| +1.59E+02 | -8.3E-05 | +4.7E-01 | 8.3E-03 | 6.4E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 34| +1.48E+02 | +2.1E-02 | -6.9E-01 | 2.5E-01 | 9.4E+00 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 4| +2.51E+02 | -9.4E+00 | +8.8E-01 | 1.2E-01 | 3.3E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 38| +1.48E+02 | -3.1E-05 | +5.7E-01 | 1.5E-02 | 1.8E-01 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 19| +2.21E+02 | -1.2E+00 | +4.9E-02 | 5.0E-01 | 2.1E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:09.703 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0069 and h = 1.38872e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:09.703 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0069: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:09 fides(INFO) 111| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.5E-07 | 4.3E-02 | 1.0E-06 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 57| +1.77E+02 | +1.4E+02 | -6.5E+00 | 4.5E-01 | 4.1E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 35| +1.48E+02 | -1.2E-02 | +7.4E-01 | 6.2E-02 | 9.4E+00 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 113| +1.59E+02 | -4.1E-05 | +8.5E-01 | 8.3E-03 | 1.7E-01 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 5| +2.51E+02 | +8.2E+00 | -2.3E+00 | 2.5E-01 | 1.9E+01 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 20| +2.13E+02 | -7.3E+00 | +7.8E-01 | 1.2E-01 | 6.6E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 1| +2.56E+09 | -6.6E+12 | +1.1E-01 | 1.0E+00 | 2.2E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 39| +1.48E+02 | -1.4E-05 | +9.5E-01 | 1.5E-02 | 3.3E-01 | 6.0E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 112| +1.48E+02 | +7.4E-06 | -7.0E+02 | 1.4E-07 | 4.3E-02 | 2.5E-07 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 36| +1.48E+02 | -2.9E-03 | +6.1E-01 | 6.2E-02 | 1.9E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 6| +2.50E+02 | -1.6E+00 | +6.5E-01 | 6.2E-02 | 1.9E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 21| +2.05E+02 | -8.7E+00 | +1.3E+00 | 2.5E-01 | 1.8E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 2| +4.81E+08 | -2.1E+09 | +8.8E-01 | 2.5E-01 | 9.3E+09 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 114| +1.59E+02 | -2.4E-06 | +5.2E-01 | 8.3E-03 | 4.1E-02 | 6.8E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 40| +1.48E+02 | -7.4E-06 | +5.9E-01 | 3.1E-02 | 8.1E-02 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 113| +1.48E+02 | +5.8E-06 | -2.2E+03 | 3.4E-08 | 4.3E-02 | 6.2E-08 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 7| +2.50E+02 | -1.4E-03 | +6.7E-02 | 6.2E-02 | 1.8E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 37| +1.48E+02 | -2.2E-03 | +6.4E-01 | 6.2E-02 | 3.6E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 22| +1.94E+02 | -1.1E+01 | +9.7E-01 | 5.0E-01 | 3.2E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 3| +7.29E+07 | -4.1E+08 | +8.9E-01 | 5.0E-01 | 1.6E+09 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 41| +1.48E+02 | -5.0E-06 | +1.0E+00 | 3.1E-02 | 1.6E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 115| +1.59E+02 | -1.3E-06 | +2.0E+00 | 8.3E-03 | 1.1E-02 | 5.1E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 1.35E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:09 fides(INFO) 114| +1.48E+02 | +4.0E-06 | -6.1E+03 | 8.6E-09 | 4.3E-02 | 1.6E-08 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 38| +1.48E+02 | -7.8E-04 | +5.2E-01 | 6.2E-02 | 1.0E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 8| +2.50E+02 | +9.3E-04 | -6.0E-02 | 1.6E-02 | 1.6E+00 | 4.3E-02 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 4| +1.11E+07 | -6.2E+07 | +8.9E-01 | 5.0E-01 | 2.4E+08 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:09.842 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0854 and h = 2.28973e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:09.842 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0854: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:09 fides(INFO) 42| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 3.1E-02 | 2.1E-02 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 23| +1.94E+02 | +8.6E+00 | -1.9E+00 | 1.0E+00 | 4.2E+01 | 2.5E+00 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 9| +2.50E+02 | -8.1E-03 | +6.5E-01 | 3.9E-03 | 1.6E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 5| +1.70E+06 | -9.4E+06 | +9.0E-01 | 5.0E-01 | 3.6E+07 | 9.7E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 115| +1.48E+02 | +6.4E-06 | -3.9E+04 | 2.1E-09 | 4.3E-02 | 3.9E-09 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 39| +1.48E+02 | -5.9E-04 | +5.2E-01 | 6.2E-02 | 1.7E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 43| +1.48E+02 | -1.3E-06 | +1.2E+00 | 1.5E-02 | 3.1E-02 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 1.27E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 10| +2.50E+02 | -1.5E-07 | +5.2E-03 | 3.9E-03 | 6.7E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:09.892 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.732 and h = 3.21785e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:09.892 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.732: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:09 fides(INFO) 116| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.4E-10 | 4.3E-02 | 9.8E-10 | 2d |0\n", + "2023-02-17 16:05:09.895 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 123.347 and h = 8.2092e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:09.895 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 123.347: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:09 fides(INFO) 24| +1.94E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 4.2E+01 | 5.8E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 40| +1.48E+02 | -2.6E-04 | +3.5E-01 | 6.2E-02 | 6.7E-01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 11| +2.50E+02 | +3.9E-08 | -1.6E-03 | 9.8E-04 | 6.7E-02 | 2.7E-03 | 2d |0\n", + "2023-02-17 16:05:09.925 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 147.013 and h = 1.79811e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:09.925 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 147.013: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:09 fides(INFO) 25| +1.94E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 4.2E+01 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 58| +1.71E+02 | -5.8E+00 | +6.8E-01 | 1.1E-01 | 4.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 6| +2.63E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 5.5E+06 | 9.5E-01 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 117| +1.48E+02 | +2.3E-06 | -2.2E+05 | 1.3E-10 | 4.3E-02 | 2.4E-10 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 41| +1.48E+02 | -1.8E-04 | +2.6E-01 | 6.2E-02 | 9.3E-01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 12| +2.50E+02 | -8.1E-06 | +3.2E-01 | 2.4E-04 | 6.7E-02 | 6.4E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 26| +1.92E+02 | -1.3E+00 | +9.9E-01 | 1.6E-02 | 4.2E+01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) 118| +1.48E+02 | +2.9E-06 | -1.1E+06 | 3.4E-11 | 4.3E-02 | 6.1E-11 | 2d |0\n", + "2023-02-17 16:05:09 fides(INFO) 13| +2.50E+02 | -2.2E-06 | +2.1E-01 | 2.4E-04 | 4.2E-02 | 4.3E-04 | 2d |1\n", + "2023-02-17 16:05:09 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:09 fides(INFO) 0| +1.10E+14 | NaN | NaN | 1.0E+00 | 5.1E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:09 fides(INFO) 42| +1.48E+02 | -2.5E-05 | +3.3E-02 | 6.2E-02 | 5.0E-01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 27| +1.90E+02 | -2.4E+00 | +9.8E-01 | 3.1E-02 | 4.1E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 0| +5.57E+12 | NaN | NaN | 1.0E+00 | 2.6E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:10 fides(INFO) 119| +1.48E+02 | +4.2E-06 | -6.5E+06 | 8.4E-12 | 4.3E-02 | 1.5E-11 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 7| +4.11E+04 | -2.2E+05 | +9.0E-01 | 5.0E-01 | 8.6E+05 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 14| +2.50E+02 | -2.9E-06 | +7.3E-01 | 6.1E-05 | 3.2E-02 | 1.6E-04 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 43| +1.48E+02 | -2.6E-04 | +7.3E-01 | 1.6E-02 | 7.4E-01 | 7.1E-03 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 1| +1.08E+08 | -1.1E+14 | +8.2E-02 | 1.0E+00 | 5.1E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 28| +1.86E+02 | -4.3E+00 | +9.8E-01 | 6.2E-02 | 4.0E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 1| +1.50E+09 | -5.6E+12 | +8.6E-02 | 1.0E+00 | 2.6E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 15| +2.50E+02 | -1.1E-09 | +9.6E-03 | 6.1E-05 | 4.5E-03 | 1.7E-04 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 120| +1.48E+02 | +1.6E-06 | -9.7E+06 | 2.1E-12 | 4.3E-02 | 3.8E-12 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 2| +2.44E+08 | -1.3E+09 | +8.9E-01 | 2.5E-01 | 6.5E+09 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 44| +1.48E+02 | -5.8E-05 | +8.4E-01 | 1.6E-02 | 3.6E-01 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 16| +2.50E+02 | -5.9E-08 | +6.6E-01 | 1.5E-05 | 4.5E-03 | 2.7E-05 | 2d |1\n", + "2023-02-17 16:05:10 fides(WARNING) Stopping as function difference 5.90E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:10 fides(INFO) 121| +1.48E+02 | +3.6E-06 | -8.8E+07 | 5.2E-13 | 4.3E-02 | 9.5E-13 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 29| +1.77E+02 | -9.0E+00 | +1.1E+00 | 1.2E-01 | 4.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 3| +3.70E+07 | -2.1E+08 | +8.9E-01 | 5.0E-01 | 1.0E+09 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 2| +1.69E+07 | -9.1E+07 | +8.9E-01 | 2.5E-01 | 3.5E+08 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 45| +1.48E+02 | -3.7E-05 | +8.4E-01 | 3.1E-02 | 3.0E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 59| +1.63E+02 | -8.4E+00 | +8.7E-01 | 1.1E-01 | 8.0E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 122| +1.48E+02 | +3.2E-06 | -3.2E+08 | 1.3E-13 | 4.3E-02 | 2.4E-13 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 30| +1.62E+02 | -1.5E+01 | +8.6E-01 | 2.5E-01 | 4.9E+01 | 5.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 4| +5.64E+06 | -3.1E+07 | +8.9E-01 | 5.0E-01 | 1.5E+08 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 46| +1.48E+02 | -4.9E-05 | +9.3E-01 | 6.2E-02 | 2.4E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 3| +2.62E+06 | -1.4E+07 | +8.9E-01 | 5.0E-01 | 5.5E+07 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 123| +1.48E+02 | +3.2E-06 | -1.3E+09 | 3.3E-14 | 4.3E-02 | 6.0E-14 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 8| +6.58E+03 | -3.5E+04 | +9.0E-01 | 5.0E-01 | 1.3E+05 | 9.2E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 31| +1.62E+02 | +7.2E+01 | -5.0E+00 | 5.0E-01 | 1.0E+02 | 9.7E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 5| +8.66E+05 | -4.8E+06 | +8.9E-01 | 5.0E-01 | 2.3E+07 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10.187 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.882 and h = 4.14838e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:10.188 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.882: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:10 fides(INFO) 47| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 2.7E-01 | 4.4E-02 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 0| +4.28E+11 | NaN | NaN | 1.0E+00 | 2.0E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:10 fides(INFO) 4| +4.31E+05 | -2.2E+06 | +8.6E-01 | 1.0E+00 | 8.6E+06 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 124| +1.48E+02 | +6.8E-06 | -1.1E+10 | 8.2E-15 | 4.3E-02 | 1.5E-14 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 6| +1.34E+05 | -7.3E+05 | +9.0E-01 | 1.0E+00 | 3.5E+06 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 32| +1.55E+02 | -7.2E+00 | +7.5E-01 | 1.2E-01 | 1.0E+02 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 48| +1.48E+02 | -1.9E-05 | +7.7E-01 | 3.1E-02 | 2.7E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 7| +2.10E+04 | -1.1E+05 | +9.0E-01 | 1.0E+00 | 5.4E+05 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 9| +1.18E+03 | -5.4E+03 | +9.0E-01 | 5.0E-01 | 2.1E+04 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 125| +1.48E+02 | +4.5E-06 | -2.8E+10 | 2.0E-15 | 4.3E-02 | 3.7E-15 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 5| +6.72E+04 | -3.6E+05 | +9.0E-01 | 2.0E+00 | 1.3E+06 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 8| +3.45E+03 | -1.8E+04 | +9.0E-01 | 1.0E+00 | 8.5E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 1| +5.82E+05 | -4.3E+11 | +8.9E-02 | 1.0E+00 | 2.0E+12 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 33| +1.53E+02 | -2.2E+00 | +1.0E+00 | 1.2E-01 | 6.5E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 49| +1.48E+02 | -2.3E-05 | +8.5E-01 | 6.2E-02 | 1.5E-01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 126| +1.48E+02 | +3.8E-06 | -9.7E+10 | 5.1E-16 | 4.3E-02 | 9.3E-16 | 2d |0\n", + "2023-02-17 16:05:10 fides(WARNING) Stopping as trust region radius 1.28E-16 is smaller than machine precision.\n", + "2023-02-17 16:05:10 fides(INFO) 9| +7.11E+02 | -2.7E+03 | +9.0E-01 | 1.0E+00 | 1.3E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 2| +9.11E+04 | -4.9E+05 | +9.0E-01 | 2.5E-01 | 2.7E+06 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 10| +3.53E+02 | -8.3E+02 | +9.0E-01 | 5.0E-01 | 3.4E+03 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 6| +1.05E+04 | -5.7E+04 | +9.0E-01 | 2.0E+00 | 2.1E+05 | 9.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 34| +1.51E+02 | -1.9E+00 | +4.6E-01 | 2.5E-01 | 3.0E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 3| +1.46E+04 | -7.6E+04 | +9.0E-01 | 5.0E-01 | 4.2E+05 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 50| +1.48E+02 | +2.8E-05 | -7.2E-01 | 1.2E-01 | 2.0E-01 | 3.8E-02 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 10| +2.99E+02 | -4.1E+02 | +9.0E-01 | 1.0E+00 | 2.1E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 11| +2.39E+02 | -1.1E+02 | +9.0E-01 | 1.0E+00 | 5.2E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 4| +4.15E+03 | -1.0E+04 | +6.8E-01 | 1.0E+00 | 6.6E+04 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 11| +2.35E+02 | -6.4E+01 | +1.0E+00 | 1.0E+00 | 3.1E+02 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 7| +1.72E+03 | -8.8E+03 | +9.1E-01 | 2.0E+00 | 3.2E+04 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 35| +1.50E+02 | -6.8E-01 | +2.3E-01 | 2.5E-01 | 9.0E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 5| +8.28E+02 | -3.3E+03 | +9.0E-01 | 1.0E+00 | 1.3E+04 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 51| +1.48E+02 | -1.4E-05 | +8.8E-01 | 3.1E-02 | 2.0E-01 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 6| +3.15E+02 | -5.1E+02 | +9.0E-01 | 2.0E+00 | 2.1E+03 | 3.5E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 12| +2.20E+02 | -1.9E+01 | +1.1E+00 | 1.0E+00 | 6.1E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 36| +1.49E+02 | -7.8E-01 | +9.3E-01 | 6.2E-02 | 4.3E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 52| +1.48E+02 | -9.5E-07 | +6.4E-02 | 6.2E-02 | 9.3E-02 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 12| +2.35E+02 | +9.0E+01 | -2.0E+01 | 2.0E+00 | 2.8E+01 | 4.0E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 8| +3.86E+02 | -1.3E+03 | +9.3E-01 | 2.0E+00 | 4.9E+03 | 8.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 7| +2.51E+02 | -6.4E+01 | +8.4E-01 | 4.0E+00 | 3.2E+02 | 2.3E+00 | trr |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 60| +1.63E+02 | +2.1E+01 | -2.5E+00 | 2.3E-01 | 3.8E+01 | 4.6E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 13| +2.35E+02 | +2.0E+01 | -2.5E+00 | 5.0E-01 | 2.8E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 8| +2.34E+02 | -1.7E+01 | +5.1E+00 | 4.0E+00 | 2.5E+01 | 4.2E+00 | trr |1\n", + "2023-02-17 16:05:10 fides(INFO) 53| +1.48E+02 | -5.7E-06 | +4.3E-01 | 1.6E-02 | 1.2E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 37| +1.48E+02 | -6.9E-01 | +6.4E-01 | 1.2E-01 | 3.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 14| +2.32E+02 | -3.5E+00 | +5.1E-01 | 1.2E-01 | 2.8E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 13| +2.20E+02 | +2.1E+02 | -1.3E+01 | 2.0E+00 | 3.4E+01 | 5.8E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 0| +5.24E+12 | NaN | NaN | 1.0E+00 | 2.4E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:10 fides(INFO) 15| +2.29E+02 | -3.1E+00 | +8.1E-01 | 1.2E-01 | 2.9E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 9| +2.06E+02 | -1.8E+02 | +1.0E+00 | 2.0E+00 | 7.0E+02 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:10.466 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.274 and h = 2.21878e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:10.467 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.274: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:10 fides(INFO) 54| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 6.9E-02 | 3.8E-03 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 38| +1.48E+02 | -3.1E-01 | +7.9E-01 | 1.2E-01 | 3.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 14| +2.20E+02 | +1.6E+00 | -6.3E-01 | 5.0E-01 | 3.4E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 9| +2.34E+02 | +1.1E+04 | -3.1E+02 | 4.0E+00 | 4.9E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 16| +2.29E+02 | +2.5E-01 | -1.9E-01 | 2.5E-01 | 2.2E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 55| +1.48E+02 | -5.4E-06 | +6.4E+00 | 3.9E-03 | 6.9E-02 | 9.5E-04 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 39| +1.48E+02 | -1.1E-01 | +1.8E-01 | 2.5E-01 | 1.5E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 1| +7.80E+10 | -5.2E+12 | +8.7E-02 | 1.0E+00 | 2.4E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 15| +2.14E+02 | -5.5E+00 | +7.8E-01 | 1.2E-01 | 3.4E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 10| +2.34E+02 | +1.5E+03 | -4.5E+01 | 1.0E+00 | 4.9E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 17| +2.27E+02 | -1.8E+00 | +7.9E-01 | 6.2E-02 | 2.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 56| +1.48E+02 | +3.0E-06 | -3.9E+00 | 7.8E-03 | 5.3E-02 | 1.9E-03 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 2| +1.16E+10 | -6.6E+10 | +8.9E-01 | 2.5E-01 | 3.6E+11 | 7.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 40| +1.48E+02 | -2.4E-01 | +3.2E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 18| +2.23E+02 | -3.4E+00 | +1.1E+00 | 1.2E-01 | 2.1E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 10| +2.06E+02 | +2.3E+02 | -1.4E+01 | 2.0E+00 | 8.5E+01 | 5.7E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 11| +2.17E+02 | -1.7E+01 | +6.3E-01 | 2.5E-01 | 4.9E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 16| +2.06E+02 | -8.7E+00 | +1.1E+00 | 2.5E-01 | 3.9E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 57| +1.48E+02 | +1.8E-06 | -4.1E+00 | 2.0E-03 | 5.3E-02 | 4.7E-04 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 19| +2.23E+02 | -8.5E-01 | +1.2E-01 | 2.5E-01 | 2.0E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 12| +2.16E+02 | -1.2E+00 | +5.0E-01 | 2.5E-01 | 2.4E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 41| +1.48E+02 | -9.5E-02 | +7.6E-01 | 6.2E-02 | 1.2E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 17| +2.06E+02 | -3.9E+00 | -9.5E-02 | 5.0E-01 | 3.1E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 3| +1.74E+09 | -9.9E+09 | +8.9E-01 | 5.0E-01 | 5.3E+10 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 13| +2.16E+02 | +5.5E-01 | -3.9E-01 | 2.5E-01 | 1.7E+01 | 7.3E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 20| +2.19E+02 | -3.7E+00 | +8.4E-01 | 6.2E-02 | 4.9E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 58| +1.48E+02 | +9.3E-07 | -2.6E+00 | 4.9E-04 | 5.3E-02 | 1.2E-04 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 42| +1.48E+02 | -7.8E-02 | +9.5E-01 | 1.2E-01 | 8.4E+00 | 9.7E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 11| +1.91E+02 | -1.5E+01 | +1.4E+00 | 5.0E-01 | 8.5E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 14| +2.15E+02 | -4.4E-01 | +3.1E-01 | 6.2E-02 | 1.7E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 18| +2.01E+02 | -4.8E+00 | +7.6E-01 | 1.2E-01 | 3.1E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 4| +2.61E+08 | -1.5E+09 | +8.9E-01 | 1.0E+00 | 8.0E+09 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 61| +1.63E+02 | -1.1E-01 | +9.7E-03 | 5.6E-02 | 3.8E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 21| +2.17E+02 | -2.3E+00 | +8.0E-01 | 1.2E-01 | 2.4E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 59| +1.48E+02 | -2.1E-08 | +6.2E-02 | 1.2E-04 | 5.3E-02 | 3.3E-05 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 43| +1.48E+02 | -7.0E-02 | +8.7E-01 | 2.5E-01 | 5.8E+00 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 15| +2.14E+02 | -6.6E-01 | +6.0E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 5| +3.95E+07 | -2.2E+08 | +8.9E-01 | 1.0E+00 | 1.2E+09 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 19| +1.95E+02 | -5.8E+00 | +6.8E-01 | 2.5E-01 | 4.1E+01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 22| +2.14E+02 | -2.5E+00 | +5.9E-01 | 2.5E-01 | 1.9E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 60| +1.48E+02 | +2.8E-06 | -4.1E+00 | 3.1E-05 | 5.3E-02 | 3.5E-05 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 44| +1.48E+02 | +7.5E-02 | -1.7E+00 | 5.0E-01 | 3.6E+00 | 2.1E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 12| +1.91E+02 | +4.2E+01 | -2.3E+00 | 1.0E+00 | 4.9E+01 | 2.1E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 6| +6.00E+06 | -3.3E+07 | +8.9E-01 | 1.0E+00 | 1.8E+08 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 16| +2.14E+02 | -4.9E-03 | -2.0E-02 | 6.2E-02 | 1.2E+01 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 23| +2.07E+02 | -6.8E+00 | +9.6E-01 | 2.5E-01 | 3.3E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 20| +1.89E+02 | -6.2E+00 | +3.7E-01 | 2.5E-01 | 3.9E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 61| +1.48E+02 | +3.0E-06 | -7.2E+00 | 7.6E-06 | 5.3E-02 | 1.3E-05 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 17| +2.14E+02 | -2.3E-01 | +8.6E-01 | 1.6E-02 | 1.2E+01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 7| +9.19E+05 | -5.1E+06 | +8.9E-01 | 1.0E+00 | 2.8E+07 | 9.5E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 45| +1.48E+02 | -1.3E-02 | +6.0E-01 | 1.0E-01 | 3.6E+00 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 62| +1.48E+02 | +2.6E-06 | -2.1E+01 | 1.9E-06 | 5.3E-02 | 3.2E-06 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 24| +1.82E+02 | -2.5E+01 | +1.2E+00 | 5.0E-01 | 2.5E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 18| +2.14E+02 | -3.3E-01 | +9.6E-01 | 3.1E-02 | 1.0E+01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 21| +1.80E+02 | -8.9E+00 | +8.7E-01 | 2.5E-01 | 7.0E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 13| +1.78E+02 | -1.3E+01 | +7.1E-01 | 2.5E-01 | 4.9E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 8| +1.42E+05 | -7.8E+05 | +8.9E-01 | 1.0E+00 | 4.2E+06 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 46| +1.48E+02 | +2.7E-02 | -6.9E-01 | 1.0E-01 | 2.4E+00 | 9.6E-02 | 2d |0\n", + "2023-02-17 16:05:10.784 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 37.9918 and h = 5.00215e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:10.784 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 37.9918: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:10 fides(INFO) 25| +1.82E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 9.0E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 19| +2.13E+02 | -4.8E-01 | +8.3E-01 | 6.2E-02 | 9.0E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 63| +1.48E+02 | +6.0E-06 | -1.9E+02 | 4.8E-07 | 5.3E-02 | 8.1E-07 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 22| +1.63E+02 | -1.7E+01 | +1.1E+00 | 5.0E-01 | 6.2E+01 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 47| +1.48E+02 | -6.8E-03 | +6.0E-01 | 2.5E-02 | 2.4E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 9| +2.22E+04 | -1.2E+05 | +9.0E-01 | 1.0E+00 | 6.5E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 20| +2.13E+02 | -1.1E-01 | +2.1E-01 | 1.2E-01 | 1.1E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 26| +1.68E+02 | -1.4E+01 | +8.3E-01 | 2.5E-01 | 9.0E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 14| +1.71E+02 | -6.9E+00 | +9.9E-01 | 2.5E-01 | 1.1E+02 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 64| +1.48E+02 | +1.3E-06 | -1.6E+02 | 1.2E-07 | 5.3E-02 | 2.0E-07 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 23| +1.59E+02 | -4.3E+00 | +9.0E-01 | 1.0E+00 | 6.6E+01 | 1.7E+00 | trr |1\n", + "2023-02-17 16:05:10 fides(INFO) 48| +1.48E+02 | -3.0E-03 | +9.9E-01 | 2.5E-02 | 2.1E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 62| +1.60E+02 | -2.7E+00 | +1.0E+00 | 1.4E-02 | 1.1E+02 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 21| +2.13E+02 | -3.8E-01 | +7.0E-01 | 3.1E-02 | 1.2E+01 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 27| +1.64E+02 | -4.1E+00 | +9.1E-01 | 5.0E-01 | 7.4E+01 | 5.4E-01 | trr |1\n", + "2023-02-17 16:05:10 fides(INFO) 65| +1.48E+02 | +3.1E-06 | -1.5E+03 | 3.0E-08 | 5.3E-02 | 5.1E-08 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 22| +2.13E+02 | -1.9E-01 | +8.6E-01 | 3.1E-02 | 7.4E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 49| +1.48E+02 | -4.2E-03 | +9.5E-01 | 5.0E-02 | 1.8E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 10| +3.64E+03 | -1.9E+04 | +9.0E-01 | 1.0E+00 | 1.0E+05 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 24| +1.59E+02 | +1.6E+03 | -1.2E+02 | 1.0E+00 | 7.0E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:10.914 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.723 and h = 3.11306e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:10.914 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.723: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:10 fides(INFO) 66| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.5E-09 | 5.3E-02 | 1.3E-08 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 28| +1.64E+02 | -1.6E+00 | -3.3E-01 | 5.0E-01 | 6.9E+01 | 9.0E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 15| +1.61E+02 | -1.0E+01 | +9.0E-01 | 5.0E-01 | 7.3E+01 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 23| +2.13E+02 | -2.4E-02 | +8.0E-02 | 6.2E-02 | 6.5E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 50| +1.48E+02 | -5.6E-03 | +9.2E-01 | 1.0E-01 | 1.4E+00 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 67| +1.48E+02 | +1.9E-06 | -1.5E+04 | 1.9E-09 | 5.3E-02 | 3.2E-09 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 24| +2.13E+02 | -2.2E-01 | +8.3E-01 | 1.6E-02 | 1.2E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 29| +1.59E+02 | -5.6E+00 | +8.1E-01 | 1.2E-01 | 6.9E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 11| +7.26E+02 | -2.9E+03 | +9.0E-01 | 2.0E+00 | 1.6E+04 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 25| +1.52E+02 | -7.0E+00 | +5.3E-01 | 2.3E-01 | 7.0E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 51| +1.48E+02 | +1.6E-02 | -2.0E+00 | 2.0E-01 | 1.1E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:10 fides(INFO) 16| +1.56E+02 | -4.5E+00 | +9.9E-02 | 1.0E+00 | 7.5E+01 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 25| +2.12E+02 | -9.8E-02 | +5.4E-01 | 3.1E-02 | 6.8E+00 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:10 fides(INFO) 68| +1.48E+02 | -5.6E-07 | +1.8E+04 | 4.7E-10 | 5.3E-02 | 7.9E-10 | 2d |1\n", + "2023-02-17 16:05:10 fides(WARNING) Stopping as function difference 5.55E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:10 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:10 fides(INFO) 30| +1.53E+02 | -5.5E+00 | +1.0E+00 | 2.5E-01 | 7.0E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 26| +1.49E+02 | -2.9E+00 | +9.7E-01 | 2.3E-01 | 1.4E+02 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 52| +1.48E+02 | -1.2E-03 | +4.3E-01 | 5.0E-02 | 1.1E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 26| +2.12E+02 | -2.7E-02 | +1.2E-01 | 3.1E-02 | 6.2E+00 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 31| +1.53E+02 | +2.0E+01 | -3.2E+00 | 5.0E-01 | 5.6E+01 | 7.8E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 12| +7.26E+02 | +9.4E+03 | -2.8E+01 | 2.0E+00 | 2.5E+03 | 3.8E+00 | trr |0\n", + "2023-02-17 16:05:11 fides(INFO) 17| +1.53E+02 | -3.1E+00 | +1.0E+00 | 2.5E-01 | 7.8E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 63| +1.59E+02 | -1.2E+00 | +8.4E-01 | 2.8E-02 | 3.6E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 27| +1.49E+02 | +1.3E+00 | -6.9E-01 | 4.7E-01 | 3.3E+01 | 6.9E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 53| +1.48E+02 | +1.1E-03 | -2.3E-01 | 5.0E-02 | 9.6E-01 | 1.7E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 27| +2.12E+02 | -9.1E-02 | +9.0E-01 | 7.8E-03 | 8.7E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 32| +1.51E+02 | -2.6E+00 | +7.3E-01 | 1.2E-01 | 5.6E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 28| +2.12E+02 | -8.2E-02 | +7.4E-01 | 1.6E-02 | 6.4E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 54| +1.48E+02 | -9.9E-04 | +5.4E-01 | 1.3E-02 | 9.6E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:11.099 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 208.039 and h = 1.4974e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:11.099 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 208.039: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:11 fides(INFO) 13| +7.26E+02 | +0.0E+00 | +0.0E+00 | 4.3E-01 | 2.5E+03 | 8.8E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 28| +1.48E+02 | -8.3E-01 | +4.9E-01 | 1.2E-01 | 3.3E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 18| +1.53E+02 | -3.9E-01 | +1.0E+00 | 5.0E-01 | 4.0E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 33| +1.49E+02 | -1.2E+00 | +8.6E-01 | 1.2E-01 | 5.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 29| +2.12E+02 | -6.2E-02 | +8.4E-01 | 1.6E-02 | 4.5E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 55| +1.48E+02 | -7.5E-04 | +9.4E-01 | 1.3E-02 | 2.1E+00 | 5.8E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 0| +3.71E+02 | NaN | NaN | 1.0E+00 | 1.4E+02 | NaN | NaN |1\n", + "2023-02-17 16:05:11.147 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 172.17 and h = 5.26904e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:11.147 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 172.17: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:11 fides(INFO) 34| +1.49E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 3.2E+01 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 30| +2.12E+02 | -5.4E-02 | +4.9E-01 | 3.1E-02 | 4.9E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 29| +1.48E+02 | -4.0E-01 | +4.6E-01 | 1.2E-01 | 4.7E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 14| +3.80E+02 | -3.5E+02 | +8.5E-01 | 1.1E-01 | 2.5E+03 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 19| +1.52E+02 | -8.7E-01 | +7.8E-01 | 1.0E+00 | 2.3E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 56| +1.48E+02 | -7.6E-04 | +9.4E-01 | 2.5E-02 | 4.2E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 1| +3.36E+02 | -3.5E+01 | +2.1E-02 | 1.0E+00 | 1.4E+02 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 31| +2.12E+02 | -8.0E-03 | +3.5E-02 | 3.1E-02 | 5.3E+00 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 35| +1.49E+02 | -6.2E-01 | +7.4E-01 | 6.2E-02 | 3.2E+01 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 30| +1.48E+02 | -1.2E-01 | +7.7E-01 | 1.2E-01 | 9.1E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 57| +1.48E+02 | -4.3E-04 | +4.5E-01 | 5.0E-02 | 9.4E-01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 2| +2.85E+02 | -5.1E+01 | +9.0E-01 | 2.5E-01 | 1.8E+02 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 20| +1.51E+02 | -3.6E-01 | +9.9E-01 | 2.0E+00 | 3.9E+01 | 1.0E+00 | trr |1\n", + "2023-02-17 16:05:11 fides(INFO) 32| +2.12E+02 | -8.0E-02 | +8.8E-01 | 7.8E-03 | 7.6E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 15| +2.32E+02 | -1.5E+02 | +8.8E-01 | 2.1E-01 | 8.4E+02 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 36| +1.48E+02 | -3.6E-01 | +7.7E-01 | 6.2E-02 | 4.0E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 31| +1.48E+02 | -9.2E-02 | +9.3E-01 | 2.3E-01 | 5.5E+00 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 33| +2.12E+02 | -5.0E-02 | +6.1E-01 | 1.6E-02 | 5.1E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 58| +1.48E+02 | +2.6E-03 | -1.2E+00 | 5.0E-02 | 4.0E-01 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 21| +1.51E+02 | +1.7E-01 | -1.2E+00 | 2.0E+00 | 4.7E+00 | 9.1E-01 | trr |0\n", + "2023-02-17 16:05:11 fides(INFO) 3| +2.67E+02 | -1.8E+01 | +1.7E-01 | 5.0E-01 | 5.6E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 37| +1.48E+02 | -3.0E-01 | +4.8E-01 | 1.2E-01 | 1.8E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 32| +1.48E+02 | +7.5E-03 | -8.6E-02 | 4.7E-01 | 5.0E+00 | 5.5E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 59| +1.48E+02 | +1.5E-04 | -1.6E-01 | 1.3E-02 | 4.0E-01 | 5.0E-03 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 34| +2.12E+02 | -2.2E-02 | +4.2E-01 | 1.6E-02 | 3.6E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 16| +2.11E+02 | -2.1E+01 | +8.5E-01 | 4.3E-01 | 1.3E+02 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 4| +2.52E+02 | -1.5E+01 | +8.1E-01 | 1.2E-01 | 1.1E+02 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 64| +1.57E+02 | -1.7E+00 | +8.4E-01 | 5.6E-02 | 2.9E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 22| +1.51E+02 | -9.5E-02 | +1.0E+00 | 2.3E-01 | 4.7E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 38| +1.48E+02 | +1.0E+00 | -9.7E-01 | 1.2E-01 | 3.1E+01 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 35| +2.12E+02 | -4.0E-02 | +5.6E-01 | 1.6E-02 | 4.7E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 33| +1.48E+02 | -3.1E-02 | +7.6E-01 | 1.2E-01 | 5.0E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 60| +1.48E+02 | -3.9E-05 | +6.2E-02 | 3.1E-03 | 4.0E-01 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 5| +2.52E+02 | -4.8E-02 | -2.8E-02 | 2.5E-01 | 2.8E+01 | 6.0E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 36| +2.12E+02 | -1.6E-02 | +3.3E-01 | 1.6E-02 | 3.4E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 23| +1.51E+02 | -2.1E-01 | +1.3E+00 | 4.7E-01 | 6.5E+00 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 39| +1.48E+02 | -2.6E-01 | +6.8E-01 | 3.1E-02 | 3.1E+01 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 34| +1.48E+02 | -4.3E-02 | +6.3E-01 | 2.3E-01 | 3.8E+00 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 61| +1.48E+02 | -3.7E-04 | +9.5E-01 | 7.9E-04 | 1.8E+00 | 5.5E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 37| +2.12E+02 | -3.5E-02 | +5.2E-01 | 1.6E-02 | 4.4E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 6| +2.50E+02 | -2.0E+00 | +7.3E-01 | 6.2E-02 | 2.8E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 24| +1.51E+02 | -4.8E-01 | +1.0E+00 | 9.4E-01 | 9.9E+00 | 3.2E-01 | trr |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 40| +1.48E+02 | -5.2E-02 | +8.1E-01 | 3.1E-02 | 6.5E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 35| +1.48E+02 | +1.5E-01 | -1.1E+00 | 2.3E-01 | 6.3E+00 | 2.5E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 62| +1.48E+02 | -3.1E-05 | +1.0E+00 | 1.6E-03 | 1.5E-01 | 6.9E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 38| +2.12E+02 | -1.4E-02 | +2.9E-01 | 1.6E-02 | 3.2E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 17| +2.11E+02 | +1.7E+02 | -1.5E+01 | 8.5E-01 | 3.1E+01 | 1.6E+00 | trr |0\n", + "2023-02-17 16:05:11 fides(INFO) 7| +2.50E+02 | -1.8E-02 | +1.2E-01 | 6.2E-02 | 5.1E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 41| +1.48E+02 | -7.6E-02 | +9.4E-01 | 6.2E-02 | 1.3E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 25| +1.51E+02 | +4.7E-01 | -4.4E-01 | 9.4E-01 | 4.8E+01 | 3.7E-01 | trr |0\n", + "2023-02-17 16:05:11 fides(INFO) 36| +1.48E+02 | -2.2E-02 | +5.4E-01 | 5.8E-02 | 6.3E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 39| +2.12E+02 | -3.0E-02 | +4.8E-01 | 1.6E-02 | 4.1E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 8| +2.50E+02 | -3.2E-02 | +3.2E-01 | 1.6E-02 | 4.1E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 63| +1.48E+02 | -3.8E-05 | +9.4E-01 | 3.1E-03 | 2.3E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 42| +1.48E+02 | -5.1E-02 | +5.7E-01 | 1.2E-01 | 4.1E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 40| +2.12E+02 | -1.2E-02 | +2.7E-01 | 1.6E-02 | 3.0E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 37| +1.48E+02 | -1.1E-02 | +8.5E-01 | 5.8E-02 | 2.4E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 26| +1.50E+02 | -4.2E-01 | +9.8E-01 | 4.7E-02 | 4.8E+01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 64| +1.48E+02 | -5.1E-05 | +8.8E-01 | 6.3E-03 | 8.6E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 43| +1.48E+02 | +1.4E-01 | -8.1E-01 | 1.2E-01 | 5.6E+00 | 8.6E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 18| +2.08E+02 | -3.4E+00 | +4.1E-01 | 1.6E-01 | 3.1E+01 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 9| +2.50E+02 | -7.8E-03 | +1.9E-01 | 1.6E-02 | 2.7E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 41| +2.12E+02 | -2.6E-02 | +4.5E-01 | 1.6E-02 | 3.9E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 65| +1.48E+02 | -7.4E-05 | +9.6E-01 | 1.3E-02 | 1.8E-01 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 38| +1.48E+02 | -1.4E-02 | +7.9E-01 | 1.2E-01 | 5.3E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 27| +1.50E+02 | -4.1E-01 | +8.8E-01 | 9.4E-02 | 1.3E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 65| +1.56E+02 | -1.1E+00 | +4.5E-01 | 1.1E-01 | 5.5E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 10| +2.50E+02 | -1.2E-02 | +7.4E-01 | 3.9E-03 | 2.1E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 39| +1.48E+02 | -4.5E-03 | +1.6E-01 | 2.3E-01 | 1.6E+00 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 44| +1.48E+02 | -3.4E-02 | +5.7E-01 | 3.1E-02 | 5.6E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 42| +2.12E+02 | -1.1E-02 | +2.6E-01 | 1.6E-02 | 2.9E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 66| +1.48E+02 | -1.1E-04 | +9.1E-01 | 2.5E-02 | 8.0E-02 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 11| +2.50E+02 | +7.2E-06 | -9.2E-03 | 3.9E-03 | 3.7E-01 | 9.9E-03 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 28| +1.50E+02 | -1.2E-01 | +8.3E-01 | 1.9E-01 | 1.8E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 43| +2.12E+02 | -2.3E-02 | +4.3E-01 | 1.6E-02 | 3.6E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 45| +1.48E+02 | -1.6E-02 | +8.7E-01 | 3.1E-02 | 6.4E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 19| +1.99E+02 | -8.5E+00 | +9.5E-01 | 1.6E-01 | 9.1E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 67| +1.48E+02 | -7.9E-05 | +3.8E-01 | 5.0E-02 | 2.9E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 40| +1.48E+02 | -1.7E-02 | +3.7E-01 | 5.8E-02 | 5.5E+00 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 12| +2.50E+02 | -4.0E-04 | +5.9E-01 | 9.8E-04 | 3.7E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 29| +1.50E+02 | +5.5E-03 | -2.2E-01 | 3.8E-01 | 2.0E+00 | 9.9E-02 | trr |0\n", + "2023-02-17 16:05:11 fides(INFO) 46| +1.48E+02 | -2.2E-02 | +9.1E-01 | 6.2E-02 | 2.7E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 44| +2.12E+02 | -1.1E-02 | +2.7E-01 | 1.6E-02 | 2.7E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 68| +1.48E+02 | +1.4E-03 | -1.9E+00 | 5.0E-02 | 2.0E-01 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 41| +1.48E+02 | -3.0E-03 | +3.5E-01 | 5.8E-02 | 1.4E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 13| +2.50E+02 | -3.5E-08 | +1.6E-03 | 9.8E-04 | 5.8E-02 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 45| +2.12E+02 | -2.0E-02 | +4.1E-01 | 1.6E-02 | 3.4E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 30| +1.50E+02 | -9.2E-03 | +7.6E-01 | 3.5E-02 | 2.0E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 69| +1.48E+02 | +4.1E-05 | -1.5E-01 | 1.3E-02 | 2.0E-01 | 3.6E-03 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 47| +1.48E+02 | +7.5E-03 | -2.5E-01 | 1.2E-01 | 4.2E+00 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 20| +1.94E+02 | -5.8E+00 | +5.3E-01 | 3.2E-01 | 4.2E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 42| +1.48E+02 | -3.9E-03 | +6.6E-01 | 5.8E-02 | 3.8E+00 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 46| +2.12E+02 | -1.1E-02 | +2.8E-01 | 1.6E-02 | 2.6E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 14| +2.50E+02 | -2.2E-06 | +1.1E-01 | 2.4E-04 | 5.8E-02 | 6.4E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 70| +1.48E+02 | -2.8E-05 | +1.9E-01 | 3.1E-03 | 2.0E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 48| +1.48E+02 | -8.3E-03 | +7.3E-01 | 3.1E-02 | 4.2E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 31| +1.50E+02 | -4.4E-03 | +8.8E-01 | 7.0E-02 | 4.0E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 43| +1.48E+02 | -1.6E-03 | +7.3E-01 | 5.8E-02 | 6.7E-01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 47| +2.12E+02 | -1.8E-02 | +4.1E-01 | 1.6E-02 | 3.2E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 15| +2.50E+02 | -4.5E-06 | +9.0E-01 | 6.1E-05 | 5.1E-02 | 1.1E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 32| +1.50E+02 | -4.5E-04 | +7.2E-01 | 1.4E-01 | 9.6E-01 | 1.2E-02 | trr |1\n", + "2023-02-17 16:05:11 fides(INFO) 49| +1.48E+02 | -7.2E-03 | +7.7E-01 | 3.1E-02 | 1.7E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 71| +1.48E+02 | -7.9E-05 | +9.3E-01 | 7.9E-04 | 8.5E-01 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:11.838 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.1643 and h = 1.42051e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:11.838 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.1643: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:11 fides(INFO) 44| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.8E-02 | 1.5E+00 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 48| +2.12E+02 | -1.1E-02 | +3.0E-01 | 1.6E-02 | 2.5E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 50| +1.48E+02 | -4.3E-03 | +3.0E-01 | 6.2E-02 | 3.9E+00 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 16| +2.50E+02 | -3.0E-06 | +6.0E-01 | 1.2E-04 | 3.2E-02 | 2.2E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 49| +2.12E+02 | -1.7E-02 | +4.2E-01 | 1.6E-02 | 3.0E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 33| +1.50E+02 | +6.5E-05 | -2.0E-01 | 1.4E-01 | 5.2E-01 | 1.0E-02 | trr |0\n", + "2023-02-17 16:05:11 fides(INFO) 72| +1.48E+02 | -5.7E-06 | +1.6E+00 | 1.6E-03 | 5.8E-02 | 3.7E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 45| +1.48E+02 | -6.5E-04 | +9.4E-01 | 1.5E-02 | 1.5E+00 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 73| +1.48E+02 | -2.7E-06 | +4.9E-01 | 3.1E-03 | 5.4E-02 | 7.1E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 66| +1.55E+02 | -8.8E-01 | +4.3E-01 | 1.1E-01 | 1.9E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 21| +1.86E+02 | -7.9E+00 | +5.9E-01 | 3.2E-01 | 1.2E+02 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 17| +2.50E+02 | +1.6E-11 | -1.2E-04 | 1.2E-04 | 4.9E-03 | 3.1E-04 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:11 fides(INFO) 50| +2.12E+02 | -1.2E-02 | +3.3E-01 | 1.6E-02 | 2.3E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 51| +1.48E+02 | +1.1E-01 | -2.7E+00 | 6.2E-02 | 1.7E+00 | 5.5E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 46| +1.48E+02 | -8.0E-04 | +9.8E-01 | 2.9E-02 | 2.7E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 34| +1.50E+02 | -1.4E-04 | +8.5E-01 | 6.2E-03 | 5.2E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 74| +1.48E+02 | -6.6E-06 | +1.4E+00 | 3.1E-03 | 3.8E-02 | 6.7E-04 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 51| +2.12E+02 | -1.7E-02 | +4.4E-01 | 1.6E-02 | 2.8E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 18| +2.50E+02 | +1.6E-11 | -1.2E-04 | 3.1E-05 | 4.9E-03 | 7.8E-05 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 47| +1.48E+02 | -1.1E-03 | +9.0E-01 | 5.8E-02 | 7.6E-01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 52| +1.48E+02 | +3.0E-02 | -1.1E+00 | 1.6E-02 | 1.7E+00 | 3.2E-02 | 2d |0\n", + "2023-02-17 16:05:11 fides(INFO) 35| +1.50E+02 | -2.7E-05 | +5.7E-01 | 1.2E-02 | 1.4E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:11 fides(INFO) 75| +1.48E+02 | -7.1E-06 | +8.7E-01 | 6.3E-03 | 5.6E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 22| +1.82E+02 | -3.9E+00 | +9.2E-01 | 3.2E-01 | 1.2E+02 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 52| +2.12E+02 | -1.2E-02 | +3.7E-01 | 1.6E-02 | 2.2E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 19| +2.50E+02 | -6.4E-08 | +7.9E-01 | 7.6E-06 | 4.9E-03 | 2.0E-05 | 2d |1\n", + "2023-02-17 16:05:12 fides(WARNING) Stopping as function difference 6.38E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:12 fides(INFO) 48| +1.48E+02 | -1.4E-03 | +7.4E-01 | 1.2E-01 | 3.1E-01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 53| +1.48E+02 | -7.1E-03 | +6.3E-01 | 3.9E-03 | 1.7E+00 | 8.5E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 36| +1.50E+02 | -1.1E-06 | +9.1E-02 | 1.2E-02 | 1.4E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 53| +2.12E+02 | -1.6E-02 | +4.7E-01 | 1.6E-02 | 2.6E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 76| +1.48E+02 | -1.3E-05 | +9.6E-01 | 1.3E-02 | 3.3E-02 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:12.047 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.6153 and h = 1.60736e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:12.047 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.6153: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:12 fides(INFO) 49| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 1.1E+00 | 6.9E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 54| +1.48E+02 | -6.0E-04 | +9.7E-01 | 3.9E-03 | 1.6E+00 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 23| +1.81E+02 | -1.1E+00 | +9.7E-01 | 6.3E-01 | 4.5E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 54| +2.12E+02 | -1.3E-02 | +1.0E+00 | 1.6E-02 | 2.0E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 77| +1.48E+02 | -2.3E-05 | +1.1E+00 | 2.5E-02 | 6.5E-02 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 37| +1.50E+02 | -4.6E-06 | +3.9E-01 | 3.1E-03 | 1.9E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 50| +1.48E+02 | -7.1E-04 | +7.0E-01 | 2.9E-02 | 1.1E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 55| +1.48E+02 | -8.9E-04 | +9.4E-01 | 7.8E-03 | 5.8E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 55| +2.12E+02 | -2.9E-02 | +1.0E+00 | 3.1E-02 | 1.4E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 24| +1.81E+02 | +6.2E+00 | -4.8E+00 | 1.3E+00 | 3.3E+01 | 2.5E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 0| +1.34E+06 | NaN | NaN | 1.0E+00 | 6.1E+06 | NaN | NaN |1\n", + "2023-02-17 16:05:12 fides(INFO) 78| +1.48E+02 | -1.6E-05 | +6.3E-01 | 5.0E-02 | 3.3E-02 | 7.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 38| +1.50E+02 | +1.1E-07 | -3.6E-02 | 3.1E-03 | 5.1E-02 | 9.7E-04 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 56| +1.48E+02 | -1.2E-03 | +9.6E-01 | 1.6E-02 | 1.3E+00 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 56| +2.12E+02 | -2.7E-02 | +1.1E+00 | 6.2E-02 | 2.3E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 51| +1.48E+02 | -2.6E-04 | +1.0E+00 | 2.9E-02 | 2.2E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 1| +1.14E+03 | -1.3E+06 | +1.1E-01 | 1.0E+00 | 6.1E+06 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 25| +1.80E+02 | -3.4E-01 | +3.2E-01 | 3.2E-01 | 3.3E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 79| +1.48E+02 | +2.3E-04 | -3.5E+00 | 5.0E-02 | 4.3E-02 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 57| +2.11E+02 | -3.2E-02 | +2.9E-01 | 1.2E-01 | 1.1E+00 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 39| +1.50E+02 | -1.2E-06 | +8.9E-01 | 7.8E-04 | 5.1E-02 | 2.4E-04 | 2d |1\n", + "2023-02-17 16:05:12 fides(WARNING) Stopping as function difference 1.19E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:12 fides(INFO) 2| +4.50E+02 | -6.9E+02 | +9.0E-01 | 2.5E-01 | 3.7E+03 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 57| +1.48E+02 | -2.0E-03 | +9.0E-01 | 3.1E-02 | 4.0E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 52| +1.48E+02 | -4.2E-04 | +9.7E-01 | 5.8E-02 | 1.7E-01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 3| +2.97E+02 | -1.5E+02 | +9.1E-01 | 5.0E-01 | 6.1E+02 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 58| +2.11E+02 | -1.8E-01 | +1.4E+00 | 1.2E-01 | 6.7E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 67| +1.55E+02 | +1.3E+00 | -1.5E+00 | 1.1E-01 | 3.3E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 80| +1.48E+02 | -7.5E-07 | +3.6E-02 | 1.3E-02 | 4.3E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 53| +1.48E+02 | -6.1E-04 | +9.6E-01 | 1.2E-01 | 2.1E-01 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 26| +1.79E+02 | -1.2E+00 | +8.4E-01 | 3.2E-01 | 3.8E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 58| +1.48E+02 | -6.3E-04 | +1.6E-01 | 6.2E-02 | 1.3E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 4| +2.51E+02 | -4.7E+01 | +7.6E-01 | 1.0E+00 | 9.8E+01 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 59| +2.11E+02 | -3.6E-01 | +1.2E+00 | 2.5E-01 | 2.9E+00 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 81| +1.48E+02 | -6.3E-06 | +8.9E-01 | 3.1E-03 | 6.2E-02 | 4.4E-04 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 54| +1.48E+02 | -4.3E-04 | +7.1E-01 | 2.3E-01 | 9.3E-02 | 9.5E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 5| +2.27E+02 | -2.3E+01 | +4.0E+00 | 2.0E+00 | 2.5E+01 | 3.8E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 59| +1.48E+02 | +7.6E-03 | -9.4E-01 | 1.6E-02 | 9.2E-01 | 1.7E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 60| +2.07E+02 | -3.5E+00 | +2.6E+00 | 5.0E-01 | 2.8E+00 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 27| +1.79E+02 | +4.8E+00 | -5.3E+00 | 6.3E-01 | 1.9E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 82| +1.48E+02 | -2.3E-06 | +8.6E-01 | 6.3E-03 | 7.4E-02 | 5.6E-04 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 55| +1.48E+02 | +1.9E-02 | -1.2E+01 | 2.3E-01 | 2.7E-01 | 7.0E-02 | trr |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 60| +1.48E+02 | -3.8E-04 | +7.3E-02 | 3.9E-03 | 9.2E-01 | 8.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 0| +9.11E+06 | NaN | NaN | 1.0E+00 | 4.2E+07 | NaN | NaN |1\n", + "2023-02-17 16:05:12 fides(INFO) 61| +2.07E+02 | +1.0E+02 | -8.3E+00 | 1.0E+00 | 9.9E+00 | 2.6E+00 | trr |0\n", + "2023-02-17 16:05:12 fides(INFO) 6| +2.27E+02 | +1.5E+04 | -7.0E+02 | 4.0E+00 | 4.2E+01 | 1.2E+01 | trr |0\n", + "2023-02-17 16:05:12 fides(INFO) 28| +1.79E+02 | -9.2E-02 | +1.9E-01 | 1.6E-01 | 1.9E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 83| +1.48E+02 | -9.2E-07 | +6.3E-01 | 1.3E-02 | 9.9E-03 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(WARNING) Stopping as function difference 9.23E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:12 fides(INFO) 56| +1.48E+02 | +5.4E-04 | -8.0E-01 | 5.7E-02 | 2.7E-01 | 1.7E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 1| +1.64E+03 | -9.1E+06 | +1.1E-01 | 1.0E+00 | 4.2E+07 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 62| +2.01E+02 | -6.2E+00 | +1.4E+00 | 2.5E-01 | 9.9E+00 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 61| +1.48E+02 | -1.8E-03 | +9.5E-01 | 9.8E-04 | 3.9E+00 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 7| +2.27E+02 | +2.6E+02 | -1.2E+01 | 1.0E+00 | 4.2E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 57| +1.48E+02 | -1.1E-04 | +5.4E-01 | 1.4E-02 | 2.7E-01 | 4.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 62| +1.48E+02 | -3.2E-04 | +8.2E-01 | 2.0E-03 | 5.3E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 8| +2.18E+02 | -9.3E+00 | +4.2E-01 | 2.5E-01 | 4.2E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 2| +5.48E+02 | -1.1E+03 | +9.0E-01 | 2.5E-01 | 5.9E+03 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 29| +1.79E+02 | -1.0E-01 | +9.7E-01 | 3.9E-02 | 1.9E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 63| +1.72E+02 | -2.9E+01 | +2.0E+00 | 5.0E-01 | 3.6E+01 | 8.7E-01 | trr |1\n", + "2023-02-17 16:05:12 fides(INFO) 58| +1.48E+02 | -1.8E-05 | +1.0E+00 | 1.4E-02 | 2.9E-01 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 9| +2.14E+02 | -4.2E+00 | +5.9E-01 | 2.5E-01 | 4.8E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 3| +3.02E+02 | -2.5E+02 | +9.1E-01 | 5.0E-01 | 1.0E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 63| +1.48E+02 | -2.5E-04 | +8.9E-01 | 3.9E-03 | 7.8E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 64| +1.72E+02 | +8.7E+02 | -2.7E+01 | 5.0E-01 | 4.9E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 4| +2.58E+02 | -4.4E+01 | +8.4E-01 | 1.0E+00 | 1.9E+02 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 10| +2.13E+02 | -2.6E-01 | +1.0E-01 | 2.5E-01 | 1.5E+01 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 30| +1.79E+02 | -9.2E-02 | +8.6E-01 | 7.9E-02 | 1.6E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 68| +1.55E+02 | +9.2E-01 | -1.4E+00 | 2.8E-02 | 3.3E+01 | 7.5E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 59| +1.48E+02 | -1.7E-05 | +1.1E+00 | 2.8E-02 | 4.8E-02 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 64| +1.48E+02 | -2.2E-04 | +8.0E-01 | 7.8E-03 | 2.3E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 5| +2.58E+02 | +2.7E+03 | -2.1E+02 | 2.0E+00 | 3.1E+01 | 4.1E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 0| +1.54E+13 | NaN | NaN | 1.0E+00 | 7.1E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:12 fides(INFO) 65| +1.69E+02 | -3.0E+00 | +2.5E-01 | 1.2E-01 | 4.9E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 11| +2.12E+02 | -1.3E+00 | +7.0E-01 | 6.2E-02 | 2.4E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 60| +1.48E+02 | -1.7E-05 | +8.7E-01 | 5.7E-02 | 8.5E-02 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 6| +2.58E+02 | +4.5E+02 | -3.0E+01 | 5.0E-01 | 3.1E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 65| +1.48E+02 | -2.4E-04 | +9.0E-01 | 1.6E-02 | 3.5E-01 | 7.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 31| +1.79E+02 | -1.4E-01 | +7.6E-01 | 1.6E-01 | 1.5E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 1| +1.08E+07 | -1.5E+13 | +8.4E-02 | 1.0E+00 | 7.1E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 66| +1.60E+02 | -8.8E+00 | +7.2E-01 | 1.2E-01 | 9.3E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 12| +2.12E+02 | -5.9E-01 | +1.0E+00 | 6.2E-02 | 7.5E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 7| +2.50E+02 | -7.4E+00 | +8.2E-01 | 1.2E-01 | 3.1E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 66| +1.48E+02 | -3.3E-04 | +8.6E-01 | 3.1E-02 | 1.7E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 61| +1.48E+02 | +1.0E-04 | -2.8E+00 | 1.1E-01 | 4.4E-02 | 2.1E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 13| +2.11E+02 | -8.7E-01 | +9.4E-01 | 1.2E-01 | 7.4E+00 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 32| +1.79E+02 | +2.8E-01 | -1.5E+00 | 3.2E-01 | 1.0E+01 | 5.4E-01 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 67| +1.53E+02 | -7.3E+00 | +6.4E-01 | 1.2E-01 | 6.9E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 8| +2.50E+02 | +4.4E-01 | -5.8E-01 | 2.5E-01 | 1.0E+01 | 6.1E-01 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 2| +1.65E+06 | -9.1E+06 | +8.9E-01 | 2.5E-01 | 5.0E+07 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 62| +1.48E+02 | +2.2E-06 | -1.6E-01 | 2.8E-02 | 4.4E-02 | 5.2E-03 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 67| +1.48E+02 | +4.0E-04 | -5.8E-01 | 6.2E-02 | 4.1E-01 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 9| +2.50E+02 | +3.7E-01 | -5.0E-01 | 6.2E-02 | 1.0E+01 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 14| +2.09E+02 | -1.7E+00 | +7.7E-01 | 2.5E-01 | 1.0E+01 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 68| +1.51E+02 | -1.7E+00 | +3.2E-01 | 1.2E-01 | 4.7E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:12.603 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1383 and h = 1.69942e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:12.603 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1383: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:12 fides(INFO) 3| +2.56E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 7.7E+06 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 33| +1.79E+02 | -5.1E-02 | +6.3E-01 | 7.9E-02 | 1.0E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 63| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.1E-03 | 4.4E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:12.618 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.406 and h = 2.66838e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:12.619 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.406: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:12 fides(INFO) 68| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 4.1E-01 | 7.5E-03 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 10| +2.50E+02 | -3.0E-01 | +8.5E-01 | 1.6E-02 | 1.0E+01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 15| +2.04E+02 | -5.2E+00 | +1.0E+00 | 5.0E-01 | 1.8E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 4| +4.44E+04 | -2.1E+05 | +8.7E-01 | 1.0E+00 | 1.2E+06 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 69| +1.51E+02 | +1.6E+01 | -2.7E+00 | 1.2E-01 | 9.4E+01 | 3.6E-01 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 11| +2.50E+02 | +3.0E-02 | -2.0E-01 | 3.1E-02 | 4.8E+00 | 7.8E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 64| +1.48E+02 | +7.2E-07 | -2.8E-01 | 1.8E-03 | 4.4E-02 | 3.4E-04 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 69| +1.48E+02 | -6.7E-05 | +9.3E-01 | 3.9E-03 | 4.1E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 5| +7.00E+03 | -3.7E+04 | +9.0E-01 | 2.0E+00 | 2.0E+05 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 34| +1.79E+02 | -6.4E-02 | +8.2E-01 | 7.9E-02 | 1.1E+01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 12| +2.50E+02 | -6.6E-02 | +8.1E-01 | 7.8E-03 | 4.8E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 16| +2.04E+02 | +1.6E+02 | -1.8E+01 | 1.0E+00 | 1.5E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 70| +1.48E+02 | -6.2E-05 | +8.7E-01 | 7.8E-03 | 5.2E-02 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 65| +1.48E+02 | +2.0E-06 | -1.0E+00 | 4.4E-04 | 4.4E-02 | 1.2E-04 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 70| +1.51E+02 | +4.9E-01 | -1.4E-01 | 3.1E-02 | 9.4E+01 | 8.4E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 6| +1.25E+03 | -5.7E+03 | +9.0E-01 | 2.0E+00 | 3.1E+04 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 13| +2.50E+02 | +1.2E-03 | -6.2E-02 | 1.6E-02 | 1.8E+00 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 17| +1.98E+02 | -6.1E+00 | +1.2E+00 | 2.5E-01 | 1.5E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 35| +1.79E+02 | +1.4E-02 | -2.4E-01 | 1.6E-01 | 7.4E+00 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 71| +1.50E+02 | -1.3E+00 | +8.2E-01 | 7.8E-03 | 9.4E+01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 66| +1.48E+02 | +2.5E-07 | -1.3E-01 | 1.1E-04 | 4.4E-02 | 9.0E-05 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 71| +1.48E+02 | -1.0E-04 | +9.8E-01 | 1.6E-02 | 6.5E-02 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 7| +3.67E+02 | -8.8E+02 | +9.0E-01 | 2.0E+00 | 4.9E+03 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 14| +2.50E+02 | -9.9E-03 | +7.1E-01 | 3.9E-03 | 1.8E+00 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 69| +1.55E+02 | +7.1E-02 | -1.6E-01 | 7.0E-03 | 3.3E+01 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 67| +1.48E+02 | +2.2E-06 | -1.4E+00 | 2.8E-05 | 4.4E-02 | 5.5E-05 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 18| +1.98E+02 | +2.5E+01 | -2.4E+00 | 5.0E-01 | 3.0E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 72| +1.48E+02 | -1.5E-04 | +9.8E-01 | 3.1E-02 | 1.3E-01 | 8.8E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 72| +1.49E+02 | -6.0E-01 | +9.0E-01 | 1.6E-02 | 4.2E+01 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 15| +2.50E+02 | -2.1E-05 | +8.1E-02 | 3.9E-03 | 2.0E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 8| +2.31E+02 | -1.4E+02 | +9.2E-01 | 2.0E+00 | 7.7E+02 | 4.4E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 36| +1.79E+02 | -2.2E-02 | +7.6E-01 | 3.9E-02 | 7.4E+00 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 19| +1.90E+02 | -7.6E+00 | +1.2E+00 | 1.2E-01 | 3.0E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 16| +2.50E+02 | -8.1E-05 | +3.5E-01 | 9.8E-04 | 2.0E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 68| +1.48E+02 | +2.6E-06 | -4.9E+00 | 6.9E-06 | 4.4E-02 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 73| +1.49E+02 | -7.1E-01 | +7.0E-01 | 3.1E-02 | 2.8E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 73| +1.48E+02 | -1.1E-04 | +6.6E-01 | 6.2E-02 | 4.3E-02 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 9| +2.31E+02 | +1.1E+02 | -4.5E+00 | 4.0E+00 | 1.1E+02 | 7.3E+00 | trr |0\n", + "2023-02-17 16:05:12 fides(INFO) 17| +2.50E+02 | -6.3E-06 | +7.5E-02 | 9.8E-04 | 1.2E-01 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:12.833 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 213.323 and h = 2.13543e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:12.833 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 213.323: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:12 fides(INFO) 37| +1.79E+02 | +0.0E+00 | +0.0E+00 | 7.9E-02 | 7.9E+00 | 3.5E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 20| +1.73E+02 | -1.7E+01 | +1.0E+00 | 2.5E-01 | 3.0E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 18| +2.50E+02 | -3.5E-05 | +7.9E-01 | 2.4E-04 | 1.1E-01 | 4.7E-04 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 74| +1.48E+02 | +3.6E-03 | -7.0E+00 | 6.2E-02 | 1.5E-01 | 1.9E-02 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 69| +1.48E+02 | +4.9E-06 | -3.5E+01 | 1.7E-06 | 4.4E-02 | 3.5E-06 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 74| +1.48E+02 | -2.2E-01 | +3.5E-01 | 3.1E-02 | 3.8E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 10| +2.22E+02 | -9.6E+00 | +2.2E-01 | 6.3E-01 | 1.1E+02 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 19| +2.50E+02 | -3.1E-06 | +3.2E-01 | 4.9E-04 | 3.5E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 38| +1.79E+02 | -1.9E-02 | +1.0E+00 | 2.0E-02 | 7.9E+00 | 9.5E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 75| +1.48E+02 | -3.0E-01 | +7.4E-01 | 3.1E-02 | 3.5E+01 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 70| +1.48E+02 | +2.1E-06 | -6.0E+01 | 4.3E-07 | 4.4E-02 | 8.7E-07 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 21| +1.73E+02 | +1.7E+01 | -1.4E+00 | 5.0E-01 | 1.0E+02 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 75| +1.48E+02 | +9.0E-05 | -4.7E-01 | 1.6E-02 | 1.5E-01 | 4.9E-03 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 20| +2.50E+02 | -2.9E-06 | +3.3E-01 | 4.9E-04 | 3.3E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 11| +2.09E+02 | -1.3E+01 | +1.0E+00 | 1.6E-01 | 6.5E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 76| +1.48E+02 | -7.8E-02 | +3.8E-01 | 3.1E-02 | 1.5E+01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 76| +1.48E+02 | -3.6E-05 | +6.2E-01 | 3.9E-03 | 1.5E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 71| +1.48E+02 | +3.0E-06 | -3.3E+02 | 1.1E-07 | 4.4E-02 | 2.2E-07 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) 22| +1.63E+02 | -1.1E+01 | +9.1E-01 | 1.2E-01 | 1.0E+02 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 21| +2.50E+02 | -3.0E-06 | +3.5E-01 | 4.9E-04 | 3.2E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 12| +1.95E+02 | -1.4E+01 | +6.0E-01 | 3.2E-01 | 4.7E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 39| +1.79E+02 | -2.0E-02 | +9.2E-01 | 3.9E-02 | 6.4E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 22| +2.50E+02 | -2.9E-06 | +3.6E-01 | 4.9E-04 | 3.0E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 77| +1.48E+02 | -2.7E-01 | +6.9E-01 | 3.1E-02 | 1.5E+01 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 77| +1.48E+02 | -6.3E-06 | +7.1E-01 | 3.9E-03 | 2.1E-01 | 4.2E-04 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 23| +1.52E+02 | -1.1E+01 | +8.0E-01 | 2.5E-01 | 5.0E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 72| +1.48E+02 | +6.4E-06 | -2.8E+03 | 2.7E-08 | 4.4E-02 | 5.4E-08 | 2d |0\n", + "2023-02-17 16:05:12 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:12 fides(INFO) 70| +1.55E+02 | -1.2E-01 | +7.8E-01 | 1.8E-03 | 3.3E+01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 13| +1.77E+02 | -1.8E+01 | +8.9E-01 | 3.2E-01 | 9.3E+01 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:12 fides(INFO) 23| +2.50E+02 | -3.0E-06 | +3.9E-01 | 4.9E-04 | 2.9E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 24| +1.52E+02 | +6.1E+00 | -1.7E+00 | 5.0E-01 | 7.6E+01 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 78| +1.48E+02 | +3.6E+00 | -5.2E+00 | 3.1E-02 | 1.4E+01 | 6.0E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 40| +1.78E+02 | -3.1E-02 | +1.0E+00 | 7.9E-02 | 6.4E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 73| +1.48E+02 | +4.2E-06 | -7.4E+03 | 6.8E-09 | 4.4E-02 | 1.4E-08 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 78| +1.48E+02 | +2.4E-06 | -7.3E-01 | 3.9E-03 | 2.8E-02 | 5.0E-04 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 24| +2.50E+02 | -2.9E-06 | +4.0E-01 | 4.9E-04 | 2.8E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 14| +1.77E+02 | +5.3E+01 | -3.5E+00 | 6.3E-01 | 1.2E+02 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 79| +1.48E+02 | +1.1E-01 | -5.8E-01 | 7.8E-03 | 1.4E+01 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 25| +2.50E+02 | -3.0E-06 | +4.2E-01 | 4.9E-04 | 2.7E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 79| +1.48E+02 | -4.3E-06 | +2.8E+00 | 9.8E-04 | 2.8E-02 | 1.4E-04 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 41| +1.78E+02 | +6.6E-03 | -2.4E-01 | 1.6E-01 | 4.1E+00 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 25| +1.50E+02 | -1.9E+00 | +7.9E-01 | 1.2E-01 | 7.6E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 26| +2.50E+02 | -2.9E-06 | +4.3E-01 | 4.9E-04 | 2.6E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 15| +1.63E+02 | -1.4E+01 | +1.0E+00 | 1.6E-01 | 1.2E+02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 74| +1.48E+02 | +1.7E-07 | -1.2E+03 | 1.7E-09 | 4.4E-02 | 3.4E-09 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 80| +1.48E+02 | -2.9E-02 | +6.0E-01 | 2.0E-03 | 1.4E+01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 80| +1.48E+02 | -1.0E-06 | +6.1E-01 | 2.0E-03 | 7.0E-02 | 2.9E-04 | 2d |1\n", + "2023-02-17 16:05:13 fides(WARNING) Stopping as function difference 1.05E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:13 fides(INFO) 27| +2.50E+02 | -3.0E-06 | +4.5E-01 | 4.9E-04 | 2.6E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 16| +1.53E+02 | -9.5E+00 | +8.3E-01 | 3.2E-01 | 6.9E+01 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 26| +1.49E+02 | -1.3E+00 | +6.4E-01 | 2.4E-01 | 3.7E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 42| +1.78E+02 | -9.1E-03 | +7.5E-01 | 3.9E-02 | 4.1E+00 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 81| +1.48E+02 | -2.3E-02 | +9.7E-01 | 2.0E-03 | 6.0E+00 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 28| +2.50E+02 | -2.9E-06 | +4.6E-01 | 4.9E-04 | 2.5E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 75| +1.48E+02 | +2.5E-06 | -7.2E+04 | 4.2E-10 | 4.4E-02 | 8.5E-10 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 27| +1.49E+02 | +1.6E+01 | -5.5E+00 | 2.4E-01 | 2.8E+01 | 4.7E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 29| +2.50E+02 | -3.0E-06 | +4.8E-01 | 4.9E-04 | 2.4E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 17| +1.50E+02 | -3.6E+00 | +5.4E-01 | 6.3E-01 | 1.1E+02 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 43| +1.78E+02 | -8.1E-03 | +7.5E-01 | 3.9E-02 | 4.5E+00 | 6.6E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 82| +1.48E+02 | -3.2E-02 | +8.8E-01 | 3.9E-03 | 6.4E+00 | 8.4E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 76| +1.48E+02 | +3.9E-06 | -4.5E+05 | 1.1E-10 | 4.4E-02 | 2.1E-10 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 30| +2.50E+02 | -2.9E-06 | +4.8E-01 | 4.9E-04 | 2.3E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 28| +1.48E+02 | -3.0E-01 | +3.1E-01 | 5.9E-02 | 2.8E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 18| +1.50E+02 | +3.2E+00 | -1.1E+00 | 6.3E-01 | 1.1E+02 | 6.8E-01 | trr |0\n", + "2023-02-17 16:05:13 fides(INFO) 83| +1.48E+02 | -6.3E-03 | +2.3E-01 | 7.8E-03 | 7.4E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 31| +2.50E+02 | -3.0E-06 | +5.0E-01 | 4.9E-04 | 2.3E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 44| +1.78E+02 | +1.6E-03 | -1.3E-01 | 7.9E-02 | 3.3E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 77| +1.48E+02 | +2.5E-06 | -1.1E+06 | 2.6E-11 | 4.4E-02 | 5.3E-11 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 71| +1.55E+02 | -5.4E-02 | +9.5E-01 | 3.5E-03 | 1.5E+01 | 9.6E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 29| +1.48E+02 | -2.9E-01 | +8.0E-01 | 5.9E-02 | 2.2E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 84| +1.48E+02 | -1.7E-02 | +9.2E-01 | 2.0E-03 | 6.3E+00 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 19| +1.48E+02 | -1.3E+00 | +9.3E-01 | 7.1E-02 | 1.1E+02 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 32| +2.50E+02 | -2.9E-06 | +5.0E-01 | 4.9E-04 | 2.3E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 0| +4.20E+12 | NaN | NaN | 1.0E+00 | 1.9E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:13 fides(INFO) 45| +1.78E+02 | -4.2E-03 | +7.6E-01 | 2.0E-02 | 3.3E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 78| +1.48E+02 | +1.2E-06 | -2.1E+06 | 6.6E-12 | 4.4E-02 | 1.3E-11 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 30| +1.48E+02 | -8.3E-02 | +2.7E-01 | 1.2E-01 | 2.0E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 33| +2.50E+02 | -3.0E-06 | +5.2E-01 | 4.9E-04 | 2.2E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 20| +1.48E+02 | -5.8E-01 | +7.8E-01 | 1.4E-01 | 2.7E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 85| +1.48E+02 | -1.7E-02 | +6.1E-01 | 3.9E-03 | 4.6E+00 | 8.5E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 79| +1.48E+02 | +2.4E-06 | -1.7E+07 | 1.6E-12 | 4.4E-02 | 3.3E-12 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 1| +4.24E+06 | -4.2E+12 | +8.7E-02 | 1.0E+00 | 1.9E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 34| +2.50E+02 | -2.9E-06 | +5.2E-01 | 4.9E-04 | 2.2E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 31| +1.48E+02 | +2.7E-01 | -4.4E-01 | 1.2E-01 | 1.4E+01 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 46| +1.78E+02 | -7.1E-03 | +9.8E-01 | 3.9E-02 | 3.6E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 80| +1.48E+02 | +3.1E-06 | -8.9E+07 | 4.1E-13 | 4.4E-02 | 8.3E-13 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 35| +2.50E+02 | -3.0E-06 | +5.3E-01 | 4.9E-04 | 2.2E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 21| +1.48E+02 | -2.0E-01 | +8.9E-01 | 2.8E-01 | 3.7E+01 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 86| +1.48E+02 | -4.8E-03 | +2.6E-01 | 3.9E-03 | 7.3E+00 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 2| +6.58E+05 | -3.6E+06 | +9.0E-01 | 2.5E-01 | 2.0E+07 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:13.358 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 83.5233 and h = 1.6975e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:13.358 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 83.5233: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:13 fides(INFO) 32| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.0E-02 | 1.4E+01 | 3.4E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 36| +2.50E+02 | -2.9E-06 | +5.3E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 87| +1.48E+02 | -9.4E-03 | +9.6E-01 | 3.9E-03 | 7.9E+00 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 22| +1.48E+02 | +2.8E+00 | -2.5E+01 | 5.7E-01 | 6.0E+00 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 47| +1.78E+02 | -8.8E-05 | -1.8E-02 | 7.9E-02 | 2.6E+00 | 9.4E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 81| +1.48E+02 | +2.6E-06 | -3.0E+08 | 1.0E-13 | 4.4E-02 | 2.1E-13 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 37| +2.50E+02 | -3.0E-06 | +5.4E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 33| +1.48E+02 | -7.7E-02 | +9.2E-01 | 7.4E-03 | 1.4E+01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 3| +1.03E+05 | -5.5E+05 | +9.0E-01 | 5.0E-01 | 3.0E+06 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 38| +2.50E+02 | -2.9E-06 | +5.5E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 82| +1.48E+02 | +3.6E-06 | -1.7E+09 | 2.6E-14 | 4.4E-02 | 5.2E-14 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 23| +1.48E+02 | -3.8E-02 | +6.6E-01 | 1.4E-01 | 6.0E+00 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 88| +1.48E+02 | -1.4E-02 | +7.3E-01 | 7.8E-03 | 2.8E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 34| +1.48E+02 | -8.4E-02 | +8.0E-01 | 1.5E-02 | 1.5E+01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 4| +1.64E+04 | -8.7E+04 | +9.0E-01 | 1.0E+00 | 4.7E+05 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 48| +1.78E+02 | -2.9E-03 | +7.7E-01 | 2.0E-02 | 2.6E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 39| +2.50E+02 | -3.0E-06 | +5.5E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 24| +1.48E+02 | +9.8E-02 | -1.6E+00 | 1.4E-01 | 6.6E+00 | 9.3E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 83| +1.48E+02 | +3.4E-06 | -6.2E+09 | 6.4E-15 | 4.4E-02 | 1.3E-14 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 5| +2.79E+03 | -1.4E+04 | +9.0E-01 | 1.0E+00 | 7.5E+04 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 89| +1.48E+02 | -6.6E-03 | +3.9E-01 | 7.8E-03 | 6.7E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 25| +1.48E+02 | -1.5E-02 | +5.9E-01 | 3.5E-02 | 6.6E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 40| +2.50E+02 | -4.6E-06 | +1.0E+00 | 4.9E-04 | 2.0E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 35| +1.48E+02 | -5.7E-02 | +8.0E-01 | 3.0E-02 | 1.1E+01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 49| +1.78E+02 | -4.1E-03 | +8.1E-01 | 3.9E-02 | 2.8E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 90| +1.48E+02 | +1.6E-02 | -2.4E+00 | 7.8E-03 | 1.9E+00 | 9.1E-03 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 84| +1.48E+02 | -2.4E-07 | +1.8E+09 | 1.6E-15 | 4.4E-02 | 3.2E-15 | 2d |1\n", + "2023-02-17 16:05:13 fides(WARNING) Stopping as function difference 2.41E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:13 fides(INFO) 41| +2.50E+02 | -7.0E-06 | +1.0E+00 | 9.8E-04 | 4.2E-03 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 6| +6.31E+02 | -2.2E+03 | +9.1E-01 | 2.0E+00 | 1.2E+04 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 36| +1.48E+02 | -4.6E-02 | +9.4E-01 | 5.9E-02 | 7.7E+00 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 26| +1.48E+02 | -1.1E-02 | +4.4E-01 | 3.5E-02 | 3.6E+00 | 9.3E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 50| +1.78E+02 | +1.3E-02 | -1.2E+00 | 7.9E-02 | 2.0E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 42| +2.50E+02 | -1.4E-05 | +1.0E+00 | 2.0E-03 | 8.9E-03 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 91| +1.48E+02 | +9.8E-03 | -2.5E+00 | 2.0E-03 | 1.9E+00 | 4.1E-03 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 72| +1.55E+02 | -7.6E-02 | +8.2E-01 | 7.0E-03 | 7.5E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 7| +2.91E+02 | -3.4E+02 | +9.1E-01 | 2.0E+00 | 1.9E+03 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 37| +1.48E+02 | -4.3E-02 | +7.8E-01 | 1.2E-01 | 5.8E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 92| +1.48E+02 | -3.6E-04 | +2.2E-01 | 4.9E-04 | 1.9E+00 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 27| +1.48E+02 | +7.5E-04 | -3.3E-02 | 3.5E-02 | 6.6E+00 | 3.5E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 43| +2.50E+02 | -2.8E-05 | +1.1E+00 | 3.9E-03 | 1.2E-02 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 51| +1.78E+02 | -1.9E-03 | +5.6E-01 | 2.0E-02 | 2.0E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 44| +2.50E+02 | -5.6E-05 | +1.0E+00 | 7.8E-03 | 2.1E-02 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 28| +1.48E+02 | -8.1E-03 | +8.1E-01 | 8.9E-03 | 6.6E+00 | 9.0E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 38| +1.48E+02 | +6.4E-01 | -6.7E+00 | 2.4E-01 | 2.4E+00 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 93| +1.48E+02 | -5.6E-04 | +9.9E-01 | 1.2E-04 | 3.3E+00 | 2.2E-04 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 8| +2.21E+02 | -7.0E+01 | +1.3E+00 | 2.0E+00 | 2.7E+02 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 45| +2.50E+02 | -1.1E-04 | +1.0E+00 | 1.6E-02 | 3.9E-02 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 39| +1.48E+02 | +1.0E-02 | -3.2E-01 | 5.9E-02 | 2.4E+00 | 7.5E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 29| +1.48E+02 | -3.2E-03 | +9.3E-01 | 1.8E-02 | 1.4E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 52| +1.78E+02 | -1.9E-03 | +7.9E-01 | 2.0E-02 | 2.2E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 0| +2.98E+09 | NaN | NaN | 1.0E+00 | 1.4E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:13 fides(INFO) 46| +2.50E+02 | -2.3E-04 | +1.0E+00 | 3.1E-02 | 7.6E-02 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 94| +1.48E+02 | -6.8E-04 | +1.0E+00 | 2.4E-04 | 2.5E+00 | 4.5E-04 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 9| +2.21E+02 | +4.6E+04 | -1.3E+03 | 2.0E+00 | 5.2E+01 | 5.8E+00 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 47| +2.50E+02 | -5.0E-04 | +1.1E+00 | 6.2E-02 | 1.5E-01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 30| +1.48E+02 | -3.8E-03 | +9.6E-01 | 3.5E-02 | 2.2E+00 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 40| +1.48E+02 | -6.9E-03 | +6.8E-01 | 1.5E-02 | 2.4E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 53| +1.78E+02 | -1.1E-03 | +3.1E-01 | 3.9E-02 | 1.8E+00 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 48| +2.50E+02 | -1.4E-03 | +1.3E+00 | 1.2E-01 | 3.0E-01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 95| +1.48E+02 | -9.9E-04 | +9.4E-01 | 4.9E-04 | 1.4E+00 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 1| +4.43E+04 | -3.0E+09 | +9.3E-02 | 1.0E+00 | 1.4E+10 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 41| +1.48E+02 | -2.9E-03 | +8.7E-01 | 1.5E-02 | 2.7E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 31| +1.48E+02 | +2.1E-03 | -4.0E-01 | 7.1E-02 | 8.2E-01 | 4.7E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 10| +2.21E+02 | +2.8E+01 | -8.8E-01 | 5.0E-01 | 5.2E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 49| +2.50E+02 | -6.8E-03 | +1.9E+00 | 2.5E-01 | 5.9E-01 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 42| +1.48E+02 | -4.1E-03 | +9.5E-01 | 3.0E-02 | 1.6E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 54| +1.78E+02 | -1.1E-03 | +1.7E-01 | 3.9E-02 | 1.8E+00 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 2| +8.94E+03 | -3.5E+04 | +8.9E-01 | 2.5E-01 | 1.8E+05 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 50| +2.50E+02 | -8.2E-02 | +3.3E+00 | 5.0E-01 | 1.2E+00 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 32| +1.48E+02 | -1.2E-03 | +5.4E-01 | 1.8E-02 | 8.2E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 96| +1.48E+02 | -7.9E-04 | +7.9E-01 | 9.8E-04 | 1.1E+00 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 3| +1.58E+03 | -7.4E+03 | +9.0E-01 | 5.0E-01 | 3.1E+04 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 11| +2.06E+02 | -1.5E+01 | +9.3E-01 | 1.2E-01 | 5.2E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 51| +2.47E+02 | -2.4E+00 | +4.8E+00 | 1.0E+00 | 2.3E+00 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 43| +1.48E+02 | -3.4E-03 | +6.6E-01 | 5.9E-02 | 1.6E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 73| +1.55E+02 | +3.3E-02 | -5.3E-01 | 1.4E-02 | 7.1E+00 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 55| +1.78E+02 | -1.5E-03 | +7.4E-01 | 9.9E-03 | 1.3E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 33| +1.48E+02 | -1.3E-03 | +4.6E-01 | 1.8E-02 | 2.0E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 4| +4.27E+02 | -1.2E+03 | +9.0E-01 | 1.0E+00 | 4.9E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 97| +1.48E+02 | -7.3E-04 | +9.8E-01 | 2.0E-03 | 2.3E+00 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 52| +2.31E+02 | -1.6E+01 | +1.8E+00 | 2.0E+00 | 8.6E+00 | 3.7E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 12| +2.01E+02 | -4.9E+00 | +2.2E-01 | 2.5E-01 | 4.3E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 5| +2.63E+02 | -1.6E+02 | +8.8E-01 | 1.0E+00 | 7.8E+02 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 44| +1.48E+02 | +2.6E-02 | -2.3E+00 | 5.9E-02 | 1.0E+00 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 34| +1.48E+02 | -2.1E-04 | +1.2E-01 | 1.8E-02 | 5.5E-01 | 6.0E-03 | 2d |1\n", + "2023-02-17 16:05:13.862 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.905 and h = 3.56407e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:13.862 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.905: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:13 fides(INFO) 98| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 5.3E-01 | 5.2E-03 | 2d |0\n", + "2023-02-17 16:05:13 fides(INFO) 56| +1.78E+02 | -8.2E-04 | +8.0E-01 | 9.9E-03 | 1.4E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 53| +2.31E+02 | +7.7E+00 | -1.1E+00 | 4.0E+00 | 4.1E+01 | 1.2E+00 | trr |0\n", + "2023-02-17 16:05:13 fides(INFO) 45| +1.48E+02 | -5.8E-04 | +1.4E-01 | 1.5E-02 | 1.0E+00 | 8.4E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 35| +1.48E+02 | -5.4E-04 | +7.7E-01 | 4.4E-03 | 6.2E-01 | 7.9E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 54| +2.30E+02 | -1.7E+00 | +7.7E-01 | 1.4E-01 | 4.1E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 99| +1.48E+02 | -1.6E-04 | +9.8E-01 | 9.8E-04 | 5.3E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 6| +2.50E+02 | -1.3E+01 | +7.5E-01 | 1.0E+00 | 1.0E+02 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 13| +1.98E+02 | -3.5E+00 | +9.4E-01 | 6.2E-02 | 6.6E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 57| +1.78E+02 | -8.6E-04 | +9.3E-01 | 2.0E-02 | 1.3E+00 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 46| +1.48E+02 | -1.0E-03 | +8.9E-01 | 3.7E-03 | 2.1E+00 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 36| +1.48E+02 | -3.2E-04 | +6.8E-01 | 8.9E-03 | 4.2E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 55| +2.23E+02 | -6.5E+00 | +1.2E+00 | 2.8E-01 | 3.8E+01 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:13 fides(INFO) 100| +1.48E+02 | -2.6E-04 | +1.0E+00 | 2.0E-03 | 8.1E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 7| +2.44E+02 | -5.2E+00 | +6.4E+00 | 1.0E+00 | 5.5E+00 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 47| +1.48E+02 | -5.4E-04 | +7.1E-01 | 7.4E-03 | 3.9E-01 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 14| +1.94E+02 | -3.5E+00 | +9.2E-01 | 1.2E-01 | 5.1E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:13 fides(INFO) 58| +1.78E+02 | -1.2E-03 | +1.0E+00 | 3.9E-02 | 1.2E+00 | 9.6E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 56| +2.17E+02 | -6.6E+00 | +9.8E-01 | 5.5E-01 | 2.0E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 37| +1.48E+02 | -1.8E-04 | +9.1E-01 | 8.9E-03 | 2.2E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 101| +1.48E+02 | -4.1E-04 | +1.0E+00 | 3.9E-03 | 4.2E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 8| +2.16E+02 | -2.8E+01 | +2.0E+00 | 2.0E+00 | 1.5E+01 | 3.6E+00 | 2d |1\n", + "2023-02-17 16:05:14.026 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.61 and h = 3.16878e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:14.027 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.61: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:14 fides(INFO) 48| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.4E-03 | 4.4E-01 | 5.5E-03 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 57| +2.17E+02 | +8.6E+01 | -1.7E+01 | 1.1E+00 | 3.3E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 38| +1.48E+02 | -2.4E-04 | +7.6E-01 | 1.8E-02 | 5.1E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 102| +1.48E+02 | -8.5E-04 | +1.0E+00 | 7.8E-03 | 4.6E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 59| +1.78E+02 | +1.8E-03 | -1.0E+00 | 7.9E-02 | 8.1E-01 | 7.2E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 9| +2.16E+02 | +8.9E+02 | -4.8E+01 | 4.0E+00 | 2.7E+01 | 1.2E+01 | trr |0\n", + "2023-02-17 16:05:14 fides(INFO) 58| +2.15E+02 | -2.0E+00 | +6.1E-01 | 2.5E-01 | 3.3E+01 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 49| +1.48E+02 | -9.2E-05 | +1.0E+00 | 1.9E-03 | 4.4E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 39| +1.48E+02 | +6.3E-04 | -1.1E+00 | 3.5E-02 | 2.0E-01 | 6.4E-03 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 10| +2.16E+02 | +2.9E+01 | -3.6E+00 | 1.0E+00 | 2.7E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 103| +1.48E+02 | -1.4E-03 | +9.5E-01 | 1.6E-02 | 2.9E-01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 60| +1.78E+02 | -3.3E-04 | +5.7E-01 | 2.0E-02 | 8.1E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 59| +2.12E+02 | -2.4E+00 | +4.6E-01 | 2.5E-01 | 2.7E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 50| +1.48E+02 | -1.5E-04 | +9.8E-01 | 3.7E-03 | 2.6E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 40| +1.48E+02 | -1.0E-04 | +5.6E-01 | 8.9E-03 | 2.0E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 15| +1.93E+02 | -1.1E+00 | +1.0E+00 | 2.5E-01 | 2.3E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 11| +2.16E+02 | +3.8E+00 | -6.2E-01 | 2.5E-01 | 2.7E+01 | 6.3E-01 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 60| +2.12E+02 | +1.1E-01 | -1.1E-01 | 2.5E-01 | 1.4E+01 | 6.6E-01 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 104| +1.48E+02 | -2.0E-03 | +7.5E-01 | 3.1E-02 | 3.1E-01 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 74| +1.55E+02 | -1.7E-02 | +7.7E-01 | 3.5E-03 | 7.1E+00 | 8.1E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 61| +1.78E+02 | +3.3E-05 | -4.2E-02 | 2.0E-02 | 8.6E-01 | 3.1E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 51| +1.48E+02 | -2.3E-04 | +9.2E-01 | 7.4E-03 | 3.9E-01 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 41| +1.48E+02 | -7.7E-05 | +6.2E-01 | 8.9E-03 | 2.4E-01 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 61| +2.12E+02 | -6.5E-01 | +8.3E-01 | 6.3E-02 | 1.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 12| +2.13E+02 | -2.9E+00 | +8.4E-01 | 6.2E-02 | 2.7E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 105| +1.48E+02 | -2.8E-03 | +5.0E-01 | 6.2E-02 | 1.1E+00 | 9.7E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 52| +1.48E+02 | -3.8E-04 | +9.7E-01 | 1.5E-02 | 2.0E-01 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 62| +2.11E+02 | -8.7E-01 | +6.2E-01 | 1.3E-01 | 1.0E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 13| +2.12E+02 | -7.5E-01 | +3.3E-01 | 1.2E-01 | 1.3E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 42| +1.48E+02 | -6.0E-05 | +7.2E-01 | 8.9E-03 | 1.4E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 62| +1.78E+02 | -2.5E-04 | +8.1E-01 | 4.9E-03 | 8.6E-01 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 106| +1.48E+02 | +2.0E-03 | -5.2E-01 | 6.2E-02 | 2.4E+00 | 9.6E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 14| +2.10E+02 | -2.1E+00 | +6.9E-01 | 1.2E-01 | 2.6E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 53| +1.48E+02 | -3.9E-04 | +7.0E-01 | 3.0E-02 | 4.1E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 63| +2.10E+02 | -5.7E-01 | +6.0E-01 | 1.3E-01 | 8.3E+00 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 43| +1.48E+02 | -4.0E-05 | +5.8E-01 | 8.9E-03 | 1.5E-01 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 16| +1.78E+02 | -1.5E+01 | +2.2E+00 | 5.0E-01 | 2.3E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 15| +2.09E+02 | -1.5E+00 | +5.4E-01 | 1.2E-01 | 1.3E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 63| +1.78E+02 | -1.9E-04 | +8.1E-01 | 9.9E-03 | 6.8E-01 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 107| +1.48E+02 | -2.9E-04 | +1.3E-01 | 1.6E-02 | 2.4E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 54| +1.48E+02 | +1.5E-03 | -1.5E+00 | 3.0E-02 | 2.5E-01 | 7.4E-03 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 64| +2.10E+02 | -2.4E-01 | +1.9E-01 | 1.3E-01 | 1.1E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 44| +1.48E+02 | -3.1E-05 | +5.4E-01 | 8.9E-03 | 1.1E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 16| +2.06E+02 | -2.5E+00 | +6.6E-01 | 1.2E-01 | 2.8E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 64| +1.78E+02 | -2.5E-04 | +6.8E-01 | 2.0E-02 | 7.5E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 65| +2.09E+02 | -5.4E-01 | +8.9E-01 | 3.1E-02 | 1.5E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 108| +1.48E+02 | -1.0E-03 | +9.3E-01 | 3.9E-03 | 2.9E+00 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 55| +1.48E+02 | -4.0E-05 | +1.0E-01 | 7.4E-03 | 2.5E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 45| +1.48E+02 | -1.9E-05 | +3.1E-01 | 8.9E-03 | 1.3E-01 | 5.3E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 17| +2.04E+02 | -2.1E+00 | +7.1E-01 | 1.2E-01 | 1.8E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 66| +2.09E+02 | -2.2E-01 | +9.8E-01 | 6.3E-02 | 4.9E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 109| +1.48E+02 | +3.4E-03 | -7.9E+00 | 7.8E-03 | 2.8E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 46| +1.48E+02 | -8.9E-07 | +1.1E-02 | 8.9E-03 | 1.1E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 65| +1.78E+02 | +2.6E-04 | -3.7E-01 | 2.0E-02 | 5.4E-01 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 56| +1.48E+02 | -1.5E-04 | +8.9E-01 | 1.9E-03 | 9.1E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 18| +2.02E+02 | -1.9E+00 | +6.4E-01 | 1.2E-01 | 2.4E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 17| +1.78E+02 | +1.7E+01 | -1.2E+00 | 1.0E+00 | 7.0E+01 | 2.9E+00 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 67| +2.09E+02 | -1.6E-01 | +9.0E-01 | 1.3E-01 | 2.5E+00 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 47| +1.48E+02 | -3.0E-05 | +7.1E-01 | 2.2E-03 | 1.5E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 110| +1.48E+02 | +3.3E-05 | -1.2E-01 | 1.8E-03 | 2.8E-01 | 3.1E-03 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 57| +1.48E+02 | -6.5E-05 | +8.0E-01 | 3.7E-03 | 1.0E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 19| +2.00E+02 | -2.7E+00 | +9.3E-01 | 1.2E-01 | 1.9E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 75| +1.55E+02 | -2.8E-02 | +9.4E-01 | 7.0E-03 | 4.5E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 68| +2.09E+02 | -5.2E-02 | +8.6E-01 | 2.5E-01 | 2.9E+00 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 66| +1.78E+02 | -1.5E-04 | +6.9E-01 | 4.9E-03 | 5.4E-01 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 20| +1.90E+02 | -1.0E+01 | +1.7E+00 | 2.5E-01 | 2.1E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 48| +1.48E+02 | -7.8E-06 | +9.6E-01 | 2.2E-03 | 8.6E-02 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 111| +1.48E+02 | -1.4E-04 | +8.9E-01 | 4.6E-04 | 2.8E-01 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 69| +2.09E+02 | -4.3E-02 | +2.1E+00 | 2.5E-01 | 1.3E+00 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 58| +1.48E+02 | -5.8E-05 | +8.5E-01 | 7.4E-03 | 8.8E-02 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 18| +1.69E+02 | -9.4E+00 | +1.2E+00 | 2.5E-01 | 7.0E+01 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 21| +1.90E+02 | -2.0E+00 | -3.4E-01 | 5.0E-01 | 2.8E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 49| +1.48E+02 | -5.0E-06 | +6.4E-01 | 4.4E-03 | 4.3E-02 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 67| +1.78E+02 | -1.0E-04 | +1.0E+00 | 4.9E-03 | 6.0E-01 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 112| +1.48E+02 | -5.3E-05 | +1.0E+00 | 9.2E-04 | 4.0E-01 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 59| +1.48E+02 | -7.7E-05 | +8.0E-01 | 1.5E-02 | 7.8E-02 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 70| +2.09E+02 | -1.1E-01 | +2.5E+00 | 2.5E-01 | 9.3E-01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 22| +1.80E+02 | -9.2E+00 | +1.2E+00 | 1.2E-01 | 2.8E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 50| +1.48E+02 | +3.8E-08 | -7.5E-03 | 4.4E-03 | 7.3E-02 | 8.8E-04 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 113| +1.48E+02 | -3.5E-05 | +8.3E-01 | 1.8E-03 | 1.4E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 71| +2.08E+02 | -3.1E-01 | +2.3E+00 | 2.5E-01 | 1.8E+00 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 68| +1.78E+02 | -1.2E-04 | +9.3E-01 | 9.9E-03 | 5.1E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 60| +1.48E+02 | +1.9E-04 | -9.5E-01 | 3.0E-02 | 2.2E-01 | 1.6E-02 | 2d |0\n", + "2023-02-17 16:05:14.613 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 95.0225 and h = 1.18628e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:14.613 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 95.0225: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:14 fides(INFO) 23| +1.80E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 4.4E+01 | 6.0E-01 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 72| +2.08E+02 | +1.8E+00 | -6.1E+00 | 2.5E-01 | 4.0E+00 | 7.0E-01 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 114| +1.48E+02 | +1.2E-04 | -3.3E+00 | 3.7E-03 | 1.3E-01 | 4.6E-03 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 51| +1.48E+02 | -3.1E-06 | +1.7E+00 | 1.1E-03 | 7.3E-02 | 2.2E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 69| +1.78E+02 | -1.8E-04 | +1.0E+00 | 2.0E-02 | 5.1E-01 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 24| +1.75E+02 | -5.4E+00 | +1.1E+00 | 6.2E-02 | 4.4E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 61| +1.48E+02 | -3.8E-05 | +6.0E-01 | 7.4E-03 | 2.2E-01 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 115| +1.48E+02 | -1.4E-05 | +8.8E-01 | 9.2E-04 | 1.3E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 73| +2.08E+02 | -1.6E-01 | +1.2E+00 | 6.3E-02 | 4.0E+00 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 52| +1.48E+02 | +6.0E-06 | -1.3E+00 | 2.2E-03 | 2.1E-02 | 6.8E-04 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 70| +1.78E+02 | +1.2E-05 | -4.9E-02 | 3.9E-02 | 3.7E-01 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 25| +1.64E+02 | -1.1E+01 | +1.0E+00 | 1.2E-01 | 4.7E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 62| +1.48E+02 | -1.9E-05 | +4.9E-01 | 7.4E-03 | 7.7E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 116| +1.48E+02 | +1.0E-04 | -4.8E+00 | 1.8E-03 | 1.2E-01 | 1.9E-03 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 74| +2.08E+02 | -5.9E-01 | +7.0E-01 | 1.3E-01 | 4.8E+00 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 26| +1.57E+02 | -7.6E+00 | +4.7E-01 | 2.5E-01 | 5.9E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 71| +1.78E+02 | -6.7E-05 | +7.6E-01 | 9.9E-03 | 3.7E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 53| +1.48E+02 | -2.0E-07 | +6.1E-02 | 5.5E-04 | 2.1E-02 | 3.8E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 75| +2.06E+02 | -1.4E+00 | +1.5E+00 | 1.3E-01 | 1.0E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 63| +1.48E+02 | -2.3E-05 | +5.6E-01 | 7.4E-03 | 1.8E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 117| +1.48E+02 | +7.5E-05 | -5.2E+00 | 4.6E-04 | 1.2E-01 | 5.2E-04 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 19| +1.66E+02 | -3.0E+00 | +7.7E-01 | 5.0E-01 | 3.8E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 27| +1.50E+02 | -6.6E+00 | +9.6E-01 | 2.5E-01 | 1.7E+02 | 7.0E-01 | trr |1\n", + "2023-02-17 16:05:14.763 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.642 and h = 2.79391e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:14.763 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.642: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:14 fides(INFO) 64| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.4E-03 | 6.7E-02 | 8.8E-04 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 76| +2.03E+02 | -3.5E+00 | +1.3E+00 | 2.5E-01 | 5.5E+00 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 54| +1.48E+02 | -1.4E-06 | +7.5E-01 | 1.4E-04 | 1.1E-01 | 6.5E-05 | 2d |1\n", + "2023-02-17 16:05:14 fides(WARNING) Stopping as function difference 1.43E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:14 fides(INFO) 118| +1.48E+02 | +6.3E-05 | -5.4E+00 | 1.1E-04 | 1.2E-01 | 1.9E-04 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 72| +1.78E+02 | +1.7E-05 | -9.9E-02 | 2.0E-02 | 4.0E-01 | 1.6E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 28| +1.48E+02 | -1.5E+00 | +6.2E-01 | 2.5E-01 | 5.0E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 77| +2.03E+02 | +1.6E+01 | -1.5E+00 | 5.0E-01 | 2.5E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 76| +1.55E+02 | +1.6E-01 | -3.1E+00 | 1.4E-02 | 4.2E+00 | 2.8E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 65| +1.48E+02 | -4.5E-06 | +3.7E-01 | 1.9E-03 | 6.7E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 119| +1.48E+02 | -1.9E-06 | +4.0E-01 | 2.9E-05 | 1.2E-01 | 5.0E-05 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 29| +1.48E+02 | -5.2E-01 | +9.7E-01 | 2.5E-01 | 4.8E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 78| +1.99E+02 | -3.4E+00 | +6.4E-01 | 1.3E-01 | 2.5E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 73| +1.78E+02 | -5.0E-05 | +7.9E-01 | 4.9E-03 | 4.0E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 66| +1.48E+02 | -1.1E-05 | +1.6E+00 | 1.9E-03 | 1.8E-01 | 4.9E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 120| +1.48E+02 | -7.8E-07 | +4.1E-01 | 2.9E-05 | 1.2E-01 | 5.0E-05 | 2d |1\n", + "2023-02-17 16:05:14 fides(WARNING) Stopping as function difference 7.82E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:14 fides(INFO) 79| +1.97E+02 | -2.9E+00 | +8.4E-01 | 1.3E-01 | 1.5E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 30| +1.48E+02 | -8.9E-02 | +2.0E-01 | 5.0E-01 | 1.9E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 67| +1.48E+02 | -6.2E-06 | +8.9E-01 | 3.7E-03 | 2.7E-02 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 74| +1.78E+02 | -5.3E-05 | +8.0E-01 | 9.9E-03 | 3.2E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 0| +1.31E+11 | NaN | NaN | 1.0E+00 | 6.0E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:14 fides(INFO) 68| +1.48E+02 | -1.0E-05 | +8.4E-01 | 7.4E-03 | 8.4E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 31| +1.48E+02 | +8.5E-04 | -1.1E-02 | 1.2E-01 | 1.9E+01 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 80| +1.97E+02 | +8.7E+00 | -2.4E+00 | 2.5E-01 | 1.3E+01 | 4.3E-01 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 75| +1.78E+02 | +2.1E-05 | -1.6E-01 | 2.0E-02 | 3.4E-01 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:14 fides(INFO) 1| +1.53E+05 | -1.3E+11 | +8.8E-02 | 1.0E+00 | 6.0E+11 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 69| +1.48E+02 | -4.2E-06 | +2.3E-01 | 1.5E-02 | 3.2E-02 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 20| +1.60E+02 | -6.0E+00 | +4.7E-01 | 1.0E+00 | 9.6E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 81| +1.96E+02 | -6.2E-01 | +5.3E-01 | 6.3E-02 | 1.3E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 32| +1.48E+02 | -1.7E-01 | +7.8E-01 | 3.1E-02 | 1.9E+01 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 76| +1.78E+02 | -3.6E-05 | +7.8E-01 | 4.9E-03 | 3.4E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:14 fides(INFO) 70| +1.48E+02 | -1.3E-05 | +5.2E-01 | 3.7E-03 | 9.4E-02 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:14 fides(INFO) 82| +1.96E+02 | -3.9E-01 | +4.5E-01 | 6.3E-02 | 9.0E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 33| +1.48E+02 | -4.3E-02 | +2.9E-01 | 6.2E-02 | 8.1E+00 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 2| +2.41E+04 | -1.3E+05 | +9.0E-01 | 2.5E-01 | 7.0E+05 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 0| +4.56E+02 | NaN | NaN | 1.0E+00 | 3.3E+02 | NaN | NaN |1\n", + "2023-02-17 16:05:15 fides(INFO) 83| +1.95E+02 | -3.7E-01 | +6.8E-01 | 6.3E-02 | 1.0E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 3| +3.93E+03 | -2.0E+04 | +9.0E-01 | 5.0E-01 | 1.1E+05 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 77| +1.78E+02 | -3.7E-05 | +7.0E-01 | 9.9E-03 | 2.7E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 71| +1.48E+02 | -3.5E-08 | +8.7E-03 | 3.7E-03 | 4.8E-02 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 21| +1.56E+02 | -4.0E+00 | +9.7E-01 | 1.0E+00 | 1.2E+02 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 34| +1.48E+02 | -2.6E-02 | +6.1E-01 | 6.2E-02 | 9.4E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 1| +3.80E+02 | -7.6E+01 | +1.2E-01 | 1.0E+00 | 3.3E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 77| +1.55E+02 | -1.0E-02 | +6.0E-01 | 3.5E-03 | 4.2E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 4| +7.99E+02 | -3.1E+03 | +9.0E-01 | 1.0E+00 | 1.7E+04 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 72| +1.48E+02 | +4.6E-07 | -8.5E-01 | 9.3E-04 | 2.2E-02 | 1.9E-04 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 84| +1.95E+02 | -3.1E-01 | +9.2E-01 | 6.3E-02 | 7.2E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 2| +3.36E+02 | -4.5E+01 | +9.9E-01 | 2.5E-01 | 6.4E+01 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 78| +1.78E+02 | -1.3E-05 | +1.8E-01 | 9.9E-03 | 2.8E-01 | 8.5E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 35| +1.48E+02 | -1.2E-02 | +5.0E-01 | 6.2E-02 | 4.9E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 5| +3.19E+02 | -4.8E+02 | +9.0E-01 | 1.0E+00 | 2.7E+03 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 3| +2.66E+02 | -7.0E+01 | +8.4E-01 | 5.0E-01 | 6.2E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 73| +1.48E+02 | +1.7E-07 | -9.3E-01 | 2.3E-04 | 2.2E-02 | 4.8E-05 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 22| +1.56E+02 | +6.1E+01 | -2.3E+01 | 2.0E+00 | 4.1E+01 | 4.8E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 6| +2.51E+02 | -6.8E+01 | +8.8E-01 | 1.0E+00 | 4.1E+02 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 85| +1.95E+02 | -3.7E-01 | +8.4E-01 | 1.3E-01 | 2.8E+00 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 36| +1.48E+02 | -7.6E-03 | +3.8E-01 | 6.2E-02 | 5.9E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 79| +1.78E+02 | -3.6E-05 | +7.1E-01 | 2.5E-03 | 2.1E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 4| +2.66E+02 | +6.6E+03 | -3.4E+02 | 1.0E+00 | 3.9E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 74| +1.48E+02 | -6.6E-08 | +7.5E-01 | 5.8E-05 | 2.2E-02 | 1.3E-05 | 2d |1\n", + "2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 6.57E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:15 fides(INFO) 7| +2.22E+02 | -2.9E+01 | +2.1E+00 | 2.0E+00 | 4.3E+01 | 3.6E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 37| +1.48E+02 | +4.8E-03 | -2.8E-01 | 6.2E-02 | 2.0E+00 | 5.5E-02 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 86| +1.94E+02 | -7.3E-01 | +1.3E+00 | 2.5E-01 | 5.0E+00 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 23| +1.56E+02 | +4.9E+00 | -7.2E+00 | 5.0E-01 | 4.1E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 5| +2.50E+02 | -1.6E+01 | +7.2E-01 | 2.5E-01 | 3.9E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 80| +1.78E+02 | -1.6E-05 | +9.2E-01 | 2.5E-03 | 2.3E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 38| +1.48E+02 | -3.9E-03 | +6.1E-01 | 1.6E-02 | 2.0E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 8| +2.22E+02 | +4.5E+03 | -3.9E+02 | 4.0E+00 | 3.4E+01 | 4.6E+00 | trr |0\n", + "2023-02-17 16:05:15 fides(INFO) 6| +2.50E+02 | +5.5E-01 | -4.4E-01 | 2.5E-01 | 1.5E+01 | 6.1E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 87| +1.94E+02 | +9.1E-01 | -1.2E+00 | 5.0E-01 | 4.6E+00 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 9| +2.22E+02 | +4.8E+01 | -3.1E+00 | 3.9E-01 | 3.4E+01 | 9.8E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 39| +1.48E+02 | -2.4E-03 | +9.7E-01 | 1.6E-02 | 4.5E+00 | 6.1E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 7| +2.50E+02 | -3.7E-01 | +2.7E-01 | 6.2E-02 | 1.5E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 81| +1.78E+02 | -1.6E-05 | +9.1E-01 | 4.9E-03 | 2.0E-01 | 5.7E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 88| +1.93E+02 | -3.2E-01 | +8.6E-01 | 1.3E-01 | 4.6E+00 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 24| +1.55E+02 | -5.8E-01 | +1.1E+00 | 1.2E-01 | 4.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 8| +2.50E+02 | -1.7E-01 | +2.8E-01 | 6.2E-02 | 1.1E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 40| +1.48E+02 | -8.2E-04 | +9.4E-01 | 3.1E-02 | 1.2E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 10| +2.15E+02 | -6.9E+00 | +8.9E-01 | 9.8E-02 | 3.4E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 82| +1.78E+02 | -2.3E-05 | +9.9E-01 | 9.9E-03 | 2.0E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 9| +2.50E+02 | +7.5E-02 | -2.7E-01 | 6.2E-02 | 6.6E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 0| +9.51E+13 | NaN | NaN | 1.0E+00 | 4.4E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:15 fides(INFO) 89| +1.93E+02 | -3.5E-01 | +1.9E-01 | 2.5E-01 | 7.6E+00 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 41| +1.48E+02 | -1.1E-03 | +9.5E-01 | 6.2E-02 | 1.5E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 11| +2.15E+02 | +7.1E+00 | -1.3E+00 | 2.0E-01 | 2.3E+01 | 4.8E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 1| +9.94E+08 | -9.5E+13 | +8.3E-02 | 1.0E+00 | 4.4E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 78| +1.55E+02 | +3.9E-02 | -1.6E+00 | 3.5E-03 | 4.8E+00 | 9.1E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 10| +2.50E+02 | -1.4E-01 | +7.0E-01 | 1.6E-02 | 6.6E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 90| +1.92E+02 | -8.5E-01 | +1.3E+00 | 6.3E-02 | 1.9E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 25| +1.55E+02 | -3.0E-01 | +4.9E-01 | 2.5E-01 | 2.2E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 12| +2.13E+02 | -2.2E+00 | +8.7E-01 | 4.9E-02 | 2.3E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 42| +1.48E+02 | -2.5E-04 | +1.9E-01 | 1.2E-01 | 8.2E-01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 83| +1.78E+02 | +6.7E-06 | -1.6E-01 | 2.0E-02 | 1.6E-01 | 6.2E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 11| +2.50E+02 | -2.0E-04 | +2.5E-02 | 1.6E-02 | 1.2E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 2| +1.55E+08 | -8.4E+08 | +8.9E-01 | 2.5E-01 | 4.3E+09 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 13| +2.13E+02 | +7.7E-01 | -6.4E-01 | 9.8E-02 | 1.3E+01 | 2.5E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 91| +1.91E+02 | -1.4E+00 | +1.2E+00 | 1.3E-01 | 9.2E+00 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 43| +1.48E+02 | +5.0E-04 | -1.5E-01 | 3.1E-02 | 8.2E-01 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 84| +1.78E+02 | -1.0E-05 | +7.3E-01 | 4.9E-03 | 1.6E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 3| +2.36E+07 | -1.3E+08 | +8.9E-01 | 5.0E-01 | 6.6E+08 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 12| +2.50E+02 | -2.7E-03 | +4.2E-01 | 3.9E-03 | 1.1E+00 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 26| +1.54E+02 | -6.9E-01 | +6.5E-01 | 2.5E-01 | 4.8E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 14| +2.13E+02 | -5.2E-01 | +8.2E-01 | 2.4E-02 | 1.3E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 4| +3.63E+06 | -2.0E+07 | +8.9E-01 | 5.0E-01 | 1.0E+08 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 92| +1.86E+02 | -4.8E+00 | +1.6E+00 | 2.5E-01 | 1.1E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 44| +1.48E+02 | -6.6E-04 | +5.4E-01 | 7.8E-03 | 8.2E-01 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 13| +2.50E+02 | -9.0E-05 | +4.1E-02 | 3.9E-03 | 6.0E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 5| +5.63E+05 | -3.1E+06 | +9.0E-01 | 5.0E-01 | 1.5E+07 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 85| +1.78E+02 | -9.9E-06 | +7.6E-01 | 4.9E-03 | 1.7E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 6| +8.81E+04 | -4.7E+05 | +9.0E-01 | 5.0E-01 | 2.4E+06 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 45| +1.48E+02 | -3.3E-04 | +9.6E-01 | 7.8E-03 | 1.6E+00 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 15| +2.13E+02 | +1.8E-03 | -2.9E-02 | 4.9E-02 | 6.7E+00 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 14| +2.50E+02 | -9.1E-04 | +7.7E-01 | 9.8E-04 | 5.7E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 86| +1.78E+02 | -3.4E-06 | +1.5E-01 | 9.9E-03 | 1.4E-01 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 7| +1.40E+04 | -7.4E+04 | +9.0E-01 | 5.0E-01 | 3.7E+05 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 15| +2.50E+02 | -8.7E-07 | +7.3E-03 | 2.0E-03 | 1.4E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 16| +2.13E+02 | -1.0E-01 | +8.0E-01 | 1.2E-02 | 6.7E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 46| +1.48E+02 | -1.5E-04 | +6.8E-01 | 1.6E-02 | 3.0E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 27| +1.54E+02 | -7.9E-02 | +7.8E-01 | 2.5E-01 | 1.3E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 8| +2.39E+03 | -1.2E+04 | +9.0E-01 | 5.0E-01 | 5.9E+04 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 9| +5.58E+02 | -1.8E+03 | +9.0E-01 | 5.0E-01 | 9.4E+03 | 5.5E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 93| +1.86E+02 | +1.8E+02 | -2.9E+01 | 5.0E-01 | 5.7E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 16| +2.50E+02 | -5.7E-05 | +6.4E-01 | 4.9E-04 | 1.4E-01 | 8.6E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 17| +2.12E+02 | -1.4E-01 | +9.7E-01 | 2.4E-02 | 5.6E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 47| +1.48E+02 | -4.1E-05 | +4.3E-01 | 1.6E-02 | 2.4E-01 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 87| +1.78E+02 | -1.5E-05 | +6.0E-01 | 2.5E-03 | 1.4E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 10| +2.88E+02 | -2.7E+02 | +9.0E-01 | 5.0E-01 | 1.5E+03 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 17| +2.50E+02 | -3.3E-07 | +5.3E-01 | 4.9E-04 | 7.1E-03 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 3.30E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:15 fides(INFO) 11| +2.50E+02 | -3.8E+01 | +8.3E-01 | 1.0E+00 | 2.3E+02 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 18| +2.12E+02 | -1.4E-01 | +6.8E-01 | 4.9E-02 | 5.5E+00 | 6.9E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 48| +1.48E+02 | -1.5E-05 | +8.3E-01 | 1.6E-02 | 1.2E-01 | 2.9E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 28| +1.54E+02 | -9.8E-03 | +3.6E-01 | 5.0E-01 | 4.1E+00 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 12| +2.50E+02 | -4.6E-01 | +3.9E-01 | 2.0E+00 | 1.7E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 88| +1.78E+02 | -3.8E-06 | +9.1E-01 | 2.5E-03 | 1.1E-01 | 3.0E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 94| +1.86E+02 | +2.7E+00 | -1.2E+00 | 1.3E-01 | 5.7E+01 | 3.4E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 79| +1.55E+02 | -1.3E-03 | +1.4E-01 | 8.8E-04 | 4.8E+00 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 49| +1.48E+02 | -3.8E-06 | +2.6E-01 | 3.1E-02 | 1.1E-01 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 19| +2.12E+02 | +2.0E-02 | -9.4E-02 | 4.9E-02 | 6.4E+00 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 13| +2.50E+02 | +1.4E-01 | -3.5E-01 | 2.0E+00 | 7.7E+00 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 89| +1.78E+02 | -5.9E-06 | +1.0E+00 | 4.9E-03 | 1.1E-01 | 4.1E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 29| +1.54E+02 | +1.0E-02 | -3.5E-01 | 5.0E-01 | 5.2E+00 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 14| +2.50E+02 | -1.6E-01 | +8.5E-01 | 1.1E-02 | 7.7E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 95| +1.84E+02 | -1.7E+00 | +1.5E+00 | 3.1E-02 | 5.7E+01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 50| +1.48E+02 | +5.1E-07 | -2.8E-02 | 3.1E-02 | 5.9E-02 | 5.0E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 20| +2.12E+02 | -1.1E-01 | +7.9E-01 | 1.2E-02 | 6.4E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 15| +2.50E+02 | +1.1E-02 | -1.4E-01 | 2.1E-02 | 3.7E+00 | 4.7E-02 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 0| +1.65E+08 | NaN | NaN | 1.0E+00 | 7.6E+08 | NaN | NaN |1\n", + "2023-02-17 16:05:15 fides(INFO) 16| +2.50E+02 | -3.2E-02 | +8.5E-01 | 4.5E-03 | 3.7E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 90| +1.78E+02 | -7.3E-06 | +9.2E-01 | 9.9E-03 | 9.7E-02 | 7.4E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 51| +1.48E+02 | -8.3E-06 | +1.3E+00 | 7.8E-03 | 5.9E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 96| +1.79E+02 | -5.4E+00 | +8.9E-01 | 6.3E-02 | 6.0E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 21| +2.12E+02 | -4.7E-02 | +5.4E-01 | 2.4E-02 | 4.1E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 17| +2.50E+02 | +1.2E-03 | -6.3E-02 | 9.1E-03 | 1.8E+00 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 30| +1.54E+02 | -1.1E-02 | +7.8E-01 | 1.2E-01 | 5.2E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 52| +1.48E+02 | -3.3E-06 | +9.8E-01 | 1.6E-02 | 9.9E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 1| +1.45E+03 | -1.6E+08 | +1.0E-01 | 1.0E+00 | 7.6E+08 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 18| +2.50E+02 | -7.4E-03 | +8.6E-01 | 2.1E-03 | 1.8E+00 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 22| +2.12E+02 | -4.8E-02 | +3.7E-01 | 2.4E-02 | 5.9E+00 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 97| +1.70E+02 | -9.0E+00 | +9.8E-01 | 1.3E-01 | 3.5E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 91| +1.78E+02 | -3.8E-06 | +3.7E-01 | 2.0E-02 | 9.5E-02 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 19| +2.50E+02 | +1.4E-04 | -3.0E-02 | 4.2E-03 | 8.9E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 2| +5.27E+02 | -9.2E+02 | +9.2E-01 | 2.5E-01 | 4.8E+03 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:15.736 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1579 and h = 1.35913e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:15.736 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1579: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:15 fides(INFO) 53| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 2.0E-02 | 4.7E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 20| +2.50E+02 | -1.8E-03 | +8.6E-01 | 1.0E-03 | 8.9E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 3| +2.92E+02 | -2.3E+02 | +8.9E-01 | 5.0E-01 | 9.8E+02 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 23| +2.12E+02 | -1.5E-02 | +1.2E-01 | 2.4E-02 | 4.6E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 31| +1.54E+02 | -3.4E-03 | +9.9E-01 | 2.5E-01 | 1.7E+00 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 92| +1.78E+02 | +5.7E-04 | -5.2E+00 | 2.0E-02 | 5.3E-02 | 2.6E-02 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 4| +2.59E+02 | -3.3E+01 | +8.3E-01 | 1.0E+00 | 1.4E+02 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 21| +2.50E+02 | +1.6E-05 | -1.5E-02 | 2.1E-03 | 4.4E-01 | 5.3E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 54| +1.48E+02 | -2.6E-06 | +2.0E+00 | 7.8E-03 | 2.0E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 98| +1.70E+02 | +5.5E+00 | -4.3E-01 | 2.5E-01 | 4.4E+01 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 24| +2.12E+02 | -5.1E-02 | +8.9E-01 | 6.1E-03 | 6.2E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 22| +2.50E+02 | -4.4E-04 | +8.6E-01 | 5.1E-04 | 4.4E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 5| +2.59E+02 | +1.3E+03 | -8.4E+01 | 2.0E+00 | 3.4E+01 | 4.2E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 32| +1.54E+02 | -3.9E-03 | +1.1E+00 | 5.0E-01 | 1.7E+00 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:15.818 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 212.759 and h = 2.82009e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:15.818 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 212.759: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:15 fides(INFO) 55| +1.48E+02 | +1.5E-06 | -8.5E-01 | 1.6E-02 | 4.7E-02 | 2.3E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 23| +2.50E+02 | +2.0E-06 | -7.3E-03 | 1.0E-03 | 2.2E-01 | 2.6E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 93| +1.78E+02 | +0.0E+00 | +0.0E+00 | 4.9E-03 | 5.3E-02 | 6.5E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 6| +2.59E+02 | +2.7E+02 | -1.7E+01 | 5.0E-01 | 3.4E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 24| +2.50E+02 | -1.1E-04 | +8.6E-01 | 2.5E-04 | 2.2E-01 | 6.5E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 99| +1.66E+02 | -3.9E+00 | +8.5E-01 | 6.3E-02 | 4.4E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 80| +1.55E+02 | -1.4E-03 | +1.0E+00 | 2.2E-04 | 4.5E+00 | 4.0E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 25| +2.12E+02 | -3.8E-02 | +6.7E-01 | 1.2E-02 | 4.4E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 56| +1.48E+02 | +2.2E-06 | -3.4E+00 | 3.9E-03 | 4.7E-02 | 5.8E-04 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 7| +2.51E+02 | -8.3E+00 | +8.3E-01 | 1.2E-01 | 3.4E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 33| +1.54E+02 | -1.9E-03 | +6.5E-01 | 1.0E+00 | 4.6E-01 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 25| +2.50E+02 | +2.5E-07 | -3.6E-03 | 5.0E-04 | 1.1E-01 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 94| +1.78E+02 | -5.8E-06 | +6.8E-01 | 1.2E-03 | 5.3E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 8| +2.51E+02 | +4.1E+00 | -1.5E+00 | 2.5E-01 | 1.8E+01 | 5.8E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 26| +2.50E+02 | -2.7E-05 | +8.6E-01 | 1.3E-04 | 1.1E-01 | 3.2E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 26| +2.12E+02 | -2.3E-02 | +6.2E-01 | 1.2E-02 | 3.1E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 57| +1.48E+02 | +2.5E-06 | -7.1E+00 | 9.8E-04 | 4.7E-02 | 1.5E-04 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 27| +2.50E+02 | +3.1E-08 | -1.8E-03 | 2.5E-04 | 5.5E-02 | 6.5E-04 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 34| +1.54E+02 | +9.7E-02 | -7.4E+00 | 1.0E+00 | 6.1E-01 | 2.0E-01 | trr |0\n", + "2023-02-17 16:05:15 fides(INFO) 9| +2.50E+02 | -1.3E+00 | +5.9E-01 | 6.2E-02 | 1.8E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 100| +1.66E+02 | -9.8E-02 | -4.1E-02 | 1.3E-01 | 2.9E+01 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 27| +2.12E+02 | -2.8E-02 | +6.3E-01 | 1.2E-02 | 3.8E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 95| +1.78E+02 | -1.4E-06 | +8.2E-01 | 1.2E-03 | 6.4E-02 | 6.1E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 1.45E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 10| +2.50E+02 | -1.3E-02 | +1.4E-01 | 6.2E-02 | 4.1E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 28| +2.50E+02 | -6.7E-06 | +8.6E-01 | 6.2E-05 | 5.5E-02 | 1.6E-04 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 58| +1.48E+02 | +1.1E-06 | -3.8E+00 | 2.4E-04 | 4.7E-02 | 3.8E-05 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 29| +2.50E+02 | +3.8E-09 | -9.0E-04 | 1.2E-04 | 2.7E-02 | 3.2E-04 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 35| +1.54E+02 | -2.4E-03 | +5.6E-01 | 5.1E-02 | 6.1E-01 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 28| +2.12E+02 | -1.5E-02 | +4.4E-01 | 1.2E-02 | 2.9E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 11| +2.50E+02 | -3.7E-03 | +4.7E-02 | 1.6E-02 | 3.3E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 101| +1.65E+02 | -1.3E+00 | +7.3E-01 | 3.1E-02 | 2.9E+01 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:15 fides(INFO) 30| +2.50E+02 | -1.7E-06 | +8.6E-01 | 3.1E-05 | 2.7E-02 | 8.1E-05 | 2d |1\n", + "2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 1.67E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:15 fides(INFO) 59| +1.48E+02 | +4.8E-06 | -1.8E+01 | 6.1E-05 | 4.7E-02 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:15 fides(INFO) 12| +2.50E+02 | -2.0E-02 | +8.9E-01 | 3.9E-03 | 3.3E+00 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 29| +2.12E+02 | -2.6E-02 | +5.8E-01 | 1.2E-02 | 3.7E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 36| +1.54E+02 | -4.8E-04 | +1.0E+00 | 5.1E-02 | 2.1E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:15 fides(INFO) 13| +2.50E+02 | -9.9E-03 | +5.1E-01 | 7.8E-03 | 2.0E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 102| +1.63E+02 | -1.7E+00 | +9.7E-01 | 3.1E-02 | 4.7E+01 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 60| +1.48E+02 | +3.8E-06 | -1.5E+01 | 1.5E-05 | 4.7E-02 | 1.1E-05 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 30| +2.12E+02 | -1.1E-02 | +3.6E-01 | 1.2E-02 | 2.7E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 14| +2.50E+02 | -1.2E-05 | +3.7E-03 | 7.8E-03 | 6.2E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 61| +1.48E+02 | +3.9E-06 | -1.5E+01 | 3.8E-06 | 4.7E-02 | 1.0E-05 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 37| +1.54E+02 | -7.3E-04 | +1.2E+00 | 1.0E-01 | 2.7E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 15| +2.50E+02 | -1.2E-03 | +6.7E-01 | 2.0E-03 | 6.4E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 31| +2.12E+02 | -2.3E-02 | +5.4E-01 | 1.2E-02 | 3.5E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 0| +1.33E+09 | NaN | NaN | 1.0E+00 | 6.1E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:16 fides(INFO) 62| +1.48E+02 | +5.4E-06 | -5.3E+01 | 9.5E-07 | 4.7E-02 | 2.5E-06 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 16| +2.50E+02 | -1.4E-05 | +9.4E-01 | 2.0E-03 | 1.1E-02 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 38| +1.54E+02 | -6.6E-05 | +8.6E-02 | 2.0E-01 | 1.3E-01 | 2.8E-02 | trr |1\n", + "2023-02-17 16:05:16 fides(INFO) 103| +1.61E+02 | -2.2E+00 | +8.5E-01 | 6.3E-02 | 2.6E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 81| +1.55E+02 | -1.9E-03 | +1.0E+00 | 4.4E-04 | 3.4E+00 | 8.2E-04 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 1| +1.40E+06 | -1.3E+09 | +9.5E-02 | 1.0E+00 | 6.1E+09 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 0| +1.62E+11 | NaN | NaN | 1.0E+00 | 7.4E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:16 fides(INFO) 32| +2.12E+02 | -9.2E-03 | +3.1E-01 | 1.2E-02 | 2.6E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 17| +2.50E+02 | -2.8E-05 | +9.4E-01 | 3.9E-03 | 1.7E-02 | 9.3E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 63| +1.48E+02 | +3.6E-06 | -1.3E+02 | 2.4E-07 | 4.7E-02 | 6.2E-07 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 18| +2.50E+02 | -5.7E-05 | +9.7E-01 | 7.8E-03 | 2.0E-02 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 39| +1.54E+02 | +4.5E-03 | -1.1E+00 | 3.1E-02 | 2.8E-01 | 6.3E-02 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 104| +1.58E+02 | -2.9E+00 | +6.1E-01 | 1.3E-01 | 4.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 2| +2.19E+05 | -1.2E+06 | +9.0E-01 | 2.5E-01 | 6.4E+06 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 64| +1.48E+02 | +4.2E-06 | -5.8E+02 | 6.0E-08 | 4.7E-02 | 1.6E-07 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 1| +1.28E+06 | -1.6E+11 | +9.1E-02 | 1.0E+00 | 7.4E+11 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 33| +2.12E+02 | -2.0E-02 | +5.0E-01 | 1.2E-02 | 3.3E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 19| +2.50E+02 | -1.2E-04 | +1.0E+00 | 1.6E-02 | 2.3E-02 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 3| +3.43E+04 | -1.8E+05 | +9.0E-01 | 5.0E-01 | 1.0E+06 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 2| +2.77E+05 | -1.0E+06 | +8.9E-01 | 2.5E-01 | 4.6E+06 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 40| +1.54E+02 | -8.6E-04 | +6.4E-01 | 7.8E-03 | 2.8E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 20| +2.50E+02 | -2.6E-04 | +1.0E+00 | 3.1E-02 | 2.5E-02 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 65| +1.48E+02 | +8.8E-07 | -4.9E+02 | 1.5E-08 | 4.7E-02 | 3.9E-08 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 34| +2.12E+02 | -8.1E-03 | +2.9E-01 | 1.2E-02 | 2.4E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 105| +1.54E+02 | -4.0E+00 | +6.8E-01 | 1.3E-01 | 3.6E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 4| +5.57E+03 | -2.9E+04 | +9.0E-01 | 5.0E-01 | 1.6E+05 | 8.9E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 21| +2.50E+02 | -6.0E-04 | +1.1E+00 | 6.2E-02 | 2.9E-02 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 3| +4.42E+04 | -2.3E+05 | +9.0E-01 | 5.0E-01 | 8.5E+05 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:16.222 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0112 and h = 1.07533e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:16.223 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0112: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:16 fides(INFO) 66| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.7E-09 | 4.7E-02 | 9.7E-09 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 22| +2.50E+02 | -1.6E-03 | +1.2E+00 | 1.2E-01 | 3.1E-02 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 41| +1.54E+02 | -1.2E-04 | +6.7E-01 | 7.8E-03 | 8.3E-02 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 35| +2.12E+02 | -1.7E-02 | +4.6E-01 | 1.2E-02 | 3.1E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 5| +1.06E+03 | -4.5E+03 | +9.0E-01 | 5.0E-01 | 2.5E+04 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 4| +7.14E+03 | -3.7E+04 | +9.0E-01 | 1.0E+00 | 1.3E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 67| +1.48E+02 | +3.4E-06 | -3.0E+04 | 9.3E-10 | 4.7E-02 | 2.4E-09 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 23| +2.50E+02 | -5.9E-03 | +1.5E+00 | 2.5E-01 | 3.8E-02 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 5| +1.28E+03 | -5.9E+03 | +9.0E-01 | 1.0E+00 | 2.1E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 6| +3.55E+02 | -7.0E+02 | +9.0E-01 | 5.0E-01 | 3.9E+03 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 36| +2.12E+02 | -7.5E-03 | +2.8E-01 | 1.2E-02 | 2.3E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 106| +1.54E+02 | +5.3E+00 | -1.0E+00 | 1.3E-01 | 5.8E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 42| +1.54E+02 | -4.8E-05 | +2.0E-01 | 7.8E-03 | 1.1E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 24| +2.50E+02 | -3.9E-02 | +2.2E+00 | 5.0E-01 | 4.4E-02 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 6| +3.74E+02 | -9.1E+02 | +9.0E-01 | 1.0E+00 | 3.4E+03 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 68| +1.48E+02 | +3.9E-06 | -1.4E+05 | 2.3E-10 | 4.7E-02 | 6.1E-10 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 7| +2.50E+02 | -1.1E+02 | +9.0E-01 | 1.0E+00 | 6.1E+02 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 37| +2.12E+02 | -1.5E-02 | +4.4E-01 | 1.2E-02 | 2.9E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 7| +2.55E+02 | -1.2E+02 | +8.7E-01 | 1.0E+00 | 5.3E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 43| +1.54E+02 | -1.0E-04 | +7.9E-01 | 1.9E-03 | 7.6E-02 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 69| +1.48E+02 | +3.7E-07 | -5.2E+04 | 5.8E-11 | 4.7E-02 | 1.5E-10 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 25| +2.49E+02 | -8.1E-01 | +4.2E+00 | 1.0E+00 | 1.7E-01 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 38| +2.12E+02 | -7.2E-03 | +2.8E-01 | 1.2E-02 | 2.2E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 8| +2.41E+02 | -8.4E+00 | +7.4E-01 | 2.0E+00 | 7.8E+01 | 5.9E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 107| +1.54E+02 | +1.2E+00 | -4.8E-01 | 3.1E-02 | 5.8E+01 | 7.7E-02 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 8| +2.39E+02 | -1.5E+01 | +1.2E+00 | 2.0E+00 | 5.9E+01 | 3.9E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 26| +2.32E+02 | -1.7E+01 | +5.1E+00 | 2.0E+00 | 2.5E+00 | 3.9E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 82| +1.55E+02 | -2.1E-03 | +9.8E-01 | 8.8E-04 | 1.7E+00 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 44| +1.54E+02 | -5.7E-05 | +5.3E-01 | 3.9E-03 | 1.0E-01 | 5.3E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 70| +1.48E+02 | +4.8E-06 | -2.7E+06 | 1.5E-11 | 4.7E-02 | 3.8E-11 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 9| +2.33E+02 | -8.3E+00 | +6.4E-01 | 2.0E+00 | 1.4E+01 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 39| +2.12E+02 | -1.3E-02 | +4.2E-01 | 1.2E-02 | 2.7E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 9| +2.39E+02 | +6.9E+01 | -1.4E+01 | 4.0E+00 | 3.0E+01 | 6.6E+00 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 108| +1.54E+02 | -5.2E-01 | +5.3E-01 | 7.9E-03 | 5.8E+01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 45| +1.54E+02 | -4.4E-05 | +4.6E-01 | 3.9E-03 | 5.3E-02 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 71| +1.48E+02 | +4.2E-06 | -9.5E+06 | 3.6E-12 | 4.7E-02 | 9.5E-12 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 27| +2.32E+02 | +2.5E+02 | -1.5E+01 | 4.0E+00 | 3.4E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 40| +2.12E+02 | -7.0E-03 | +2.8E-01 | 1.2E-02 | 2.1E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 10| +2.39E+02 | +1.5E+01 | -1.6E+00 | 1.0E+00 | 3.0E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 28| +2.32E+02 | +1.9E+01 | -1.8E+00 | 1.0E+00 | 3.4E+01 | 3.0E+00 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 72| +1.48E+02 | +2.0E-06 | -1.8E+07 | 9.1E-13 | 4.7E-02 | 2.4E-12 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 11| +2.39E+02 | +1.2E+01 | -1.4E+00 | 2.5E-01 | 3.0E+01 | 6.3E-01 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 46| +1.54E+02 | -2.3E-05 | +2.1E-01 | 3.9E-03 | 7.2E-02 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 109| +1.53E+02 | -2.4E-01 | +9.9E-01 | 7.9E-03 | 2.4E+01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 41| +2.12E+02 | -1.2E-02 | +4.1E-01 | 1.2E-02 | 2.5E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 29| +2.32E+02 | +8.3E+00 | -8.0E-01 | 2.5E-01 | 3.4E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 12| +2.36E+02 | -3.5E+00 | +8.4E-01 | 6.2E-02 | 3.0E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 73| +1.48E+02 | -2.3E-06 | +8.4E+07 | 2.3E-13 | 4.7E-02 | 5.9E-13 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 30| +2.28E+02 | -4.1E+00 | +8.7E-01 | 6.2E-02 | 3.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 42| +2.12E+02 | -6.9E-03 | +3.0E-01 | 1.2E-02 | 2.0E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 13| +2.35E+02 | -1.2E+00 | +3.5E-01 | 1.2E-01 | 1.8E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 47| +1.54E+02 | -3.3E-05 | +8.3E-01 | 9.7E-04 | 4.4E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 31| +2.28E+02 | -3.7E-01 | +6.1E-02 | 1.2E-01 | 2.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 74| +1.48E+02 | +1.5E-07 | -2.7E+06 | 4.5E-13 | 4.7E-02 | 1.2E-12 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 110| +1.53E+02 | -3.9E-01 | +9.0E-01 | 1.6E-02 | 1.9E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 14| +2.31E+02 | -3.8E+00 | +7.4E-01 | 1.2E-01 | 3.9E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 43| +2.12E+02 | -1.1E-02 | +4.2E-01 | 1.2E-02 | 2.4E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 32| +2.26E+02 | -1.8E+00 | +9.2E-01 | 3.1E-02 | 4.1E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 48| +1.54E+02 | -2.4E-05 | +5.7E-01 | 1.9E-03 | 6.1E-02 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 75| +1.48E+02 | +6.5E-06 | -4.7E+08 | 1.1E-13 | 4.7E-02 | 3.0E-13 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 10| +2.13E+02 | -1.9E+01 | +7.5E-01 | 2.0E+00 | 3.3E+01 | 4.2E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 15| +2.29E+02 | -1.6E+00 | +4.5E-01 | 1.2E-01 | 2.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 33| +2.24E+02 | -1.9E+00 | +8.4E-01 | 6.2E-02 | 2.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 44| +2.12E+02 | -7.0E-03 | +3.2E-01 | 1.2E-02 | 1.9E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 16| +2.26E+02 | -3.5E+00 | +7.4E-01 | 1.2E-01 | 3.7E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 76| +1.48E+02 | +8.7E-06 | -2.5E+09 | 2.8E-14 | 4.7E-02 | 7.4E-14 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 111| +1.52E+02 | -5.8E-01 | +9.4E-01 | 3.1E-02 | 2.7E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 49| +1.54E+02 | -1.9E-05 | +6.5E-01 | 1.9E-03 | 4.1E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 34| +2.21E+02 | -3.0E+00 | +1.1E+00 | 1.2E-01 | 1.7E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 17| +2.24E+02 | -1.4E+00 | +4.0E-01 | 1.2E-01 | 2.0E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 45| +2.12E+02 | -1.0E-02 | +4.3E-01 | 1.2E-02 | 2.2E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 83| +1.55E+02 | -1.3E-03 | +9.9E-01 | 1.8E-03 | 1.6E+00 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 11| +2.13E+02 | +2.1E+02 | -1.6E+01 | 2.0E+00 | 4.2E+01 | 4.5E+00 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 77| +1.48E+02 | +5.7E-06 | -6.6E+09 | 7.1E-15 | 4.7E-02 | 1.9E-14 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 35| +2.19E+02 | -2.2E+00 | +8.5E-01 | 2.5E-01 | 1.8E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 18| +2.21E+02 | -3.2E+00 | +7.2E-01 | 1.2E-01 | 3.6E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 50| +1.54E+02 | -1.3E-05 | +4.5E-01 | 1.9E-03 | 3.6E-02 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 46| +2.12E+02 | -1.9E-02 | +9.6E-01 | 1.2E-02 | 1.8E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 36| +2.18E+02 | -8.3E-01 | +7.5E-02 | 5.0E-01 | 2.4E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 78| +1.48E+02 | +5.4E-06 | -2.5E+10 | 1.8E-15 | 4.7E-02 | 4.6E-15 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 112| +1.52E+02 | -7.8E-01 | +9.4E-01 | 6.3E-02 | 1.6E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 19| +2.20E+02 | -8.3E-01 | +2.6E-01 | 1.2E-01 | 1.9E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 37| +2.14E+02 | -3.7E+00 | +6.3E-01 | 1.2E-01 | 4.5E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 51| +1.54E+02 | -9.0E-06 | +2.6E-01 | 1.9E-03 | 3.7E-02 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 47| +2.12E+02 | +3.2E-02 | -8.1E-01 | 2.4E-02 | 1.2E+00 | 5.0E-02 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 79| +1.48E+02 | +4.8E-06 | -8.8E+10 | 4.4E-16 | 4.7E-02 | 1.2E-15 | 2d |0\n", + "2023-02-17 16:05:16 fides(WARNING) Stopping as trust region radius 1.11E-16 is smaller than machine precision.\n", + "2023-02-17 16:05:16 fides(INFO) 38| +2.13E+02 | -1.1E+00 | +5.1E-01 | 1.2E-01 | 1.4E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 20| +2.18E+02 | -2.7E+00 | +6.5E-01 | 1.2E-01 | 3.5E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 48| +2.12E+02 | -5.5E-03 | +5.2E-01 | 6.1E-03 | 1.2E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 52| +1.54E+02 | -7.7E-06 | +2.0E-01 | 1.9E-03 | 2.8E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 39| +2.11E+02 | -2.1E+00 | +7.8E-01 | 1.2E-01 | 2.4E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 113| +1.51E+02 | -4.7E-01 | +5.7E-01 | 1.3E-01 | 1.7E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 21| +2.16E+02 | -1.1E+00 | +4.0E-01 | 1.2E-01 | 1.7E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 49| +2.12E+02 | -7.4E-03 | +9.4E-01 | 6.1E-03 | 1.3E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 53| +1.54E+02 | -9.0E-06 | +8.1E-01 | 4.9E-04 | 3.4E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 40| +2.07E+02 | -3.4E+00 | +8.4E-01 | 2.5E-01 | 1.2E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 22| +2.13E+02 | -3.0E+00 | +7.8E-01 | 1.2E-01 | 2.8E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:16.826 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 106.88 and h = 5.48355e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:16.826 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 106.88: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:16 fides(INFO) 12| +2.13E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 4.2E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 41| +1.94E+02 | -1.4E+01 | +1.5E+00 | 5.0E-01 | 2.6E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 50| +2.12E+02 | +1.7E-03 | -1.1E-01 | 1.2E-02 | 1.1E+00 | 2.3E-02 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 54| +1.54E+02 | -6.0E-06 | +5.0E-01 | 9.7E-04 | 2.3E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 23| +2.06E+02 | -7.7E+00 | +1.2E+00 | 2.5E-01 | 1.6E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 84| +1.55E+02 | -2.7E-03 | +1.0E+00 | 3.5E-03 | 1.4E+00 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:16 fides(INFO) 0| +1.85E+12 | NaN | NaN | 1.0E+00 | 8.5E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:16 fides(INFO) 51| +2.12E+02 | -3.0E-03 | +6.5E-01 | 3.1E-03 | 1.1E+00 | 6.3E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 42| +1.94E+02 | +5.1E+03 | -1.7E+02 | 1.0E+00 | 2.9E+01 | 2.2E+00 | trr |0\n", + "2023-02-17 16:05:16 fides(INFO) 1| +2.10E+09 | -1.8E+12 | +8.5E-02 | 1.0E+00 | 8.5E+12 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 24| +1.95E+02 | -1.0E+01 | +5.5E-01 | 5.0E-01 | 3.5E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 55| +1.54E+02 | -4.6E-06 | +4.7E-01 | 9.7E-04 | 1.7E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 114| +1.51E+02 | -1.6E-01 | +3.1E-01 | 1.3E-01 | 2.1E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 52| +2.12E+02 | -3.7E-03 | +1.0E+00 | 3.1E-03 | 1.0E+00 | 6.3E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 43| +1.77E+02 | -1.7E+01 | +1.0E+00 | 2.5E-01 | 2.9E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 2| +3.18E+08 | -1.8E+09 | +8.9E-01 | 2.5E-01 | 9.7E+09 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 25| +1.75E+02 | -2.1E+01 | +8.6E-01 | 5.0E-01 | 6.0E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 56| +1.54E+02 | -2.9E-06 | +2.9E-01 | 9.7E-04 | 2.0E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 44| +1.77E+02 | -1.2E+01 | -2.0E-01 | 5.0E-01 | 9.9E+01 | 9.3E-01 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 53| +2.12E+02 | -7.0E-03 | +1.0E+00 | 6.1E-03 | 9.4E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 3| +4.90E+07 | -2.7E+08 | +8.9E-01 | 5.0E-01 | 1.5E+09 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:16 fides(INFO) 26| +1.75E+02 | +6.0E+04 | -1.8E+03 | 1.0E+00 | 1.0E+02 | 2.2E+00 | 2d |0\n", + "2023-02-17 16:05:16 fides(INFO) 4| +7.48E+06 | -4.2E+07 | +8.9E-01 | 1.0E+00 | 2.2E+08 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 57| +1.54E+02 | -3.3E-06 | +3.1E-01 | 9.7E-04 | 1.4E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 45| +1.66E+02 | -1.1E+01 | +9.8E-01 | 1.2E-01 | 9.9E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 54| +2.12E+02 | -1.2E-02 | +9.9E-01 | 1.2E-02 | 8.8E-01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 27| +1.63E+02 | -1.2E+01 | +3.7E-01 | 2.5E-01 | 1.0E+02 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 5| +1.15E+06 | -6.3E+06 | +9.0E-01 | 1.0E+00 | 3.4E+07 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 13| +2.06E+02 | -7.3E+00 | +8.5E-01 | 1.2E-01 | 4.2E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 58| +1.54E+02 | -6.0E-07 | +6.4E-02 | 9.7E-04 | 1.5E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 6| +1.78E+05 | -9.7E+05 | +9.0E-01 | 1.0E+00 | 5.2E+06 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 46| +1.52E+02 | -1.4E+01 | +7.9E-01 | 2.5E-01 | 5.9E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 115| +1.51E+02 | -5.6E-03 | +1.3E-02 | 1.3E-01 | 1.6E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 55| +2.12E+02 | -2.5E-02 | +1.0E+00 | 2.4E-02 | 8.6E-01 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 28| +1.51E+02 | -1.2E+01 | +9.6E-01 | 2.5E-01 | 2.5E+02 | 3.5E-01 | trr |1\n", + "2023-02-17 16:05:17 fides(INFO) 7| +2.79E+04 | -1.5E+05 | +9.0E-01 | 1.0E+00 | 8.1E+05 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 8| +4.54E+03 | -2.3E+04 | +9.0E-01 | 1.0E+00 | 1.3E+05 | 7.8E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 85| +1.55E+02 | -3.3E-03 | +1.0E+00 | 7.0E-03 | 1.9E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 47| +1.51E+02 | -1.3E+00 | +2.1E-01 | 5.0E-01 | 1.1E+02 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 59| +1.54E+02 | -3.0E-06 | +8.6E-01 | 2.4E-04 | 1.1E-02 | 5.2E-04 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 56| +2.12E+02 | -5.2E-02 | +1.1E+00 | 4.9E-02 | 8.0E-01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 29| +1.51E+02 | +5.9E-01 | -2.9E-01 | 2.5E-01 | 5.0E+01 | 3.4E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 9| +8.89E+02 | -3.7E+03 | +9.0E-01 | 1.0E+00 | 2.0E+04 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 57| +2.11E+02 | -1.3E-01 | +1.2E+00 | 9.8E-02 | 1.0E+00 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 48| +1.48E+02 | -2.4E+00 | +8.2E-01 | 1.0E-01 | 6.8E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 10| +3.24E+02 | -5.7E+02 | +9.1E-01 | 1.0E+00 | 3.1E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 30| +1.50E+02 | -1.3E+00 | +8.1E-01 | 6.2E-02 | 5.0E+01 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 60| +1.54E+02 | -2.0E-06 | +5.0E-01 | 4.9E-04 | 2.5E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 11| +2.37E+02 | -8.7E+01 | +9.3E-01 | 1.0E+00 | 4.7E+02 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 58| +2.11E+02 | -5.4E-01 | +1.7E+00 | 2.0E-01 | 2.1E+00 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 116| +1.51E+02 | -1.1E-01 | +9.8E-01 | 1.1E-02 | 7.6E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 49| +1.48E+02 | +1.3E+00 | -1.0E+00 | 2.1E-01 | 2.4E+01 | 2.4E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 31| +1.49E+02 | -7.1E-01 | +6.6E-01 | 1.2E-01 | 4.5E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 61| +1.54E+02 | -9.9E-07 | +4.4E-01 | 4.9E-04 | 9.8E-03 | 8.5E-04 | 2d |1\n", + "2023-02-17 16:05:17 fides(WARNING) Stopping as function difference 9.90E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:17.202 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 148.098 and h = 1.74276e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:17.202 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 148.098: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 59| +2.07E+02 | -3.4E+00 | +2.0E+00 | 3.9E-01 | 5.3E+00 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 50| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.1E-02 | 2.4E+01 | 7.1E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 12| +2.37E+02 | -3.1E+01 | -7.3E-01 | 2.0E+00 | 5.8E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 32| +1.49E+02 | +9.6E-02 | -1.4E-01 | 1.2E-01 | 3.0E+01 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 60| +2.07E+02 | +9.3E+01 | -1.7E+01 | 7.8E-01 | 1.9E+01 | 2.0E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 13| +2.24E+02 | -1.2E+01 | +9.6E-01 | 5.0E-01 | 5.8E+01 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 61| +2.05E+02 | -2.5E+00 | +9.4E-01 | 2.0E-01 | 1.9E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 33| +1.48E+02 | -7.1E-01 | +8.5E-01 | 3.1E-02 | 3.0E+01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 51| +1.48E+02 | -3.1E-01 | +8.5E-01 | 1.3E-02 | 2.4E+01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 14| +1.90E+02 | -1.6E+01 | +1.2E+00 | 2.5E-01 | 3.8E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 62| +1.99E+02 | -5.8E+00 | +3.0E-01 | 3.9E-01 | 3.2E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:17.296 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.7814 and h = 9.97554e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:17.296 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.7814: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:17 fides(INFO) 52| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.6E-02 | 2.4E+01 | 2.3E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 117| +1.51E+02 | -4.8E-02 | +9.2E-01 | 2.3E-02 | 5.6E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 34| +1.48E+02 | -2.2E-01 | +9.6E-01 | 6.2E-02 | 2.2E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 14| +2.24E+02 | -3.2E+00 | -2.8E+00 | 1.0E+00 | 3.1E+01 | 1.6E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 0| +8.25E+04 | NaN | NaN | 1.0E+00 | 3.8E+05 | NaN | NaN |1\n", + "2023-02-17 16:05:17 fides(INFO) 53| +1.48E+02 | -1.0E-01 | +9.5E-01 | 6.4E-03 | 2.4E+01 | 8.8E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 63| +1.93E+02 | -6.6E+00 | +1.4E-01 | 3.9E-01 | 8.1E+01 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:17.330 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.4894 and h = 1.16646e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:17.330 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.4894: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:17 fides(INFO) 35| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 1.2E+01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 1| +3.63E+02 | -8.2E+04 | +1.1E-01 | 1.0E+00 | 3.8E+05 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 15| +2.20E+02 | -4.9E+00 | +3.7E-01 | 2.5E-01 | 3.1E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 36| +1.48E+02 | -1.2E-01 | +9.0E-01 | 3.1E-02 | 1.2E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 64| +1.81E+02 | -1.2E+01 | +7.5E-01 | 9.8E-02 | 9.0E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 2| +3.32E+02 | -3.2E+01 | +9.2E-01 | 2.5E-01 | 5.0E+01 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 54| +1.48E+02 | -1.2E-01 | +7.6E-01 | 1.3E-02 | 1.3E+01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 118| +1.51E+02 | -6.4E-03 | +1.5E+00 | 2.3E-02 | 1.2E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 16| +2.06E+02 | -1.3E+01 | +8.9E-01 | 2.5E-01 | 7.9E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 86| +1.55E+02 | -4.1E-03 | +3.6E-01 | 1.4E-02 | 1.0E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 65| +1.81E+02 | +1.6E+00 | -1.2E-01 | 2.0E-01 | 4.8E+01 | 5.1E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 3| +2.77E+02 | -5.5E+01 | +9.8E-01 | 5.0E-01 | 3.7E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 37| +1.48E+02 | -1.1E-01 | +9.5E-01 | 6.2E-02 | 2.1E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 4| +2.77E+02 | +6.4E+03 | -2.6E+02 | 1.0E+00 | 4.2E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 55| +1.48E+02 | -6.5E-02 | +9.1E-01 | 2.6E-02 | 1.9E+01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 66| +1.75E+02 | -5.4E+00 | +9.3E-01 | 4.9E-02 | 4.8E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 17| +1.79E+02 | -2.8E+01 | +1.1E+00 | 5.0E-01 | 3.2E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 38| +1.48E+02 | -9.0E-02 | +8.3E-01 | 1.2E-01 | 6.6E+00 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 5| +2.54E+02 | -2.2E+01 | +9.0E-01 | 2.5E-01 | 4.2E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 56| +1.48E+02 | -2.7E-02 | +5.2E-01 | 5.1E-02 | 4.7E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 67| +1.67E+02 | -8.4E+00 | +1.0E+00 | 9.8E-02 | 4.1E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 18| +1.79E+02 | +1.8E+03 | -8.2E+01 | 1.0E+00 | 1.2E+02 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 6| +2.54E+02 | +7.1E+01 | -7.5E+00 | 5.0E-01 | 2.8E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:17.483 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 125.418 and h = 8.51644e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:17.484 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 125.418: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:17 fides(INFO) 119| +1.51E+02 | +0.0E+00 | +0.0E+00 | 2.3E-02 | 1.5E+00 | 4.8E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 39| +1.48E+02 | +1.2E+00 | -5.1E+00 | 2.5E-01 | 7.7E+00 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 7| +2.50E+02 | -4.2E+00 | +5.5E-01 | 1.2E-01 | 2.8E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 57| +1.48E+02 | -1.1E-02 | +2.6E-01 | 5.1E-02 | 9.1E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 68| +1.62E+02 | -4.6E+00 | +4.8E-01 | 2.0E-01 | 4.1E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 40| +1.48E+02 | +1.3E-03 | -2.5E-02 | 6.2E-02 | 7.7E+00 | 7.9E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 15| +1.90E+02 | +4.9E+01 | -2.8E+00 | 5.0E-01 | 4.8E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 19| +1.60E+02 | -1.8E+01 | +8.4E-01 | 2.5E-01 | 1.2E+02 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 8| +2.50E+02 | -1.6E-01 | +2.4E-01 | 1.2E-01 | 1.2E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 58| +1.48E+02 | +8.0E-02 | -1.2E+00 | 5.1E-02 | 2.2E+00 | 5.7E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 69| +1.51E+02 | -1.2E+01 | +7.2E-01 | 2.0E-01 | 6.9E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 20| +1.51E+02 | -9.0E+00 | +8.8E-01 | 5.0E-01 | 1.2E+02 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 9| +2.50E+02 | -9.9E-02 | +2.6E-01 | 3.1E-02 | 7.6E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 41| +1.48E+02 | -2.0E-02 | +7.7E-01 | 1.6E-02 | 7.7E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 10| +2.50E+02 | -3.4E-02 | +1.9E-01 | 3.1E-02 | 5.7E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 59| +1.48E+02 | -5.2E-04 | +4.9E-03 | 1.3E-02 | 2.2E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 70| +1.51E+02 | +2.7E+02 | -7.7E+00 | 2.0E-01 | 8.4E+01 | 5.1E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 120| +1.51E+02 | -5.6E-03 | +1.1E+00 | 5.7E-03 | 1.5E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 21| +1.50E+02 | -1.9E+00 | +3.7E-01 | 1.0E+00 | 9.2E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 42| +1.48E+02 | -1.3E-02 | +7.5E-01 | 3.1E-02 | 3.5E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 11| +2.50E+02 | -5.3E-02 | +7.6E-01 | 7.8E-03 | 4.2E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 71| +1.51E+02 | +1.2E+01 | -1.2E+00 | 4.9E-02 | 8.4E+01 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 60| +1.48E+02 | -8.1E-03 | +9.6E-01 | 3.2E-03 | 6.6E+00 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 12| +2.50E+02 | +1.6E-04 | -2.7E-02 | 1.6E-02 | 1.0E+00 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 22| +1.50E+02 | +9.7E+01 | -1.7E+01 | 1.0E+00 | 7.2E+01 | 1.9E+00 | trr |0\n", + "2023-02-17 16:05:17 fides(INFO) 43| +1.48E+02 | -1.5E-02 | +8.0E-01 | 6.2E-02 | 4.6E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 87| +1.55E+02 | -1.2E-02 | +1.1E+00 | 1.4E-02 | 6.1E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 13| +2.50E+02 | -1.8E-03 | +3.1E-01 | 3.9E-03 | 1.0E+00 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 72| +1.49E+02 | -1.3E+00 | +4.8E-01 | 1.2E-02 | 8.4E+01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 61| +1.48E+02 | -5.4E-03 | +8.5E-01 | 6.4E-03 | 2.1E+00 | 8.1E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 44| +1.48E+02 | +4.5E-02 | -1.5E+00 | 1.2E-01 | 1.9E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 23| +1.50E+02 | +2.6E+00 | -9.5E-01 | 2.2E-01 | 7.2E+01 | 4.7E-01 | 2d |0\n", + "2023-02-17 16:05:17.680 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 148.597 and h = 1.48907e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:17.680 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 148.597: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:17 fides(INFO) 121| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.1E-02 | 6.2E-01 | 2.4E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 14| +2.50E+02 | -2.2E-04 | +8.8E-02 | 3.9E-03 | 6.6E-01 | 7.3E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 73| +1.49E+02 | -5.1E-01 | +9.6E-01 | 1.2E-02 | 2.2E+01 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 62| +1.48E+02 | -5.5E-03 | +7.8E-01 | 1.3E-02 | 2.6E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 45| +1.48E+02 | -6.4E-03 | +5.3E-01 | 3.1E-02 | 1.9E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 15| +2.50E+02 | -9.5E-04 | +7.9E-01 | 9.8E-04 | 5.9E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 24| +1.49E+02 | -8.5E-01 | +7.4E-01 | 5.6E-02 | 7.2E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 74| +1.48E+02 | -3.2E-01 | +5.1E-01 | 2.4E-02 | 1.9E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 16| +1.80E+02 | -9.8E+00 | +1.0E+00 | 1.2E-01 | 4.8E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 16| +2.50E+02 | +8.8E-07 | -5.1E-03 | 2.0E-03 | 1.8E-01 | 4.9E-03 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 63| +1.48E+02 | -2.1E-03 | +5.0E-01 | 2.6E-02 | 8.1E-01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 46| +1.48E+02 | -5.4E-03 | +6.0E-01 | 3.1E-02 | 3.7E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 25| +1.48E+02 | -8.8E-01 | +6.9E-01 | 5.6E-02 | 2.2E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 17| +2.50E+02 | -8.9E-05 | +5.8E-01 | 4.9E-04 | 1.8E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 75| +1.48E+02 | -3.1E-01 | +5.0E-01 | 2.4E-02 | 4.2E+01 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 18| +2.50E+02 | -7.5E-09 | +1.1E-03 | 4.9E-04 | 3.3E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 64| +1.48E+02 | -1.5E-03 | +7.8E-01 | 2.6E-02 | 9.6E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 47| +1.48E+02 | -2.6E-03 | +4.2E-01 | 3.1E-02 | 9.2E-01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 26| +1.48E+02 | -9.9E-02 | +9.3E-01 | 5.6E-02 | 2.5E+01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 76| +1.48E+02 | -1.6E-01 | +2.8E-01 | 2.4E-02 | 3.0E+01 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 122| +1.51E+02 | -3.0E-03 | +1.0E+00 | 2.8E-03 | 6.2E-01 | 6.0E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 19| +2.50E+02 | -2.1E-06 | +3.4E-01 | 1.2E-04 | 3.3E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:17 fides(WARNING) Stopping as function difference 2.08E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:17 fides(INFO) 65| +1.48E+02 | -1.5E-03 | +6.6E-01 | 5.1E-02 | 5.0E-01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 77| +1.48E+02 | +1.9E-01 | -3.5E-01 | 2.4E-02 | 1.5E+01 | 5.6E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 48| +1.48E+02 | -1.7E-03 | +2.6E-01 | 3.1E-02 | 1.8E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 27| +1.48E+02 | -6.9E-02 | +8.6E-01 | 1.1E-01 | 1.3E+01 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 49| +1.48E+02 | -3.8E-04 | +5.7E-02 | 3.1E-02 | 4.7E-01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 66| +1.48E+02 | +1.0E-03 | -2.9E-01 | 5.1E-02 | 6.0E-01 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 28| +1.48E+02 | +5.3E-02 | -7.0E-01 | 2.2E-01 | 1.2E+01 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 78| +1.48E+02 | -1.1E-01 | +7.5E-01 | 6.1E-03 | 1.5E+01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 88| +1.55E+02 | -1.1E-02 | +8.7E-01 | 2.8E-02 | 1.3E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 50| +1.48E+02 | -1.8E-03 | +7.2E-01 | 7.8E-03 | 1.6E+00 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 67| +1.48E+02 | -7.1E-04 | +6.3E-01 | 1.3E-02 | 6.0E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 79| +1.48E+02 | -8.6E-02 | +7.4E-01 | 6.1E-03 | 1.9E+01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 123| +1.51E+02 | -5.0E-03 | +1.0E+00 | 5.7E-03 | 7.4E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 17| +1.67E+02 | -1.3E+01 | +1.1E+00 | 2.5E-01 | 7.2E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 29| +1.48E+02 | -2.5E-02 | +7.2E-01 | 5.6E-02 | 1.2E+01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 0| +3.21E+02 | NaN | NaN | 1.0E+00 | 6.2E+01 | NaN | NaN |1\n", + "2023-02-17 16:05:17 fides(INFO) 51| +1.48E+02 | -5.0E-04 | +8.4E-01 | 7.8E-03 | 8.3E-01 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 80| +1.48E+02 | -6.5E-02 | +7.7E-01 | 6.1E-03 | 1.1E+01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:17 fides(INFO) 30| +1.48E+02 | -1.4E-02 | +7.1E-01 | 5.6E-02 | 6.4E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 68| +1.48E+02 | -4.2E-04 | +9.6E-01 | 1.3E-02 | 9.6E-01 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 1| +3.21E+02 | +4.3E+02 | -5.6E+00 | 1.0E+00 | 6.2E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:17 fides(INFO) 52| +1.48E+02 | -4.8E-04 | +9.1E-01 | 1.6E-02 | 3.7E-01 | 6.7E-03 | 2d |1\n", + "2023-02-17 16:05:17 fides(INFO) 81| +1.48E+02 | -5.7E-02 | +7.3E-01 | 1.2E-02 | 1.1E+01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 69| +1.48E+02 | -5.7E-04 | +9.7E-01 | 2.6E-02 | 2.2E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 31| +1.48E+02 | -9.6E-03 | +6.6E-01 | 5.6E-02 | 7.1E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 82| +1.48E+02 | -5.1E-02 | +9.4E-01 | 1.2E-02 | 8.9E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 53| +1.48E+02 | -6.3E-04 | +8.3E-01 | 3.1E-02 | 4.0E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 2| +2.80E+02 | -4.0E+01 | +9.6E-01 | 2.5E-01 | 6.2E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 70| +1.48E+02 | -6.9E-04 | +8.2E-01 | 5.1E-02 | 4.2E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 32| +1.48E+02 | -5.2E-03 | +5.1E-01 | 5.6E-02 | 3.7E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 83| +1.48E+02 | +2.1E-03 | -4.7E-02 | 2.4E-02 | 5.7E+00 | 4.9E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 124| +1.51E+02 | -9.3E-03 | +1.0E+00 | 1.1E-02 | 6.5E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 71| +1.48E+02 | +4.6E-03 | -3.1E+00 | 1.0E-01 | 2.6E-01 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 3| +2.54E+02 | -2.6E+01 | +2.9E-01 | 5.0E-01 | 5.4E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 54| +1.48E+02 | +8.5E-04 | -6.5E-01 | 6.2E-02 | 2.8E-01 | 1.6E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 33| +1.48E+02 | -3.3E-03 | +3.4E-01 | 5.6E-02 | 4.6E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 84| +1.48E+02 | -1.1E-02 | +4.4E-01 | 6.1E-03 | 5.7E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 72| +1.48E+02 | -6.8E-05 | +1.2E-01 | 2.6E-02 | 2.6E-01 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 55| +1.48E+02 | -2.2E-04 | +4.7E-01 | 1.6E-02 | 2.8E-01 | 4.3E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 34| +1.48E+02 | -8.4E-04 | +8.3E-02 | 5.6E-02 | 2.3E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 4| +2.28E+02 | -2.7E+01 | +3.4E-01 | 5.0E-01 | 1.6E+02 | 1.3E+00 | trr |1\n", + "2023-02-17 16:05:18 fides(INFO) 85| +1.48E+02 | -1.9E-02 | +7.3E-01 | 6.1E-03 | 1.0E+01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 73| +1.48E+02 | -2.6E-04 | +7.4E-01 | 6.4E-03 | 6.1E-01 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 89| +1.55E+02 | -3.5E-03 | +3.7E-01 | 5.6E-02 | 1.2E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 35| +1.48E+02 | -3.9E-03 | +7.8E-01 | 1.4E-02 | 3.9E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 56| +1.48E+02 | -2.6E-04 | +5.1E-01 | 1.6E-02 | 7.1E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 5| +2.10E+02 | -1.8E+01 | +8.4E-01 | 5.0E-01 | 1.2E+02 | 9.0E-01 | trr |1\n", + "2023-02-17 16:05:18 fides(INFO) 125| +1.51E+02 | -1.5E-02 | +9.6E-01 | 2.3E-02 | 5.4E-01 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 36| +1.48E+02 | -8.9E-04 | +5.7E-01 | 2.8E-02 | 1.3E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 86| +1.48E+02 | -6.1E-03 | +8.1E-01 | 6.1E-03 | 3.6E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 74| +1.48E+02 | -6.5E-05 | +8.5E-01 | 6.4E-03 | 1.4E-01 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 18| +1.59E+02 | -7.6E+00 | +9.5E-01 | 5.0E-01 | 6.4E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 57| +1.48E+02 | -9.3E-05 | +2.6E-01 | 1.6E-02 | 2.3E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 6| +2.10E+02 | +3.0E+00 | -1.1E+00 | 1.0E+00 | 1.7E+01 | 2.6E+00 | trr |0\n", + "2023-02-17 16:05:18 fides(INFO) 87| +1.48E+02 | -6.2E-03 | +9.5E-01 | 1.2E-02 | 2.9E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 75| +1.48E+02 | -7.0E-05 | +8.8E-01 | 1.3E-02 | 5.9E-02 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 37| +1.48E+02 | -4.7E-04 | +8.7E-01 | 2.8E-02 | 1.2E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 58| +1.48E+02 | -1.4E-04 | +2.8E-01 | 1.6E-02 | 6.3E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 88| +1.48E+02 | -5.2E-03 | +6.7E-01 | 2.4E-02 | 1.8E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:18.263 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.9411 and h = 2.74506e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:18.263 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.9411: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:18 fides(INFO) 76| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.6E-02 | 1.4E-01 | 6.6E-03 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 7| +2.10E+02 | +3.5E+00 | -8.7E-01 | 2.5E-01 | 1.7E+01 | 6.7E-01 | trr |0\n", + "2023-02-17 16:05:18 fides(INFO) 38| +1.48E+02 | -5.7E-04 | +9.4E-01 | 5.6E-02 | 8.1E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 59| +1.48E+02 | +4.7E-05 | -1.0E-01 | 1.6E-02 | 2.5E-01 | 4.0E-03 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 8| +2.07E+02 | -2.5E+00 | +1.0E+00 | 6.2E-02 | 1.7E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 89| +1.48E+02 | -5.3E-03 | +9.7E-01 | 2.4E-02 | 1.4E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 126| +1.51E+02 | -8.3E-03 | +6.3E-01 | 4.5E-02 | 4.6E-01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 77| +1.48E+02 | -3.5E-05 | +1.1E+00 | 6.4E-03 | 1.4E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 39| +1.48E+02 | -2.7E-04 | +5.7E-01 | 1.1E-01 | 1.1E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 9| +2.06E+02 | -1.6E+00 | +9.2E-01 | 1.2E-01 | 1.2E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 60| +1.48E+02 | -9.4E-05 | +5.6E-01 | 3.9E-03 | 2.5E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 78| +1.48E+02 | -5.3E-05 | +9.6E-01 | 1.3E-02 | 7.7E-02 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 90| +1.48E+02 | -7.1E-03 | +1.0E+00 | 4.9E-02 | 5.7E-01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 40| +1.48E+02 | +7.1E-03 | -3.8E+00 | 1.1E-01 | 3.3E-01 | 4.1E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 61| +1.48E+02 | -6.1E-05 | +9.4E-01 | 3.9E-03 | 6.2E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 10| +2.00E+02 | -5.3E+00 | +1.7E+00 | 2.5E-01 | 1.4E+01 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 91| +1.48E+02 | -1.3E-02 | +1.1E+00 | 9.8E-02 | 9.1E-01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 79| +1.48E+02 | -8.0E-05 | +9.8E-01 | 2.6E-02 | 8.9E-02 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 41| +1.48E+02 | +4.1E-05 | -6.7E-02 | 2.8E-02 | 3.3E-01 | 1.0E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 62| +1.48E+02 | -4.5E-05 | +1.0E+00 | 7.8E-03 | 7.3E-02 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 11| +2.00E+02 | +1.7E+01 | -1.7E+00 | 5.0E-01 | 2.0E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 80| +1.48E+02 | -8.7E-05 | +1.0E+00 | 5.1E-02 | 4.7E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 19| +1.58E+02 | -1.4E+00 | +1.0E+00 | 1.0E+00 | 7.7E+01 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 92| +1.48E+02 | -9.6E-03 | +3.9E-01 | 2.0E-01 | 2.3E+00 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 42| +1.48E+02 | -1.2E-04 | +6.2E-01 | 7.0E-03 | 3.3E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 90| +1.55E+02 | +1.5E-03 | -2.4E-01 | 5.6E-02 | 2.7E+00 | 2.9E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 127| +1.51E+02 | -3.0E-03 | +9.3E-01 | 4.5E-02 | 4.5E-01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 12| +1.93E+02 | -6.9E+00 | +1.3E+00 | 1.2E-01 | 2.0E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 63| +1.48E+02 | -5.4E-05 | +7.4E-01 | 1.6E-02 | 2.2E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 81| +1.48E+02 | +2.1E-05 | -8.9E-01 | 1.0E-01 | 6.7E-02 | 7.8E-03 | trr |0\n", + "2023-02-17 16:05:18 fides(INFO) 43| +1.48E+02 | -7.2E-05 | +9.8E-01 | 7.0E-03 | 7.4E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 93| +1.48E+02 | -9.5E-03 | +7.6E-01 | 2.0E-01 | 5.4E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 64| +1.48E+02 | -1.5E-05 | +2.0E-01 | 1.6E-02 | 8.4E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 13| +1.73E+02 | -2.0E+01 | +1.1E+00 | 2.5E-01 | 3.5E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 82| +1.48E+02 | -4.9E-06 | +4.6E-01 | 1.8E-02 | 6.7E-02 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 65| +1.48E+02 | -4.3E-05 | +6.9E-01 | 3.9E-03 | 2.9E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 94| +1.48E+02 | -5.2E-03 | +1.5E+00 | 2.0E-01 | 1.6E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 44| +1.48E+02 | -2.0E-05 | +8.0E-01 | 1.4E-02 | 2.1E-01 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 14| +1.68E+02 | -5.9E+00 | +3.9E-01 | 5.0E-01 | 7.4E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 83| +1.48E+02 | +1.2E-05 | -7.1E-01 | 1.8E-02 | 2.7E-02 | 3.9E-03 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 95| +1.48E+02 | -1.4E-03 | +5.1E-01 | 2.0E-01 | 7.2E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 45| +1.48E+02 | -2.4E-05 | +9.3E-01 | 2.8E-02 | 2.8E-01 | 5.8E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 66| +1.48E+02 | -4.5E-06 | +4.3E-01 | 3.9E-03 | 5.4E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 128| +1.51E+02 | -3.9E-04 | +1.4E+00 | 4.5E-02 | 4.1E-01 | 7.7E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 84| +1.48E+02 | -3.8E-06 | +7.6E-01 | 4.5E-03 | 2.7E-02 | 9.9E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 15| +1.60E+02 | -7.7E+00 | +8.1E-01 | 5.0E-01 | 1.3E+02 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 67| +1.48E+02 | -1.0E-05 | +1.6E+00 | 3.9E-03 | 2.2E-02 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 46| +1.48E+02 | -2.3E-05 | +7.7E-01 | 5.6E-02 | 1.6E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 96| +1.48E+02 | -8.4E-04 | +9.8E-01 | 2.0E-01 | 4.1E-01 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:18.650 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 183.579 and h = 4.55724e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:18.650 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 183.579: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:18 fides(INFO) 16| +1.60E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 5.0E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 85| +1.48E+02 | -6.5E-07 | +2.4E-01 | 9.0E-03 | 3.3E-02 | 8.6E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 47| +1.48E+02 | +3.8E-04 | -4.8E+00 | 1.1E-01 | 1.4E-01 | 2.1E-02 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 97| +1.48E+02 | -2.0E-04 | +1.7E+00 | 2.0E-01 | 2.4E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 68| +1.48E+02 | -1.4E-05 | +1.3E+00 | 7.8E-03 | 6.2E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 86| +1.48E+02 | -1.4E-06 | +2.3E+00 | 2.2E-03 | 1.7E-02 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(WARNING) Stopping as function difference 1.44E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:18 fides(INFO) 17| +1.56E+02 | -3.5E+00 | +9.4E-01 | 2.3E-01 | 5.0E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 20| +1.58E+02 | +1.5E+00 | -8.6E+00 | 2.0E+00 | 4.7E+01 | 6.1E+00 | trr |0\n", + "2023-02-17 16:05:18 fides(INFO) 69| +1.48E+02 | -9.0E-06 | +5.7E-01 | 1.6E-02 | 2.4E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 48| +1.48E+02 | -8.7E-07 | +2.8E-02 | 2.8E-02 | 1.4E-01 | 5.3E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 98| +1.48E+02 | -9.9E-04 | +1.5E+00 | 2.0E-01 | 1.8E-01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 129| +1.51E+02 | -1.2E-04 | +9.9E-01 | 4.5E-02 | 9.1E-02 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 18| +1.49E+02 | -6.9E+00 | +1.3E+00 | 4.6E-01 | 5.0E+01 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 70| +1.48E+02 | -1.0E-05 | +9.8E-01 | 1.6E-02 | 4.7E-02 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 49| +1.48E+02 | -1.5E-05 | +5.9E-01 | 7.0E-03 | 1.5E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 99| +1.48E+02 | -1.2E-03 | +1.4E+00 | 2.0E-01 | 2.6E-01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 19| +1.49E+02 | +2.1E+01 | -9.6E+00 | 9.2E-01 | 5.3E+01 | 8.2E-01 | trr |0\n", + "2023-02-17 16:05:18 fides(INFO) 71| +1.48E+02 | +7.4E-05 | -3.6E+00 | 3.1E-02 | 2.6E-02 | 2.3E-03 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 91| +1.55E+02 | -2.5E-03 | +6.8E-01 | 2.8E-03 | 2.7E+00 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 50| +1.48E+02 | -4.1E-06 | +1.4E+00 | 7.0E-03 | 1.1E-01 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 100| +1.48E+02 | -7.8E-04 | +1.4E+00 | 2.0E-01 | 3.0E-01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:18.802 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 68.1343 and h = 1.67073e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:18.803 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 68.1343: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 20| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 5.3E+01 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 51| +1.48E+02 | -5.2E-07 | +2.2E-01 | 1.4E-02 | 7.3E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 72| +1.48E+02 | +2.5E-05 | -2.1E+00 | 7.8E-03 | 2.6E-02 | 9.4E-04 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 0| +3.01E+13 | NaN | NaN | 1.0E+00 | 1.4E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 130| +1.51E+02 | -4.7E-06 | +1.1E+00 | 4.5E-02 | 9.5E-02 | 3.3E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 21| +1.49E+02 | -5.5E-01 | +9.1E-01 | 2.9E-02 | 5.3E+01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 101| +1.48E+02 | -3.8E-04 | +1.4E+00 | 2.0E-01 | 1.5E-01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 52| +1.48E+02 | -1.1E-06 | +9.4E-01 | 3.5E-03 | 7.1E-02 | 4.6E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(WARNING) Stopping as function difference 1.13E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:18 fides(INFO) 73| +1.48E+02 | +1.7E-05 | -1.9E+00 | 2.0E-03 | 2.6E-02 | 7.1E-04 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 1| +1.44E+07 | -3.0E+13 | +8.2E-02 | 1.0E+00 | 1.4E+14 | 3.2E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 2| +2.20E+06 | -1.2E+07 | +8.9E-01 | 2.5E-01 | 6.6E+07 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 22| +1.48E+02 | -5.6E-01 | +9.4E-01 | 5.8E-02 | 1.4E+01 | 9.7E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 74| +1.48E+02 | +1.6E-05 | -2.0E+00 | 4.9E-04 | 2.6E-02 | 6.6E-04 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 3| +3.38E+05 | -1.9E+06 | +8.9E-01 | 5.0E-01 | 1.0E+07 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 102| +1.48E+02 | -1.8E-04 | +1.4E+00 | 2.0E-01 | 2.6E-02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 4| +5.60E+04 | -2.8E+05 | +8.7E-01 | 1.0E+00 | 1.6E+06 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 21| +1.56E+02 | -1.6E+00 | +9.1E-01 | 5.0E-01 | 4.7E+01 | 1.3E+00 | trr |1\n", + "2023-02-17 16:05:18 fides(INFO) 23| +1.48E+02 | +4.3E-01 | -9.2E-01 | 1.2E-01 | 7.4E+00 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:18 fides(INFO) 5| +8.88E+03 | -4.7E+04 | +9.0E-01 | 1.0E+00 | 2.4E+05 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 75| +1.48E+02 | -2.6E-06 | +4.8E-01 | 1.2E-04 | 2.6E-02 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 103| +1.48E+02 | -1.1E-04 | +1.4E+00 | 2.0E-01 | 3.4E-02 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 6| +1.56E+03 | -7.3E+03 | +9.0E-01 | 1.0E+00 | 3.8E+04 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 7| +4.27E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 5.9E+03 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 24| +1.48E+02 | -9.2E-02 | +6.4E-01 | 2.9E-02 | 7.4E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 76| +1.48E+02 | -2.1E-07 | +2.3E-01 | 1.2E-04 | 8.4E-02 | 3.4E-05 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 131| +1.51E+02 | -6.9E-07 | +1.3E+00 | 4.5E-02 | 2.8E-02 | 1.9E-04 | 2d |1\n", + "2023-02-17 16:05:18 fides(WARNING) Stopping as function difference 6.90E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:18 fides(INFO) 104| +1.48E+02 | -5.9E-05 | +1.5E+00 | 3.9E-01 | 4.0E-02 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) 8| +2.64E+02 | -1.6E+02 | +8.9E-01 | 1.0E+00 | 9.2E+02 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:18 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:18 fides(INFO) 0| +1.63E+13 | NaN | NaN | 1.0E+00 | 7.5E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:19 fides(INFO) 77| +1.48E+02 | -2.0E-06 | +2.0E+01 | 3.1E-05 | 1.5E-02 | 1.3E-05 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 9| +2.33E+02 | -3.1E+01 | +1.2E+00 | 1.0E+00 | 1.2E+02 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 25| +1.48E+02 | -1.3E-01 | +9.4E-01 | 2.9E-02 | 4.3E+00 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 1| +1.16E+07 | -1.6E+13 | +8.4E-02 | 1.0E+00 | 7.5E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 105| +1.48E+02 | -2.8E-05 | +1.3E+00 | 3.9E-01 | 1.3E-02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 92| +1.55E+02 | -8.4E-04 | +9.3E-01 | 2.8E-03 | 1.3E+00 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 26| +1.48E+02 | -1.5E-01 | +8.7E-01 | 5.8E-02 | 5.6E+00 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 10| +2.33E+02 | +6.2E+01 | -1.3E+01 | 2.0E+00 | 2.2E+01 | 6.0E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 78| +1.48E+02 | +3.4E-07 | -2.4E+00 | 6.1E-05 | 2.4E-02 | 1.6E-05 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 2| +1.77E+06 | -9.8E+06 | +8.9E-01 | 2.5E-01 | 5.3E+07 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 106| +1.48E+02 | -1.5E-05 | +1.3E+00 | 3.9E-01 | 8.3E-03 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 11| +2.33E+02 | +2.3E+00 | -6.2E-01 | 5.0E-01 | 2.2E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 3| +2.75E+05 | -1.5E+06 | +9.0E-01 | 5.0E-01 | 8.2E+06 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 27| +1.48E+02 | -7.8E-02 | +2.0E-01 | 1.2E-01 | 3.8E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 107| +1.48E+02 | -1.3E-05 | +2.0E+00 | 3.9E-01 | 1.5E-02 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 79| +1.48E+02 | +2.0E-06 | -2.1E+01 | 1.5E-05 | 2.4E-02 | 8.3E-06 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 12| +2.32E+02 | -8.6E-01 | +1.8E-01 | 1.2E-01 | 2.2E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 4| +4.30E+04 | -2.3E+05 | +9.0E-01 | 1.0E+00 | 1.3E+06 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:19.102 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 82.3892 and h = 4.26295e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:19.102 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 82.3892: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:19 fides(INFO) 28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.9E-02 | 1.3E+01 | 5.4E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 13| +2.30E+02 | -1.8E+00 | +9.1E-01 | 3.1E-02 | 3.9E+01 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 0| +6.04E+09 | NaN | NaN | 1.0E+00 | 2.2E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:19 fides(INFO) 108| +1.48E+02 | +1.4E-06 | -6.3E-01 | 3.9E-01 | 5.6E-03 | 2.3E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 22| +1.54E+02 | -2.6E+00 | +1.0E+00 | 5.0E-01 | 8.5E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 14| +2.28E+02 | -1.9E+00 | +8.6E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 5| +6.90E+03 | -3.6E+04 | +9.0E-01 | 1.0E+00 | 2.0E+05 | 8.5E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 1| +2.23E+07 | -6.0E+09 | +1.2E-01 | 1.0E+00 | 2.2E+10 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 80| +1.48E+02 | +1.0E-06 | -1.2E+01 | 3.8E-06 | 2.4E-02 | 6.6E-06 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 29| +1.48E+02 | -7.8E-02 | +9.0E-01 | 7.2E-03 | 1.3E+01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 109| +1.48E+02 | +2.0E-06 | -1.5E+00 | 6.6E-02 | 5.6E-03 | 5.7E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 15| +2.25E+02 | -3.3E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 2| +3.45E+06 | -1.9E+07 | +8.9E-01 | 2.5E-01 | 1.0E+08 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:19.180 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 82.9518 and h = 2.54562e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:19 fides(INFO) 81| +1.48E+02 | -1.2E-07 | +3.7E+00 | 9.5E-07 | 2.4E-02 | 1.7E-06 | 2d |1\n", + "2023-02-17 16:05:19.180 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 82.9518: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:19 fides(WARNING) Stopping as function difference 1.25E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 30| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.4E-02 | 5.8E+00 | 2.6E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 16| +2.22E+02 | -3.0E+00 | +1.0E+00 | 2.5E-01 | 2.0E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 110| +1.48E+02 | +3.0E-06 | -7.9E+00 | 1.7E-02 | 5.6E-03 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 3| +5.50E+05 | -2.9E+06 | +9.0E-01 | 5.0E-01 | 1.6E+07 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 31| +1.48E+02 | -3.2E-02 | +9.3E-01 | 3.6E-03 | 5.8E+00 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 17| +2.22E+02 | +4.3E+00 | -1.1E+00 | 5.0E-01 | 2.1E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 6| +1.26E+03 | -5.6E+03 | +9.0E-01 | 1.0E+00 | 3.1E+04 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 93| +1.55E+02 | -9.2E-04 | +7.3E-01 | 5.6E-03 | 3.2E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 4| +9.46E+04 | -4.6E+05 | +8.9E-01 | 1.0E+00 | 2.4E+06 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 111| +1.48E+02 | +2.3E-06 | -2.3E+01 | 4.1E-03 | 5.6E-03 | 3.5E-03 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 32| +1.48E+02 | -3.9E-02 | +8.8E-01 | 7.2E-03 | 4.9E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 18| +2.21E+02 | -5.4E-01 | +8.7E-02 | 1.2E-01 | 2.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 5| +1.50E+04 | -8.0E+04 | +9.0E-01 | 2.0E+00 | 3.8E+05 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 112| +1.48E+02 | +4.4E-06 | -1.5E+02 | 1.0E-03 | 5.6E-03 | 8.8E-04 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 19| +2.20E+02 | -1.7E+00 | +8.8E-01 | 3.1E-02 | 3.9E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 6| +2.54E+03 | -1.3E+04 | +9.0E-01 | 2.0E+00 | 6.0E+04 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 7| +3.71E+02 | -8.8E+02 | +9.0E-01 | 1.0E+00 | 4.9E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 33| +1.48E+02 | -4.7E-02 | +7.9E-01 | 1.4E-02 | 5.2E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 20| +2.18E+02 | -1.3E+00 | +7.5E-01 | 6.2E-02 | 2.5E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 113| +1.48E+02 | +1.9E-06 | -1.8E+02 | 2.6E-04 | 5.6E-03 | 2.2E-04 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 7| +5.75E+02 | -2.0E+03 | +9.0E-01 | 2.0E+00 | 9.6E+03 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 0| +2.54E+08 | NaN | NaN | 1.0E+00 | 1.2E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:19 fides(INFO) 23| +1.53E+02 | -4.4E-01 | +1.0E+00 | 1.0E+00 | 3.4E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:19.338 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.009 and h = 2.78692e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:19 fides(INFO) 8| +2.31E+02 | -1.4E+02 | +9.2E-01 | 1.0E+00 | 7.8E+02 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:19.339 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.009: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:19 fides(INFO) 34| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.9E-02 | 2.5E+00 | 4.4E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 21| +2.17E+02 | -1.0E+00 | +4.8E-01 | 1.2E-01 | 1.5E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 114| +1.48E+02 | +2.9E-06 | -4.5E+02 | 6.5E-05 | 5.6E-03 | 5.5E-05 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 1| +4.19E+03 | -2.5E+08 | +1.0E-01 | 1.0E+00 | 1.2E+09 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 8| +2.83E+02 | -2.9E+02 | +8.9E-01 | 2.0E+00 | 1.5E+03 | 4.2E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 22| +2.16E+02 | -1.5E+00 | +5.7E-01 | 1.2E-01 | 3.0E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 9| +2.31E+02 | -7.6E+00 | -1.7E-01 | 2.0E+00 | 1.1E+02 | 4.0E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 35| +1.48E+02 | -1.3E-02 | +8.5E-01 | 7.2E-03 | 2.5E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 115| +1.48E+02 | +3.9E-06 | -7.4E+02 | 1.6E-05 | 5.6E-03 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 9| +2.34E+02 | -5.0E+01 | +1.1E+00 | 4.0E+00 | 2.2E+02 | 3.3E+00 | trr |1\n", + "2023-02-17 16:05:19 fides(INFO) 23| +2.16E+02 | +4.5E-01 | -3.4E-01 | 1.2E-01 | 1.5E+01 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 2| +1.07E+03 | -3.1E+03 | +9.1E-01 | 2.5E-01 | 1.3E+04 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 36| +1.48E+02 | -1.6E-02 | +8.0E-01 | 1.4E-02 | 2.6E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 116| +1.48E+02 | +4.0E-06 | -7.9E+02 | 4.0E-06 | 5.6E-03 | 3.9E-06 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 10| +2.34E+02 | +9.9E+02 | -4.3E+01 | 4.0E+00 | 3.4E+01 | 1.2E+01 | trr |0\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 10| +2.08E+02 | -2.3E+01 | +9.7E-01 | 5.0E-01 | 1.1E+02 | 9.7E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 24| +2.15E+02 | -6.5E-01 | +8.1E-01 | 3.1E-02 | 1.5E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 3| +4.00E+02 | -6.7E+02 | +9.1E-01 | 5.0E-01 | 2.7E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 37| +1.48E+02 | -2.3E-02 | +8.8E-01 | 2.9E-02 | 1.8E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 25| +2.14E+02 | -8.9E-01 | +9.9E-01 | 6.2E-02 | 1.2E+01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 117| +1.48E+02 | +4.0E-06 | -8.0E+02 | 1.0E-06 | 5.6E-03 | 1.9E-06 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 11| +1.66E+02 | -4.2E+01 | +9.2E-01 | 9.9E-01 | 4.1E+01 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 11| +2.34E+02 | +6.6E+01 | -5.4E+00 | 1.0E+00 | 3.4E+01 | 2.9E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 4| +2.93E+02 | -1.1E+02 | +8.8E-01 | 1.0E+00 | 4.5E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 12| +2.34E+02 | +2.7E+00 | -3.2E-01 | 2.5E-01 | 3.4E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 26| +2.14E+02 | -7.9E-01 | +7.4E-01 | 1.2E-01 | 1.2E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 38| +1.48E+02 | -4.1E-02 | +7.8E-01 | 5.8E-02 | 2.5E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 118| +1.48E+02 | +1.7E-07 | -6.1E+01 | 2.5E-07 | 5.6E-03 | 6.3E-07 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 94| +1.55E+02 | -5.9E-04 | +9.5E-01 | 5.6E-03 | 9.6E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 5| +2.57E+02 | -3.6E+01 | +8.3E-01 | 2.0E+00 | 6.1E+01 | 3.7E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 12| +1.66E+02 | +4.4E+01 | -2.9E+00 | 2.0E+00 | 1.7E+02 | 1.3E+00 | trr |0\n", + "2023-02-17 16:05:19 fides(INFO) 27| +2.14E+02 | +4.2E-01 | -3.2E-01 | 1.2E-01 | 1.4E+01 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 13| +2.29E+02 | -4.4E+00 | +9.0E-01 | 6.2E-02 | 3.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 24| +1.53E+02 | -8.0E-01 | +5.0E-01 | 2.0E+00 | 3.9E+01 | 8.7E-01 | trr |1\n", + "2023-02-17 16:05:19 fides(INFO) 6| +2.57E+02 | +4.7E+01 | -1.1E+01 | 4.0E+00 | 3.5E+01 | 1.1E+01 | trr |0\n", + "2023-02-17 16:05:19 fides(INFO) 39| +1.48E+02 | +1.5E-01 | -1.8E+00 | 1.2E-01 | 1.7E+00 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 14| +2.26E+02 | -3.0E+00 | +5.2E-01 | 1.2E-01 | 2.6E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 28| +2.13E+02 | -6.3E-01 | +7.9E-01 | 3.1E-02 | 1.4E+01 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 119| +1.48E+02 | +6.6E-07 | -8.0E+02 | 6.3E-08 | 5.6E-03 | 1.6E-07 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 7| +2.57E+02 | +1.8E+02 | -1.1E+01 | 9.4E-01 | 3.5E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 13| +1.56E+02 | -1.1E+01 | +9.8E-01 | 1.2E-01 | 1.7E+02 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 25| +1.53E+02 | +7.1E+01 | -7.4E+01 | 2.0E+00 | 1.6E+01 | 5.5E+00 | trr |0\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 40| +1.48E+02 | -9.7E-03 | +3.9E-01 | 2.9E-02 | 1.7E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 15| +2.22E+02 | -4.1E+00 | +8.2E-01 | 1.2E-01 | 3.8E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 29| +2.12E+02 | -4.7E-01 | +7.7E-01 | 6.2E-02 | 8.9E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 8| +2.57E+02 | +8.1E-01 | -1.4E-01 | 2.3E-01 | 3.5E+01 | 6.2E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 120| +1.48E+02 | +4.5E-06 | -2.1E+04 | 1.6E-08 | 5.6E-03 | 3.9E-08 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 14| +1.52E+02 | -3.8E+00 | +3.0E-01 | 2.4E-01 | 6.1E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 16| +2.19E+02 | -3.8E+00 | +4.6E-01 | 2.5E-01 | 2.4E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 41| +1.48E+02 | +7.5E-03 | -2.4E-01 | 2.9E-02 | 1.5E+00 | 4.2E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 9| +2.53E+02 | -4.7E+00 | +9.2E-01 | 5.9E-02 | 3.5E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 121| +1.48E+02 | +4.3E-06 | -7.9E+04 | 4.0E-09 | 5.6E-03 | 9.9E-09 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 30| +2.12E+02 | -4.6E-01 | +5.7E-01 | 1.2E-01 | 1.2E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 10| +2.51E+02 | -1.7E+00 | +2.9E-01 | 1.2E-01 | 2.5E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 17| +2.12E+02 | -7.1E+00 | +7.3E-01 | 2.5E-01 | 5.7E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 26| +1.52E+02 | -5.0E-01 | +8.9E-01 | 5.0E-01 | 1.6E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 42| +1.48E+02 | -5.7E-03 | +4.9E-01 | 7.2E-03 | 1.5E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 31| +2.12E+02 | -2.4E-01 | +2.0E-01 | 1.2E-01 | 1.1E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 122| +1.48E+02 | +1.7E-08 | -1.3E+03 | 9.9E-10 | 5.6E-03 | 2.5E-09 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 15| +1.49E+02 | -3.3E+00 | +9.6E-01 | 2.4E-01 | 1.8E+02 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 18| +2.10E+02 | -1.2E+00 | +6.9E-02 | 2.5E-01 | 2.5E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 11| +2.50E+02 | -7.6E-01 | +3.8E-01 | 1.2E-01 | 2.2E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 27| +1.52E+02 | +4.7E+01 | -1.8E+02 | 1.0E+00 | 2.4E+01 | 2.5E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 32| +2.11E+02 | -6.6E-01 | +7.8E-01 | 3.1E-02 | 1.8E+01 | 6.6E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 12| +2.50E+02 | +2.4E-01 | -3.5E-01 | 1.2E-01 | 1.0E+01 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 123| +1.48E+02 | +5.2E-07 | -1.6E+05 | 2.5E-10 | 5.6E-03 | 6.2E-10 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 16| +1.49E+02 | +8.2E+00 | -5.7E+00 | 4.8E-01 | 3.0E+01 | 6.5E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 43| +1.48E+02 | -4.2E-03 | +8.9E-01 | 7.2E-03 | 4.1E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 19| +2.05E+02 | -5.1E+00 | +8.5E-01 | 6.2E-02 | 6.3E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 13| +2.50E+02 | -3.4E-01 | +5.9E-01 | 2.9E-02 | 1.0E+01 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 33| +2.11E+02 | -4.2E-01 | +8.2E-01 | 6.2E-02 | 7.7E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 124| +1.48E+02 | +4.5E-07 | -5.3E+05 | 6.2E-11 | 5.6E-03 | 1.5E-10 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 17| +1.48E+02 | -5.2E-01 | +5.3E-01 | 1.2E-01 | 3.0E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 28| +1.52E+02 | -1.9E-01 | +1.0E+00 | 2.5E-01 | 2.4E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 20| +2.02E+02 | -3.3E+00 | +7.9E-01 | 1.2E-01 | 3.1E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 44| +1.48E+02 | -3.9E-03 | +9.1E-01 | 1.4E-02 | 4.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 14| +2.50E+02 | -9.7E-04 | +4.9E-02 | 2.9E-02 | 1.8E+00 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 34| +2.10E+02 | -3.5E-01 | +4.0E-01 | 1.2E-01 | 7.9E+00 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 125| +1.48E+02 | +4.6E-06 | -2.2E+07 | 1.5E-11 | 5.6E-03 | 3.9E-11 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 15| +2.50E+02 | -9.4E-04 | +5.5E-02 | 7.3E-03 | 1.7E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 18| +1.48E+02 | -2.8E-01 | +8.6E-01 | 1.2E-01 | 2.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 45| +1.48E+02 | -7.6E-03 | +9.4E-01 | 2.9E-02 | 5.2E-01 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 21| +1.94E+02 | -8.3E+00 | +1.3E+00 | 2.5E-01 | 1.8E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 29| +1.52E+02 | +1.9E+00 | -5.6E+00 | 5.0E-01 | 1.5E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 35| +2.09E+02 | -9.0E-01 | +6.7E-01 | 1.2E-01 | 1.5E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 95| +1.55E+02 | -6.7E-04 | +1.3E+00 | 1.1E-02 | 1.6E-01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 16| +2.50E+02 | -4.3E-03 | +9.0E-01 | 1.8E-03 | 1.6E+00 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 126| +1.48E+02 | +5.1E-06 | -9.7E+07 | 3.9E-12 | 5.6E-03 | 9.6E-12 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 46| +1.48E+02 | -5.5E-03 | +6.3E-01 | 5.8E-02 | 8.4E-01 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 19| +1.48E+02 | +1.9E-01 | -6.3E-01 | 2.4E-01 | 8.0E+00 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 17| +2.50E+02 | -3.0E-03 | +6.2E-01 | 3.7E-03 | 1.0E+00 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 22| +1.94E+02 | +3.1E+01 | -2.3E+00 | 5.0E-01 | 3.7E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 36| +2.09E+02 | -3.3E-01 | +3.2E-01 | 1.2E-01 | 8.2E+00 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 30| +1.52E+02 | -3.1E-01 | +9.7E-01 | 1.2E-01 | 1.5E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 127| +1.48E+02 | -1.7E-08 | +1.3E+06 | 9.7E-13 | 5.6E-03 | 2.4E-12 | 2d |1\n", + "2023-02-17 16:05:19 fides(WARNING) Stopping as function difference 1.67E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:19 fides(INFO) 47| +1.48E+02 | +2.1E-01 | -7.9E+00 | 5.8E-02 | 9.7E-01 | 8.8E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 20| +1.48E+02 | -2.8E-02 | +9.8E-02 | 6.0E-02 | 8.0E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 18| +2.50E+02 | -2.0E-06 | +3.5E-02 | 3.7E-03 | 9.8E-02 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 23| +1.84E+02 | -9.8E+00 | +1.2E+00 | 1.2E-01 | 3.7E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 37| +2.08E+02 | -9.1E-01 | +6.3E-01 | 1.2E-01 | 1.6E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 48| +1.48E+02 | +1.0E-02 | -8.1E-01 | 1.4E-02 | 9.7E-01 | 2.4E-02 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 19| +2.50E+02 | -9.4E-07 | +1.6E-02 | 9.2E-04 | 9.8E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 24| +1.67E+02 | -1.7E+01 | +8.6E-01 | 2.5E-01 | 4.5E+01 | 5.5E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 38| +2.08E+02 | -5.2E-01 | +4.6E-01 | 1.2E-01 | 8.6E+00 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 21| +1.48E+02 | -8.0E-02 | +8.6E-01 | 1.5E-02 | 1.4E+01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 31| +1.52E+02 | -6.6E-02 | +1.2E-01 | 2.5E-01 | 6.1E+00 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 20| +2.50E+02 | -2.8E-05 | +6.5E-01 | 2.3E-04 | 9.7E-02 | 6.0E-04 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 49| +1.48E+02 | -1.7E-03 | +3.6E-01 | 3.6E-03 | 9.7E-01 | 7.1E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 25| +1.67E+02 | +7.7E+01 | -4.4E+00 | 5.0E-01 | 1.3E+02 | 9.0E-01 | 2d |0\n", + "2023-02-17 16:05:19 fides(INFO) 39| +2.06E+02 | -1.4E+00 | +7.7E-01 | 1.2E-01 | 1.6E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 22| +1.48E+02 | -5.0E-02 | +7.1E-01 | 3.0E-02 | 5.9E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 21| +2.50E+02 | -1.4E-07 | +5.9E-01 | 2.3E-04 | 4.1E-03 | 6.1E-04 | 2d |1\n", + "2023-02-17 16:05:19 fides(WARNING) Stopping as function difference 1.37E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:19 fides(INFO) 32| +1.51E+02 | -1.0E-01 | +9.6E-01 | 6.2E-02 | 2.0E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 50| +1.48E+02 | -1.3E-03 | +9.2E-01 | 3.6E-03 | 3.0E+00 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 26| +1.55E+02 | -1.1E+01 | +9.2E-01 | 1.2E-01 | 1.3E+02 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 40| +2.03E+02 | -3.1E+00 | +1.2E+00 | 2.5E-01 | 1.0E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 23| +1.48E+02 | -1.2E-02 | +8.1E-01 | 3.0E-02 | 6.3E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 51| +1.48E+02 | -4.9E-04 | +9.2E-01 | 7.2E-03 | 2.8E-01 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 41| +1.81E+02 | -2.3E+01 | +1.5E+00 | 5.0E-01 | 2.1E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 24| +1.48E+02 | -7.0E-03 | +7.9E-01 | 6.0E-02 | 1.6E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 33| +1.51E+02 | -9.7E-02 | +1.0E+00 | 1.2E-01 | 1.1E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 96| +1.55E+02 | -1.3E-03 | +1.1E+00 | 2.2E-02 | 3.0E-01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 27| +1.52E+02 | -3.2E+00 | +4.0E-01 | 2.5E-01 | 6.4E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:19 fides(INFO) 0| +3.19E+13 | NaN | NaN | 1.0E+00 | 1.1E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:19 fides(INFO) 52| +1.48E+02 | -9.3E-04 | +9.5E-01 | 1.4E-02 | 2.6E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 1| +3.54E+10 | -3.2E+13 | +1.1E-01 | 1.0E+00 | 1.1E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 25| +1.48E+02 | -7.8E-03 | +9.6E-01 | 1.2E-01 | 2.7E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:19 fides(INFO) 28| +1.48E+02 | -4.0E+00 | +7.6E-01 | 2.5E-01 | 7.2E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 42| +1.81E+02 | +8.1E+03 | -2.3E+02 | 1.0E+00 | 8.1E+01 | 2.2E+00 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 2| +5.33E+09 | -3.0E+10 | +8.9E-01 | 2.5E-01 | 1.6E+11 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 0| +4.83E+06 | NaN | NaN | 1.0E+00 | 1.7E+07 | NaN | NaN |1\n", + "2023-02-17 16:05:20 fides(INFO) 53| +1.48E+02 | -4.7E-04 | +4.8E-01 | 2.9E-02 | 2.0E-01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 34| +1.51E+02 | -1.9E-01 | +1.1E+00 | 2.5E-01 | 1.1E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 26| +1.48E+02 | -1.0E-02 | +9.4E-01 | 2.4E-01 | 9.7E-01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 3| +8.04E+08 | -4.5E+09 | +8.9E-01 | 5.0E-01 | 2.4E+10 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 29| +1.48E+02 | +1.0E+01 | -8.3E+00 | 5.0E-01 | 4.5E+01 | 6.2E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 43| +1.67E+02 | -1.4E+01 | +5.2E-01 | 2.5E-01 | 8.1E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 4| +1.22E+08 | -6.8E+08 | +8.9E-01 | 5.0E-01 | 3.7E+09 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 54| +1.48E+02 | +1.7E-02 | -4.2E+00 | 2.9E-02 | 3.8E-01 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 27| +1.48E+02 | -5.8E-03 | +5.0E-01 | 4.8E-01 | 1.2E+00 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 1| +1.28E+04 | -4.8E+06 | +1.4E-01 | 1.0E+00 | 1.7E+07 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 5| +1.86E+07 | -1.0E+08 | +8.9E-01 | 5.0E-01 | 5.6E+08 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 30| +1.48E+02 | -1.8E-01 | +2.6E-01 | 1.2E-01 | 4.5E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 6| +2.87E+06 | -1.6E+07 | +8.9E-01 | 5.0E-01 | 8.6E+07 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 55| +1.48E+02 | +1.3E-03 | -7.8E-01 | 7.2E-03 | 3.8E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 28| +1.48E+02 | +4.0E-01 | -9.0E+00 | 4.8E-01 | 1.4E+00 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 44| +1.57E+02 | -9.8E+00 | +9.7E-01 | 2.5E-01 | 1.6E+02 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 2| +2.26E+03 | -1.1E+04 | +9.0E-01 | 2.5E-01 | 5.8E+04 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 31| +1.48E+02 | -2.7E-01 | +4.4E-01 | 1.2E-01 | 2.3E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 35| +1.51E+02 | -3.5E-01 | +1.4E+00 | 5.0E-01 | 1.1E+01 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 7| +4.44E+05 | -2.4E+06 | +9.0E-01 | 1.0E+00 | 1.3E+07 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 56| +1.48E+02 | -9.3E-05 | +1.2E-01 | 1.8E-03 | 3.8E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 29| +1.48E+02 | +1.1E-02 | -5.7E-01 | 1.2E-01 | 1.4E+00 | 7.4E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 45| +1.57E+02 | +2.2E+01 | -2.4E+00 | 5.0E-01 | 4.8E+01 | 9.0E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 3| +6.12E+02 | -1.6E+03 | +8.5E-01 | 5.0E-01 | 9.1E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 8| +6.95E+04 | -3.7E+05 | +9.0E-01 | 1.0E+00 | 2.0E+06 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 32| +1.48E+02 | +2.6E-01 | -6.8E-01 | 1.2E-01 | 1.5E+01 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 36| +1.51E+02 | +2.5E+00 | -4.0E+00 | 1.0E+00 | 1.0E+01 | 1.4E+00 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 4| +2.63E+02 | -3.5E+02 | +9.2E-01 | 1.0E+00 | 1.5E+03 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 57| +1.48E+02 | -3.2E-04 | +9.4E-01 | 4.5E-04 | 1.7E+00 | 6.7E-04 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 9| +1.11E+04 | -5.8E+04 | +9.0E-01 | 1.0E+00 | 3.2E+05 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 30| +1.48E+02 | -3.2E-03 | +5.3E-01 | 3.0E-02 | 1.4E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 46| +1.53E+02 | -3.8E+00 | +7.6E-01 | 1.2E-01 | 4.8E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 5| +2.12E+02 | -5.1E+01 | +8.7E-01 | 1.0E+00 | 1.8E+02 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 33| +1.48E+02 | -8.0E-02 | +6.2E-01 | 3.1E-02 | 1.5E+01 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 97| +1.55E+02 | -2.7E-03 | +1.0E+00 | 4.5E-02 | 3.4E-01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 10| +1.93E+03 | -9.2E+03 | +9.0E-01 | 1.0E+00 | 5.0E+04 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 58| +1.48E+02 | -3.7E-05 | +8.7E-01 | 9.0E-04 | 1.5E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 31| +1.48E+02 | -9.8E-04 | +9.6E-01 | 3.0E-02 | 2.6E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 34| +1.48E+02 | -5.9E-02 | +9.7E-01 | 3.1E-02 | 2.0E+01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 37| +1.50E+02 | -4.3E-01 | +1.1E+00 | 2.4E-01 | 1.0E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 11| +4.92E+02 | -1.4E+03 | +9.1E-01 | 1.0E+00 | 7.9E+03 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 47| +1.51E+02 | -2.3E+00 | +6.2E-01 | 2.5E-01 | 6.9E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 32| +1.48E+02 | -4.7E-04 | +9.4E-01 | 6.0E-02 | 3.0E-01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 6| +2.12E+02 | +2.6E+02 | -1.2E+01 | 2.0E+00 | 6.4E+01 | 5.9E+00 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 59| +1.48E+02 | -3.2E-05 | +7.2E-01 | 1.8E-03 | 2.2E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:20.266 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0723 and h = 2.40154e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:20.267 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0723: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:20 fides(INFO) 35| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 1.1E+01 | 4.3E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 12| +2.72E+02 | -2.2E+02 | +9.0E-01 | 1.0E+00 | 1.3E+03 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 7| +1.99E+02 | -1.3E+01 | +6.2E-01 | 5.0E-01 | 6.4E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 60| +1.48E+02 | -2.0E-05 | +9.7E-01 | 1.8E-03 | 7.1E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 48| +1.49E+02 | -1.6E+00 | +8.2E-01 | 2.5E-01 | 3.4E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 38| +1.50E+02 | -5.7E-01 | +8.6E-01 | 4.7E-01 | 1.0E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 33| +1.48E+02 | -4.8E-04 | +6.8E-01 | 1.2E-01 | 6.7E-01 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 8| +1.74E+02 | -2.6E+01 | +1.1E+00 | 5.0E-01 | 6.9E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 13| +2.42E+02 | -3.0E+01 | +9.2E-01 | 2.0E+00 | 1.8E+02 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 36| +1.48E+02 | -1.9E-02 | +9.6E-01 | 1.6E-02 | 1.1E+01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 61| +1.48E+02 | -3.3E-05 | +9.9E-01 | 3.6E-03 | 8.7E-02 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 9| +1.74E+02 | +1.6E+03 | -7.8E+01 | 1.0E+00 | 5.5E+01 | 1.9E+00 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 39| +1.50E+02 | -1.8E-01 | +6.6E-01 | 9.5E-01 | 1.6E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 49| +1.49E+02 | +2.9E+00 | -2.1E+00 | 5.0E-01 | 2.9E+01 | 7.0E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 14| +2.31E+02 | -1.2E+01 | +1.7E+00 | 2.0E+00 | 1.5E+01 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 34| +1.48E+02 | +1.2E-03 | -1.0E+00 | 1.2E-01 | 3.1E-01 | 4.8E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 37| +1.48E+02 | -3.0E-02 | +9.8E-01 | 3.1E-02 | 1.2E+01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 10| +1.64E+02 | -9.2E+00 | +4.7E-01 | 2.5E-01 | 5.5E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 62| +1.48E+02 | -3.8E-05 | +1.0E+00 | 7.2E-03 | 4.1E-02 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 35| +1.48E+02 | -1.4E-04 | +3.2E-01 | 3.0E-02 | 3.1E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 50| +1.49E+02 | -3.2E-01 | +5.7E-01 | 1.2E-01 | 2.9E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 15| +2.31E+02 | +7.6E+01 | -9.5E+00 | 4.0E+00 | 1.8E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:20.371 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 169.86 and h = 3.38851e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:20.371 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 169.86: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 40| +1.50E+02 | +0.0E+00 | +0.0E+00 | 9.5E-01 | 4.9E+00 | 1.2E-01 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 11| +1.53E+02 | -1.1E+01 | +8.7E-01 | 2.5E-01 | 1.4E+02 | 5.7E-01 | trr |1\n", + "2023-02-17 16:05:20 fides(INFO) 38| +1.48E+02 | -2.8E-02 | +9.4E-01 | 6.2E-02 | 8.8E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 12| +1.53E+02 | +1.6E+01 | -2.6E+00 | 2.5E-01 | 1.0E+02 | 4.8E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 63| +1.48E+02 | +8.3E-05 | -4.8E+00 | 1.4E-02 | 2.5E-02 | 2.6E-03 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 16| +2.23E+02 | -7.1E+00 | +1.5E+00 | 1.0E+00 | 1.8E+01 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 36| +1.48E+02 | -2.0E-04 | +7.1E-01 | 3.0E-02 | 9.1E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 39| +1.48E+02 | -2.8E-02 | +7.5E-01 | 1.2E-01 | 7.4E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 51| +1.48E+02 | -4.1E-01 | +8.9E-01 | 1.2E-01 | 2.5E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 41| +1.50E+02 | -1.4E-02 | +8.3E-01 | 5.6E-02 | 4.9E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 98| +1.55E+02 | -6.4E-03 | +1.1E+00 | 8.9E-02 | 3.8E-01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 13| +1.49E+02 | -4.1E+00 | +8.9E-01 | 6.2E-02 | 1.0E+02 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 64| +1.48E+02 | +3.4E-06 | -4.5E-01 | 2.1E-03 | 2.5E-02 | 6.6E-04 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 37| +1.48E+02 | -7.0E-05 | +8.9E-01 | 3.0E-02 | 1.5E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 42| +1.50E+02 | -4.2E-03 | +8.2E-01 | 1.1E-01 | 2.0E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 40| +1.48E+02 | +5.1E-01 | -5.3E+00 | 2.5E-01 | 4.6E+00 | 2.8E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 17| +2.23E+02 | +7.1E+02 | -4.1E+01 | 2.0E+00 | 4.3E+01 | 4.5E+00 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 14| +1.48E+02 | -1.4E+00 | +4.5E-01 | 1.2E-01 | 3.6E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 52| +1.48E+02 | -4.3E-01 | +9.3E-01 | 2.5E-01 | 2.0E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 65| +1.48E+02 | +2.7E-06 | -1.2E+00 | 5.2E-04 | 2.5E-02 | 1.7E-04 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 15| +1.47E+02 | -7.8E-01 | +9.0E-01 | 1.2E-01 | 6.5E+01 | 8.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 38| +1.48E+02 | -1.0E-04 | +8.9E-01 | 6.0E-02 | 2.1E-01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 41| +1.48E+02 | +3.7E-03 | -1.2E-01 | 6.2E-02 | 4.6E+00 | 6.9E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 18| +2.04E+02 | -2.0E+01 | +9.7E-01 | 5.0E-01 | 4.3E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 53| +1.48E+02 | +3.2E-01 | -6.9E-01 | 5.0E-01 | 1.5E+01 | 5.8E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 43| +1.50E+02 | -1.3E-03 | +9.6E-01 | 2.3E-01 | 9.1E-01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 16| +1.46E+02 | -4.7E-01 | +7.8E-01 | 2.5E-01 | 1.7E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 66| +1.48E+02 | +2.9E-06 | -3.5E+00 | 1.3E-04 | 2.5E-02 | 5.5E-05 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 54| +1.48E+02 | -1.1E-01 | +6.7E-01 | 1.2E-01 | 1.5E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 42| +1.48E+02 | -7.8E-03 | +7.4E-01 | 1.6E-02 | 4.6E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 19| +2.04E+02 | -9.9E+00 | -1.7E+00 | 1.0E+00 | 6.2E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 39| +1.48E+02 | -2.5E-05 | +1.5E-01 | 1.2E-01 | 1.1E-01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 44| +1.50E+02 | -1.2E-04 | +6.0E-01 | 4.5E-01 | 6.7E-01 | 3.3E-02 | trr |1\n", + "2023-02-17 16:05:20 fides(INFO) 17| +1.46E+02 | +7.2E+00 | -7.9E+00 | 5.0E-01 | 4.2E+01 | 4.1E-01 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 67| +1.48E+02 | +1.3E-06 | -3.1E+00 | 3.2E-05 | 2.5E-02 | 3.0E-05 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 43| +1.48E+02 | -3.4E-03 | +8.9E-01 | 1.6E-02 | 3.5E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 40| +1.48E+02 | -4.7E-05 | +1.3E-01 | 3.0E-02 | 2.5E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 55| +1.48E+02 | -1.0E-01 | +4.5E-01 | 1.2E-01 | 1.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 20| +1.85E+02 | -1.8E+01 | +9.9E-01 | 2.5E-01 | 6.2E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 18| +1.46E+02 | -3.0E-01 | +5.9E-01 | 5.2E-02 | 4.2E+01 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 99| +1.55E+02 | -1.5E-02 | +1.1E+00 | 1.8E-01 | 1.2E+00 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 45| +1.50E+02 | +7.4E-05 | -4.2E-01 | 4.5E-01 | 1.1E-01 | 9.1E-03 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 19| +1.46E+02 | +3.2E-01 | -1.4E+00 | 5.2E-02 | 1.0E+01 | 9.8E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 68| +1.48E+02 | +4.7E-06 | -1.6E+01 | 8.1E-06 | 2.5E-02 | 2.1E-05 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 44| +1.48E+02 | -3.0E-03 | +9.2E-01 | 3.1E-02 | 3.2E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 56| +1.48E+02 | +1.0E-03 | -1.4E-02 | 1.2E-01 | 2.1E+01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 41| +1.48E+02 | -5.8E-05 | +7.2E-01 | 7.5E-03 | 2.3E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 21| +1.74E+02 | -1.2E+01 | +1.5E-01 | 5.0E-01 | 5.0E+01 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 20| +1.46E+02 | -4.0E-02 | +5.6E-01 | 1.3E-02 | 1.0E+01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 69| +1.48E+02 | +5.0E-06 | -4.4E+01 | 2.0E-06 | 2.5E-02 | 5.4E-06 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 46| +1.50E+02 | -5.6E-05 | +7.1E-01 | 1.1E-02 | 1.1E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 42| +1.48E+02 | -1.7E-05 | +7.9E-01 | 7.5E-03 | 2.3E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 57| +1.48E+02 | -9.3E-02 | +8.0E-01 | 3.1E-02 | 2.1E+01 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 45| +1.48E+02 | -3.3E-03 | +8.3E-01 | 6.2E-02 | 2.5E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 22| +1.51E+02 | -2.2E+01 | +9.1E-01 | 1.2E-01 | 2.9E+02 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 21| +1.46E+02 | -5.9E-02 | +9.1E-01 | 1.3E-02 | 7.7E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 43| +1.48E+02 | -6.8E-06 | +3.7E-01 | 1.5E-02 | 6.3E-02 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 47| +1.50E+02 | -1.7E-05 | +1.1E+00 | 1.1E-02 | 2.5E-01 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 70| +1.48E+02 | +5.2E-06 | -1.7E+02 | 5.1E-07 | 2.5E-02 | 1.3E-06 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 46| +1.48E+02 | +1.7E-02 | -2.3E+00 | 1.2E-01 | 2.0E+00 | 8.2E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 23| +1.49E+02 | -2.8E+00 | +8.9E-01 | 2.5E-01 | 7.8E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 58| +1.48E+02 | -4.0E-02 | +7.7E-01 | 6.2E-02 | 3.8E+00 | 6.6E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 100| +1.55E+02 | +9.5E-01 | -3.5E+01 | 3.6E-01 | 7.2E+00 | 9.0E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 22| +1.46E+02 | -7.1E-02 | +9.0E-01 | 2.6E-02 | 1.3E+01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 23| +1.46E+02 | +4.0E-02 | -3.5E-01 | 5.2E-02 | 4.5E+00 | 8.6E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 71| +1.48E+02 | +6.4E-06 | -8.1E+02 | 1.3E-07 | 2.5E-02 | 3.4E-07 | 2d |0\n", + "2023-02-17 16:05:20.687 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 144.786 and h = 1.83601e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:20.687 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 144.786: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:20 fides(INFO) 44| +1.48E+02 | -9.4E-06 | +5.6E-01 | 1.5E-02 | 2.3E-01 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 24| +1.49E+02 | +2.3E+00 | -1.8E+00 | 5.0E-01 | 4.3E+01 | 6.0E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 48| +1.50E+02 | -7.6E-06 | +8.9E-01 | 2.2E-02 | 7.1E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 59| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 7.8E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 47| +1.48E+02 | -1.0E-03 | +3.8E-01 | 3.1E-02 | 2.0E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 24| +1.46E+02 | -3.0E-02 | +7.4E-01 | 1.3E-02 | 4.5E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 45| +1.48E+02 | -5.4E-06 | +1.5E+00 | 1.5E-02 | 3.2E-02 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 25| +1.48E+02 | -5.5E-01 | +7.1E-01 | 1.2E-01 | 4.3E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 49| +1.50E+02 | -1.4E-06 | +5.6E-01 | 4.3E-02 | 7.3E-02 | 6.6E-04 | trr |1\n", + "2023-02-17 16:05:20 fides(WARNING) Stopping as function difference 1.40E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 60| +1.48E+02 | -1.9E-02 | +9.7E-01 | 3.1E-02 | 7.8E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 25| +1.46E+02 | -3.0E-02 | +8.3E-01 | 1.3E-02 | 8.2E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 48| +1.48E+02 | -2.4E-04 | +8.1E-02 | 3.1E-02 | 1.5E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 72| +1.48E+02 | +5.9E-06 | -3.0E+03 | 3.2E-08 | 2.5E-02 | 8.4E-08 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 26| +1.46E+02 | -2.7E-02 | +5.9E-01 | 2.6E-02 | 3.9E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 46| +1.48E+02 | -4.8E-06 | +8.4E-01 | 3.0E-02 | 3.2E-02 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 61| +1.48E+02 | -2.6E-02 | +7.4E-01 | 6.2E-02 | 2.8E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 26| +1.48E+02 | -1.0E-01 | +3.2E-01 | 1.2E-01 | 2.6E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 49| +1.48E+02 | -1.2E-03 | +7.9E-01 | 7.8E-03 | 1.9E+00 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 27| +1.46E+02 | -6.5E-03 | +5.1E-02 | 2.6E-02 | 3.4E+00 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 47| +1.48E+02 | -1.0E-05 | +1.3E+00 | 6.0E-02 | 2.2E-02 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 27| +1.48E+02 | -2.0E-01 | +3.4E-01 | 1.2E-01 | 2.1E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 101| +1.55E+02 | -1.2E-02 | +8.2E-01 | 8.9E-02 | 7.2E+00 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 50| +1.48E+02 | -4.1E-04 | +6.0E-01 | 1.6E-02 | 8.3E-01 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 73| +1.48E+02 | +2.7E-06 | -5.5E+03 | 7.9E-09 | 2.5E-02 | 2.1E-08 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 62| +1.48E+02 | -2.6E-02 | +7.2E-01 | 6.2E-02 | 8.3E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 28| +1.46E+02 | -3.5E-02 | +8.3E-01 | 6.5E-03 | 9.0E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:20.822 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.271 and h = 1.32109e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:20.822 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.271: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:20 fides(INFO) 28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 2.6E+01 | 3.4E-01 | 2d |0\n", + "2023-02-17 16:05:20.824 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0627 and h = 1.71793e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:20.824 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0627: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:20 fides(INFO) 48| +1.48E+02 | +2.9E-05 | -2.9E+00 | 1.2E-01 | 2.1E-02 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 74| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.0E-09 | 2.5E-02 | 5.2E-09 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 29| +1.46E+02 | -1.6E-02 | +4.7E-01 | 1.3E-02 | 2.2E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 51| +1.48E+02 | -1.9E-04 | +9.1E-01 | 1.6E-02 | 7.3E-01 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 63| +1.48E+02 | -1.5E-02 | +6.0E-01 | 6.2E-02 | 1.7E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 30| +1.46E+02 | -8.6E-03 | +6.4E-01 | 1.3E-02 | 2.5E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 0| +1.14E+14 | NaN | NaN | 1.0E+00 | 5.2E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:20 fides(INFO) 49| +1.48E+02 | +1.5E-06 | -4.3E-01 | 3.0E-02 | 2.1E-02 | 5.0E-03 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 29| +1.48E+02 | -1.8E-01 | +7.1E-01 | 3.1E-02 | 2.6E+01 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 52| +1.48E+02 | -2.4E-04 | +9.8E-01 | 3.1E-02 | 5.8E-01 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 75| +1.48E+02 | +6.1E-06 | -2.0E+05 | 5.0E-10 | 2.5E-02 | 1.3E-09 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 31| +1.46E+02 | -2.3E-03 | +1.4E-01 | 1.3E-02 | 2.2E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 64| +1.48E+02 | -2.0E-02 | +6.5E-01 | 6.2E-02 | 7.4E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 30| +1.48E+02 | -1.1E-02 | +2.7E-01 | 3.1E-02 | 3.2E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:20 fides(INFO) 50| +1.48E+02 | +6.8E-07 | -6.8E-01 | 7.5E-03 | 2.1E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 76| +1.48E+02 | +3.5E-06 | -4.5E+05 | 1.2E-10 | 2.5E-02 | 3.3E-10 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 1| +6.16E+07 | -1.1E+14 | +8.2E-02 | 1.0E+00 | 5.2E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 53| +1.48E+02 | -2.0E-04 | +8.3E-01 | 6.2E-02 | 5.2E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 32| +1.46E+02 | -4.8E-03 | +7.4E-01 | 3.2E-03 | 1.8E+00 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:20.925 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 86.193 and h = 1.72762e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:20.925 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 86.193: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:20 fides(INFO) 65| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 1.4E+00 | 5.2E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 51| +1.48E+02 | +2.2E-06 | -7.3E+00 | 1.9E-03 | 2.1E-02 | 3.2E-04 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 31| +1.48E+02 | -1.7E-02 | +7.5E-01 | 3.1E-02 | 9.8E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 77| +1.48E+02 | +2.6E-06 | -1.3E+06 | 3.1E-11 | 2.5E-02 | 8.2E-11 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 33| +1.46E+02 | -3.1E-03 | +8.2E-01 | 3.2E-03 | 2.9E+00 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 54| +1.48E+02 | +4.9E-03 | -1.1E+01 | 1.2E-01 | 2.3E-01 | 4.1E-02 | trr |0\n", + "2023-02-17 16:05:20 fides(INFO) 2| +9.41E+06 | -5.2E+07 | +8.9E-01 | 2.5E-01 | 2.8E+08 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 66| +1.48E+02 | -4.0E-03 | +6.3E-01 | 1.6E-02 | 1.4E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 32| +1.48E+02 | -4.0E-03 | +6.8E-01 | 3.1E-02 | 1.9E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 34| +1.46E+02 | -4.0E-03 | +9.9E-01 | 6.5E-03 | 1.5E+00 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 52| +1.48E+02 | +4.0E-06 | -3.4E+01 | 4.7E-04 | 2.1E-02 | 7.9E-05 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 78| +1.48E+02 | +4.4E-08 | -9.1E+04 | 7.7E-12 | 2.5E-02 | 2.0E-11 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 102| +1.55E+02 | +3.2E-01 | -5.2E+00 | 1.8E-01 | 5.9E+00 | 3.7E-01 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 67| +1.48E+02 | -5.2E-03 | +9.5E-01 | 1.6E-02 | 4.9E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 55| +1.48E+02 | +1.4E-04 | -6.3E-01 | 3.0E-02 | 2.3E-01 | 1.0E-02 | 2d |0\n", + "2023-02-17 16:05:20 fides(INFO) 35| +1.46E+02 | -5.8E-03 | +8.9E-01 | 1.3E-02 | 1.6E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:20 fides(INFO) 3| +1.45E+06 | -8.0E+06 | +8.9E-01 | 5.0E-01 | 4.3E+07 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 53| +1.48E+02 | +4.1E-07 | -5.7E+00 | 1.2E-04 | 2.1E-02 | 2.1E-05 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 33| +1.48E+02 | -1.0E-03 | +6.5E-01 | 3.1E-02 | 2.0E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 36| +1.46E+02 | +4.0E-02 | -2.7E+00 | 2.6E-02 | 1.8E+00 | 3.7E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 56| +1.48E+02 | -4.8E-05 | +5.9E-01 | 7.6E-03 | 2.3E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 68| +1.48E+02 | -5.3E-03 | +9.9E-01 | 3.1E-02 | 7.2E-01 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 79| +1.48E+02 | +5.2E-06 | -4.3E+07 | 1.9E-12 | 2.5E-02 | 5.1E-12 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 54| +1.48E+02 | +1.5E-06 | -2.5E+01 | 2.9E-05 | 2.1E-02 | 7.5E-06 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 57| +1.48E+02 | -2.3E-05 | +9.9E-01 | 7.6E-03 | 3.4E-01 | 9.9E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 37| +1.46E+02 | -1.2E-03 | +2.5E-01 | 6.5E-03 | 1.8E+00 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 34| +1.48E+02 | -9.9E-06 | +6.5E-03 | 3.1E-02 | 4.8E-01 | 8.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 4| +2.35E+05 | -1.2E+06 | +8.8E-01 | 1.0E+00 | 6.7E+06 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 69| +1.48E+02 | -8.6E-03 | +9.2E-01 | 6.2E-02 | 1.8E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 80| +1.48E+02 | +8.5E-07 | -2.8E+07 | 4.8E-13 | 2.5E-02 | 1.3E-12 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 38| +1.46E+02 | -3.3E-03 | +4.5E-01 | 6.5E-03 | 1.1E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 55| +1.48E+02 | +1.8E-06 | -3.0E+01 | 7.3E-06 | 2.1E-02 | 5.7E-06 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 35| +1.48E+02 | -6.9E-04 | +7.4E-01 | 7.8E-03 | 1.4E+00 | 7.9E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 58| +1.48E+02 | -1.9E-05 | +1.1E+00 | 1.5E-02 | 1.3E-01 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 39| +1.46E+02 | -3.8E-04 | +7.1E-02 | 6.5E-03 | 2.5E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 70| +1.48E+02 | -1.3E-02 | +8.6E-01 | 1.2E-01 | 8.4E-01 | 9.7E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 81| +1.48E+02 | +7.9E-07 | -1.1E+08 | 1.2E-13 | 2.5E-02 | 3.2E-13 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 103| +1.55E+02 | +3.8E-02 | -1.3E+00 | 4.5E-02 | 5.9E+00 | 9.2E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 56| +1.48E+02 | -5.9E-07 | +1.0E+01 | 1.8E-06 | 2.1E-02 | 4.8E-06 | 2d |1\n", + "2023-02-17 16:05:21 fides(WARNING) Stopping as function difference 5.86E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 40| +1.46E+02 | -1.7E-03 | +8.7E-01 | 1.6E-03 | 8.0E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 36| +1.48E+02 | -1.1E-04 | +7.6E-01 | 7.8E-03 | 3.1E-01 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 59| +1.48E+02 | -1.1E-05 | +5.4E-01 | 3.0E-02 | 1.8E-01 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 5| +2.86E+04 | -2.1E+05 | +8.8E-01 | 2.0E+00 | 1.0E+06 | 3.7E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 71| +1.48E+02 | +1.8E-02 | -5.8E-01 | 2.5E-01 | 3.0E+00 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 82| +1.48E+02 | +3.6E-06 | -1.9E+09 | 3.0E-14 | 2.5E-02 | 8.0E-14 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 41| +1.46E+02 | -1.3E-03 | +6.2E-01 | 3.2E-03 | 7.2E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 37| +1.48E+02 | -8.5E-05 | +8.3E-01 | 1.6E-02 | 2.0E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 60| +1.48E+02 | +1.0E-04 | -1.9E+00 | 3.0E-02 | 8.2E-02 | 4.3E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 72| +1.48E+02 | -6.5E-03 | +6.5E-01 | 6.2E-02 | 3.0E+00 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 42| +1.46E+02 | -7.8E-04 | +9.8E-01 | 3.2E-03 | 9.5E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 83| +1.48E+02 | +4.0E-06 | -8.4E+09 | 7.6E-15 | 2.5E-02 | 2.0E-14 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 38| +1.48E+02 | -9.7E-05 | +8.8E-01 | 3.1E-02 | 3.3E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 61| +1.48E+02 | +4.5E-07 | -2.4E-02 | 7.6E-03 | 8.2E-02 | 1.1E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 43| +1.46E+02 | -1.2E-03 | +1.0E+00 | 6.5E-03 | 6.6E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 73| +1.48E+02 | -4.4E-03 | +6.8E-01 | 6.2E-02 | 8.8E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 84| +1.48E+02 | +4.2E-06 | -3.6E+10 | 1.9E-15 | 2.5E-02 | 5.0E-15 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 39| +1.48E+02 | +1.3E-04 | -6.9E-01 | 6.2E-02 | 1.3E-01 | 1.9E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 62| +1.48E+02 | -5.9E-06 | +6.7E-01 | 1.9E-03 | 8.2E-02 | 3.4E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 44| +1.46E+02 | -1.6E-03 | +8.3E-01 | 1.3E-02 | 5.3E-01 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 74| +1.48E+02 | -4.4E-03 | +6.7E-01 | 6.2E-02 | 2.7E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 6| +4.64E+03 | -2.4E+04 | +9.0E-01 | 2.0E+00 | 1.3E+05 | 3.3E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 0| +2.13E+14 | NaN | NaN | 1.0E+00 | 9.8E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:21 fides(INFO) 85| +1.48E+02 | +4.1E-06 | -1.4E+11 | 4.7E-16 | 2.5E-02 | 1.3E-15 | 2d |0\n", + "2023-02-17 16:05:21 fides(WARNING) Stopping as trust region radius 1.18E-16 is smaller than machine precision.\n", + "2023-02-17 16:05:21 fides(INFO) 45| +1.46E+02 | +6.0E-02 | -8.1E+00 | 2.6E-02 | 8.6E-01 | 4.3E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 40| +1.48E+02 | -3.5E-05 | +6.0E-01 | 1.6E-02 | 1.3E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 63| +1.48E+02 | -7.1E-06 | +1.8E+00 | 1.9E-03 | 1.7E-01 | 1.7E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 75| +1.48E+02 | -2.8E-03 | +6.2E-01 | 6.2E-02 | 7.4E-01 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 104| +1.55E+02 | +2.6E-03 | -1.4E-01 | 1.1E-02 | 5.9E+00 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 46| +1.46E+02 | +1.8E-03 | -7.5E-01 | 6.5E-03 | 8.6E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 7| +9.19E+02 | -3.7E+03 | +8.9E-01 | 2.0E+00 | 2.0E+04 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 64| +1.48E+02 | +1.4E-06 | -3.1E-01 | 3.8E-03 | 3.7E-02 | 4.5E-04 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 41| +1.48E+02 | -3.0E-05 | +7.2E-01 | 1.6E-02 | 2.0E-01 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 47| +1.46E+02 | -4.0E-04 | +6.0E-01 | 1.6E-03 | 8.6E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 1| +1.48E+11 | -2.1E+14 | +8.2E-02 | 1.0E+00 | 9.8E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 76| +1.48E+02 | -2.8E-03 | +5.6E-01 | 6.2E-02 | 2.2E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 8| +9.19E+02 | -1.4E+02 | -2.0E-01 | 2.0E+00 | 3.3E+03 | 2.2E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 65| +1.48E+02 | +2.1E-06 | -5.0E-01 | 9.5E-04 | 3.7E-02 | 3.1E-04 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 42| +1.48E+02 | -2.1E-05 | +6.9E-01 | 1.6E-02 | 9.4E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 48| +1.46E+02 | -1.9E-04 | +9.8E-01 | 1.6E-03 | 3.7E-01 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 2| +2.20E+10 | -1.3E+11 | +8.9E-01 | 2.5E-01 | 6.8E+11 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 77| +1.48E+02 | -1.4E-03 | +3.5E-01 | 6.2E-02 | 6.9E-01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 49| +1.46E+02 | -3.0E-04 | +1.0E+00 | 3.2E-03 | 6.2E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 9| +3.33E+02 | -5.9E+02 | +9.0E-01 | 2.1E-01 | 3.3E+03 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 43| +1.48E+02 | -1.2E-05 | +5.2E-01 | 1.6E-02 | 9.8E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 66| +1.48E+02 | -1.4E-07 | +3.5E-02 | 2.4E-04 | 3.7E-02 | 2.9E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 0| +1.86E+09 | NaN | NaN | 1.0E+00 | 8.6E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:21 fides(INFO) 50| +1.46E+02 | -5.1E-04 | +9.6E-01 | 6.5E-03 | 2.8E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 78| +1.48E+02 | -1.7E-03 | +3.0E-01 | 6.2E-02 | 2.3E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 3| +3.28E+09 | -1.9E+10 | +8.9E-01 | 5.0E-01 | 1.0E+11 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 10| +2.28E+02 | -1.0E+02 | +8.6E-01 | 4.3E-01 | 5.4E+02 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 1| +2.20E+06 | -1.9E+09 | +9.9E-02 | 1.0E+00 | 8.6E+09 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 44| +1.48E+02 | -1.5E-05 | +6.7E-01 | 1.6E-02 | 7.9E-02 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 51| +1.46E+02 | +7.0E-04 | -9.2E-01 | 1.3E-02 | 8.4E-01 | 6.3E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 67| +1.48E+02 | -8.6E-07 | +5.3E+00 | 5.9E-05 | 3.3E-02 | 1.2E-05 | 2d |1\n", + "2023-02-17 16:05:21 fides(WARNING) Stopping as function difference 8.62E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:21 fides(INFO) 105| +1.55E+02 | -8.5E-03 | +6.0E-01 | 2.8E-03 | 5.9E+00 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 79| +1.48E+02 | +1.1E-03 | -2.0E-01 | 6.2E-02 | 8.1E-01 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 11| +1.88E+02 | -4.1E+01 | +1.6E+00 | 8.5E-01 | 1.3E+02 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 4| +4.92E+08 | -2.8E+09 | +8.9E-01 | 5.0E-01 | 1.5E+10 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 52| +1.46E+02 | -1.7E-04 | +6.4E-01 | 3.2E-03 | 8.4E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 45| +1.48E+02 | -1.1E-06 | +4.7E-02 | 1.6E-02 | 7.5E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 2| +3.47E+05 | -1.9E+06 | +9.0E-01 | 2.5E-01 | 1.0E+07 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 80| +1.48E+02 | -7.4E-04 | +2.9E-01 | 1.6E-02 | 8.1E-01 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 12| +1.88E+02 | +1.8E+02 | -1.0E+01 | 8.5E-01 | 4.7E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 53| +1.46E+02 | -1.7E-05 | +4.3E-02 | 3.2E-03 | 1.7E-01 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 5| +7.40E+07 | -4.2E+08 | +8.9E-01 | 5.0E-01 | 2.3E+09 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 46| +1.48E+02 | -1.1E-05 | +1.1E+00 | 3.9E-03 | 8.3E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 81| +1.48E+02 | -1.4E-03 | +9.3E-01 | 1.6E-02 | 3.1E+00 | 8.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 3| +5.82E+04 | -2.9E+05 | +9.0E-01 | 5.0E-01 | 1.6E+06 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 54| +1.46E+02 | -1.8E-04 | +7.2E-01 | 8.1E-04 | 6.2E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 13| +1.72E+02 | -1.6E+01 | +8.2E-01 | 2.1E-01 | 4.7E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 4| +1.27E+04 | -4.5E+04 | +7.8E-01 | 1.0E+00 | 2.5E+05 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 6| +1.12E+07 | -6.3E+07 | +8.9E-01 | 5.0E-01 | 3.4E+08 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 55| +1.46E+02 | -4.9E-05 | +7.7E-01 | 8.1E-04 | 1.8E-01 | 6.1E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 47| +1.48E+02 | +1.1E-06 | -2.4E-01 | 7.8E-03 | 5.0E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 14| +1.61E+02 | -1.0E+01 | +5.5E-01 | 4.3E-01 | 5.5E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 82| +1.48E+02 | -4.8E-04 | +9.7E-01 | 3.1E-02 | 2.5E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 5| +2.16E+03 | -1.1E+04 | +9.0E-01 | 2.0E+00 | 4.1E+04 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 56| +1.46E+02 | -5.8E-05 | +1.0E+00 | 1.6E-03 | 2.9E-01 | 5.0E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 48| +1.48E+02 | +4.3E-07 | -2.9E-01 | 2.0E-03 | 5.0E-02 | 3.3E-04 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 0| +9.42E+04 | NaN | NaN | 1.0E+00 | 4.3E+05 | NaN | NaN |1\n", + "2023-02-17 16:05:21 fides(INFO) 6| +5.05E+02 | -1.7E+03 | +9.0E-01 | 2.0E+00 | 6.5E+03 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 7| +1.68E+06 | -9.5E+06 | +8.9E-01 | 5.0E-01 | 5.1E+07 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 83| +1.48E+02 | -7.6E-04 | +9.7E-01 | 6.2E-02 | 2.2E-01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 15| +1.52E+02 | -9.5E+00 | +8.4E-01 | 4.3E-01 | 8.5E+01 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 57| +1.46E+02 | -1.3E-04 | +9.6E-01 | 3.2E-03 | 1.2E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 7| +2.69E+02 | -2.4E+02 | +8.8E-01 | 2.0E+00 | 1.0E+03 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 49| +1.48E+02 | +2.5E-06 | -4.3E+00 | 4.9E-04 | 5.0E-02 | 8.3E-05 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 1| +4.02E+02 | -9.4E+04 | +1.2E-01 | 1.0E+00 | 4.3E+05 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 8| +2.44E+02 | -2.5E+01 | +9.0E-01 | 2.0E+00 | 1.4E+02 | 4.3E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 106| +1.55E+02 | -1.7E-03 | +4.9E-01 | 2.8E-03 | 3.7E+00 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 58| +1.46E+02 | -2.9E-05 | +1.6E-01 | 6.5E-03 | 6.3E-01 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 16| +1.52E+02 | +2.5E+00 | -4.9E-01 | 8.5E-01 | 5.2E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 8| +2.49E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 7.7E+06 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 84| +1.48E+02 | -1.0E-03 | +9.5E-01 | 1.2E-01 | 2.7E-01 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 2| +3.63E+02 | -3.9E+01 | +9.5E-01 | 2.5E-01 | 5.8E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 50| +1.48E+02 | +1.3E-06 | -3.5E+00 | 1.2E-04 | 5.0E-02 | 2.5E-05 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 59| +1.46E+02 | -9.3E-05 | +2.7E-01 | 1.6E-03 | 1.9E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 3| +2.89E+02 | -7.4E+01 | +9.9E-01 | 5.0E-01 | 5.2E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 17| +1.46E+02 | -6.0E+00 | +9.8E-01 | 2.1E-01 | 5.2E+01 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 9| +3.71E+04 | -2.1E+05 | +9.0E-01 | 5.0E-01 | 1.1E+06 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 60| +1.46E+02 | -3.1E-05 | +2.5E-01 | 1.6E-03 | 2.7E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 85| +1.48E+02 | -6.7E-04 | +8.8E-01 | 2.5E-01 | 1.1E-01 | 8.8E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 51| +1.48E+02 | +2.4E-06 | -7.9E+00 | 3.1E-05 | 5.0E-02 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 4| +2.89E+02 | +3.2E+03 | -6.9E+01 | 1.0E+00 | 4.9E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 18| +1.42E+02 | -4.2E+00 | +5.2E-01 | 4.3E-01 | 5.2E+01 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 61| +1.46E+02 | -5.1E-06 | +5.1E-02 | 1.6E-03 | 1.2E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 86| +1.48E+02 | +7.0E-04 | -8.6E+00 | 5.0E-01 | 2.1E-01 | 2.3E-02 | trr |0\n", + "2023-02-17 16:05:21 fides(INFO) 5| +2.60E+02 | -2.9E+01 | +9.1E-01 | 2.5E-01 | 4.9E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 10| +5.74E+03 | -3.1E+04 | +9.0E-01 | 5.0E-01 | 1.7E+05 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 52| +1.48E+02 | -2.4E-06 | +8.4E+00 | 7.6E-06 | 5.0E-02 | 1.3E-05 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 62| +1.46E+02 | -2.6E-05 | +8.0E-01 | 4.0E-04 | 1.6E-01 | 5.0E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 87| +1.48E+02 | +1.8E-05 | -4.6E-01 | 3.8E-02 | 2.1E-01 | 5.9E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 6| +2.60E+02 | +3.1E+02 | -1.7E+01 | 5.0E-01 | 3.4E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 11| +1.04E+03 | -4.7E+03 | +9.0E-01 | 5.0E-01 | 2.6E+04 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 19| +1.40E+02 | -1.5E+00 | +5.0E-01 | 4.3E-01 | 2.9E+01 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 9| +2.44E+02 | -6.9E+00 | -1.6E+00 | 4.0E+00 | 1.8E+01 | 5.3E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 63| +1.46E+02 | -1.6E-05 | +5.8E-01 | 8.1E-04 | 7.3E-02 | 7.1E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 53| +1.48E+02 | +8.9E-07 | -2.2E+00 | 1.5E-05 | 4.0E-02 | 2.2E-05 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 7| +2.51E+02 | -9.0E+00 | +8.5E-01 | 1.2E-01 | 3.4E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 88| +1.48E+02 | -8.8E-06 | +5.9E-01 | 9.4E-03 | 2.1E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 12| +3.35E+02 | -7.1E+02 | +9.0E-01 | 5.0E-01 | 4.1E+03 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 10| +2.43E+02 | -1.2E+00 | +3.1E-02 | 1.0E+00 | 1.8E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 64| +1.46E+02 | -1.0E-05 | +9.0E-01 | 8.1E-04 | 7.2E-02 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 107| +1.55E+02 | -1.4E-03 | +1.0E+00 | 2.8E-03 | 2.7E+00 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 8| +2.51E+02 | +5.4E+00 | -1.8E+00 | 2.5E-01 | 1.8E+01 | 6.5E-01 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 54| +1.48E+02 | +3.1E-06 | -2.0E+01 | 3.8E-06 | 4.0E-02 | 5.6E-06 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 20| +1.40E+02 | +3.8E-01 | -3.1E-01 | 4.3E-01 | 1.7E+01 | 7.8E-01 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 11| +2.36E+02 | -6.8E+00 | +7.5E-01 | 2.5E-01 | 5.1E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 65| +1.46E+02 | -1.5E-05 | +9.4E-01 | 1.6E-03 | 1.6E-01 | 4.5E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 89| +1.48E+02 | -4.1E-06 | +1.2E+00 | 9.4E-03 | 6.7E-02 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 9| +2.50E+02 | -1.3E+00 | +5.9E-01 | 6.2E-02 | 1.8E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 55| +1.48E+02 | +7.0E-06 | -1.6E+02 | 9.5E-07 | 4.0E-02 | 1.4E-06 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 13| +2.29E+02 | -1.1E+02 | +9.1E-01 | 5.0E-01 | 6.3E+02 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 66| +1.46E+02 | -1.3E-05 | +4.4E-01 | 3.2E-03 | 6.0E-02 | 7.6E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 12| +2.30E+02 | -6.2E+00 | +5.1E-01 | 5.0E-01 | 2.2E+01 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 21| +1.40E+02 | -3.0E-01 | +6.9E-01 | 1.1E-01 | 1.7E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 10| +2.50E+02 | -1.2E-02 | +1.3E-01 | 6.2E-02 | 4.0E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 90| +1.48E+02 | -4.1E-06 | +8.8E-01 | 1.9E-02 | 6.2E-02 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 56| +1.48E+02 | +3.7E-06 | -3.4E+02 | 2.4E-07 | 4.0E-02 | 3.5E-07 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 67| +1.46E+02 | +1.6E-04 | -1.2E+00 | 3.2E-03 | 2.0E-01 | 3.4E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 13| +2.16E+02 | -1.4E+01 | +8.9E-01 | 5.0E-01 | 6.9E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 11| +2.50E+02 | +6.8E-03 | -1.1E-01 | 1.6E-02 | 3.2E+00 | 4.1E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 91| +1.48E+02 | -3.6E-06 | +6.4E-01 | 3.8E-02 | 4.7E-02 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 14| +1.99E+02 | -3.0E+01 | +1.2E+00 | 5.0E-01 | 9.7E+01 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 68| +1.46E+02 | -1.8E-05 | +4.8E-01 | 8.1E-04 | 2.0E-01 | 8.5E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 57| +1.48E+02 | +2.6E-06 | -9.5E+02 | 6.0E-08 | 4.0E-02 | 8.7E-08 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 12| +2.50E+02 | -2.4E-02 | +8.5E-01 | 3.9E-03 | 3.2E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 22| +1.40E+02 | -2.6E-01 | +9.3E-01 | 1.1E-01 | 2.2E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 69| +1.46E+02 | -4.8E-06 | +7.2E-01 | 8.1E-04 | 5.7E-02 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 92| +1.48E+02 | -3.3E-06 | +8.1E-01 | 3.8E-02 | 3.1E-02 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 14| +1.56E+02 | -6.0E+01 | +1.6E+00 | 1.0E+00 | 3.9E+01 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 58| +1.48E+02 | +2.7E-06 | -4.0E+03 | 1.5E-08 | 4.0E-02 | 2.2E-08 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 13| +2.50E+02 | +8.1E-04 | -5.6E-02 | 7.8E-03 | 1.6E+00 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 15| +1.99E+02 | +3.0E+01 | -3.5E+00 | 1.0E+00 | 5.7E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 70| +1.46E+02 | -4.4E-06 | +8.6E-01 | 8.1E-04 | 6.3E-02 | 2.4E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 108| +1.55E+02 | -1.2E-03 | +9.4E-01 | 5.6E-03 | 1.1E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 93| +1.48E+02 | +3.3E-04 | -8.6E+00 | 7.5E-02 | 3.7E-02 | 1.2E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 15| +1.56E+02 | +1.1E+02 | -8.8E+00 | 2.0E+00 | 1.0E+02 | 9.6E-01 | trr |0\n", + "2023-02-17 16:05:21 fides(INFO) 14| +2.50E+02 | -5.9E-03 | +8.5E-01 | 2.0E-03 | 1.6E+00 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 23| +1.39E+02 | -3.7E-01 | +9.2E-01 | 2.1E-01 | 1.3E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 59| +1.48E+02 | +2.1E-06 | -1.2E+04 | 3.7E-09 | 4.0E-02 | 5.4E-09 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 71| +1.46E+02 | -5.9E-06 | +7.5E-01 | 1.6E-03 | 5.1E-02 | 2.2E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 15| +2.50E+02 | +7.7E-05 | -2.5E-02 | 3.9E-03 | 7.4E-01 | 1.0E-02 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 16| +1.52E+02 | -4.2E+00 | +9.5E-01 | 1.2E-01 | 1.0E+02 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 16| +1.81E+02 | -1.8E+01 | +1.1E+00 | 2.5E-01 | 5.7E+01 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 72| +1.46E+02 | -5.3E-06 | +5.5E-01 | 1.6E-03 | 5.0E-02 | 5.7E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 94| +1.48E+02 | +1.0E-05 | -6.8E-01 | 1.9E-02 | 3.7E-02 | 2.9E-03 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:21 fides(INFO) 60| +1.48E+02 | +4.7E-06 | -1.1E+05 | 9.3E-10 | 4.0E-02 | 1.4E-09 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 16| +2.50E+02 | -1.3E-03 | +8.3E-01 | 9.8E-04 | 7.4E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 17| +1.50E+02 | -2.0E+00 | +3.0E-01 | 2.3E-01 | 4.8E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 73| +1.46E+02 | +9.2E-06 | -4.0E-01 | 1.6E-03 | 5.9E-02 | 9.5E-04 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 24| +1.39E+02 | -4.8E-01 | +8.3E-01 | 4.3E-01 | 1.1E+01 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 95| +1.48E+02 | -5.7E-06 | +1.4E+00 | 4.7E-03 | 3.7E-02 | 7.4E-04 | 2d |1\n", + "2023-02-17 16:05:21 fides(INFO) 61| +1.48E+02 | +1.6E-06 | -1.5E+05 | 2.3E-10 | 4.0E-02 | 3.4E-10 | 2d |0\n", + "2023-02-17 16:05:21 fides(INFO) 17| +2.50E+02 | +4.9E-06 | -8.7E-03 | 2.0E-03 | 3.2E-01 | 5.0E-03 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 74| +1.46E+02 | -4.1E-06 | +6.5E-01 | 4.0E-04 | 5.9E-02 | 2.5E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 17| +1.67E+02 | -1.4E+01 | +8.9E-01 | 5.0E-01 | 5.8E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +2.50E+02 | -2.7E-04 | +8.0E-01 | 4.9E-04 | 3.2E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +1.48E+02 | -1.6E+00 | +6.1E-01 | 2.3E-01 | 1.2E+02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 96| +1.48E+02 | +3.9E-06 | -6.2E+00 | 9.4E-03 | 2.9E-02 | 9.1E-04 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 75| +1.46E+02 | -3.8E-07 | +2.3E-01 | 4.0E-04 | 6.0E-02 | 5.3E-05 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 62| +1.48E+02 | +3.3E-06 | -1.2E+06 | 5.8E-11 | 4.0E-02 | 8.5E-11 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 25| +1.39E+02 | +4.3E+00 | -5.8E+00 | 8.5E-01 | 1.2E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:22.041 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.735 and h = 9.95199e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:22.041 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.735: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:22 fides(INFO) 19| +2.50E+02 | -2.6E-07 | +4.0E-03 | 9.8E-04 | 1.0E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 19| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.3E-01 | 2.6E+01 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:22.048 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.486 and h = 4.04049e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:22.048 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.486: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:22 fides(INFO) 97| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-03 | 2.9E-02 | 2.3E-04 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 76| +1.46E+02 | -1.5E-06 | +3.3E+00 | 1.0E-04 | 4.1E-02 | 1.9E-05 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 63| +1.48E+02 | +3.0E-06 | -4.5E+06 | 1.5E-11 | 4.0E-02 | 2.1E-11 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 20| +2.50E+02 | -2.9E-05 | +7.8E-01 | 2.4E-04 | 1.0E-01 | 4.4E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +1.59E+02 | -7.7E+00 | +1.0E+00 | 1.0E+00 | 1.1E+02 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 109| +1.55E+02 | -2.1E-03 | +9.3E-01 | 1.1E-02 | 1.7E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 77| +1.46E+02 | -8.5E-07 | +1.0E+00 | 2.0E-04 | 4.6E-02 | 3.6E-05 | 2d |1\n", + "2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 8.51E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 20| +1.48E+02 | -2.1E-01 | +8.8E-01 | 5.8E-02 | 2.6E+01 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 21| +2.50E+02 | -2.3E-07 | +4.5E-02 | 4.9E-04 | 2.9E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 64| +1.48E+02 | +6.6E-06 | -3.9E+07 | 3.6E-12 | 4.0E-02 | 5.3E-12 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 98| +1.48E+02 | +5.9E-06 | -3.8E+01 | 5.9E-04 | 2.9E-02 | 5.7E-05 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 26| +1.39E+02 | -1.5E-02 | +3.4E-02 | 2.1E-01 | 1.2E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 21| +1.48E+02 | -1.6E-01 | +7.1E-01 | 1.2E-01 | 2.0E+01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 99| +1.48E+02 | +3.9E-06 | -3.0E+01 | 1.5E-04 | 2.9E-02 | 1.7E-05 | 2d |0\n", + "2023-02-17 16:05:22.130 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0572 and h = 1.54133e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:22.131 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0572: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:22 fides(INFO) 22| +2.50E+02 | -4.9E-07 | +1.0E-01 | 1.2E-04 | 2.8E-02 | 3.2E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 65| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.1E-13 | 4.0E-02 | 1.3E-12 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 23| +2.50E+02 | -1.1E-06 | +9.0E-01 | 3.1E-05 | 2.5E-02 | 5.5E-05 | 2d |1\n", + "2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 1.13E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:22 fides(INFO) 22| +1.48E+02 | -3.6E-02 | +2.4E-01 | 1.2E-01 | 1.7E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 19| +1.59E+02 | +1.8E+02 | -1.6E+02 | 2.0E+00 | 5.3E+01 | 5.5E+00 | trr |0\n", + "2023-02-17 16:05:22 fides(INFO) 66| +1.48E+02 | +3.3E-06 | -3.1E+08 | 2.3E-13 | 4.0E-02 | 3.3E-13 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 100| +1.48E+02 | +5.2E-06 | -4.3E+01 | 3.7E-05 | 2.9E-02 | 9.3E-06 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 27| +1.39E+02 | -1.3E-01 | +6.0E-01 | 5.3E-02 | 8.7E+00 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 110| +1.55E+02 | -5.9E-03 | +1.0E+00 | 2.2E-02 | 1.2E+00 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 23| +1.48E+02 | -9.7E-02 | +4.3E-01 | 2.9E-02 | 1.1E+01 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 67| +1.48E+02 | +3.5E-06 | -1.3E+09 | 5.7E-14 | 4.0E-02 | 8.3E-14 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 101| +1.48E+02 | -7.2E-07 | +6.0E+00 | 9.2E-06 | 2.9E-02 | 8.6E-06 | 2d |1\n", + "2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 7.25E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 0| +1.05E+12 | NaN | NaN | 1.0E+00 | 4.6E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 20| +1.58E+02 | -1.4E+00 | +1.0E+00 | 5.0E-01 | 5.3E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 68| +1.48E+02 | +4.8E-07 | -7.4E+08 | 1.4E-14 | 4.0E-02 | 2.1E-14 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 24| +1.48E+02 | -3.9E-02 | +6.7E-01 | 2.9E-02 | 5.8E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 1| +2.02E+10 | -1.0E+12 | +9.0E-02 | 1.0E+00 | 4.6E+12 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 28| +1.39E+02 | -9.6E-02 | +9.6E-01 | 5.3E-02 | 2.9E+01 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 0| +8.11E+12 | NaN | NaN | 1.0E+00 | 2.8E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:22 fides(INFO) 69| +1.48E+02 | +4.7E-06 | -2.9E+10 | 3.6E-15 | 4.0E-02 | 5.2E-15 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 2| +3.02E+09 | -1.7E+10 | +8.9E-01 | 2.5E-01 | 9.3E+10 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 25| +1.48E+02 | -9.3E-03 | +8.9E-01 | 2.9E-02 | 7.5E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 1| +3.54E+10 | -8.1E+12 | +1.1E-01 | 1.0E+00 | 2.8E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 3| +4.53E+08 | -2.6E+09 | +8.9E-01 | 5.0E-01 | 1.4E+10 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:22.287 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.9304 and h = 2.14384e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:22.287 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.9304: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:22 fides(INFO) 26| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.8E-02 | 2.0E+00 | 4.0E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 70| +1.48E+02 | +3.6E-06 | -8.7E+10 | 8.9E-16 | 4.0E-02 | 1.3E-15 | 2d |0\n", + "2023-02-17 16:05:22 fides(WARNING) Stopping as trust region radius 2.22E-16 is smaller than machine precision.\n", + "2023-02-17 16:05:22 fides(INFO) 2| +5.99E+09 | -2.9E+10 | +8.8E-01 | 2.5E-01 | 1.4E+11 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 29| +1.39E+02 | -4.5E-02 | +7.2E-01 | 1.1E-01 | 3.4E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 111| +1.55E+02 | -3.6E-03 | +2.9E-01 | 4.5E-02 | 1.0E+00 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 21| +1.54E+02 | -3.7E+00 | +1.0E+00 | 1.0E+00 | 6.3E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 0| +3.21E+07 | NaN | NaN | 1.0E+00 | 1.5E+08 | NaN | NaN |1\n", + "2023-02-17 16:05:22 fides(INFO) 4| +6.84E+07 | -3.8E+08 | +8.9E-01 | 5.0E-01 | 2.1E+09 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 27| +1.48E+02 | -6.2E-03 | +7.5E-01 | 1.5E-02 | 2.0E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 3| +8.99E+08 | -5.1E+09 | +8.9E-01 | 5.0E-01 | 2.1E+10 | 8.5E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 5| +1.04E+07 | -5.8E+07 | +8.9E-01 | 5.0E-01 | 3.1E+08 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 4| +1.36E+08 | -7.6E+08 | +8.9E-01 | 5.0E-01 | 3.2E+09 | 8.5E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 30| +1.39E+02 | +1.1E-02 | -1.3E-01 | 1.1E-01 | 4.2E+00 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 28| +1.48E+02 | -4.2E-03 | +9.5E-01 | 2.9E-02 | 5.4E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 1| +1.89E+03 | -3.2E+07 | +1.1E-01 | 1.0E+00 | 1.5E+08 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 6| +1.58E+06 | -8.8E+06 | +8.9E-01 | 5.0E-01 | 4.8E+07 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 5| +2.07E+07 | -1.2E+08 | +8.9E-01 | 5.0E-01 | 4.8E+08 | 8.5E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 2| +6.31E+02 | -1.3E+03 | +9.1E-01 | 2.5E-01 | 6.5E+03 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 29| +1.48E+02 | -2.8E-03 | +8.5E-01 | 5.8E-02 | 1.3E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 3| +3.08E+02 | -3.2E+02 | +9.0E-01 | 5.0E-01 | 1.3E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 6| +3.16E+06 | -1.7E+07 | +8.9E-01 | 5.0E-01 | 7.3E+07 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 22| +1.54E+02 | +2.2E+00 | -3.0E+01 | 2.0E+00 | 5.7E+01 | 6.3E+00 | trr |0\n", + "2023-02-17 16:05:22 fides(INFO) 7| +2.44E+05 | -1.3E+06 | +8.9E-01 | 5.0E-01 | 7.3E+06 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 31| +1.39E+02 | -1.9E-02 | +7.2E-01 | 2.7E-02 | 4.2E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 4| +2.56E+02 | -5.2E+01 | +8.6E-01 | 1.0E+00 | 2.0E+02 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 0| +3.56E+11 | NaN | NaN | 1.0E+00 | 1.6E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:22 fides(INFO) 7| +4.86E+05 | -2.7E+06 | +8.9E-01 | 5.0E-01 | 1.1E+07 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 30| +1.48E+02 | -1.3E-03 | +3.4E-01 | 1.2E-01 | 2.6E+00 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 8| +3.80E+04 | -2.1E+05 | +9.0E-01 | 5.0E-01 | 1.1E+06 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 112| +1.55E+02 | -2.6E-03 | +2.1E-01 | 4.5E-02 | 2.8E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 5| +2.56E+02 | +6.0E+02 | -5.2E+01 | 2.0E+00 | 3.0E+01 | 2.5E+00 | trr |0\n", + "2023-02-17 16:05:22 fides(INFO) 8| +7.55E+04 | -4.1E+05 | +9.0E-01 | 5.0E-01 | 1.7E+06 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 1| +3.50E+05 | -3.6E+11 | +8.7E-02 | 1.0E+00 | 1.6E+12 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 9| +6.10E+03 | -3.2E+04 | +9.0E-01 | 5.0E-01 | 1.7E+05 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 9| +1.19E+04 | -6.4E+04 | +9.0E-01 | 5.0E-01 | 2.7E+05 | 7.8E-01 | 2d |1\n", + "2023-02-17 16:05:22.461 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2575 and h = 1.54213e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:22.461 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2575: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:22 fides(INFO) 6| +2.56E+02 | +9.4E+01 | -7.3E+00 | 3.7E-01 | 3.0E+01 | 9.5E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 31| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 8.9E-01 | 6.5E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 32| +1.39E+02 | -1.3E-02 | +9.9E-01 | 2.7E-02 | 4.0E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 2| +5.43E+04 | -3.0E+05 | +9.0E-01 | 2.5E-01 | 1.6E+06 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 7| +2.50E+02 | -5.5E+00 | +8.5E-01 | 9.3E-02 | 3.0E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 10| +2.01E+03 | -9.9E+03 | +9.0E-01 | 5.0E-01 | 4.1E+04 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 10| +1.14E+03 | -5.0E+03 | +9.0E-01 | 5.0E-01 | 2.7E+04 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 8| +2.50E+02 | +1.6E+00 | -9.5E-01 | 1.9E-01 | 1.4E+01 | 3.7E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 32| +1.48E+02 | +2.9E-03 | -5.7E-01 | 2.9E-02 | 8.9E-01 | 1.9E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 11| +4.82E+02 | -1.5E+03 | +9.0E-01 | 5.0E-01 | 6.4E+03 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 23| +1.53E+02 | -7.1E-01 | +1.0E+00 | 5.0E-01 | 5.7E+01 | 1.6E+00 | trr |1\n", + "2023-02-17 16:05:22 fides(INFO) 3| +8.67E+03 | -4.6E+04 | +9.0E-01 | 5.0E-01 | 2.5E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 33| +1.38E+02 | -2.4E-02 | +9.7E-01 | 5.3E-02 | 3.0E+00 | 6.2E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 9| +2.50E+02 | -8.0E-01 | +6.2E-01 | 4.6E-02 | 1.4E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 11| +3.71E+02 | -7.7E+02 | +9.0E-01 | 5.0E-01 | 4.3E+03 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 12| +2.60E+02 | -2.2E+02 | +8.9E-01 | 5.0E-01 | 9.9E+02 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 4| +1.54E+03 | -7.1E+03 | +9.0E-01 | 1.0E+00 | 3.9E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 10| +2.50E+02 | -3.1E-02 | +6.2E-01 | 4.6E-02 | 2.1E+00 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 11| +2.50E+02 | -3.3E-02 | +6.6E-01 | 4.6E-02 | 1.8E+00 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 33| +1.48E+02 | +1.3E-03 | -3.4E-01 | 7.3E-03 | 8.9E-01 | 9.9E-03 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 12| +2.59E+02 | -1.1E+02 | +8.8E-01 | 5.0E-01 | 6.6E+02 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 13| +2.37E+02 | -2.4E+01 | +8.6E-01 | 5.0E-01 | 1.3E+02 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 12| +2.50E+02 | -4.3E-02 | +7.5E-01 | 4.6E-02 | 2.0E+00 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 5| +4.32E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 6.1E+03 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 113| +1.55E+02 | -6.3E-03 | +1.0E+00 | 1.1E-02 | 5.7E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 34| +1.48E+02 | -1.5E-03 | +6.4E-01 | 1.8E-03 | 8.9E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 13| +2.50E+02 | -9.2E+00 | +7.3E-01 | 5.0E-01 | 8.8E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 34| +1.38E+02 | -4.0E-02 | +9.5E-01 | 1.1E-01 | 4.8E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 13| +2.49E+02 | -4.7E-02 | +7.7E-01 | 4.6E-02 | 1.7E+00 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 14| +2.14E+02 | -2.2E+01 | +1.2E+00 | 1.0E+00 | 2.0E+01 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 6| +2.67E+02 | -1.6E+02 | +8.8E-01 | 1.0E+00 | 9.6E+02 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 14| +2.49E+02 | -1.3E-01 | +1.0E+00 | 9.3E-02 | 1.9E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 7| +2.50E+02 | -1.7E+01 | +7.9E-01 | 1.0E+00 | 1.3E+02 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 35| +1.48E+02 | -3.8E-04 | +9.6E-01 | 1.8E-03 | 1.8E+00 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 15| +2.49E+02 | -4.1E-01 | +1.3E+00 | 1.9E-01 | 2.0E+00 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 14| +2.50E+02 | +2.3E-02 | -1.5E-01 | 5.0E-01 | 5.1E+00 | 6.6E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 15| +2.14E+02 | +3.3E+02 | -3.4E+01 | 2.0E+00 | 3.7E+01 | 6.2E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 8| +2.50E+02 | -1.4E-01 | -1.0E+00 | 2.0E+00 | 3.8E+00 | 4.9E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 35| +1.38E+02 | -6.2E-02 | +8.9E-01 | 2.1E-01 | 2.3E+00 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 16| +2.47E+02 | -2.3E+00 | +1.9E+00 | 3.7E-01 | 2.8E+00 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 15| +2.50E+02 | -6.3E-02 | +8.5E-01 | 6.4E-03 | 5.1E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 36| +1.48E+02 | -2.0E-04 | +5.0E-01 | 3.6E-03 | 3.0E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 16| +2.14E+02 | +2.2E+00 | -3.4E-01 | 5.0E-01 | 3.7E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 17| +2.40E+02 | -6.7E+00 | +1.8E+00 | 7.4E-01 | 7.3E+00 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 9| +2.50E+02 | -8.6E-03 | +1.0E-01 | 5.0E-01 | 3.8E+00 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 24| +1.52E+02 | -1.9E+00 | +9.2E-01 | 1.0E+00 | 4.7E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 16| +2.50E+02 | +2.3E-03 | -6.4E-02 | 1.3E-02 | 2.5E+00 | 3.1E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 17| +2.09E+02 | -5.2E+00 | +6.9E-01 | 1.2E-01 | 3.7E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +2.36E+02 | -4.1E+00 | +1.3E+00 | 1.5E+00 | 1.4E+01 | 4.4E+00 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 36| +1.38E+02 | +5.4E-02 | -6.1E-01 | 4.3E-01 | 4.7E+00 | 4.4E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 10| +2.50E+02 | +5.7E-03 | -9.2E-02 | 1.2E-01 | 3.3E+00 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 37| +1.48E+02 | -1.8E-04 | +9.6E-01 | 3.6E-03 | 1.1E+00 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 25| +1.52E+02 | +5.7E+01 | -6.0E+02 | 2.0E+00 | 3.9E+01 | 5.8E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 17| +2.50E+02 | -1.4E-02 | +8.5E-01 | 3.0E-03 | 2.5E+00 | 7.7E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +2.06E+02 | -2.6E+00 | +5.9E-01 | 1.2E-01 | 3.1E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 11| +2.50E+02 | +5.8E-03 | -9.2E-02 | 3.1E-02 | 3.3E+00 | 7.5E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 114| +1.55E+02 | -1.9E-03 | +1.2E+00 | 2.2E-02 | 1.1E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 19| +2.36E+02 | +9.5E+01 | -9.3E+00 | 3.0E+00 | 2.4E+01 | 8.5E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 12| +2.50E+02 | -3.3E-02 | +6.7E-01 | 7.8E-03 | 3.3E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 38| +1.48E+02 | -7.9E-05 | +9.6E-01 | 7.3E-03 | 1.5E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +2.50E+02 | +2.5E-04 | -2.9E-02 | 6.0E-03 | 1.2E+00 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 37| +1.38E+02 | -2.0E-02 | +6.4E-01 | 1.1E-01 | 4.7E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 19| +2.06E+02 | -8.1E-01 | +2.2E-01 | 1.2E-01 | 2.8E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 13| +2.50E+02 | -2.2E-06 | +1.8E-02 | 7.8E-03 | 1.5E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 20| +2.36E+02 | +9.2E+00 | -1.7E+00 | 7.4E-01 | 2.4E+01 | 2.1E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 19| +2.50E+02 | -3.4E-03 | +8.5E-01 | 1.5E-03 | 1.2E+00 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 39| +1.48E+02 | -1.2E-04 | +9.2E-01 | 1.5E-02 | 2.8E-01 | 7.9E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 14| +2.50E+02 | -9.8E-07 | +7.6E-03 | 2.0E-03 | 1.5E-01 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 20| +2.04E+02 | -1.3E+00 | +8.4E-01 | 3.1E-02 | 2.9E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 21| +2.36E+02 | +3.0E+00 | -6.5E-01 | 1.9E-01 | 2.4E+01 | 4.5E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 20| +2.50E+02 | +2.5E-05 | -1.2E-02 | 2.9E-03 | 6.1E-01 | 7.3E-03 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 38| +1.38E+02 | +9.9E-02 | -1.4E+00 | 1.1E-01 | 1.7E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 15| +2.50E+02 | -5.2E-05 | +5.1E-01 | 4.9E-04 | 1.5E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 40| +1.48E+02 | -2.0E-04 | +9.7E-01 | 2.9E-02 | 1.2E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 22| +2.34E+02 | -2.0E+00 | +8.8E-01 | 4.6E-02 | 2.4E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 21| +2.04E+02 | -9.6E-02 | +1.7E-01 | 6.2E-02 | 1.4E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 21| +2.50E+02 | -8.4E-04 | +8.5E-01 | 7.4E-04 | 6.1E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 16| +2.50E+02 | -3.3E-07 | +1.2E-02 | 4.9E-04 | 6.6E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 115| +1.55E+02 | -6.8E-04 | +2.8E-01 | 2.2E-02 | 1.1E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 23| +2.32E+02 | -1.8E+00 | +7.1E-01 | 9.3E-02 | 1.8E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 41| +1.48E+02 | -2.8E-04 | +8.2E-01 | 5.8E-02 | 3.4E-01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 22| +2.50E+02 | -1.8E-05 | +3.2E-02 | 1.5E-03 | 3.0E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 22| +2.04E+02 | -2.9E-01 | +8.3E-01 | 1.6E-02 | 1.4E+01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 39| +1.38E+02 | -7.3E-03 | +3.5E-01 | 2.7E-02 | 1.7E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 17| +2.50E+02 | -1.2E-05 | +7.5E-01 | 1.2E-04 | 6.6E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 24| +2.30E+02 | -2.1E+00 | +7.9E-01 | 9.3E-02 | 2.5E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 42| +1.48E+02 | -2.1E-04 | +4.1E-01 | 1.2E-01 | 1.7E-01 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 23| +2.50E+02 | -1.7E-04 | +8.8E-01 | 3.7E-04 | 2.9E-01 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 18| +2.50E+02 | -7.4E-08 | +6.3E-02 | 2.4E-04 | 1.4E-02 | 5.8E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 23| +2.04E+02 | -7.7E-02 | +6.5E-01 | 3.1E-02 | 6.0E+00 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 25| +2.30E+02 | -2.2E-01 | -7.7E-02 | 1.9E-01 | 1.9E+01 | 4.3E-01 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:22 fides(INFO) 40| +1.38E+02 | -8.6E-03 | +8.7E-01 | 2.7E-02 | 5.2E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 19| +2.50E+02 | -4.4E-07 | +4.3E-01 | 6.1E-05 | 1.4E-02 | 1.2E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 4.40E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:22 fides(INFO) 24| +2.50E+02 | -7.4E-05 | +4.8E-01 | 7.4E-04 | 1.7E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 43| +1.48E+02 | +2.0E-03 | -1.1E+00 | 1.2E-01 | 5.7E-01 | 5.6E-02 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 24| +2.04E+02 | -3.4E-02 | +4.1E-01 | 3.1E-02 | 4.5E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 26| +2.29E+02 | -1.3E+00 | +8.9E-01 | 4.6E-02 | 1.9E+01 | 9.9E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 25| +2.50E+02 | +2.5E-08 | -1.1E-03 | 7.4E-04 | 6.5E-02 | 7.7E-04 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 41| +1.38E+02 | -9.0E-03 | +8.7E-01 | 5.3E-02 | 1.2E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 25| +2.04E+02 | -5.4E-02 | +6.3E-01 | 3.1E-02 | 4.4E+00 | 9.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 27| +2.26E+02 | -2.5E+00 | +1.1E+00 | 9.3E-02 | 1.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 116| +1.55E+02 | -3.1E-03 | +1.5E+00 | 2.2E-02 | 2.6E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 44| +1.48E+02 | -2.7E-04 | +5.1E-01 | 2.9E-02 | 5.7E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 26| +2.50E+02 | -9.4E-06 | +8.5E-01 | 8.1E-05 | 6.5E-02 | 2.0E-04 | 2d |1\n", + "2023-02-17 16:05:22.937 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 176.485 and h = 1.21791e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:22.937 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 176.485: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:22 fides(INFO) 26| +2.04E+02 | -4.1E-02 | +6.5E-01 | 3.1E-02 | 3.2E+00 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 26| +1.52E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 3.9E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:22 fides(INFO) 28| +2.24E+02 | -2.5E+00 | +6.5E-01 | 1.9E-01 | 1.8E+01 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 42| +1.38E+02 | -1.0E-02 | +4.5E-01 | 1.1E-01 | 1.6E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 27| +2.50E+02 | -4.3E-07 | +7.1E-02 | 1.6E-04 | 3.2E-02 | 3.6E-04 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 45| +1.48E+02 | -6.2E-05 | +9.4E-01 | 2.9E-02 | 1.8E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 29| +2.20E+02 | -3.2E+00 | +6.5E-01 | 1.9E-01 | 3.8E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 27| +2.04E+02 | -5.0E-02 | +7.9E-01 | 3.1E-02 | 2.9E+00 | 9.3E-02 | 2d |1\n", + "2023-02-17 16:05:22 fides(INFO) 28| +2.50E+02 | -1.9E-06 | +8.5E-01 | 4.0E-05 | 3.0E-02 | 8.7E-05 | 2d |1\n", + "2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 1.85E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:22 fides(INFO) 46| +1.48E+02 | -8.3E-05 | +9.3E-01 | 5.8E-02 | 8.7E-02 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 43| +1.38E+02 | +2.4E-02 | -4.4E-01 | 1.1E-01 | 1.9E+00 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 28| +2.03E+02 | -1.0E-01 | +1.0E+00 | 6.2E-02 | 2.3E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 30| +2.20E+02 | -1.4E-01 | -3.0E-02 | 1.9E-01 | 1.9E+01 | 4.7E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 0| +2.00E+11 | NaN | NaN | 1.0E+00 | 1.1E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:23 fides(INFO) 47| +1.48E+02 | -9.9E-05 | +8.3E-01 | 1.2E-01 | 7.9E-02 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 29| +2.03E+02 | -2.9E-01 | +1.2E+00 | 1.2E-01 | 2.1E+00 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 31| +2.19E+02 | -1.3E+00 | +8.0E-01 | 4.6E-02 | 1.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 44| +1.38E+02 | -9.8E-03 | +6.3E-01 | 2.7E-02 | 1.9E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 48| +1.48E+02 | +1.9E-03 | -6.7E+00 | 2.3E-01 | 7.6E-02 | 7.1E-02 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 117| +1.55E+02 | -2.6E-03 | +1.3E+00 | 2.2E-02 | 1.2E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 30| +2.02E+02 | -1.2E+00 | +1.6E+00 | 2.5E-01 | 2.8E+00 | 7.5E-01 | 2d |1\n", + "2023-02-17 16:05:23.071 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 104.324 and h = 1.41477e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:23.071 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 104.324: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:23 fides(INFO) 27| +1.52E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 3.9E+01 | 3.6E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 1| +1.25E+05 | -2.0E+11 | +8.0E-02 | 1.0E+00 | 1.1E+12 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 32| +2.17E+02 | -2.0E+00 | +1.1E+00 | 9.3E-02 | 1.7E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 0| +1.23E+09 | NaN | NaN | 1.0E+00 | 6.1E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:23 fides(INFO) 45| +1.38E+02 | -4.0E-03 | +9.7E-01 | 2.7E-02 | 2.4E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 49| +1.48E+02 | +3.2E-05 | -3.0E-01 | 5.8E-02 | 7.6E-02 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 31| +1.94E+02 | -7.9E+00 | +2.2E+00 | 5.0E-01 | 3.7E+00 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 33| +2.15E+02 | -2.1E+00 | +8.2E-01 | 1.9E-01 | 1.6E+01 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 50| +1.48E+02 | -1.7E-05 | +5.5E-01 | 1.5E-02 | 7.6E-02 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 34| +2.11E+02 | -3.7E+00 | +8.1E-01 | 3.7E-01 | 2.3E+01 | 9.5E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 32| +1.94E+02 | +4.8E+02 | -2.6E+01 | 1.0E+00 | 2.5E+01 | 2.5E+00 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 2| +5.32E+04 | -7.2E+04 | +9.6E-01 | 2.5E-01 | 5.9E+05 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 1| +5.39E+04 | -1.2E+09 | +8.5E-02 | 1.0E+00 | 6.1E+09 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 46| +1.38E+02 | -6.8E-03 | +9.8E-01 | 5.3E-02 | 1.0E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 51| +1.48E+02 | -6.5E-06 | +8.5E-01 | 1.5E-02 | 5.4E-02 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 35| +1.95E+02 | -1.7E+01 | +6.7E-01 | 7.4E-01 | 2.2E+01 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 33| +1.79E+02 | -1.5E+01 | +1.5E+00 | 2.5E-01 | 2.5E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 28| +1.51E+02 | -2.0E-01 | +1.0E+00 | 3.1E-02 | 3.9E+01 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 118| +1.55E+02 | -1.6E-03 | +1.3E+00 | 4.5E-02 | 4.2E-01 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 2| +8.35E+03 | -4.6E+04 | +9.0E-01 | 2.5E-01 | 2.7E+05 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 52| +1.48E+02 | -9.5E-06 | +7.9E-01 | 2.9E-02 | 2.8E-02 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 47| +1.38E+02 | -1.2E-02 | +9.5E-01 | 1.1E-01 | 1.2E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 36| +1.95E+02 | +7.6E+01 | -2.6E+00 | 7.4E-01 | 1.1E+02 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 34| +1.79E+02 | +3.4E+01 | -2.2E+00 | 5.0E-01 | 4.6E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 37| +1.78E+02 | -1.7E+01 | +8.4E-01 | 1.9E-01 | 1.1E+02 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 53| +1.48E+02 | -1.7E-05 | +9.4E-01 | 5.8E-02 | 4.8E-02 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 3| +1.39E+03 | -7.0E+03 | +9.1E-01 | 5.0E-01 | 4.2E+04 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 3| +1.25E+04 | -4.1E+04 | +9.4E-01 | 5.0E-01 | 1.9E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 35| +1.69E+02 | -1.1E+01 | +1.1E+00 | 1.2E-01 | 4.6E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 48| +1.38E+02 | -1.3E-02 | +5.7E-01 | 2.1E-01 | 1.2E+00 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 38| +1.66E+02 | -1.2E+01 | +5.0E-01 | 3.7E-01 | 4.7E+01 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 54| +1.48E+02 | -1.7E-05 | +9.6E-01 | 1.2E-01 | 1.8E-02 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 119| +1.55E+02 | -1.1E-03 | +1.6E+00 | 4.5E-02 | 4.4E-01 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 36| +1.55E+02 | -1.4E+01 | +8.2E-01 | 2.5E-01 | 6.2E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 4| +3.46E+02 | -1.0E+03 | +9.1E-01 | 1.0E+00 | 6.8E+03 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 39| +1.59E+02 | -6.7E+00 | +3.1E-01 | 3.7E-01 | 1.2E+02 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 55| +1.48E+02 | +5.0E-04 | -1.2E+01 | 2.3E-01 | 4.5E-02 | 2.3E-02 | trr |0\n", + "2023-02-17 16:05:23 fides(INFO) 49| +1.38E+02 | +3.6E-01 | -3.5E+00 | 2.1E-01 | 1.4E+00 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 37| +1.49E+02 | -5.6E+00 | +7.6E-01 | 5.0E-01 | 1.1E+02 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 40| +1.51E+02 | -8.9E+00 | +9.5E-01 | 3.7E-01 | 2.3E+02 | 3.2E-01 | trr |1\n", + "2023-02-17 16:05:23 fides(INFO) 56| +1.48E+02 | +1.9E-05 | -1.0E+00 | 3.7E-02 | 4.5E-02 | 5.8E-03 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 5| +1.68E+02 | -1.8E+02 | +1.0E+00 | 1.0E+00 | 1.2E+03 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 29| +1.51E+02 | -3.0E-01 | +1.0E+00 | 6.2E-02 | 2.3E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 50| +1.38E+02 | +5.8E-03 | -2.0E-01 | 5.3E-02 | 1.4E+00 | 4.8E-02 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 41| +1.51E+02 | +2.8E+00 | -1.1E+00 | 3.7E-01 | 4.8E+01 | 5.7E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 38| +1.49E+02 | +3.5E+00 | -1.7E+00 | 1.0E+00 | 5.2E+01 | 7.7E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 57| +1.48E+02 | -1.9E-06 | +3.4E-01 | 9.3E-03 | 4.5E-02 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 120| +1.55E+02 | -1.7E-03 | +1.3E+00 | 4.5E-02 | 6.1E-01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 6| +1.68E+02 | -3.3E+00 | -2.8E-02 | 1.0E+00 | 2.0E+02 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:23.374 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 77.935 and h = 1.24774e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:23.374 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 77.935: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:23 fides(INFO) 39| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.7E-01 | 5.2E+01 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 42| +1.49E+02 | -1.3E+00 | +7.7E-01 | 8.8E-02 | 4.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 51| +1.38E+02 | -5.3E-03 | +5.0E-01 | 1.3E-02 | 1.4E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 58| +1.48E+02 | +4.1E-07 | -6.7E-01 | 9.3E-03 | 4.6E-02 | 1.4E-03 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 4| +2.02E+03 | -1.0E+04 | +9.0E-01 | 1.0E+00 | 4.4E+04 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 43| +1.49E+02 | +8.8E-01 | -6.9E-01 | 1.8E-01 | 3.0E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 40| +1.49E+02 | -5.5E-01 | +8.8E-01 | 4.2E-02 | 5.2E+01 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 7| +1.58E+02 | -1.1E+01 | +8.9E-01 | 2.1E-01 | 2.0E+02 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 59| +1.48E+02 | +3.4E-07 | -9.7E-01 | 2.3E-03 | 4.6E-02 | 3.4E-04 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 52| +1.38E+02 | -4.2E-03 | +9.7E-01 | 1.3E-02 | 6.4E+00 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 44| +1.49E+02 | -3.3E-01 | +7.0E-01 | 4.4E-02 | 3.0E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 41| +1.48E+02 | -4.1E-01 | +9.6E-01 | 8.3E-02 | 4.1E+01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 8| +1.52E+02 | -5.7E+00 | +8.5E-01 | 4.3E-01 | 6.1E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 121| +1.55E+02 | -4.6E-03 | +1.2E+00 | 8.9E-02 | 7.5E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 60| +1.48E+02 | +8.9E-07 | -3.2E+00 | 5.8E-04 | 4.6E-02 | 8.6E-05 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 42| +1.48E+02 | -4.1E-01 | +8.1E-01 | 1.7E-01 | 3.2E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 45| +1.48E+02 | -4.8E-01 | +7.5E-01 | 4.4E-02 | 2.3E+01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 53| +1.38E+02 | -1.8E-03 | +9.8E-01 | 2.7E-02 | 6.1E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 61| +1.48E+02 | +3.9E-07 | -1.5E+00 | 1.5E-04 | 4.6E-02 | 2.4E-05 | 2d |0\n", + "2023-02-17 16:05:23.546 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 133.055 and h = 1.26071e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:23.546 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 133.055: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 30| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 9.4E+00 | 3.6E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 46| +1.48E+02 | +4.8E-02 | -1.0E-01 | 8.8E-02 | 2.6E+01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 43| +1.48E+02 | +9.7E-02 | -2.0E-01 | 3.3E-01 | 2.9E+01 | 3.7E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 9| +1.50E+02 | -2.2E+00 | +1.0E+00 | 8.5E-01 | 3.9E+01 | 8.0E-01 | trr |1\n", + "2023-02-17 16:05:23 fides(INFO) 54| +1.38E+02 | -3.5E-03 | +9.7E-01 | 5.3E-02 | 8.2E-01 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 47| +1.48E+02 | -1.7E-01 | +8.0E-01 | 2.2E-02 | 2.6E+01 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 62| +1.48E+02 | -1.0E-06 | +4.0E+00 | 3.6E-05 | 4.6E-02 | 1.2E-05 | 2d |1\n", + "2023-02-17 16:05:23 fides(WARNING) Stopping as function difference 1.03E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:23 fides(INFO) 5| +4.14E+02 | -1.6E+03 | +9.0E-01 | 1.0E+00 | 6.8E+03 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 122| +1.55E+02 | -1.0E-02 | +1.1E+00 | 1.8E-01 | 1.4E+00 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 44| +1.48E+02 | -1.8E-01 | +8.0E-01 | 8.3E-02 | 2.9E+01 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 10| +1.50E+02 | -4.8E-02 | +2.5E-01 | 8.5E-01 | 8.1E+00 | 1.0E+00 | trr |1\n", + "2023-02-17 16:05:23 fides(INFO) 55| +1.38E+02 | -5.4E-03 | +8.0E-01 | 1.1E-01 | 7.0E-01 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 48| +1.48E+02 | -2.3E-01 | +9.6E-01 | 4.4E-02 | 9.2E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 45| +1.48E+02 | -1.7E-01 | +8.5E-01 | 1.7E-01 | 1.7E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 123| +1.55E+02 | +6.4E-01 | -5.7E+01 | 3.6E-01 | 6.7E+00 | 9.0E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 49| +1.48E+02 | -1.6E-01 | +5.9E-01 | 8.8E-02 | 1.4E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 56| +1.38E+02 | +2.1E-01 | -6.3E+00 | 2.1E-01 | 6.0E-01 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 11| +1.50E+02 | -3.8E-02 | +9.0E-01 | 1.7E-01 | 1.3E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 46| +1.48E+02 | +1.0E-01 | -4.8E-01 | 3.3E-01 | 1.8E+01 | 3.3E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 50| +1.48E+02 | +2.8E-01 | -5.9E-01 | 8.8E-02 | 6.2E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 31| +1.51E+02 | -1.4E-02 | +1.0E+00 | 3.1E-02 | 9.4E+00 | 8.9E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 47| +1.48E+02 | -7.1E-02 | +7.5E-01 | 8.3E-02 | 1.8E+01 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 57| +1.38E+02 | +6.1E-03 | -6.6E-01 | 5.3E-02 | 6.0E-01 | 4.0E-02 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 0| +3.10E+09 | NaN | NaN | 1.0E+00 | 1.4E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:23 fides(INFO) 12| +1.50E+02 | -1.9E-02 | +8.5E-01 | 3.4E-01 | 2.0E+00 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 124| +1.55E+02 | -6.6E-03 | +9.7E-01 | 8.9E-02 | 6.7E+00 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:23.765 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.64 and h = 4.19393e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:23.765 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.64: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:23 fides(INFO) 48| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.3E-02 | 8.8E+00 | 6.9E-02 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 51| +1.48E+02 | -1.1E-01 | +6.1E-01 | 2.2E-02 | 6.2E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 13| +1.50E+02 | -5.3E-03 | +3.6E-01 | 6.8E-01 | 1.7E+00 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 58| +1.38E+02 | -1.4E-03 | +5.2E-01 | 1.3E-02 | 6.0E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 52| +1.48E+02 | -4.2E-02 | +8.8E-01 | 2.2E-02 | 9.9E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 1| +1.92E+04 | -3.1E+09 | +9.3E-02 | 1.0E+00 | 1.4E+10 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 49| +1.48E+02 | -2.9E-02 | +8.6E-01 | 2.1E-02 | 8.8E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 125| +1.55E+02 | -2.5E-02 | +3.9E-01 | 1.8E-01 | 1.0E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 14| +1.50E+02 | +2.2E-03 | -2.6E-01 | 6.8E-01 | 3.5E+00 | 2.8E-01 | trr |0\n", + "2023-02-17 16:05:23 fides(INFO) 53| +1.48E+02 | -6.1E-02 | +9.5E-01 | 4.4E-02 | 2.4E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 50| +1.48E+02 | -2.5E-02 | +9.6E-01 | 4.2E-02 | 1.2E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 2| +3.81E+03 | -1.5E+04 | +9.1E-01 | 2.5E-01 | 6.4E+04 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 59| +1.38E+02 | -1.1E-03 | +9.5E-01 | 1.3E-02 | 2.1E+00 | 8.8E-03 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 6| +1.81E+02 | -2.3E+02 | +8.9E-01 | 1.0E+00 | 1.0E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 54| +1.48E+02 | -7.4E-02 | +9.0E-01 | 8.8E-02 | 4.8E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 3| +8.29E+02 | -3.0E+03 | +9.1E-01 | 5.0E-01 | 1.2E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 15| +1.50E+02 | -3.8E-03 | +8.1E-01 | 1.2E-01 | 3.5E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 51| +1.48E+02 | -1.9E-02 | +9.5E-01 | 8.3E-02 | 5.1E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:23 fides(INFO) 60| +1.38E+02 | -1.6E-03 | +9.7E-01 | 2.7E-02 | 4.5E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 126| +1.55E+02 | +3.1E-01 | -3.2E+00 | 1.8E-01 | 1.2E+01 | 3.4E-01 | 2d |0\n", + "2023-02-17 16:05:23.931 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.6304 and h = 1.05166e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:23.932 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.6304: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:23 fides(INFO) 32| +1.51E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 4.6E+00 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 4| +8.29E+02 | +5.6E+03 | -3.0E+01 | 1.0E+00 | 2.0E+03 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 16| +1.50E+02 | -7.9E-04 | +7.6E-01 | 2.4E-01 | 9.1E-01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 55| +1.48E+02 | +3.2E-02 | -5.2E-01 | 1.8E-01 | 1.5E+00 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 52| +1.48E+02 | -1.9E-02 | +8.1E-01 | 1.7E-01 | 5.9E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 5| +3.55E+02 | -4.7E+02 | +8.8E-01 | 2.5E-01 | 2.0E+03 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:23.973 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 146.739 and h = 3.74372e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:23.973 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 146.739: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:23 fides(INFO) 56| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.8E-02 | 1.5E+00 | 5.0E-02 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 61| +1.38E+02 | -2.6E-03 | +9.1E-01 | 5.3E-02 | 1.8E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:23 fides(INFO) 53| +1.48E+02 | +4.3E-02 | -1.3E+00 | 3.3E-01 | 2.9E+00 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:23 fides(INFO) 17| +1.50E+02 | -1.6E-04 | +8.4E-01 | 4.7E-01 | 5.0E-01 | 1.7E-01 | trr |1\n", + "2023-02-17 16:05:24 fides(INFO) 127| +1.55E+02 | -3.7E-02 | +7.2E-01 | 4.2E-02 | 1.2E+01 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 6| +2.54E+02 | -1.0E+02 | +8.0E-01 | 5.0E-01 | 3.6E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 57| +1.48E+02 | -1.1E-02 | +6.4E-01 | 9.6E-03 | 1.5E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 54| +1.48E+02 | -5.9E-03 | +4.5E-01 | 8.3E-02 | 2.9E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 62| +1.38E+02 | +1.8E-03 | -3.4E-01 | 1.1E-01 | 4.0E-01 | 6.8E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 7| +1.53E+02 | -2.7E+01 | +8.6E-01 | 1.0E+00 | 1.5E+02 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 18| +1.50E+02 | +5.0E-05 | -4.1E-01 | 4.7E-01 | 3.0E-01 | 7.7E-03 | trr |0\n", + "2023-02-17 16:05:24 fides(INFO) 7| +2.49E+02 | -4.7E+00 | +6.1E-01 | 1.0E+00 | 4.7E+01 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 55| +1.48E+02 | -3.9E-03 | +2.8E-01 | 8.3E-02 | 3.9E+00 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 58| +1.48E+02 | -7.2E-03 | +8.7E-01 | 9.6E-03 | 3.6E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:24.073 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.1719 and h = 1.21884e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.073 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.1719: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 33| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 4.6E+00 | 3.8E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 128| +1.55E+02 | -2.4E-02 | +1.9E-01 | 4.2E-02 | 1.1E+01 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 19| +1.50E+02 | -4.8E-05 | +8.1E-01 | 1.4E-02 | 3.0E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 8| +2.43E+02 | -5.9E+00 | +1.1E+00 | 1.0E+00 | 1.6E+01 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 63| +1.38E+02 | -1.0E-03 | +5.1E-01 | 2.7E-02 | 4.0E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 56| +1.48E+02 | +6.8E-03 | -4.1E-01 | 8.3E-02 | 1.9E+00 | 5.1E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 59| +1.48E+02 | -6.9E-03 | +7.8E-01 | 1.9E-02 | 5.3E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 9| +2.27E+02 | -1.6E+01 | +1.6E+00 | 2.0E+00 | 2.4E+01 | 4.5E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 20| +1.50E+02 | -1.1E-05 | +5.6E-01 | 2.9E-02 | 7.4E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 8| +1.52E+02 | -7.5E-01 | +9.6E-01 | 1.0E+00 | 4.2E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 64| +1.38E+02 | -1.5E-03 | +4.7E-01 | 2.7E-02 | 1.9E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 60| +1.48E+02 | -1.4E-02 | +8.8E-01 | 3.8E-02 | 1.2E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 57| +1.48E+02 | -1.5E-03 | +1.6E-01 | 2.1E-02 | 1.9E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 129| +1.54E+02 | -7.7E-02 | +1.1E+00 | 1.0E-02 | 2.3E+01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 10| +2.27E+02 | +4.8E+03 | -1.3E+02 | 4.0E+00 | 3.3E+01 | 7.2E+00 | trr |0\n", + "2023-02-17 16:05:24 fides(INFO) 21| +1.50E+02 | -5.6E-07 | +7.6E-02 | 2.9E-02 | 7.5E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 9| +1.52E+02 | +8.3E+01 | -9.5E+01 | 2.0E+00 | 1.9E+01 | 4.7E+00 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 58| +1.48E+02 | -4.3E-03 | +9.4E-01 | 5.2E-03 | 5.9E+00 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 61| +1.48E+02 | +6.8E-03 | -3.8E-01 | 7.7E-02 | 6.1E-01 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 65| +1.38E+02 | -1.0E-03 | +4.3E-01 | 2.7E-02 | 4.5E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 22| +1.50E+02 | -2.7E-06 | +4.9E-01 | 7.1E-03 | 1.9E-02 | 8.7E-04 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 11| +2.27E+02 | +4.6E+01 | -4.0E+00 | 7.1E-01 | 3.3E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 130| +1.54E+02 | -3.0E-02 | +1.1E+00 | 2.1E-02 | 3.5E+00 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 62| +1.48E+02 | -3.8E-03 | +6.9E-01 | 1.9E-02 | 6.1E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 59| +1.48E+02 | -6.3E-04 | +8.8E-01 | 1.0E-02 | 5.0E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:24.245 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.9074 and h = 1.0834e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.246 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.9074: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 34| +1.51E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 4.6E+00 | 8.9E-03 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 10| +1.52E+02 | +2.3E+00 | -1.1E+01 | 5.0E-01 | 1.9E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 66| +1.38E+02 | -8.5E-04 | +3.4E-01 | 2.7E-02 | 6.9E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 12| +2.22E+02 | -5.2E+00 | +4.5E-01 | 1.8E-01 | 3.3E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 23| +1.50E+02 | -2.8E-08 | +4.4E-02 | 7.1E-03 | 2.2E-02 | 4.1E-04 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 60| +1.48E+02 | -6.7E-04 | +8.4E-01 | 2.1E-02 | 6.4E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 63| +1.48E+02 | -2.7E-03 | +3.8E-01 | 1.9E-02 | 6.8E-01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 13| +2.14E+02 | -7.9E+00 | +9.1E-01 | 1.8E-01 | 4.9E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 131| +1.54E+02 | -4.3E-02 | +1.0E+00 | 4.2E-02 | 3.0E+00 | 9.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 61| +1.48E+02 | -7.4E-04 | +9.1E-01 | 4.2E-02 | 2.8E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 64| +1.48E+02 | -4.7E-03 | +5.2E-01 | 1.9E-02 | 3.0E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 24| +1.50E+02 | -1.5E-07 | +6.6E-01 | 1.8E-03 | 1.2E-02 | 1.4E-04 | 2d |1\n", + "2023-02-17 16:05:24 fides(WARNING) Stopping as function difference 1.50E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:24 fides(INFO) 67| +1.38E+02 | -9.3E-04 | +3.2E-01 | 2.7E-02 | 5.1E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 14| +1.95E+02 | -1.9E+01 | +1.3E+00 | 3.5E-01 | 2.8E+01 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 11| +1.52E+02 | -1.4E-01 | +9.4E-01 | 1.2E-01 | 1.9E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 65| +1.48E+02 | -2.7E-03 | +6.2E-01 | 1.9E-02 | 6.9E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 62| +1.48E+02 | -1.1E-03 | +9.6E-01 | 8.3E-02 | 3.9E-01 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 132| +1.54E+02 | -7.1E-02 | +8.4E-01 | 8.3E-02 | 5.1E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 15| +1.95E+02 | -8.5E+00 | -3.6E-01 | 7.1E-01 | 5.5E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 68| +1.38E+02 | -5.6E-04 | +1.7E-01 | 2.7E-02 | 7.0E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 63| +1.48E+02 | -1.3E-03 | +9.2E-01 | 1.7E-01 | 2.4E-01 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 66| +1.48E+02 | -1.3E-03 | +3.5E-01 | 1.9E-02 | 6.8E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 16| +1.83E+02 | -1.2E+01 | +1.0E+00 | 1.8E-01 | 5.5E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 12| +1.52E+02 | -2.0E-01 | +7.0E-01 | 2.5E-01 | 2.1E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 67| +1.48E+02 | +5.7E-03 | -9.3E-01 | 1.9E-02 | 6.4E-01 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 69| +1.38E+02 | -8.7E-04 | +7.9E-01 | 6.7E-03 | 6.0E-01 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 0| +1.22E+14 | NaN | NaN | 1.0E+00 | 5.6E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:24 fides(INFO) 64| +1.48E+02 | +1.8E-03 | -1.7E+00 | 3.3E-01 | 1.5E-01 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:24.455 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 111.961 and h = 1.39991e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.456 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 111.961: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 133| +1.54E+02 | -5.6E-02 | +8.6E-01 | 1.7E-01 | 1.0E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 35| +1.51E+02 | +0.0E+00 | +0.0E+00 | 9.8E-04 | 4.6E+00 | 2.2E-03 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 65| +1.48E+02 | -1.2E-04 | +2.7E-01 | 8.3E-02 | 1.5E-01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 68| +1.48E+02 | -9.4E-04 | +4.7E-01 | 4.8E-03 | 6.4E-01 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 17| +1.67E+02 | -1.6E+01 | +6.3E-01 | 3.5E-01 | 5.7E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 70| +1.38E+02 | -6.7E-04 | +7.7E-01 | 1.3E-02 | 8.1E-01 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 13| +1.52E+02 | -1.9E-01 | +8.0E-01 | 2.5E-01 | 1.9E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 1| +7.10E+07 | -1.2E+14 | +8.3E-02 | 1.0E+00 | 5.6E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 18| +1.54E+02 | -1.3E+01 | +9.7E-01 | 3.5E-01 | 2.2E+02 | 9.7E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 69| +1.48E+02 | -5.4E-04 | +8.7E-01 | 4.8E-03 | 1.3E+00 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 66| +1.48E+02 | +1.3E-03 | -7.9E-01 | 8.3E-02 | 5.7E-01 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 134| +1.54E+02 | -1.9E-02 | +6.2E-01 | 1.7E-01 | 2.8E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 2| +1.09E+07 | -6.0E+07 | +8.9E-01 | 2.5E-01 | 3.3E+08 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 71| +1.38E+02 | -8.8E-04 | +9.9E-01 | 2.7E-02 | 3.1E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 19| +1.54E+02 | +6.4E+00 | -9.7E-01 | 7.1E-01 | 7.2E+01 | 9.7E-01 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 67| +1.48E+02 | -3.0E-04 | +6.2E-01 | 2.1E-02 | 5.7E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 70| +1.48E+02 | -5.7E-04 | +9.2E-01 | 9.6E-03 | 1.8E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 3| +1.68E+06 | -9.2E+06 | +8.9E-01 | 5.0E-01 | 5.0E+07 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 14| +1.52E+02 | -2.2E-01 | +6.7E-01 | 5.0E-01 | 2.5E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:24.587 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.6128 and h = 1.23616e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.587 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.6128: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 36| +1.51E+02 | +0.0E+00 | +0.0E+00 | 2.4E-04 | 4.6E+00 | 5.6E-04 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 72| +1.38E+02 | -1.7E-03 | +9.8E-01 | 5.3E-02 | 3.0E-01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 71| +1.48E+02 | -1.0E-03 | +8.9E-01 | 1.9E-02 | 2.1E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:24.596 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.536 and h = 2.82335e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.596 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.536: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 68| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.1E-02 | 5.3E-02 | 7.1E-03 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 20| +1.51E+02 | -3.6E+00 | +8.2E-01 | 1.8E-01 | 7.2E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 135| +1.54E+02 | -2.3E-02 | +1.0E+00 | 1.7E-01 | 1.2E+01 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 4| +2.61E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 7.7E+06 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 69| +1.48E+02 | -1.4E-05 | +1.1E+00 | 5.2E-03 | 5.3E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 5| +4.12E+04 | -2.2E+05 | +9.0E-01 | 5.0E-01 | 1.2E+06 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 72| +1.48E+02 | +1.4E-03 | -1.1E+00 | 3.8E-02 | 2.3E-01 | 4.4E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 21| +1.50E+02 | -1.2E+00 | +4.4E-01 | 3.5E-01 | 7.7E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 73| +1.38E+02 | -2.9E-03 | +9.1E-01 | 1.1E-01 | 4.1E-01 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 6| +6.71E+03 | -3.4E+04 | +9.0E-01 | 5.0E-01 | 1.9E+05 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 70| +1.48E+02 | -2.2E-05 | +9.2E-01 | 1.0E-02 | 1.0E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:24.659 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.443 and h = 3.24687e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.659 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.443: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 73| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.6E-03 | 2.3E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 136| +1.54E+02 | -1.3E-02 | +1.6E+00 | 1.7E-01 | 4.5E+00 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 22| +1.49E+02 | -3.9E-01 | +7.7E-02 | 3.5E-01 | 4.4E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 15| +1.51E+02 | -2.6E-01 | +1.2E+00 | 5.0E-01 | 1.4E+01 | 6.9E-01 | trr |1\n", + "2023-02-17 16:05:24 fides(INFO) 7| +1.25E+03 | -5.5E+03 | +9.0E-01 | 5.0E-01 | 3.0E+04 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 74| +1.38E+02 | +4.9E-02 | -5.3E+00 | 2.1E-01 | 2.9E-01 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 71| +1.48E+02 | -3.9E-05 | +9.4E-01 | 2.1E-02 | 5.5E-02 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 74| +1.48E+02 | -9.3E-05 | +8.1E-01 | 2.4E-03 | 2.3E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 8| +3.91E+02 | -8.6E+02 | +9.0E-01 | 5.0E-01 | 4.8E+03 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 23| +1.48E+02 | -9.5E-01 | +5.1E-01 | 8.9E-02 | 5.4E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 16| +1.51E+02 | -1.2E-01 | +8.4E-01 | 1.0E+00 | 7.2E+00 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:24.718 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 94.2389 and h = 1.24166e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.718 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 94.2389: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 37| +1.51E+02 | +0.0E+00 | +0.0E+00 | 6.1E-05 | 4.6E+00 | 1.4E-04 | 2d |0\n", + "2023-02-17 16:05:24.727 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.508 and h = 2.16248e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.728 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.508: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 72| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.2E-02 | 8.9E-02 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 75| +1.38E+02 | +1.4E-03 | -5.2E-01 | 5.3E-02 | 2.9E-01 | 2.8E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 75| +1.48E+02 | -1.6E-04 | +9.4E-01 | 4.8E-03 | 8.1E-02 | 5.3E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 9| +2.62E+02 | -1.3E+02 | +8.9E-01 | 5.0E-01 | 7.6E+02 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 24| +1.48E+02 | -2.6E-01 | +9.1E-01 | 8.9E-02 | 2.8E+01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 137| +1.54E+02 | -1.6E-02 | +1.2E+00 | 1.7E-01 | 1.7E+00 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 76| +1.48E+02 | -2.8E-04 | +9.8E-01 | 9.6E-03 | 1.8E-01 | 9.1E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 17| +1.51E+02 | -3.1E-01 | +1.5E+00 | 2.0E+00 | 7.5E+00 | 3.3E-01 | trr |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 10| +2.50E+02 | -1.2E+01 | +7.8E-01 | 5.0E-01 | 1.1E+02 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 73| +1.48E+02 | -2.4E-05 | +1.2E+00 | 1.0E-02 | 8.9E-02 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 76| +1.38E+02 | -3.9E-04 | +4.8E-01 | 1.3E-02 | 2.9E-01 | 7.2E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 25| +1.48E+02 | -3.1E-01 | +8.7E-01 | 1.8E-01 | 2.9E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 77| +1.48E+02 | -2.8E-04 | +8.3E-01 | 1.9E-02 | 8.6E-02 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 11| +2.50E+02 | -2.3E-04 | +3.8E-02 | 1.0E+00 | 9.9E-01 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 74| +1.48E+02 | -3.3E-05 | +9.7E-01 | 2.1E-02 | 5.8E-02 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 138| +1.54E+02 | -5.5E-03 | +1.5E+00 | 1.7E-01 | 1.5E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 18| +1.51E+02 | -4.8E-01 | +9.4E-01 | 2.0E+00 | 9.3E+00 | 4.2E-01 | trr |1\n", + "2023-02-17 16:05:24 fides(INFO) 26| +1.48E+02 | +3.8E-01 | -1.6E+00 | 3.5E-01 | 1.4E+01 | 3.3E-01 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 12| +2.50E+02 | +1.4E-04 | -2.8E-02 | 2.5E-01 | 9.4E-01 | 6.0E-01 | 2d |0\n", + "2023-02-17 16:05:24.822 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2018 and h = 1.60887e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.822 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2018: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 78| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.8E-02 | 1.8E-01 | 1.2E-02 | trr |0\n", + "2023-02-17 16:05:24 fides(INFO) 77| +1.38E+02 | -5.1E-04 | +8.1E-01 | 1.3E-02 | 1.2E+00 | 6.7E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 75| +1.48E+02 | -5.3E-05 | +9.5E-01 | 4.2E-02 | 7.3E-02 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 19| +1.51E+02 | +1.9E+00 | -1.3E+00 | 2.0E+00 | 4.8E+01 | 5.6E-01 | trr |0\n", + "2023-02-17 16:05:24 fides(INFO) 27| +1.48E+02 | -4.3E-02 | +5.1E-01 | 8.9E-02 | 1.4E+01 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 13| +2.50E+02 | +1.5E-04 | -3.1E-02 | 6.2E-02 | 9.4E-01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 78| +1.38E+02 | -6.3E-04 | +9.5E-01 | 2.7E-02 | 1.9E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 79| +1.48E+02 | +1.3E-04 | -5.2E-01 | 6.2E-03 | 1.8E-01 | 3.0E-03 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 38| +1.51E+02 | -1.5E-04 | +1.0E+00 | 1.5E-05 | 4.6E+00 | 3.5E-05 | 2d |1\n", + "2023-02-17 16:05:24.882 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.542 and h = 2.33234e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.882 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.542: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 76| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.3E-02 | 4.4E-02 | 2.3E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 139| +1.54E+02 | -5.3E-03 | +1.4E+00 | 1.7E-01 | 1.0E+00 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 28| +1.48E+02 | -4.4E-02 | +4.8E-01 | 8.9E-02 | 1.2E+01 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 20| +1.50E+02 | -7.5E-01 | +8.6E-01 | 8.9E-02 | 4.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 14| +2.50E+02 | +1.5E-04 | -3.1E-02 | 1.6E-02 | 9.4E-01 | 3.8E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 80| +1.48E+02 | -4.6E-05 | +6.3E-01 | 1.5E-03 | 1.8E-01 | 7.9E-04 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 77| +1.48E+02 | -2.1E-05 | +9.8E-01 | 2.1E-02 | 4.4E-02 | 5.7E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 79| +1.38E+02 | -9.6E-04 | +6.9E-01 | 5.3E-02 | 2.3E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 29| +1.48E+02 | -2.1E-02 | +2.8E-01 | 8.9E-02 | 1.3E+01 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 15| +2.50E+02 | -1.1E-03 | +2.1E-01 | 3.9E-03 | 9.4E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 81| +1.48E+02 | -1.7E-05 | +1.0E+00 | 1.5E-03 | 1.6E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 21| +1.50E+02 | -2.0E-01 | +6.3E-01 | 1.8E-01 | 1.2E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 78| +1.48E+02 | -3.4E-05 | +9.7E-01 | 4.2E-02 | 6.2E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 140| +1.54E+02 | -3.3E-03 | +1.4E+00 | 1.7E-01 | 7.0E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 80| +1.38E+02 | +3.6E-03 | -9.5E-01 | 5.3E-02 | 3.3E-01 | 2.7E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:24 fides(INFO) 16| +2.50E+02 | -1.1E-03 | +8.7E-01 | 9.8E-04 | 7.3E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 30| +1.48E+02 | +3.0E-02 | -3.0E-01 | 8.9E-02 | 6.8E+00 | 7.7E-02 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 82| +1.48E+02 | -2.5E-05 | +9.9E-01 | 3.1E-03 | 5.1E-02 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 79| +1.48E+02 | -4.2E-05 | +9.6E-01 | 8.3E-02 | 3.2E-02 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 22| +1.50E+02 | -1.2E-02 | +9.6E-01 | 1.8E-01 | 3.8E+00 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:24.994 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 94.9704 and h = 1.35144e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:24.994 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 94.9704: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:24 fides(INFO) 39| +1.51E+02 | +0.0E+00 | +0.0E+00 | 3.1E-05 | 4.5E+00 | 7.0E-05 | 2d |0\n", + "2023-02-17 16:05:24 fides(INFO) 31| +1.48E+02 | -2.3E-02 | +2.8E-01 | 2.2E-02 | 6.8E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:24 fides(INFO) 17| +2.50E+02 | -3.1E-04 | +3.4E-01 | 2.0E-03 | 4.0E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 81| +1.38E+02 | -5.1E-04 | +5.1E-01 | 1.3E-02 | 3.3E-01 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 83| +1.48E+02 | -3.0E-05 | +8.6E-01 | 6.2E-03 | 1.1E-01 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 80| +1.48E+02 | -1.2E-05 | +4.7E-01 | 1.7E-01 | 4.8E-02 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 23| +1.50E+02 | +3.0E-02 | -8.8E-01 | 3.6E-01 | 1.2E+00 | 1.4E-01 | trr |0\n", + "2023-02-17 16:05:25 fides(INFO) 32| +1.48E+02 | -2.0E-02 | +8.0E-01 | 2.2E-02 | 8.7E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 141| +1.54E+02 | -1.8E-03 | +1.4E+00 | 1.7E-01 | 7.8E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 18| +2.50E+02 | +2.5E-06 | -8.0E-03 | 2.0E-03 | 2.4E-01 | 4.8E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 84| +1.48E+02 | +1.5E-04 | -2.3E+00 | 1.2E-02 | 5.4E-02 | 3.0E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 81| +1.48E+02 | +2.1E-03 | -1.3E+01 | 1.7E-01 | 6.4E-02 | 2.1E-02 | trr |0\n", + "2023-02-17 16:05:25 fides(INFO) 82| +1.38E+02 | -3.2E-04 | +8.1E-01 | 1.3E-02 | 4.4E-01 | 6.1E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 33| +1.48E+02 | -5.4E-03 | +5.8E-01 | 4.4E-02 | 2.6E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 24| +1.50E+02 | -3.2E-03 | +8.6E-01 | 1.7E-02 | 1.2E+00 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 19| +2.50E+02 | -1.6E-04 | +7.2E-01 | 4.9E-04 | 2.4E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 85| +1.48E+02 | -2.4E-06 | +1.0E-01 | 3.1E-03 | 5.4E-02 | 8.1E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 82| +1.48E+02 | +8.3E-05 | -1.2E+00 | 1.5E-02 | 6.4E-02 | 5.2E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 34| +1.48E+02 | -1.9E-03 | +8.6E-01 | 4.4E-02 | 3.0E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 20| +2.50E+02 | +2.0E-09 | -4.6E-04 | 4.9E-04 | 2.9E-02 | 1.2E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 83| +1.38E+02 | -5.3E-04 | +8.8E-01 | 2.7E-02 | 1.8E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 25| +1.50E+02 | -4.6E-03 | +9.1E-01 | 3.3E-02 | 1.4E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 142| +1.54E+02 | -1.0E-03 | +1.4E+00 | 1.7E-01 | 2.3E-01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 86| +1.48E+02 | -9.0E-06 | +8.1E-01 | 7.7E-04 | 1.3E-01 | 7.8E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 35| +1.48E+02 | -1.3E-03 | +5.8E-01 | 8.9E-02 | 7.3E-01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 83| +1.48E+02 | -7.3E-06 | +3.4E-01 | 3.7E-03 | 6.4E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:25.130 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 137.357 and h = 1.59524e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.130 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 137.357: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 40| +1.51E+02 | +0.0E+00 | +0.0E+00 | 7.6E-06 | 4.5E+00 | 1.7E-05 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 21| +2.50E+02 | -8.2E-07 | +1.7E-01 | 1.2E-04 | 2.9E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 84| +1.38E+02 | -3.0E-04 | +1.8E-01 | 5.3E-02 | 2.2E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 87| +1.48E+02 | -6.9E-06 | +8.7E-01 | 1.5E-03 | 2.7E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 26| +1.50E+02 | -5.2E-03 | +8.9E-01 | 6.6E-02 | 1.7E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 36| +1.48E+02 | -6.0E-04 | +6.7E-01 | 8.9E-02 | 1.6E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 84| +1.48E+02 | -1.8E-06 | +7.3E-01 | 3.7E-03 | 1.3E-01 | 2.7E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 22| +2.50E+02 | -1.1E-06 | +8.8E-01 | 3.1E-05 | 2.3E-02 | 5.9E-05 | 2d |1\n", + "2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 1.08E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:25 fides(INFO) 88| +1.48E+02 | -6.1E-06 | +9.5E-01 | 3.1E-03 | 2.1E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 37| +1.48E+02 | +3.6E-04 | -4.3E-01 | 8.9E-02 | 3.6E-01 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 85| +1.48E+02 | -2.1E-06 | +3.2E+01 | 3.7E-03 | 1.1E-02 | 2.2E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 27| +1.50E+02 | -2.7E-03 | +6.6E-01 | 1.3E-01 | 9.8E-01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 143| +1.54E+02 | -6.4E-04 | +1.3E+00 | 3.3E-01 | 5.7E-01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 85| +1.38E+02 | -8.7E-04 | +3.8E-01 | 1.3E-02 | 4.6E-01 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 89| +1.48E+02 | -4.8E-06 | +5.7E-01 | 6.2E-03 | 3.0E-02 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 86| +1.48E+02 | +2.4E-06 | -4.6E+01 | 7.5E-03 | 7.2E-03 | 4.1E-04 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 28| +1.50E+02 | -2.5E-04 | +1.6E-01 | 1.3E-01 | 1.1E+00 | 2.6E-02 | trr |1\n", + "2023-02-17 16:05:25 fides(INFO) 38| +1.48E+02 | -1.9E-04 | +7.0E-01 | 2.2E-02 | 3.6E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 86| +1.38E+02 | -3.5E-04 | +5.9E-01 | 1.3E-02 | 7.5E-01 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 90| +1.48E+02 | +2.6E-04 | -6.1E+00 | 6.2E-03 | 3.6E-02 | 3.9E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 144| +1.54E+02 | -3.3E-04 | +1.3E+00 | 3.3E-01 | 1.9E-01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 87| +1.48E+02 | -2.2E-06 | +1.0E+02 | 1.9E-03 | 7.2E-03 | 1.0E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 29| +1.50E+02 | -8.3E-04 | +5.2E-01 | 3.0E-02 | 1.8E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 41| +1.51E+02 | -1.8E-05 | +9.7E-01 | 1.9E-06 | 4.5E+00 | 4.3E-06 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 39| +1.48E+02 | -6.3E-05 | +9.4E-01 | 2.2E-02 | 5.1E-01 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 0| +1.23E+14 | NaN | NaN | 1.0E+00 | 5.6E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:25 fides(INFO) 87| +1.38E+02 | -2.5E-04 | +7.5E-01 | 1.3E-02 | 1.9E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 91| +1.48E+02 | +9.5E-05 | -3.5E+00 | 1.5E-03 | 3.6E-02 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 88| +1.48E+02 | -2.4E-07 | +7.6E+00 | 3.7E-03 | 5.7E-03 | 2.0E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 2.41E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 30| +1.50E+02 | -7.7E-05 | +5.7E-01 | 3.0E-02 | 7.1E-01 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 40| +1.48E+02 | -5.6E-05 | +8.4E-01 | 4.4E-02 | 2.2E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 1| +9.94E+11 | -1.2E+14 | +8.2E-02 | 1.0E+00 | 5.6E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 92| +1.48E+02 | +2.8E-05 | -1.5E+00 | 3.9E-04 | 3.6E-02 | 8.5E-04 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 145| +1.54E+02 | -1.5E-04 | +1.4E+00 | 3.3E-01 | 1.8E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 88| +1.38E+02 | -4.1E-04 | +7.3E-01 | 2.7E-02 | 2.6E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 41| +1.48E+02 | -6.0E-05 | +7.6E-01 | 8.9E-02 | 2.7E-01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 31| +1.50E+02 | +3.6E-05 | -4.1E-01 | 3.0E-02 | 6.1E-02 | 6.7E-03 | trr |0\n", + "2023-02-17 16:05:25 fides(INFO) 2| +1.47E+11 | -8.5E+11 | +8.9E-01 | 2.5E-01 | 4.6E+12 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 93| +1.48E+02 | -1.7E-06 | +2.5E-01 | 9.6E-05 | 3.6E-02 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 3| +2.19E+10 | -1.3E+11 | +8.9E-01 | 5.0E-01 | 6.8E+11 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 146| +1.54E+02 | -9.2E-05 | +1.4E+00 | 3.3E-01 | 9.7E-02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 42| +1.48E+02 | +6.0E-04 | -3.3E+00 | 1.8E-01 | 1.3E-01 | 5.3E-02 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 32| +1.50E+02 | -2.9E-05 | +7.7E-01 | 6.3E-03 | 6.1E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 89| +1.38E+02 | -1.5E-04 | +1.6E-01 | 2.7E-02 | 2.0E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 4| +3.26E+09 | -1.9E+10 | +8.9E-01 | 5.0E-01 | 1.0E+11 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:25.403 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 85.3984 and h = 1.13613e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.403 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 85.3984: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) 42| +1.51E+02 | +0.0E+00 | +0.0E+00 | 3.8E-06 | 4.5E+00 | 8.7E-06 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 5| +4.90E+08 | -2.8E+09 | +8.9E-01 | 5.0E-01 | 1.5E+10 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 94| +1.48E+02 | -3.3E-06 | +1.2E+01 | 2.4E-05 | 4.5E-02 | 1.3E-05 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 43| +1.48E+02 | -5.1E-06 | +7.7E-02 | 4.4E-02 | 1.3E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 6| +7.38E+07 | -4.2E+08 | +8.9E-01 | 5.0E-01 | 2.3E+09 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 0| +2.27E+09 | NaN | NaN | 1.0E+00 | 1.0E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:25 fides(INFO) 147| +1.54E+02 | -4.9E-05 | +1.4E+00 | 3.3E-01 | 2.1E-02 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 33| +1.50E+02 | -1.1E-05 | +8.4E-01 | 1.3E-02 | 1.4E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 90| +1.38E+02 | -4.6E-04 | +6.0E-01 | 6.7E-03 | 3.9E-01 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 95| +1.48E+02 | +4.0E-06 | -2.2E+01 | 4.8E-05 | 1.4E-02 | 2.8E-05 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 7| +1.12E+07 | -6.3E+07 | +8.9E-01 | 5.0E-01 | 3.4E+08 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 44| +1.48E+02 | -3.1E-05 | +7.5E-01 | 1.1E-02 | 2.4E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 8| +1.70E+06 | -9.5E+06 | +8.9E-01 | 5.0E-01 | 5.1E+07 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 34| +1.50E+02 | -2.3E-06 | +5.8E-01 | 2.5E-02 | 7.8E-02 | 7.5E-04 | trr |1\n", + "2023-02-17 16:05:25 fides(INFO) 96| +1.48E+02 | +2.7E-06 | -1.6E+01 | 1.2E-05 | 1.4E-02 | 2.5E-05 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 148| +1.54E+02 | -2.6E-05 | +1.4E+00 | 3.3E-01 | 9.4E-03 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 1| +1.35E+06 | -2.3E+09 | +9.7E-02 | 1.0E+00 | 1.0E+10 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 45| +1.48E+02 | -9.5E-06 | +7.1E-01 | 2.2E-02 | 6.8E-02 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 9| +2.61E+05 | -1.4E+06 | +8.9E-01 | 5.0E-01 | 7.8E+06 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 97| +1.48E+02 | +3.7E-06 | -4.7E+01 | 3.0E-06 | 1.4E-02 | 7.1E-06 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 91| +1.38E+02 | -1.1E-04 | +9.8E-01 | 6.7E-03 | 3.1E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 2| +2.13E+05 | -1.1E+06 | +9.0E-01 | 2.5E-01 | 6.4E+06 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 35| +1.50E+02 | +2.5E-06 | -5.7E-01 | 2.5E-02 | 2.0E-02 | 1.5E-03 | trr |0\n", + "2023-02-17 16:05:25 fides(INFO) 149| +1.54E+02 | -1.4E-05 | +1.4E+00 | 3.3E-01 | 9.2E-03 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 10| +4.03E+04 | -2.2E+05 | +9.0E-01 | 5.0E-01 | 1.2E+06 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 46| +1.48E+02 | -6.7E-06 | +1.2E+00 | 2.2E-02 | 5.2E-02 | 5.8E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 3| +3.59E+04 | -1.8E+05 | +9.0E-01 | 5.0E-01 | 9.9E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 98| +1.48E+02 | +2.4E-06 | -1.1E+02 | 7.5E-07 | 1.4E-02 | 1.8E-06 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 92| +1.38E+02 | -2.4E-04 | +1.0E+00 | 1.3E-02 | 1.3E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 36| +1.50E+02 | -1.6E-06 | +8.4E-01 | 4.0E-04 | 2.0E-02 | 3.8E-04 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 47| +1.48E+02 | -5.3E-06 | +6.6E-01 | 4.4E-02 | 5.8E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 4| +5.68E+03 | -3.0E+04 | +9.0E-01 | 1.0E+00 | 1.6E+05 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 11| +6.40E+03 | -3.4E+04 | +9.0E-01 | 5.0E-01 | 1.8E+05 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:25.573 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 114.461 and h = 1.42314e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.573 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 114.461: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 150| +1.54E+02 | -7.9E-06 | +1.4E+00 | 3.3E-01 | 5.7E-03 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 43| +1.51E+02 | +0.0E+00 | +0.0E+00 | 9.5E-07 | 4.5E+00 | 2.2E-06 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 99| +1.48E+02 | +3.0E-06 | -5.4E+02 | 1.9E-07 | 1.4E-02 | 4.4E-07 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 5| +1.04E+03 | -4.6E+03 | +9.0E-01 | 1.0E+00 | 2.4E+04 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:25.590 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 168.763 and h = 2.32709e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.590 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 168.763: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) 93| +1.38E+02 | -4.2E-04 | +9.8E-01 | 2.7E-02 | 4.6E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 37| +1.50E+02 | +0.0E+00 | +0.0E+00 | 7.9E-04 | 1.1E-02 | 3.5E-04 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 48| +1.48E+02 | -7.0E-06 | +1.2E+00 | 4.4E-02 | 3.3E-02 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 12| +1.18E+03 | -5.2E+03 | +9.0E-01 | 5.0E-01 | 2.9E+04 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 6| +3.31E+02 | -7.1E+02 | +9.0E-01 | 1.0E+00 | 3.9E+03 | 7.6E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 151| +1.54E+02 | -4.2E-06 | +1.3E+00 | 3.3E-01 | 3.9E-03 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 100| +1.48E+02 | -5.3E-08 | +3.8E+01 | 4.7E-08 | 1.4E-02 | 1.1E-07 | 2d |1\n", + "2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 5.31E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:25 fides(INFO) 13| +3.70E+02 | -8.1E+02 | +9.0E-01 | 5.0E-01 | 4.5E+03 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 38| +1.50E+02 | -1.7E-07 | +8.8E-01 | 2.0E-04 | 1.1E-02 | 8.9E-05 | 2d |1\n", + "2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 1.74E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:25 fides(INFO) 94| +1.38E+02 | -6.3E-04 | +7.2E-01 | 5.3E-02 | 1.1E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 49| +1.48E+02 | +4.9E-06 | -5.2E-01 | 8.9E-02 | 3.7E-02 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 7| +2.31E+02 | -1.0E+02 | +8.7E-01 | 1.0E+00 | 6.2E+02 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 14| +2.52E+02 | -1.2E+02 | +8.8E-01 | 5.0E-01 | 6.9E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 152| +1.54E+02 | -2.1E-06 | +1.3E+00 | 3.3E-01 | 2.0E-03 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 50| +1.48E+02 | +7.5E-07 | -2.5E-01 | 2.2E-02 | 3.7E-02 | 4.6E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 95| +1.38E+02 | +9.1E-03 | -2.5E+00 | 5.3E-02 | 2.5E-01 | 2.5E-02 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 15| +2.40E+02 | -1.2E+01 | +7.3E-01 | 1.0E+00 | 9.1E+01 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 8| +2.04E+02 | -2.7E+01 | +1.1E+00 | 2.0E+00 | 1.1E+02 | 3.7E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 153| +1.54E+02 | -6.1E-07 | +8.8E-01 | 3.3E-01 | 1.2E-03 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 6.15E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:25 fides(INFO) 51| +1.48E+02 | +2.3E-07 | -2.4E-01 | 5.5E-03 | 3.7E-02 | 1.1E-03 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 16| +2.32E+02 | -8.6E+00 | +1.1E+00 | 1.0E+00 | 1.7E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 96| +1.38E+02 | -1.4E-04 | +1.4E-01 | 1.3E-02 | 2.5E-01 | 6.3E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 9| +2.04E+02 | +1.3E+03 | -5.7E+01 | 4.0E+00 | 4.6E+01 | 4.4E+00 | trr |0\n", + "2023-02-17 16:05:25.751 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 95.8575 and h = 1.32106e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.752 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 95.8575: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) 44| +1.51E+02 | +0.0E+00 | +0.0E+00 | 2.4E-07 | 4.5E+00 | 5.4E-07 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 17| +2.22E+02 | -9.5E+00 | +2.3E-01 | 2.0E+00 | 4.5E+01 | 4.4E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 52| +1.48E+02 | +3.1E-06 | -8.0E+00 | 1.4E-03 | 3.7E-02 | 2.8E-04 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 0| +7.56E+07 | NaN | NaN | 1.0E+00 | 3.5E+08 | NaN | NaN |1\n", + "2023-02-17 16:05:25 fides(INFO) 18| +2.05E+02 | -1.7E+01 | +9.8E-01 | 5.0E-01 | 5.7E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 53| +1.48E+02 | +9.8E-07 | -4.0E+00 | 3.5E-04 | 3.7E-02 | 7.2E-05 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 10| +2.04E+02 | +2.9E+01 | -1.7E+00 | 6.1E-01 | 4.6E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 97| +1.38E+02 | -2.1E-04 | +8.1E-01 | 3.3E-03 | 4.0E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 0| +2.91E+12 | NaN | NaN | 1.0E+00 | 1.3E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:25 fides(INFO) 54| +1.48E+02 | +3.3E-06 | -1.6E+01 | 8.7E-05 | 3.7E-02 | 2.1E-05 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 1| +1.15E+03 | -7.6E+07 | +1.0E-01 | 1.0E+00 | 3.5E+08 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 19| +2.05E+02 | +3.0E+02 | -1.6E+01 | 1.0E+00 | 3.0E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 11| +1.95E+02 | -9.4E+00 | +9.2E-01 | 1.5E-01 | 4.6E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 98| +1.38E+02 | -1.5E-04 | +7.3E-01 | 6.7E-03 | 1.9E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 55| +1.48E+02 | +1.8E-06 | -9.2E+00 | 2.2E-05 | 3.7E-02 | 1.3E-05 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 2| +4.22E+02 | -7.3E+02 | +8.9E-01 | 2.5E-01 | 3.0E+03 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 20| +1.93E+02 | -1.3E+01 | +1.1E+00 | 2.5E-01 | 3.0E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 0| +2.93E+04 | NaN | NaN | 1.0E+00 | 1.3E+05 | NaN | NaN |1\n", + "2023-02-17 16:05:25 fides(INFO) 1| +1.31E+08 | -2.9E+12 | +8.7E-02 | 1.0E+00 | 1.3E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 12| +1.84E+02 | -1.1E+01 | +7.4E-01 | 3.0E-01 | 5.2E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 3| +2.61E+02 | -1.6E+02 | +8.8E-01 | 5.0E-01 | 5.4E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 99| +1.38E+02 | -8.6E-05 | +9.8E-01 | 6.7E-03 | 1.3E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 56| +1.48E+02 | +1.6E-06 | -8.3E+00 | 5.4E-06 | 3.7E-02 | 9.9E-06 | 2d |0\n", + "2023-02-17 16:05:25.897 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 100 and h = 1.26382e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.897 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 100: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) 45| +1.51E+02 | +0.0E+00 | +0.0E+00 | 6.0E-08 | 4.5E+00 | 1.4E-07 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 21| +1.93E+02 | -1.0E+01 | -3.3E-02 | 5.0E-01 | 4.8E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 1| +4.30E+02 | -2.9E+04 | +1.2E-01 | 1.0E+00 | 1.3E+05 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 4| +2.55E+02 | -6.8E+00 | +2.9E-01 | 1.0E+00 | 7.7E+01 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 57| +1.48E+02 | +3.5E-07 | -4.8E+00 | 1.4E-06 | 3.7E-02 | 2.5E-06 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 13| +1.77E+02 | -7.0E+00 | +4.1E-01 | 3.0E-01 | 8.9E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 22| +1.84E+02 | -8.9E+00 | +1.1E+00 | 1.2E-01 | 4.8E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 5| +2.42E+02 | -1.3E+01 | +1.2E+00 | 1.0E+00 | 5.6E+01 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 2| +2.22E+07 | -1.1E+08 | +8.9E-01 | 2.5E-01 | 5.9E+08 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:25 fides(INFO) 100| +1.38E+02 | -1.7E-04 | +9.9E-01 | 1.3E-02 | 7.1E-02 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 2| +3.86E+02 | -4.4E+01 | +9.8E-01 | 2.5E-01 | 6.2E+01 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:25.952 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1525 and h = 2.26931e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:25.952 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1525: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:25 fides(INFO) 58| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.4E-07 | 3.7E-02 | 6.2E-07 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 14| +1.69E+02 | -8.1E+00 | +8.9E-01 | 3.0E-01 | 1.1E+02 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 6| +2.42E+02 | +3.1E+02 | -1.0E+01 | 2.0E+00 | 2.7E+01 | 3.9E+00 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 23| +1.68E+02 | -1.5E+01 | +9.7E-01 | 2.5E-01 | 5.6E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 3| +3.17E+02 | -6.8E+01 | +8.3E-01 | 5.0E-01 | 5.8E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 59| +1.48E+02 | +2.8E-08 | -5.6E+00 | 8.5E-08 | 3.7E-02 | 1.5E-07 | 2d |0\n", + "2023-02-17 16:05:25 fides(INFO) 101| +1.38E+02 | -3.3E-04 | +9.9E-01 | 2.7E-02 | 1.3E-01 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:25 fides(INFO) 7| +2.13E+02 | -2.9E+01 | +1.5E+00 | 5.0E-01 | 2.7E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 15| +1.63E+02 | -5.7E+00 | +4.1E-01 | 6.1E-01 | 5.5E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 3| +4.98E+06 | -1.7E+07 | +9.0E-01 | 5.0E-01 | 9.1E+07 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 24| +1.55E+02 | -1.3E+01 | +6.9E-01 | 5.0E-01 | 7.3E+01 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 4| +2.26E+02 | -9.2E+01 | +8.5E-01 | 1.0E+00 | 8.9E+01 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 60| +1.48E+02 | +3.1E-06 | -2.4E+03 | 2.1E-08 | 3.7E-02 | 3.9E-08 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 16| +1.58E+02 | -5.4E+00 | +9.5E-01 | 6.1E-01 | 1.7E+02 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 8| +1.99E+02 | -1.5E+01 | +1.2E+00 | 1.0E+00 | 5.0E+01 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 102| +1.38E+02 | -6.2E-04 | +9.6E-01 | 5.3E-02 | 7.0E-02 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 25| +1.53E+02 | -2.5E+00 | +2.0E-01 | 5.0E-01 | 5.7E+01 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 61| +1.48E+02 | +1.3E-06 | -4.1E+03 | 5.3E-09 | 3.7E-02 | 9.7E-09 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 4| +8.59E+05 | -4.1E+06 | +9.0E-01 | 1.0E+00 | 1.6E+07 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 17| +1.58E+02 | +1.8E+01 | -3.5E+00 | 1.2E+00 | 3.4E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 5| +2.26E+02 | +5.5E+02 | -2.1E+01 | 2.0E+00 | 2.7E+01 | 5.1E+00 | trr |0\n", + "2023-02-17 16:05:26 fides(INFO) 103| +1.38E+02 | +2.9E-03 | -2.1E+00 | 1.1E-01 | 8.4E-02 | 3.3E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 26| +1.48E+02 | -4.2E+00 | +6.1E-01 | 1.1E-01 | 6.8E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 46| +1.51E+02 | -1.3E-07 | +8.7E-01 | 1.5E-08 | 4.5E+00 | 3.4E-08 | 2d |1\n", + "2023-02-17 16:05:26 fides(WARNING) Stopping as function difference 1.29E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:26 fides(INFO) 18| +1.55E+02 | -3.1E+00 | +8.8E-01 | 2.1E-01 | 3.4E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 9| +1.99E+02 | +5.3E+04 | -1.3E+03 | 2.0E+00 | 5.0E+01 | 4.7E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 62| +1.48E+02 | +5.8E-07 | -7.3E+03 | 1.3E-09 | 3.7E-02 | 2.4E-09 | 2d |0\n", + "2023-02-17 16:05:26.114 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 201.089 and h = 7.23664e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:26.115 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 201.089: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:26 fides(INFO) 27| +1.48E+02 | +1.3E+00 | -9.5E-01 | 1.1E-01 | 3.1E+01 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 6| +2.26E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 2.7E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 5| +1.43E+05 | -7.2E+05 | +9.0E-01 | 2.0E+00 | 2.8E+06 | 2.3E+00 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 63| +1.48E+02 | +2.9E-06 | -1.5E+05 | 3.3E-10 | 3.7E-02 | 6.0E-10 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 104| +1.38E+02 | -1.3E-04 | +3.0E-01 | 2.7E-02 | 8.4E-02 | 8.3E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 19| +1.50E+02 | -4.7E+00 | +1.1E+00 | 4.3E-01 | 6.0E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 10| +1.61E+02 | -3.7E+01 | +1.1E+00 | 5.0E-01 | 5.0E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 7| +2.21E+02 | -4.9E+00 | +8.1E-01 | 1.2E-01 | 2.7E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 28| +1.48E+02 | -4.9E-01 | +6.8E-01 | 2.8E-02 | 3.1E+01 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 64| +1.48E+02 | +2.7E-06 | -5.3E+05 | 8.3E-11 | 3.7E-02 | 1.5E-10 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 20| +1.50E+02 | +4.7E-01 | -2.8E-01 | 8.5E-01 | 1.5E+01 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 8| +2.08E+02 | -1.2E+01 | +1.4E+00 | 2.5E-01 | 2.0E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 105| +1.38E+02 | +4.1E-03 | -2.1E+00 | 2.7E-02 | 2.1E-01 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 11| +1.56E+02 | -4.6E+00 | +9.5E-01 | 1.0E+00 | 9.1E+01 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 29| +1.48E+02 | -2.1E-01 | +9.2E-01 | 2.8E-02 | 2.5E+01 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 6| +2.37E+04 | -1.2E+05 | +9.0E-01 | 2.0E+00 | 4.7E+05 | 3.6E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 65| +1.48E+02 | +2.7E-06 | -2.2E+06 | 2.1E-11 | 3.7E-02 | 3.8E-11 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 21| +1.49E+02 | -1.1E+00 | +8.3E-01 | 1.3E-01 | 1.5E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 9| +2.08E+02 | -1.5E+00 | -1.2E-01 | 5.0E-01 | 3.3E+01 | 8.1E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 0| +1.12E+14 | NaN | NaN | 1.0E+00 | 5.2E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:26 fides(INFO) 12| +1.56E+02 | +7.5E+01 | -7.0E+00 | 2.0E+00 | 8.2E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 106| +1.38E+02 | +6.0E-04 | -7.9E-01 | 6.7E-03 | 2.1E-01 | 5.7E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 30| +1.48E+02 | -8.9E-02 | +8.5E-01 | 5.7E-02 | 1.0E+01 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 66| +1.48E+02 | +2.9E-06 | -9.2E+06 | 5.2E-12 | 3.7E-02 | 9.4E-12 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 10| +2.02E+02 | -6.1E+00 | +9.3E-01 | 1.2E-01 | 3.3E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 1| +8.83E+08 | -1.1E+14 | +8.3E-02 | 1.0E+00 | 5.2E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 22| +1.49E+02 | +2.3E+01 | -9.5E+00 | 2.6E-01 | 1.0E+01 | 4.8E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 13| +1.51E+02 | -5.3E+00 | +7.2E-01 | 1.9E-01 | 8.2E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 31| +1.48E+02 | +4.5E-01 | -5.9E+00 | 1.1E-01 | 6.9E+00 | 3.2E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 107| +1.38E+02 | +6.3E-05 | -1.6E-01 | 1.7E-03 | 2.1E-01 | 3.1E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 67| +1.48E+02 | +2.1E-06 | -2.7E+07 | 1.3E-12 | 3.7E-02 | 2.4E-12 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 11| +1.93E+02 | -9.1E+00 | +9.1E-01 | 2.5E-01 | 4.4E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:26.296 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 93.9924 and h = 1.89086e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:26.296 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 93.9924: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:26 fides(INFO) 23| +1.49E+02 | +1.5E-02 | -4.4E-02 | 6.5E-02 | 1.0E+01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 14| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.9E-01 | 9.0E+01 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 32| +1.48E+02 | +4.8E-04 | -1.8E-02 | 2.8E-02 | 6.9E+00 | 7.9E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 108| +1.38E+02 | -1.1E-04 | +7.5E-01 | 4.2E-04 | 2.1E-01 | 8.8E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 68| +1.48E+02 | +2.5E-06 | -1.3E+08 | 3.2E-13 | 3.7E-02 | 5.9E-13 | 2d |0\n", + "2023-02-17 16:05:26.333 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 149.627 and h = 2.79486e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:26.333 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 149.627: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:26 fides(INFO) 24| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 1.0E+01 | 3.1E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 15| +1.50E+02 | -1.4E+00 | +9.4E-01 | 4.7E-02 | 9.0E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 12| +1.81E+02 | -1.2E+01 | +8.2E-01 | 5.0E-01 | 5.6E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 2| +1.73E+08 | -7.1E+08 | +8.9E-01 | 2.5E-01 | 3.8E+09 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 7| +3.98E+03 | -2.0E+04 | +9.1E-01 | 4.0E+00 | 7.7E+04 | 1.9E+00 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 33| +1.48E+02 | -1.0E-02 | +8.0E-01 | 7.1E-03 | 6.9E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 69| +1.48E+02 | +2.7E-06 | -5.5E+08 | 8.1E-14 | 3.7E-02 | 1.5E-13 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 25| +1.49E+02 | -5.8E-02 | +9.4E-01 | 4.1E-03 | 1.0E+01 | 8.1E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 109| +1.38E+02 | -2.5E-05 | +9.9E-01 | 4.2E-04 | 4.1E-01 | 1.6E-04 | 2d |1\n", + "2023-02-17 16:05:26.373 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 110.183 and h = 2.72528e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:26 fides(INFO) 16| +1.49E+02 | -7.5E-01 | +6.9E-01 | 9.4E-02 | 4.8E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:26.374 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 110.183: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:26 fides(INFO) 13| +1.81E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 7.6E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 34| +1.48E+02 | -6.1E-03 | +9.6E-01 | 1.4E-02 | 3.4E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 3| +3.61E+07 | -1.4E+08 | +9.1E-01 | 5.0E-01 | 6.1E+08 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 70| +1.48E+02 | +2.6E-06 | -2.2E+09 | 2.0E-14 | 3.7E-02 | 3.7E-14 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 26| +1.49E+02 | -9.6E-02 | +9.2E-01 | 8.1E-03 | 9.2E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 110| +1.38E+02 | +1.9E-05 | -1.5E-01 | 8.3E-04 | 1.2E-01 | 1.8E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 8| +3.98E+03 | +2.9E+07 | -4.3E+04 | 4.0E+00 | 1.2E+04 | 4.0E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 17| +1.48E+02 | -6.0E-01 | +9.6E-01 | 9.4E-02 | 5.3E+01 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 14| +1.76E+02 | -5.2E+00 | +7.9E-01 | 2.5E-01 | 7.6E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 35| +1.48E+02 | -9.4E-03 | +8.1E-01 | 2.8E-02 | 3.3E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 71| +1.48E+02 | +1.6E-06 | -5.3E+09 | 5.0E-15 | 3.7E-02 | 9.2E-15 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 4| +5.59E+06 | -3.1E+07 | +8.9E-01 | 1.0E+00 | 1.2E+08 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 27| +1.49E+02 | -1.1E-01 | +6.8E-01 | 1.6E-02 | 9.8E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 18| +1.48E+02 | -4.1E-01 | +6.9E-01 | 1.9E-01 | 3.0E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 15| +1.73E+02 | -2.9E+00 | +8.6E-01 | 5.0E-01 | 5.1E+01 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 111| +1.38E+02 | -3.0E-05 | +7.7E-01 | 2.1E-04 | 1.2E-01 | 4.6E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 36| +1.48E+02 | +2.9E-02 | -4.5E+00 | 5.7E-02 | 5.5E-01 | 7.5E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 72| +1.48E+02 | +8.8E-07 | -1.2E+10 | 1.3E-15 | 3.7E-02 | 2.3E-15 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 28| +1.49E+02 | -9.7E-02 | +9.9E-01 | 1.6E-02 | 6.3E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 5| +8.13E+05 | -4.8E+06 | +9.0E-01 | 2.0E+00 | 1.8E+07 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 19| +1.48E+02 | +2.1E-01 | -3.7E-01 | 1.9E-01 | 3.0E+01 | 2.4E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 37| +1.48E+02 | +2.2E-04 | -1.1E-01 | 1.4E-02 | 5.5E-01 | 1.9E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 73| +1.48E+02 | +2.8E-06 | -1.4E+11 | 3.2E-16 | 3.7E-02 | 5.8E-16 | 2d |0\n", + "2023-02-17 16:05:26 fides(WARNING) Stopping as trust region radius 7.88E-17 is smaller than machine precision.\n", + "2023-02-17 16:05:26 fides(INFO) 16| +1.72E+02 | -9.8E-01 | +8.3E-01 | 1.0E+00 | 2.6E+01 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 112| +1.38E+02 | -9.3E-06 | +1.0E+00 | 4.2E-04 | 1.9E-01 | 1.3E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 20| +1.48E+02 | -1.8E-01 | +7.7E-01 | 4.7E-02 | 3.0E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 29| +1.48E+02 | -1.4E-01 | +9.6E-01 | 3.2E-02 | 1.2E+01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 38| +1.48E+02 | -4.4E-04 | +7.1E-01 | 3.5E-03 | 5.5E-01 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 6| +1.19E+05 | -6.9E+05 | +9.0E-01 | 2.0E+00 | 2.8E+06 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 113| +1.38E+02 | -1.2E-05 | +9.3E-01 | 8.3E-04 | 7.9E-02 | 2.6E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 30| +1.48E+02 | -2.6E-01 | +9.8E-01 | 6.5E-02 | 5.8E+00 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 21| +1.48E+02 | -1.0E-01 | +8.8E-01 | 9.4E-02 | 1.6E+01 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 17| +1.71E+02 | -6.7E-01 | +7.0E-01 | 2.0E+00 | 1.5E+01 | 1.0E+00 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 39| +1.48E+02 | +7.8E-05 | -1.8E-01 | 3.5E-03 | 5.8E-01 | 9.0E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 9| +8.88E+02 | -3.1E+03 | +8.6E-01 | 7.6E-01 | 1.2E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 7| +1.79E+04 | -1.0E+05 | +9.0E-01 | 2.0E+00 | 4.3E+05 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 22| +1.48E+02 | -7.5E-02 | +7.7E-01 | 1.9E-01 | 1.6E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 31| +1.48E+02 | -2.5E-01 | +7.2E-01 | 1.3E-01 | 1.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 114| +1.38E+02 | -2.0E-05 | +9.2E-01 | 1.7E-03 | 1.1E-01 | 4.9E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 40| +1.48E+02 | -1.1E-04 | +7.4E-01 | 8.8E-04 | 5.8E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 18| +1.71E+02 | -8.7E-02 | +4.2E-01 | 2.0E+00 | 2.1E+01 | 2.5E-01 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 23| +1.48E+02 | +1.0E+00 | -5.4E+00 | 3.8E-01 | 7.1E+00 | 3.7E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 8| +2.80E+03 | -1.5E+04 | +9.0E-01 | 2.0E+00 | 6.7E+04 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 32| +1.48E+02 | +5.2E-01 | -1.0E+00 | 1.3E-01 | 5.8E+00 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 0| +7.69E+12 | NaN | NaN | 1.0E+00 | 3.5E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:26 fides(INFO) 115| +1.38E+02 | -3.9E-05 | +1.0E+00 | 3.3E-03 | 7.0E-02 | 9.6E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 41| +1.48E+02 | -2.5E-05 | +7.3E-01 | 8.8E-04 | 2.7E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 24| +1.48E+02 | -9.4E-03 | +8.2E-02 | 9.4E-02 | 7.1E+00 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 19| +1.71E+02 | -2.1E-03 | +1.3E-02 | 2.0E+00 | 6.5E+00 | 4.3E-01 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 33| +1.48E+02 | -9.3E-02 | +3.4E-01 | 3.2E-02 | 5.8E+00 | 6.9E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 9| +5.59E+02 | -2.2E+03 | +9.1E-01 | 2.0E+00 | 1.1E+04 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 42| +1.48E+02 | -1.5E-05 | +1.1E+00 | 8.8E-04 | 2.2E-01 | 3.7E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 116| +1.38E+02 | -7.0E-05 | +9.8E-01 | 6.7E-03 | 7.5E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 25| +1.48E+02 | -3.0E-02 | +8.9E-01 | 2.4E-02 | 8.6E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 34| +1.48E+02 | -9.3E-02 | +5.2E-01 | 3.2E-02 | 6.4E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 1| +8.84E+10 | -7.6E+12 | +8.6E-02 | 1.0E+00 | 3.5E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 10| +2.39E+02 | -3.2E+02 | +9.2E-01 | 2.0E+00 | 1.7E+03 | 5.7E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 20| +1.71E+02 | -5.0E-02 | +6.7E-01 | 1.5E-01 | 7.6E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 43| +1.48E+02 | -1.3E-05 | +8.4E-01 | 1.8E-03 | 1.8E-01 | 2.2E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 26| +1.48E+02 | -1.0E-02 | +2.2E-01 | 4.7E-02 | 3.3E+00 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 35| +1.48E+02 | -4.0E-02 | +9.7E-01 | 3.2E-02 | 5.5E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 117| +1.38E+02 | -1.4E-04 | +9.9E-01 | 1.3E-02 | 6.5E-02 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 44| +1.48E+02 | -8.8E-06 | +6.8E-01 | 3.5E-03 | 1.4E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 21| +1.71E+02 | -5.9E-03 | +8.5E-01 | 1.5E-01 | 4.6E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 11| +2.39E+02 | +7.4E+01 | -1.7E+00 | 4.0E+00 | 2.7E+02 | 8.5E+00 | trr |0\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 10| +2.85E+02 | -6.0E+02 | +9.2E-01 | 1.5E+00 | 2.6E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 36| +1.48E+02 | -6.2E-02 | +9.5E-01 | 6.5E-02 | 2.1E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 2| +1.32E+10 | -7.5E+10 | +8.9E-01 | 2.5E-01 | 4.1E+11 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 27| +1.48E+02 | -1.3E-02 | +9.3E-01 | 1.2E-02 | 1.0E+01 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 118| +1.38E+02 | -2.7E-04 | +1.0E+00 | 2.7E-02 | 6.5E-02 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 45| +1.48E+02 | +2.4E-04 | -4.5E+00 | 3.5E-03 | 5.8E-02 | 6.0E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 22| +1.71E+02 | -3.4E-05 | +7.4E-02 | 2.9E-01 | 3.5E-01 | 1.5E-02 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 12| +1.96E+02 | -4.3E+01 | +9.1E-01 | 7.1E-01 | 2.7E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:26.755 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.898 and h = 2.79382e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:26 fides(INFO) 37| +1.48E+02 | -6.4E-02 | +7.6E-01 | 1.3E-01 | 3.7E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:26.755 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.898: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:26 fides(INFO) 28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-02 | 9.6E-01 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 3| +1.99E+09 | -1.1E+10 | +8.9E-01 | 5.0E-01 | 6.1E+10 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 46| +1.48E+02 | +2.3E-05 | -9.3E-01 | 8.8E-04 | 5.8E-02 | 1.5E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 13| +1.96E+02 | +2.8E+01 | -2.9E+00 | 1.4E+00 | 6.6E+01 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 119| +1.38E+02 | -4.7E-04 | +9.0E-01 | 5.3E-02 | 6.5E-02 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 4| +3.02E+08 | -1.7E+09 | +8.9E-01 | 5.0E-01 | 9.2E+09 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 29| +1.48E+02 | -6.8E-04 | +8.6E-01 | 5.9E-03 | 9.6E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 38| +1.48E+02 | +7.6E-01 | -5.7E+00 | 2.6E-01 | 2.5E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 23| +1.71E+02 | -3.2E-06 | +7.1E-03 | 2.9E-02 | 4.0E-01 | 3.5E-03 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) 47| +1.48E+02 | -3.7E-06 | +2.9E-01 | 2.2E-04 | 5.8E-02 | 4.0E-04 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 5| +4.59E+07 | -2.6E+08 | +8.9E-01 | 5.0E-01 | 1.4E+09 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 14| +1.84E+02 | -1.2E+01 | +1.0E+00 | 3.5E-01 | 6.6E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 30| +1.48E+02 | -5.9E-04 | +8.9E-01 | 1.2E-02 | 1.6E+00 | 6.7E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 120| +1.38E+02 | +1.4E-02 | -6.7E+00 | 1.1E-01 | 1.0E-01 | 3.3E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 11| +2.85E+02 | +3.6E+02 | -7.6E+00 | 1.5E+00 | 3.1E+02 | 2.2E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 39| +1.48E+02 | +4.4E-03 | -7.9E-02 | 5.5E-02 | 2.5E+00 | 4.2E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 24| +1.71E+02 | +1.4E-06 | -3.8E-03 | 2.8E-03 | 3.8E-01 | 3.8E-03 | trr |0\n", + "2023-02-17 16:05:26 fides(INFO) 48| +1.48E+02 | +2.7E-07 | -1.8E-01 | 2.2E-04 | 8.8E-02 | 1.5E-04 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 15| +1.83E+02 | -1.2E+00 | +1.6E-01 | 7.1E-01 | 1.9E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 6| +7.05E+06 | -3.9E+07 | +8.9E-01 | 5.0E-01 | 2.1E+08 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 31| +1.48E+02 | -4.6E-04 | +8.6E-01 | 2.4E-02 | 6.7E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 40| +1.48E+02 | -1.3E-02 | +5.9E-01 | 1.4E-02 | 2.5E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 121| +1.38E+02 | +4.9E-04 | -8.2E-01 | 2.7E-02 | 1.0E-01 | 8.3E-03 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 49| +1.48E+02 | -5.0E-06 | +4.4E+00 | 5.5E-05 | 8.8E-02 | 4.3E-05 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 16| +1.79E+02 | -3.4E+00 | +8.2E-01 | 1.8E-01 | 5.0E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 25| +1.71E+02 | -1.7E-04 | +7.8E-01 | 4.6E-04 | 3.8E-01 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 7| +1.09E+06 | -6.0E+06 | +9.0E-01 | 1.0E+00 | 3.2E+07 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 32| +1.48E+02 | -3.8E-04 | +9.3E-01 | 4.7E-02 | 1.1E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 41| +1.48E+02 | -8.9E-03 | +9.5E-01 | 1.4E-02 | 6.2E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 50| +1.48E+02 | +5.8E-06 | -1.8E+01 | 1.1E-04 | 2.2E-02 | 6.4E-05 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 17| +1.71E+02 | -8.0E+00 | +1.6E+00 | 3.5E-01 | 1.5E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 33| +1.48E+02 | -4.0E-04 | +8.7E-01 | 9.4E-02 | 4.7E-01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 8| +1.70E+05 | -9.2E+05 | +9.0E-01 | 1.0E+00 | 5.0E+06 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 26| +1.71E+02 | -3.4E-05 | +4.9E-01 | 9.3E-04 | 2.3E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 122| +1.38E+02 | -7.0E-05 | +4.2E-01 | 6.7E-03 | 1.0E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 42| +1.48E+02 | -9.9E-03 | +9.7E-01 | 2.7E-02 | 9.7E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 51| +1.48E+02 | +2.8E-06 | -1.4E+01 | 2.8E-05 | 2.2E-02 | 2.2E-05 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 18| +1.71E+02 | +3.0E+02 | -2.0E+01 | 7.1E-01 | 2.1E+01 | 1.6E+00 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 34| +1.48E+02 | +7.5E-04 | -1.0E+00 | 1.9E-01 | 6.7E-01 | 8.2E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 9| +2.68E+04 | -1.4E+05 | +9.0E-01 | 1.0E+00 | 7.8E+05 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 43| +1.48E+02 | -1.2E-02 | +7.9E-01 | 5.5E-02 | 2.6E+00 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 52| +1.48E+02 | +3.9E-06 | -2.4E+01 | 6.9E-06 | 2.2E-02 | 1.5E-05 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) 19| +1.62E+02 | -9.5E+00 | +1.2E+00 | 1.8E-01 | 2.1E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 123| +1.38E+02 | -8.0E-05 | +7.7E-01 | 6.7E-03 | 3.9E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 12| +2.47E+02 | -3.8E+01 | +7.3E-01 | 2.0E-01 | 3.1E+02 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 27| +1.71E+02 | -7.2E-07 | +3.4E-02 | 9.3E-04 | 7.9E-02 | 7.6E-04 | trr |1\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 10| +4.40E+03 | -2.2E+04 | +9.0E-01 | 1.0E+00 | 1.2E+05 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 35| +1.48E+02 | -1.6E-04 | +6.1E-01 | 4.7E-02 | 6.7E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 44| +1.48E+02 | +3.3E-02 | -1.1E+00 | 1.1E-01 | 1.1E+00 | 6.7E-02 | 2d |0\n", + "2023-02-17 16:05:26 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:26 fides(INFO) 20| +1.53E+02 | -8.3E+00 | +5.2E-01 | 3.5E-01 | 3.1E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:26 fides(INFO) 53| +1.48E+02 | +1.4E-06 | -1.6E+01 | 1.7E-06 | 2.2E-02 | 4.9E-06 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 124| +1.38E+02 | -1.1E-04 | +9.2E-01 | 1.3E-02 | 6.8E-02 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 11| +8.75E+02 | -3.5E+03 | +9.1E-01 | 1.0E+00 | 1.9E+04 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 28| +1.71E+02 | -9.9E-06 | +6.4E-01 | 1.4E-04 | 7.1E-02 | 3.4E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 36| +1.48E+02 | -8.3E-05 | +4.2E-01 | 4.7E-02 | 2.9E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 45| +1.48E+02 | -3.6E-03 | +3.1E-01 | 2.7E-02 | 1.1E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 12| +3.28E+02 | -5.5E+02 | +9.1E-01 | 1.0E+00 | 3.0E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 54| +1.48E+02 | +4.5E-06 | -1.7E+02 | 4.3E-07 | 2.2E-02 | 1.2E-06 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 21| +1.51E+02 | -2.4E+00 | +9.6E-01 | 3.5E-01 | 1.2E+02 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 125| +1.38E+02 | -1.1E-04 | +3.9E-01 | 2.7E-02 | 7.3E-02 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 37| +1.48E+02 | -7.3E-05 | +3.1E-01 | 4.7E-02 | 5.2E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 13| +2.49E+02 | -7.9E+01 | +9.0E-01 | 2.0E+00 | 4.7E+02 | 1.3E+00 | trr |1\n", + "2023-02-17 16:05:27 fides(INFO) 29| +1.71E+02 | -8.2E-07 | +8.0E+00 | 1.4E-04 | 2.1E-02 | 2.3E-05 | trr |1\n", + "2023-02-17 16:05:27 fides(WARNING) Stopping as function difference 8.24E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:27 fides(INFO) 46| +1.48E+02 | -6.3E-03 | +4.6E-01 | 2.7E-02 | 3.9E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 55| +1.48E+02 | +7.1E-07 | -1.1E+02 | 1.1E-07 | 2.2E-02 | 3.1E-07 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 22| +1.51E+02 | +4.0E-01 | -2.8E-01 | 7.1E-01 | 6.6E+01 | 8.1E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 38| +1.48E+02 | +4.8E-05 | -1.8E-01 | 4.7E-02 | 2.2E-01 | 1.6E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 126| +1.38E+02 | +1.9E-03 | -1.4E+00 | 2.7E-02 | 2.1E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 14| +2.29E+02 | -1.9E+01 | +1.5E+00 | 2.0E+00 | 5.4E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 47| +1.48E+02 | -2.5E-03 | +3.4E-01 | 2.7E-02 | 9.6E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 56| +1.48E+02 | +3.7E-06 | -2.2E+03 | 2.7E-08 | 2.2E-02 | 7.7E-08 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 23| +1.49E+02 | -1.6E+00 | +7.3E-01 | 1.8E-01 | 6.6E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 39| +1.48E+02 | -5.2E-05 | +4.6E-01 | 1.2E-02 | 2.2E-01 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 15| +2.29E+02 | +6.1E+02 | -3.0E+01 | 2.0E+00 | 3.3E+01 | 3.5E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 13| +2.19E+02 | -2.8E+01 | +8.4E-01 | 2.0E-01 | 3.5E+02 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 127| +1.38E+02 | -1.5E-04 | +4.1E-01 | 6.7E-03 | 2.1E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 24| +1.48E+02 | -9.6E-01 | +9.8E-01 | 1.8E-01 | 6.9E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 48| +1.48E+02 | -3.0E-03 | +3.5E-01 | 2.7E-02 | 2.3E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 16| +2.08E+02 | -2.2E+01 | +7.3E-01 | 5.0E-01 | 3.3E+01 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 40| +1.48E+02 | -4.7E-05 | +8.9E-01 | 1.2E-02 | 6.1E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 57| +1.48E+02 | +4.0E-06 | -9.6E+03 | 6.7E-09 | 2.2E-02 | 1.9E-08 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 49| +1.48E+02 | +1.4E-03 | -1.9E-01 | 2.7E-02 | 8.8E-01 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 25| +1.48E+02 | -6.1E-01 | +8.2E-01 | 3.5E-01 | 2.9E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 0| +2.51E+02 | NaN | NaN | 1.0E+00 | 2.5E+01 | NaN | NaN |1\n", + "2023-02-17 16:05:27 fides(INFO) 128| +1.38E+02 | -6.6E-05 | +6.4E-01 | 6.7E-03 | 1.8E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:27.170 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0041 and h = 1.08836e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:27 fides(INFO) 17| +1.74E+02 | -3.4E+01 | +1.1E+00 | 5.0E-01 | 9.3E+01 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:27.171 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0041: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:27 fides(INFO) 41| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-02 | 8.5E-02 | 7.8E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 58| +1.48E+02 | +3.8E-06 | -3.6E+04 | 1.7E-09 | 2.2E-02 | 4.8E-09 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 50| +1.48E+02 | -1.3E-03 | +4.4E-01 | 6.8E-03 | 8.8E-01 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 26| +1.48E+02 | +4.7E+01 | -3.5E+01 | 7.1E-01 | 2.0E+01 | 1.7E+00 | trr |0\n", + "2023-02-17 16:05:27 fides(INFO) 42| +1.48E+02 | -1.7E-05 | +1.0E+00 | 5.9E-03 | 8.5E-02 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 1| +2.51E+02 | +2.0E+04 | -8.4E+02 | 1.0E+00 | 2.5E+01 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 129| +1.38E+02 | -5.4E-05 | +8.4E-01 | 6.7E-03 | 7.3E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 59| +1.48E+02 | +5.9E-06 | -2.3E+05 | 4.2E-10 | 2.2E-02 | 1.2E-09 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 18| +1.74E+02 | +6.4E+03 | -2.0E+02 | 1.0E+00 | 6.8E+01 | 2.0E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 51| +1.48E+02 | -1.3E-03 | +9.3E-01 | 6.8E-03 | 2.7E+00 | 6.0E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 27| +1.48E+02 | +1.3E+00 | -2.3E+00 | 1.8E-01 | 2.0E+01 | 4.2E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 43| +1.48E+02 | -1.3E-05 | +9.4E-01 | 1.2E-02 | 2.3E-01 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 2| +2.51E+02 | +2.4E+01 | -1.9E+00 | 2.5E-01 | 2.5E+01 | 6.1E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 19| +1.56E+02 | -1.7E+01 | +8.1E-01 | 2.5E-01 | 6.8E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 130| +1.38E+02 | -1.0E-04 | +9.2E-01 | 1.3E-02 | 7.2E-02 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 28| +1.48E+02 | -9.1E-02 | +4.6E-01 | 4.4E-02 | 2.0E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 52| +1.48E+02 | -8.8E-04 | +9.8E-01 | 1.4E-02 | 2.9E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 14| +2.17E+02 | -2.3E+00 | +5.5E-01 | 4.1E-01 | 1.8E+02 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 60| +1.48E+02 | +2.3E-06 | -3.4E+05 | 1.1E-10 | 2.2E-02 | 3.0E-10 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 44| +1.48E+02 | -1.3E-05 | +8.1E-01 | 2.4E-02 | 4.7E-02 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 131| +1.38E+02 | -8.7E-05 | +3.3E-01 | 2.7E-02 | 6.9E-02 | 6.1E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 20| +1.53E+02 | -3.2E+00 | +9.5E-01 | 5.0E-01 | 1.1E+02 | 1.6E+00 | trr |1\n", + "2023-02-17 16:05:27 fides(INFO) 53| +1.48E+02 | -1.4E-03 | +9.6E-01 | 2.7E-02 | 4.2E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 29| +1.48E+02 | -4.4E-02 | +4.4E-01 | 4.4E-02 | 8.9E+00 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 3| +2.49E+02 | -2.2E+00 | +6.1E-01 | 6.2E-02 | 2.5E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 61| +1.48E+02 | +3.9E-06 | -2.4E+06 | 2.6E-11 | 2.2E-02 | 7.5E-11 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 45| +1.48E+02 | -1.6E-05 | +5.7E-01 | 4.7E-02 | 1.4E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 54| +1.48E+02 | -1.7E-03 | +9.2E-01 | 5.5E-02 | 2.8E-01 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 21| +1.53E+02 | +7.2E-01 | -2.2E-01 | 1.0E+00 | 5.8E+01 | 7.4E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 30| +1.48E+02 | -2.2E-02 | +5.1E-01 | 4.4E-02 | 5.5E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 132| +1.38E+02 | +1.2E-02 | -5.8E+00 | 2.7E-02 | 1.7E-01 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 4| +2.49E+02 | -1.8E-01 | +6.1E-01 | 6.2E-02 | 5.3E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 62| +1.48E+02 | +4.5E-06 | -1.1E+07 | 6.6E-12 | 2.2E-02 | 1.9E-11 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 46| +1.48E+02 | +1.8E-05 | -4.3E-01 | 4.7E-02 | 6.3E-02 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 15| +2.16E+02 | -6.6E-01 | +7.3E-01 | 4.1E-01 | 1.6E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 22| +1.50E+02 | -2.6E+00 | +7.4E-01 | 2.5E-01 | 5.8E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 55| +1.48E+02 | +6.0E-03 | -4.5E+00 | 1.1E-01 | 1.3E-01 | 8.0E-02 | trr |0\n", + "2023-02-17 16:05:27 fides(INFO) 31| +1.48E+02 | -4.7E-03 | +7.7E-01 | 4.4E-02 | 2.8E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 63| +1.48E+02 | +4.3E-06 | -4.2E+07 | 1.6E-12 | 2.2E-02 | 4.7E-12 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 133| +1.38E+02 | +3.1E-03 | -3.3E+00 | 6.7E-03 | 1.7E-01 | 9.3E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 47| +1.48E+02 | -4.0E-06 | +2.3E-01 | 1.2E-02 | 6.3E-02 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 5| +2.49E+02 | -2.8E-01 | +7.8E-01 | 6.2E-02 | 5.7E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 56| +1.48E+02 | -1.2E-04 | +2.0E-01 | 2.7E-02 | 1.3E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 23| +1.49E+02 | -1.4E+00 | +9.5E-01 | 2.5E-01 | 8.6E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 64| +1.48E+02 | +4.0E-06 | -1.6E+08 | 4.1E-13 | 2.2E-02 | 1.2E-12 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 32| +1.48E+02 | -2.6E-03 | +4.8E-01 | 8.9E-02 | 2.2E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 134| +1.38E+02 | +1.1E-04 | -2.6E-01 | 1.7E-03 | 1.7E-01 | 3.3E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 48| +1.48E+02 | -6.0E-06 | +7.3E-01 | 2.9E-03 | 2.5E-01 | 8.3E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 24| +1.48E+02 | -6.4E-01 | +9.9E-01 | 5.0E-01 | 3.4E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 65| +1.48E+02 | +4.5E-06 | -6.9E+08 | 1.0E-13 | 2.2E-02 | 2.9E-13 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 16| +2.16E+02 | -5.6E-02 | -4.4E-01 | 4.1E-01 | 6.3E+01 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 57| +1.48E+02 | -2.0E-04 | +2.5E-01 | 6.8E-03 | 3.9E-01 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 6| +2.48E+02 | -6.8E-01 | +1.1E+00 | 1.2E-01 | 5.1E+00 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 33| +1.48E+02 | +1.3E-02 | -1.0E+00 | 8.9E-02 | 1.0E+00 | 9.4E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 49| +1.48E+02 | -3.0E-06 | +3.2E+00 | 2.9E-03 | 1.8E-02 | 8.2E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 58| +1.48E+02 | -1.6E-04 | +8.9E-01 | 1.7E-03 | 1.1E+00 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 25| +1.48E+02 | -4.2E-01 | +6.1E-01 | 1.0E+00 | 3.0E+01 | 9.1E-01 | trr |1\n", + "2023-02-17 16:05:27 fides(INFO) 135| +1.38E+02 | -8.8E-05 | +7.3E-01 | 4.2E-04 | 1.7E-01 | 8.4E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 66| +1.48E+02 | +4.6E-06 | -2.9E+09 | 2.6E-14 | 2.2E-02 | 7.3E-14 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 34| +1.48E+02 | -2.0E-03 | +4.5E-01 | 2.2E-02 | 1.0E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 7| +2.45E+02 | -3.4E+00 | +1.6E+00 | 2.5E-01 | 8.1E+00 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 50| +1.48E+02 | +2.1E-07 | -1.4E-01 | 5.9E-03 | 1.7E-02 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 59| +1.48E+02 | -5.6E-05 | +8.7E-01 | 3.4E-03 | 1.0E-01 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 26| +1.48E+02 | +1.1E+01 | -1.8E+01 | 1.0E+00 | 1.1E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 17| +2.16E+02 | -3.1E-01 | +1.0E+00 | 9.4E-02 | 6.3E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 67| +1.48E+02 | +4.1E-06 | -1.0E+10 | 6.4E-15 | 2.2E-02 | 1.8E-14 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 136| +1.38E+02 | -1.0E-05 | +9.1E-01 | 4.2E-04 | 1.9E-01 | 1.3E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 35| +1.48E+02 | -9.6E-04 | +8.6E-01 | 2.2E-02 | 2.5E+00 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 51| +1.48E+02 | +5.1E-07 | -1.2E+00 | 1.5E-03 | 1.7E-02 | 4.0E-04 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 60| +1.48E+02 | -5.0E-05 | +8.3E-01 | 6.8E-03 | 1.2E-01 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 27| +1.48E+02 | -9.3E-02 | +2.3E-01 | 1.5E-01 | 1.1E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 68| +1.48E+02 | +4.0E-06 | -4.0E+10 | 1.6E-15 | 2.2E-02 | 4.6E-15 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 36| +1.48E+02 | -6.1E-04 | +8.1E-01 | 4.4E-02 | 4.8E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 8| +2.19E+02 | -2.6E+01 | +2.2E+00 | 5.0E-01 | 1.7E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 137| +1.38E+02 | -1.5E-05 | +8.9E-01 | 8.3E-04 | 9.0E-02 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 52| +1.48E+02 | -2.6E-07 | +1.9E+00 | 3.7E-04 | 1.7E-02 | 1.0E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(WARNING) Stopping as function difference 2.58E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:27 fides(INFO) 61| +1.48E+02 | -7.9E-05 | +9.1E-01 | 1.4E-02 | 8.3E-02 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 28| +1.48E+02 | -7.1E-02 | +6.8E-01 | 3.7E-02 | 1.9E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:27.544 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2248 and h = 8.49905e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:27.544 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2248: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:27 fides(INFO) 37| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.9E-02 | 1.2E+00 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 69| +1.48E+02 | +3.9E-06 | -1.5E+11 | 4.0E-16 | 2.2E-02 | 1.1E-15 | 2d |0\n", + "2023-02-17 16:05:27 fides(WARNING) Stopping as trust region radius 1.00E-16 is smaller than machine precision.\n", + "2023-02-17 16:05:27 fides(INFO) 18| +2.16E+02 | -4.3E-02 | -8.6E-02 | 1.9E-01 | 3.2E+00 | 4.7E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 138| +1.38E+02 | -2.0E-05 | +9.4E-01 | 1.7E-03 | 1.7E-01 | 3.9E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 38| +1.48E+02 | -2.5E-04 | +8.3E-01 | 2.2E-02 | 1.2E+00 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 62| +1.48E+02 | +3.9E-05 | -2.8E-01 | 2.7E-02 | 1.8E-01 | 1.4E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 29| +1.48E+02 | -1.9E-02 | +7.6E-01 | 3.7E-02 | 3.9E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 139| +1.38E+02 | -2.5E-05 | +8.7E-01 | 3.3E-03 | 6.6E-02 | 7.2E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 63| +1.48E+02 | -3.2E-05 | +7.2E-01 | 6.8E-03 | 1.8E-01 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 39| +1.48E+02 | -1.2E-04 | +6.4E-01 | 4.4E-02 | 2.7E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 30| +1.48E+02 | -9.9E-03 | +9.2E-01 | 7.3E-02 | 7.7E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 9| +2.19E+02 | +2.1E+02 | -9.7E+00 | 1.0E+00 | 5.0E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 19| +2.16E+02 | -3.8E-02 | +1.1E+00 | 4.7E-02 | 3.2E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 140| +1.38E+02 | -4.7E-05 | +1.0E+00 | 6.7E-03 | 8.1E-02 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 64| +1.48E+02 | -2.2E-05 | +6.9E-01 | 6.8E-03 | 6.6E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 40| +1.48E+02 | +3.4E-05 | -1.3E-01 | 4.4E-02 | 3.9E-01 | 9.7E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 31| +1.48E+02 | +2.0E-03 | -4.7E-01 | 1.5E-01 | 1.1E+00 | 6.4E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 0| +1.95E+08 | NaN | NaN | 1.0E+00 | 9.0E+08 | NaN | NaN |1\n", + "2023-02-17 16:05:27 fides(INFO) 65| +1.48E+02 | -2.0E-05 | +5.7E-01 | 6.8E-03 | 1.9E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 41| +1.48E+02 | -6.6E-05 | +7.8E-01 | 1.1E-02 | 3.9E-01 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 32| +1.48E+02 | -1.7E-03 | +7.5E-01 | 3.7E-02 | 1.1E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 0| +2.66E+08 | NaN | NaN | 1.0E+00 | 1.2E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:27 fides(INFO) 141| +1.38E+02 | -9.1E-05 | +9.9E-01 | 1.3E-02 | 6.1E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 10| +2.05E+02 | -1.4E+01 | +6.8E-01 | 2.5E-01 | 5.0E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 1| +4.07E+04 | -1.9E+08 | +9.8E-02 | 1.0E+00 | 9.0E+08 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 1| +2.73E+05 | -2.7E+08 | +1.0E-01 | 1.0E+00 | 1.2E+09 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 42| +1.48E+02 | -4.0E-05 | +9.3E-01 | 2.2E-02 | 1.9E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 66| +1.48E+02 | -8.2E-06 | +3.1E-01 | 6.8E-03 | 6.1E-02 | 9.2E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 20| +2.15E+02 | -8.7E-02 | +1.1E+00 | 9.4E-02 | 1.9E+00 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 33| +1.48E+02 | -4.0E-05 | +2.0E-02 | 7.3E-02 | 2.0E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 142| +1.38E+02 | -1.8E-04 | +9.8E-01 | 2.7E-02 | 6.5E-02 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 2| +4.40E+04 | -2.3E+05 | +9.0E-01 | 2.5E-01 | 1.2E+06 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 2| +7.17E+03 | -3.4E+04 | +9.0E-01 | 2.5E-01 | 1.8E+05 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 43| +1.48E+02 | -5.0E-05 | +9.1E-01 | 4.4E-02 | 1.7E-01 | 9.9E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 34| +1.48E+02 | -1.0E-03 | +3.6E-01 | 1.8E-02 | 5.7E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 67| +1.48E+02 | -1.5E-05 | +4.3E-01 | 6.8E-03 | 1.6E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 3| +7.74E+03 | -3.6E+04 | +9.0E-01 | 5.0E-01 | 2.0E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 11| +2.01E+02 | -5.0E+00 | +7.0E-01 | 2.5E-01 | 4.0E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 143| +1.38E+02 | +2.2E-04 | -6.8E-01 | 5.3E-02 | 6.5E-02 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 3| +1.60E+03 | -5.6E+03 | +9.1E-01 | 5.0E-01 | 2.9E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 21| +2.15E+02 | +4.3E-01 | -3.7E+00 | 1.9E-01 | 1.0E+01 | 4.4E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 4| +1.72E+03 | -6.0E+03 | +9.1E-01 | 1.0E+00 | 3.1E+04 | 6.8E-01 | trr |1\n", + "2023-02-17 16:05:27 fides(INFO) 44| +1.48E+02 | -5.3E-06 | +7.9E-02 | 8.9E-02 | 1.1E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 35| +1.48E+02 | -2.9E-04 | +5.8E-01 | 1.8E-02 | 1.2E+00 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 68| +1.48E+02 | +9.2E-06 | -2.6E-01 | 6.8E-03 | 6.7E-02 | 1.0E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 4| +1.60E+03 | +3.5E+04 | -8.3E+01 | 1.0E+00 | 5.0E+03 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 5| +4.61E+02 | -1.3E+03 | +9.0E-01 | 1.0E+00 | 5.3E+03 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 45| +1.48E+02 | +2.0E-04 | -7.1E-01 | 2.2E-02 | 1.1E-01 | 9.5E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 144| +1.38E+02 | -6.1E-05 | +5.7E-01 | 1.3E-02 | 6.5E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 36| +1.48E+02 | -9.1E-05 | +5.8E-01 | 1.8E-02 | 2.9E-01 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 69| +1.48E+02 | -4.2E-06 | +3.3E-01 | 1.7E-03 | 6.7E-02 | 3.4E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 6| +2.62E+02 | -2.0E+02 | +9.0E-01 | 2.0E+00 | 8.5E+02 | 3.9E+00 | trr |1\n", + "2023-02-17 16:05:27 fides(INFO) 46| +1.48E+02 | -3.2E-05 | +3.6E-01 | 5.5E-03 | 1.1E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 12| +1.93E+02 | -7.4E+00 | +1.1E+00 | 2.5E-01 | 3.8E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 37| +1.48E+02 | -7.0E-05 | +7.1E-01 | 1.8E-02 | 3.1E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 22| +2.15E+02 | -6.4E-02 | +1.1E+00 | 4.7E-02 | 1.0E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 5| +5.17E+02 | -1.1E+03 | +9.1E-01 | 2.5E-01 | 5.0E+03 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 70| +1.48E+02 | -4.4E-06 | +8.2E-01 | 1.7E-03 | 1.8E-01 | 3.6E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 7| +2.38E+02 | -2.4E+01 | +1.0E+00 | 4.0E+00 | 1.1E+02 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 145| +1.38E+02 | +7.2E-05 | -2.9E-01 | 1.3E-02 | 1.4E-01 | 3.7E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 47| +1.48E+02 | -1.6E-05 | +9.2E-01 | 5.5E-03 | 3.7E-01 | 6.5E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 6| +3.08E+02 | -2.1E+02 | +6.8E-01 | 5.0E-01 | 1.0E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 38| +1.48E+02 | -5.1E-05 | +7.0E-01 | 1.8E-02 | 2.8E-01 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 71| +1.48E+02 | -6.4E-06 | +1.8E+00 | 3.4E-03 | 2.1E-02 | 6.6E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 8| +2.38E+02 | +3.4E+01 | -6.3E+00 | 4.0E+00 | 2.4E+01 | 5.0E+00 | trr |0\n", + "2023-02-17 16:05:27 fides(INFO) 48| +1.48E+02 | -6.9E-07 | +3.5E-01 | 1.1E-02 | 3.3E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(WARNING) Stopping as function difference 6.90E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:27 fides(INFO) 146| +1.38E+02 | -4.5E-05 | +6.7E-01 | 3.3E-03 | 1.4E-01 | 9.2E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 7| +2.51E+02 | -5.7E+01 | +8.4E-01 | 5.0E-01 | 2.8E+02 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 23| +2.15E+02 | -1.2E-01 | +7.2E-01 | 9.4E-02 | 6.2E+00 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 9| +2.38E+02 | +1.6E+00 | -3.9E-01 | 6.9E-01 | 2.4E+01 | 2.0E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 39| +1.48E+02 | -4.4E-05 | +7.4E-01 | 1.8E-02 | 2.0E-01 | 2.9E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 13| +1.81E+02 | -1.2E+01 | +8.0E-01 | 5.0E-01 | 3.3E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 72| +1.48E+02 | -4.6E-06 | +7.9E-01 | 6.8E-03 | 5.6E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 8| +2.50E+02 | -1.1E+00 | +3.8E-01 | 1.0E+00 | 2.6E+01 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 40| +1.48E+02 | -2.9E-05 | +5.3E-01 | 1.8E-02 | 2.7E-01 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 73| +1.48E+02 | +6.7E-07 | -7.7E-02 | 1.4E-02 | 2.2E-02 | 1.5E-03 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 147| +1.38E+02 | -2.1E-05 | +9.9E-01 | 3.3E-03 | 7.8E-02 | 6.0E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:27 fides(INFO) 10| +2.38E+02 | +1.3E+00 | -3.2E-01 | 1.7E-01 | 2.4E+01 | 4.3E-01 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 24| +2.15E+02 | -1.6E-01 | +7.4E-01 | 9.4E-02 | 2.9E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 41| +1.48E+02 | -1.4E-05 | +2.8E-01 | 1.8E-02 | 1.4E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 148| +1.38E+02 | -4.1E-05 | +1.0E+00 | 6.7E-03 | 5.9E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 74| +1.48E+02 | -3.8E-06 | +1.3E+00 | 3.4E-03 | 2.2E-02 | 3.8E-04 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 11| +2.36E+02 | -1.9E+00 | +8.7E-01 | 4.3E-02 | 2.4E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 14| +1.81E+02 | -6.7E-01 | -5.0E-01 | 1.0E+00 | 1.5E+02 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:27 fides(INFO) 42| +1.48E+02 | -4.4E-06 | +5.4E-02 | 1.8E-02 | 2.5E-01 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 9| +2.50E+02 | -2.9E-01 | +2.9E-02 | 1.0E+00 | 1.2E+01 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:27 fides(INFO) 75| +1.48E+02 | +1.6E-06 | -3.0E-01 | 6.8E-03 | 6.5E-02 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 149| +1.38E+02 | -7.9E-05 | +9.9E-01 | 1.3E-02 | 6.8E-02 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 25| +2.15E+02 | -1.7E-01 | +9.8E-01 | 9.4E-02 | 3.2E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 12| +2.34E+02 | -2.2E+00 | +9.0E-01 | 8.6E-02 | 1.9E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 0| +1.64E+11 | NaN | NaN | 1.0E+00 | 7.4E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:28 fides(INFO) 43| +1.48E+02 | -1.9E-05 | +3.6E-01 | 4.6E-03 | 1.3E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 76| +1.48E+02 | +1.3E-06 | -7.2E-01 | 1.7E-03 | 6.5E-02 | 4.1E-04 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 150| +1.38E+02 | -1.5E-04 | +1.0E+00 | 2.7E-02 | 5.9E-02 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 10| +2.49E+02 | -8.7E-01 | +5.1E-01 | 2.5E-01 | 1.7E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 13| +2.30E+02 | -3.6E+00 | +9.8E-01 | 1.7E-01 | 2.4E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:28.049 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.543 and h = 3.35461e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:28.049 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.543: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:28 fides(INFO) 44| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.6E-03 | 3.8E-01 | 7.2E-04 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 26| +2.15E+02 | -1.5E-01 | +3.9E-01 | 1.9E-01 | 1.9E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 1| +3.11E+09 | -1.6E+11 | +8.7E-02 | 1.0E+00 | 7.4E+11 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 77| +1.48E+02 | +1.7E-06 | -2.1E+00 | 4.3E-04 | 6.5E-02 | 1.0E-04 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 15| +1.69E+02 | -1.2E+01 | +9.8E-01 | 2.5E-01 | 1.5E+02 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 151| +1.38E+02 | -2.5E-04 | +8.5E-01 | 5.3E-02 | 6.2E-02 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 45| +1.48E+02 | -1.7E-05 | +9.9E-01 | 1.1E-03 | 3.8E-01 | 2.0E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 14| +2.28E+02 | -2.3E+00 | +2.9E-01 | 3.4E-01 | 2.2E+01 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 78| +1.48E+02 | -2.3E-06 | +3.9E+00 | 1.1E-04 | 6.5E-02 | 3.0E-05 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 2| +4.64E+08 | -2.6E+09 | +8.9E-01 | 2.5E-01 | 1.4E+10 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 15| +2.18E+02 | -9.5E+00 | +8.3E-01 | 3.4E-01 | 5.4E+01 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 46| +1.48E+02 | -3.4E-06 | +1.0E+00 | 2.3E-03 | 4.0E-02 | 3.6E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 11| +2.48E+02 | -6.8E-01 | +4.8E-01 | 2.5E-01 | 1.0E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 152| +1.38E+02 | +3.9E-02 | -1.9E+01 | 1.1E-01 | 9.7E-02 | 3.4E-02 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 27| +2.15E+02 | -1.9E-01 | +1.1E+00 | 1.9E-01 | 3.5E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 16| +1.69E+02 | +8.9E+00 | -1.6E+00 | 5.0E-01 | 4.4E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 79| +1.48E+02 | +4.9E-06 | -2.7E+01 | 2.1E-04 | 6.9E-03 | 5.2E-05 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 16| +1.99E+02 | -1.9E+01 | +4.2E-01 | 6.9E-01 | 2.5E+01 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 47| +1.48E+02 | -6.6E-06 | +2.6E+00 | 4.6E-03 | 1.0E-01 | 6.3E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 3| +6.92E+07 | -3.9E+08 | +8.9E-01 | 5.0E-01 | 2.1E+09 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 153| +1.38E+02 | +1.9E-03 | -3.0E+00 | 2.7E-02 | 9.7E-02 | 8.6E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 80| +1.48E+02 | +5.6E-06 | -7.7E+01 | 5.3E-05 | 6.9E-03 | 1.8E-05 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 12| +2.47E+02 | -1.4E+00 | +7.4E-01 | 2.5E-01 | 1.5E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 17| +1.99E+02 | +3.2E+01 | -2.2E+00 | 6.9E-01 | 1.5E+02 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 48| +1.48E+02 | +2.7E-06 | -7.8E-01 | 9.2E-03 | 2.6E-02 | 1.2E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 28| +2.14E+02 | -1.7E-01 | +1.4E-01 | 3.8E-01 | 1.4E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 154| +1.38E+02 | +5.5E-07 | -6.5E-03 | 6.7E-03 | 9.7E-02 | 2.2E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 4| +1.04E+07 | -5.9E+07 | +8.9E-01 | 5.0E-01 | 3.2E+08 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 81| +1.48E+02 | +3.1E-06 | -6.9E+01 | 1.3E-05 | 6.9E-03 | 1.2E-05 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 17| +1.65E+02 | -3.7E+00 | +8.2E-01 | 1.2E-01 | 4.4E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 18| +1.77E+02 | -2.1E+01 | +9.9E-01 | 1.7E-01 | 1.5E+02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 49| +1.48E+02 | +1.4E-06 | -6.6E-01 | 2.3E-03 | 2.6E-02 | 3.3E-04 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 13| +2.46E+02 | -1.4E+00 | +6.1E-01 | 2.5E-01 | 1.2E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 82| +1.48E+02 | +3.2E-07 | -1.0E+01 | 3.3E-06 | 6.9E-03 | 7.3E-06 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 155| +1.38E+02 | -3.3E-05 | +7.0E-01 | 1.7E-03 | 9.7E-02 | 6.3E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 5| +1.56E+06 | -8.8E+06 | +8.9E-01 | 5.0E-01 | 4.8E+07 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 29| +2.14E+02 | -9.0E-02 | +1.1E+00 | 9.4E-02 | 3.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 50| +1.48E+02 | -1.0E-06 | +5.9E-01 | 5.7E-04 | 2.6E-02 | 1.7E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(WARNING) Stopping as function difference 1.02E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:28 fides(INFO) 19| +1.59E+02 | -1.9E+01 | +6.8E-01 | 3.4E-01 | 5.9E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 14| +2.43E+02 | -2.7E+00 | +7.9E-01 | 2.5E-01 | 2.1E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 6| +2.38E+05 | -1.3E+06 | +8.9E-01 | 5.0E-01 | 7.2E+06 | 9.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 156| +1.38E+02 | -1.4E-05 | +9.4E-01 | 1.7E-03 | 2.4E-01 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 83| +1.48E+02 | -4.8E-08 | +4.5E+00 | 8.3E-07 | 6.9E-03 | 1.8E-06 | 2d |1\n", + "2023-02-17 16:05:28 fides(WARNING) Stopping as function difference 4.76E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:28 fides(INFO) 18| +1.55E+02 | -9.5E+00 | +1.1E+00 | 2.5E-01 | 8.3E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 20| +1.59E+02 | +4.1E+01 | -3.7E+00 | 3.4E-01 | 1.8E+02 | 5.7E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 7| +3.68E+04 | -2.0E+05 | +8.9E-01 | 5.0E-01 | 1.1E+06 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 15| +2.38E+02 | -4.9E+00 | +6.5E-01 | 5.0E-01 | 1.9E+01 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 30| +2.14E+02 | -9.2E-02 | +9.5E-01 | 1.9E-01 | 3.3E+00 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 157| +1.38E+02 | -1.6E-05 | +9.6E-01 | 3.3E-03 | 6.0E-02 | 4.9E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 8| +5.70E+03 | -3.1E+04 | +9.0E-01 | 5.0E-01 | 1.7E+05 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 21| +1.51E+02 | -8.1E+00 | +8.9E-01 | 7.6E-02 | 1.8E+02 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 19| +1.55E+02 | -2.7E-01 | -1.1E-02 | 5.0E-01 | 5.1E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 16| +2.29E+02 | -9.2E+00 | +9.1E-01 | 5.0E-01 | 4.7E+01 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 158| +1.38E+02 | -3.1E-05 | +1.0E+00 | 6.7E-03 | 6.2E-02 | 9.3E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 9| +9.75E+02 | -4.7E+03 | +9.1E-01 | 5.0E-01 | 2.6E+04 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 22| +1.49E+02 | -2.0E+00 | +9.2E-01 | 1.5E-01 | 5.5E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 31| +2.14E+02 | -1.3E-01 | +7.0E-01 | 3.8E-01 | 5.3E+00 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 17| +2.29E+02 | +2.5E+01 | -3.2E+00 | 1.0E+00 | 2.9E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 0| +2.62E+11 | NaN | NaN | 1.0E+00 | 9.5E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 10| +7.50E+02 | -2.2E+02 | +9.7E-02 | 5.0E-01 | 3.8E+03 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 159| +1.38E+02 | -5.8E-05 | +9.6E-01 | 1.3E-02 | 5.8E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 23| +1.49E+02 | +1.6E+00 | -1.6E+00 | 3.0E-01 | 3.7E+01 | 4.1E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 0| +1.18E+11 | NaN | NaN | 1.0E+00 | 5.4E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 20| +1.55E+02 | -9.1E-01 | +9.5E-01 | 9.3E-02 | 5.1E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 18| +2.29E+02 | -1.8E-01 | -1.2E-01 | 2.5E-01 | 2.9E+01 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 32| +2.14E+02 | -1.0E-01 | +1.2E+00 | 3.8E-01 | 1.3E+01 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 11| +2.94E+02 | -4.6E+02 | +9.2E-01 | 1.2E-01 | 3.6E+03 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 24| +1.48E+02 | -3.3E-01 | +7.0E-01 | 7.6E-02 | 3.7E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 1| +1.03E+09 | -2.6E+11 | +1.1E-01 | 1.0E+00 | 9.5E+11 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 1| +2.17E+08 | -1.2E+11 | +9.2E-02 | 1.0E+00 | 5.4E+11 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 160| +1.38E+02 | -3.8E-05 | +2.4E-01 | 2.7E-02 | 6.0E-02 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 12| +1.83E+02 | -1.1E+02 | +8.5E-01 | 2.5E-01 | 9.1E+02 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 19| +2.26E+02 | -3.1E+00 | +8.9E-01 | 6.2E-02 | 2.9E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 25| +1.48E+02 | -3.2E-01 | +5.8E-01 | 7.6E-02 | 2.8E+01 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 21| +1.54E+02 | -2.6E-01 | +8.2E-01 | 1.9E-01 | 1.3E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 2| +1.56E+08 | -8.7E+08 | +8.9E-01 | 2.5E-01 | 4.7E+09 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 33| +2.14E+02 | -1.2E-01 | +5.8E-01 | 7.5E-01 | 7.1E+00 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 2| +3.32E+07 | -1.8E+08 | +8.9E-01 | 2.5E-01 | 1.0E+09 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 13| +1.72E+02 | -1.1E+01 | +7.6E-01 | 5.0E-01 | 1.5E+02 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 161| +1.38E+02 | +8.5E-05 | -2.1E-01 | 6.7E-03 | 1.5E-01 | 3.5E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 20| +2.20E+02 | -5.6E+00 | +1.1E+00 | 1.2E-01 | 2.9E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 3| +2.38E+07 | -1.3E+08 | +8.9E-01 | 5.0E-01 | 7.2E+08 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 3| +5.10E+06 | -2.8E+07 | +8.9E-01 | 5.0E-01 | 1.5E+08 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 26| +1.48E+02 | -6.1E-02 | +1.6E-01 | 7.6E-02 | 1.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 22| +1.54E+02 | -1.4E-01 | +8.6E-01 | 3.7E-01 | 2.2E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 34| +2.14E+02 | -5.4E-02 | +1.4E+00 | 7.5E-01 | 1.1E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 14| +1.71E+02 | -6.7E-01 | +6.7E-01 | 1.0E+00 | 1.3E+01 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 162| +1.38E+02 | -7.4E-05 | +6.9E-01 | 1.7E-03 | 1.5E-01 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 21| +2.09E+02 | -1.1E+01 | +1.2E+00 | 2.5E-01 | 3.0E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 4| +3.66E+06 | -2.0E+07 | +8.9E-01 | 1.0E+00 | 1.1E+08 | 9.7E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 27| +1.48E+02 | -1.1E-01 | +8.0E-01 | 1.9E-02 | 2.2E+01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 4| +7.91E+05 | -4.3E+06 | +8.9E-01 | 1.0E+00 | 2.3E+07 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 23| +1.54E+02 | -1.2E-02 | +5.1E-01 | 7.4E-01 | 3.6E+00 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 5| +5.66E+05 | -3.1E+06 | +9.0E-01 | 1.0E+00 | 1.7E+07 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 22| +2.09E+02 | -1.8E+00 | -5.4E-01 | 5.0E-01 | 3.1E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 28| +1.48E+02 | -7.0E-02 | +6.5E-01 | 3.8E-02 | 1.4E+01 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 5| +1.24E+05 | -6.7E+05 | +9.0E-01 | 2.0E+00 | 3.6E+06 | 3.9E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 163| +1.38E+02 | -1.7E-05 | +8.1E-01 | 1.7E-03 | 2.0E-01 | 3.5E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 35| +2.14E+02 | -7.3E-02 | +7.5E-01 | 7.5E-01 | 3.2E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 15| +1.71E+02 | -1.3E-01 | +6.7E-01 | 1.0E+00 | 1.1E+01 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 6| +8.84E+04 | -4.8E+05 | +9.0E-01 | 1.0E+00 | 2.6E+06 | 8.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 6| +1.96E+04 | -1.0E+05 | +9.0E-01 | 4.0E+00 | 5.6E+05 | 1.6E+00 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 164| +1.38E+02 | -1.4E-05 | +8.9E-01 | 3.3E-03 | 6.0E-02 | 4.5E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 29| +1.48E+02 | -3.8E-02 | +5.8E-01 | 3.8E-02 | 1.0E+01 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 23| +2.03E+02 | -6.0E+00 | +9.5E-01 | 1.2E-01 | 3.1E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 24| +1.54E+02 | +1.5E-01 | -5.1E+00 | 7.4E-01 | 1.8E+00 | 3.3E-01 | trr |0\n", + "2023-02-17 16:05:28 fides(INFO) 7| +1.40E+04 | -7.4E+04 | +9.0E-01 | 1.0E+00 | 4.0E+05 | 8.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 7| +3.28E+03 | -1.6E+04 | +9.0E-01 | 4.0E+00 | 8.8E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 16| +1.71E+02 | -2.8E-02 | +8.1E-01 | 1.0E+00 | 4.7E+00 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 36| +2.14E+02 | -1.6E-02 | +1.4E+00 | 7.5E-01 | 4.7E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 30| +1.48E+02 | -3.1E-02 | +6.4E-01 | 3.8E-02 | 1.1E+01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 24| +1.89E+02 | -1.5E+01 | +1.1E+00 | 2.5E-01 | 4.0E+01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 8| +2.35E+03 | -1.2E+04 | +9.1E-01 | 1.0E+00 | 6.3E+04 | 8.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 8| +7.03E+02 | -2.6E+03 | +9.0E-01 | 4.0E+00 | 1.4E+04 | 1.2E+00 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 25| +1.54E+02 | -4.9E-03 | +8.4E-01 | 9.0E-02 | 1.8E+00 | 6.6E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 31| +1.48E+02 | -1.9E-02 | +3.9E-01 | 3.8E-02 | 5.1E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 165| +1.38E+02 | -2.5E-05 | +9.2E-01 | 6.7E-03 | 6.2E-02 | 8.1E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 9| +5.18E+02 | -1.8E+03 | +9.2E-01 | 1.0E+00 | 9.9E+03 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 17| +1.71E+02 | -3.2E-03 | +5.4E-01 | 2.0E+00 | 1.8E+00 | 1.1E+00 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 25| +1.89E+02 | -5.0E+00 | -3.4E-01 | 5.0E-01 | 4.5E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 37| +2.14E+02 | -1.0E-02 | +1.0E+00 | 7.5E-01 | 2.2E+00 | 7.6E-03 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 9| +3.02E+02 | -4.0E+02 | +9.1E-01 | 4.0E+00 | 2.2E+03 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 10| +2.23E+02 | -3.0E+02 | +1.0E+00 | 1.0E+00 | 1.4E+03 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 32| +1.48E+02 | -6.2E-03 | +1.7E-01 | 3.8E-02 | 3.7E+00 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 26| +1.54E+02 | -4.2E-03 | +6.5E-01 | 1.8E-01 | 1.8E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 26| +1.79E+02 | -9.6E+00 | +1.0E+00 | 1.2E-01 | 4.5E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 166| +1.38E+02 | -4.1E-05 | +7.2E-01 | 1.3E-02 | 5.9E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 18| +1.71E+02 | -1.2E-04 | +4.8E-02 | 2.0E+00 | 1.5E+00 | 1.4E-02 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 11| +1.99E+02 | -2.4E+01 | +9.8E-01 | 1.0E+00 | 1.4E+02 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 10| +2.21E+02 | -8.1E+01 | +1.2E+00 | 4.0E+00 | 3.3E+02 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 38| +2.14E+02 | -3.0E-04 | +9.4E-01 | 7.5E-01 | 2.2E+00 | 1.4E-03 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 33| +1.48E+02 | -5.0E-03 | +7.4E-01 | 9.5E-03 | 1.3E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 27| +1.59E+02 | -2.0E+01 | +1.0E+00 | 2.5E-01 | 5.8E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 167| +1.38E+02 | +3.5E-04 | -1.9E+00 | 1.3E-02 | 7.7E-02 | 3.8E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 27| +1.54E+02 | -1.4E-03 | +3.8E-01 | 1.8E-01 | 7.8E-01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 19| +1.71E+02 | -7.2E-06 | +2.1E-03 | 3.0E-02 | 1.1E+00 | 1.4E-02 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 12| +1.99E+02 | +4.4E+02 | -2.4E+01 | 2.0E+00 | 3.8E+01 | 5.9E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 34| +1.48E+02 | -2.3E-03 | +7.8E-01 | 9.5E-03 | 2.1E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 28| +1.59E+02 | +3.0E+01 | -2.1E+00 | 5.0E-01 | 7.3E+01 | 8.5E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 11| +2.21E+02 | +1.1E+03 | -3.7E+01 | 4.0E+00 | 2.9E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 39| +2.14E+02 | -4.6E-06 | +1.7E-01 | 7.5E-01 | 2.1E+00 | 5.5E-04 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 28| +1.54E+02 | +2.0E-04 | -6.0E-02 | 1.8E-01 | 8.8E-01 | 9.4E-02 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 168| +1.38E+02 | +1.7E-05 | -3.1E-01 | 3.3E-03 | 7.7E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 20| +1.71E+02 | -5.6E-04 | +2.6E-01 | 5.2E-03 | 1.1E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 12| +2.21E+02 | +7.1E+00 | -1.2E+00 | 1.0E+00 | 2.9E+01 | 2.9E+00 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 13| +1.94E+02 | -4.5E+00 | +2.2E-01 | 5.0E-01 | 3.8E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 35| +1.48E+02 | -9.7E-04 | +5.6E-01 | 1.9E-02 | 5.3E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 29| +1.53E+02 | -6.7E+00 | +8.1E-01 | 1.2E-01 | 7.3E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 169| +1.38E+02 | -9.1E-08 | +2.9E-03 | 8.3E-04 | 7.7E-02 | 7.0E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 13| +2.21E+02 | +3.5E+00 | -4.7E-01 | 2.5E-01 | 2.9E+01 | 6.5E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 36| +1.48E+02 | -8.1E-04 | +5.1E-01 | 1.9E-02 | 1.0E+00 | 5.7E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 40| +2.14E+02 | +1.2E-07 | -1.1E-02 | 3.8E-04 | 2.1E+00 | 5.3E-04 | trr |0\n", + "2023-02-17 16:05:28 fides(INFO) 29| +1.54E+02 | -1.0E-03 | +8.0E-01 | 4.5E-02 | 8.8E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 30| +1.50E+02 | -2.8E+00 | +9.0E-01 | 2.5E-01 | 7.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 14| +1.85E+02 | -9.2E+00 | +8.7E-01 | 1.2E-01 | 8.4E+01 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 21| +1.71E+02 | -3.1E-04 | +3.0E-01 | 5.2E-03 | 9.2E-01 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 37| +1.48E+02 | -4.7E-04 | +3.1E-01 | 1.9E-02 | 5.6E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 170| +1.38E+02 | -1.2E-05 | +9.8E-01 | 2.1E-04 | 3.7E-01 | 6.8E-05 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 31| +1.50E+02 | +4.9E+00 | -1.6E+00 | 5.0E-01 | 4.5E+01 | 5.3E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 14| +2.18E+02 | -3.3E+00 | +8.5E-01 | 6.2E-02 | 2.9E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 15| +1.75E+02 | -1.0E+01 | +1.3E+00 | 2.5E-01 | 3.6E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 30| +1.54E+02 | -6.0E-04 | +8.2E-01 | 9.0E-02 | 4.2E-01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 22| +1.71E+02 | -7.9E-06 | +1.7E-02 | 5.2E-03 | 6.1E-01 | 5.8E-03 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 15| +2.16E+02 | -1.6E+00 | +5.3E-01 | 1.2E-01 | 1.8E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 38| +1.48E+02 | +2.2E-04 | -1.2E-01 | 1.9E-02 | 5.9E-01 | 6.9E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 41| +2.14E+02 | -4.4E-06 | +8.1E-01 | 6.5E-05 | 2.1E+00 | 1.4E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 32| +1.49E+02 | -1.2E+00 | +7.2E-01 | 1.2E-01 | 4.5E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 16| +1.75E+02 | +1.1E+01 | -1.4E+00 | 5.0E-01 | 2.4E+01 | 9.2E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 171| +1.38E+02 | -3.4E-06 | +1.1E+00 | 4.2E-04 | 6.3E-02 | 1.0E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 31| +1.54E+02 | -8.5E-04 | +1.1E+00 | 1.8E-01 | 3.8E-01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 16| +2.14E+02 | -2.7E+00 | +7.2E-01 | 1.2E-01 | 2.9E+01 | 2.7E-01 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 39| +1.48E+02 | -3.9E-04 | +6.1E-01 | 4.8E-03 | 5.9E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 23| +1.71E+02 | -1.4E-04 | +7.8E-01 | 5.8E-04 | 5.0E-01 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 33| +1.48E+02 | -4.1E-01 | +5.5E-01 | 1.2E-01 | 4.4E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 17| +1.69E+02 | -6.2E+00 | +1.0E+00 | 1.2E-01 | 2.4E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 42| +2.14E+02 | -5.0E-07 | +1.8E-01 | 1.3E-04 | 2.1E+00 | 2.4E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 17| +2.11E+02 | -2.5E+00 | +6.5E-01 | 1.2E-01 | 1.8E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 172| +1.38E+02 | -3.1E-06 | +8.8E-01 | 8.3E-04 | 6.2E-02 | 1.0E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 32| +1.54E+02 | +6.3E-04 | -7.2E-01 | 3.6E-01 | 3.1E-01 | 8.3E-02 | trr |0\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 40| +1.48E+02 | -2.2E-04 | +9.6E-01 | 4.8E-03 | 1.0E+00 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 24| +1.71E+02 | -7.0E-05 | +5.8E-01 | 1.2E-03 | 3.1E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 34| +1.48E+02 | -3.8E-01 | +3.7E-01 | 1.2E-01 | 2.5E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 18| +1.60E+02 | -8.5E+00 | +8.5E-01 | 2.5E-01 | 5.6E+01 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 18| +2.08E+02 | -3.3E+00 | +7.6E-01 | 1.2E-01 | 2.7E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 173| +1.38E+02 | -3.5E-06 | +5.5E-01 | 1.7E-03 | 6.6E-02 | 1.9E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 41| +1.48E+02 | -3.0E-04 | +7.9E-01 | 9.5E-03 | 2.6E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 33| +1.54E+02 | -3.0E-04 | +8.0E-01 | 6.8E-02 | 3.1E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 43| +2.14E+02 | -9.1E-07 | +8.2E-01 | 3.2E-05 | 2.1E+00 | 7.5E-05 | 2d |1\n", + "2023-02-17 16:05:28 fides(WARNING) Stopping as function difference 9.13E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:28 fides(INFO) 25| +1.71E+02 | -1.7E-06 | +5.8E-02 | 1.2E-03 | 1.4E-01 | 1.7E-03 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 35| +1.48E+02 | +7.8E-02 | -1.1E-01 | 1.2E-01 | 1.2E+01 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 19| +2.07E+02 | -5.6E-01 | +4.8E-02 | 2.5E-01 | 1.8E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 19| +1.55E+02 | -4.8E+00 | +7.9E-01 | 5.0E-01 | 7.0E+01 | 1.1E+00 | trr |1\n", + "2023-02-17 16:05:28 fides(INFO) 174| +1.38E+02 | -8.5E-06 | +1.4E+00 | 1.7E-03 | 6.0E-02 | 1.9E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 42| +1.48E+02 | -9.6E-05 | +1.7E-01 | 1.9E-02 | 6.1E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 20| +2.03E+02 | -4.2E+00 | +8.2E-01 | 6.2E-02 | 5.4E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 26| +1.71E+02 | -8.6E-06 | +6.6E-01 | 1.6E-04 | 1.2E-01 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 36| +1.48E+02 | -2.3E-01 | +7.6E-01 | 3.1E-02 | 1.2E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) 34| +1.54E+02 | -4.5E-04 | +9.8E-01 | 1.4E-01 | 1.6E-01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:28 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:28 fides(INFO) 20| +1.55E+02 | +9.5E+01 | -1.1E+01 | 5.0E-01 | 1.0E+02 | 8.3E-01 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 43| +1.48E+02 | +8.2E-05 | -1.4E-01 | 4.8E-03 | 3.2E-01 | 3.7E-03 | 2d |0\n", + "2023-02-17 16:05:28 fides(INFO) 21| +2.01E+02 | -2.5E+00 | +8.8E-01 | 1.2E-01 | 2.0E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 37| +1.48E+02 | -7.8E-02 | +3.5E-01 | 6.2E-02 | 8.4E+00 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 175| +1.38E+02 | -1.2E-05 | +9.7E-01 | 3.3E-03 | 6.1E-02 | 3.7E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 35| +1.54E+02 | +2.2E-03 | -2.9E+00 | 2.7E-01 | 1.7E-01 | 4.6E-02 | trr |0\n", + "2023-02-17 16:05:29 fides(INFO) 21| +1.50E+02 | -5.4E+00 | +7.7E-01 | 1.2E-01 | 1.0E+02 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 27| +1.71E+02 | -3.9E-06 | +7.3E-01 | 1.6E-04 | 8.2E-02 | 4.3E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 22| +1.91E+02 | -9.1E+00 | +1.5E+00 | 2.5E-01 | 1.5E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 44| +1.48E+02 | -7.1E-05 | +1.9E-01 | 1.2E-03 | 3.2E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 38| +1.48E+02 | -3.2E-02 | +7.9E-01 | 6.2E-02 | 8.4E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 36| +1.54E+02 | -1.8E-04 | +5.5E-01 | 4.0E-02 | 1.7E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 22| +1.48E+02 | -1.6E+00 | +9.7E-01 | 2.3E-01 | 6.7E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 176| +1.38E+02 | -2.4E-05 | +9.9E-01 | 6.7E-03 | 6.0E-02 | 7.3E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 28| +1.71E+02 | +3.9E-07 | -4.3E+00 | 1.6E-04 | 1.2E-02 | 8.0E-05 | trr |0\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 0| +6.60E+09 | NaN | NaN | 1.0E+00 | 3.1E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:29 fides(INFO) 45| +1.48E+02 | -2.1E-04 | +9.7E-01 | 3.0E-04 | 1.4E+00 | 3.5E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 23| +1.83E+02 | -9.0E+00 | +3.6E-01 | 5.0E-01 | 4.0E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 39| +1.48E+02 | -3.0E-02 | +8.4E-01 | 1.2E-01 | 3.2E+00 | 8.6E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 23| +1.48E+02 | +4.3E+00 | -2.3E+00 | 4.7E-01 | 2.0E+01 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 177| +1.38E+02 | -4.6E-05 | +1.0E+00 | 1.3E-02 | 5.9E-02 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 46| +1.48E+02 | -8.0E-06 | +8.6E-01 | 6.0E-04 | 1.0E-01 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 37| +1.54E+02 | -1.1E-04 | +7.1E-01 | 4.0E-02 | 2.1E-01 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 29| +1.71E+02 | -8.7E-07 | +1.4E+01 | 7.2E-06 | 1.2E-02 | 2.0E-05 | 2d |1\n", + "2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 8.74E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 40| +1.48E+02 | -1.8E-02 | +9.1E-01 | 2.5E-01 | 7.6E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 1| +1.51E+04 | -6.6E+09 | +9.3E-02 | 1.0E+00 | 3.1E+10 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 24| +1.68E+02 | -1.5E+01 | +4.4E-01 | 5.0E-01 | 1.5E+02 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 24| +1.48E+02 | -2.4E-01 | +1.5E-01 | 1.2E-01 | 2.0E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 47| +1.48E+02 | -1.1E-05 | +9.5E-01 | 1.2E-03 | 1.2E-01 | 5.8E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 38| +1.54E+02 | -1.7E-04 | +1.0E+00 | 4.0E-02 | 7.8E-02 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 41| +1.48E+02 | +3.3E-02 | -4.0E+00 | 5.0E-01 | 1.2E+00 | 2.3E-01 | trr |0\n", + "2023-02-17 16:05:29 fides(INFO) 178| +1.38E+02 | -8.5E-05 | +9.6E-01 | 2.7E-02 | 6.0E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 25| +1.53E+02 | -1.4E+01 | +9.8E-01 | 5.0E-01 | 2.3E+02 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 25| +1.48E+02 | -5.3E-01 | +9.5E-01 | 2.9E-02 | 7.0E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 2| +2.53E+03 | -1.3E+04 | +9.0E-01 | 2.5E-01 | 6.9E+04 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 48| +1.48E+02 | -1.8E-05 | +9.1E-01 | 2.4E-03 | 5.7E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 42| +1.48E+02 | -1.2E-03 | +3.0E-01 | 1.1E-01 | 1.2E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 39| +1.54E+02 | +1.2E-04 | -6.4E-01 | 7.9E-02 | 2.0E-01 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 179| +1.38E+02 | +1.3E-03 | -6.4E+00 | 5.3E-02 | 6.0E-02 | 7.7E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 26| +1.53E+02 | +3.2E+02 | -3.1E+01 | 1.0E+00 | 6.2E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 26| +1.48E+02 | -3.4E-02 | +5.9E-01 | 5.9E-02 | 5.9E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 49| +1.48E+02 | -3.0E-05 | +1.0E+00 | 4.8E-03 | 1.1E-01 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 43| +1.48E+02 | +9.5E-03 | -8.5E-01 | 1.1E-01 | 1.2E+00 | 5.1E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 3| +6.21E+02 | -1.9E+03 | +8.4E-01 | 5.0E-01 | 1.1E+04 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 40| +1.54E+02 | -5.4E-05 | +7.3E-01 | 2.0E-02 | 2.0E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 27| +1.52E+02 | -1.1E+00 | +8.3E-02 | 2.5E-01 | 6.2E+01 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 27| +1.48E+02 | -2.3E-02 | +9.6E-01 | 5.9E-02 | 1.1E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 180| +1.38E+02 | +3.9E-05 | -6.4E-01 | 1.3E-02 | 6.0E-02 | 2.0E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 50| +1.48E+02 | -4.5E-05 | +9.5E-01 | 9.5E-03 | 5.2E-02 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 44| +1.48E+02 | -2.0E-03 | +5.8E-01 | 2.7E-02 | 1.2E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 4| +2.36E+02 | -3.8E+02 | +9.2E-01 | 1.0E+00 | 1.8E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 0| +5.61E+08 | NaN | NaN | 1.0E+00 | 2.6E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:29 fides(INFO) 28| +1.50E+02 | -2.1E+00 | +9.6E-01 | 6.2E-02 | 1.1E+02 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 28| +1.48E+02 | -1.8E-02 | +9.0E-01 | 1.2E-01 | 3.7E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 51| +1.48E+02 | -5.8E-05 | +8.2E-01 | 1.9E-02 | 1.5E-01 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 41| +1.54E+02 | -3.1E-05 | +9.9E-01 | 2.0E-02 | 1.2E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 45| +1.48E+02 | -4.5E-04 | +9.8E-01 | 2.7E-02 | 1.0E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 181| +1.38E+02 | -7.5E-06 | +4.3E-01 | 3.3E-03 | 6.0E-02 | 5.3E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 29| +1.49E+02 | -1.3E+00 | +6.3E-01 | 1.2E-01 | 5.7E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 29| +1.48E+02 | -8.7E-03 | +3.6E-01 | 2.3E-01 | 6.4E+00 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 42| +1.54E+02 | -4.7E-05 | +1.1E+00 | 4.0E-02 | 7.7E-02 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 5| +1.91E+02 | -4.6E+01 | +9.0E-01 | 1.0E+00 | 2.2E+02 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 52| +1.48E+02 | +2.7E-04 | -2.1E+00 | 3.8E-02 | 7.7E-02 | 4.2E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 46| +1.48E+02 | -5.9E-04 | +9.7E-01 | 5.4E-02 | 5.5E-01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 182| +1.38E+02 | -1.4E-05 | +7.1E-01 | 3.3E-03 | 1.1E-01 | 5.2E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 30| +1.48E+02 | -7.0E-01 | +9.6E-01 | 1.2E-01 | 6.6E+01 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 1| +3.31E+06 | -5.6E+08 | +9.3E-02 | 1.0E+00 | 2.6E+09 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 30| +1.48E+02 | +1.2E-01 | -1.8E+00 | 2.3E-01 | 2.7E+00 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 6| +1.91E+02 | +2.4E+03 | -1.7E+02 | 2.0E+00 | 8.4E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 53| +1.48E+02 | -1.1E-05 | +2.4E-01 | 9.5E-03 | 7.7E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 47| +1.48E+02 | -7.4E-04 | +9.4E-01 | 1.1E-01 | 6.0E-01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 43| +1.54E+02 | -2.6E-05 | +6.6E-01 | 7.9E-02 | 3.3E-02 | 5.6E-03 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 31| +1.48E+02 | -2.1E-01 | +6.2E-01 | 2.5E-01 | 2.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 183| +1.38E+02 | -9.0E-06 | +5.6E-01 | 3.3E-03 | 6.0E-02 | 4.8E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 31| +1.48E+02 | +2.1E-02 | -5.5E-01 | 5.9E-02 | 2.7E+00 | 5.7E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 54| +1.48E+02 | -2.1E-05 | +8.9E-01 | 2.4E-03 | 1.9E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 7| +1.82E+02 | -8.3E+00 | +4.1E-01 | 3.4E-01 | 8.4E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 48| +1.48E+02 | +2.9E-03 | -3.3E+00 | 2.2E-01 | 3.3E-01 | 7.3E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 44| +1.54E+02 | +7.6E-04 | -3.9E+00 | 7.9E-02 | 4.7E-02 | 2.2E-02 | trr |0\n", + "2023-02-17 16:05:29 fides(INFO) 32| +1.48E+02 | +9.3E-01 | -1.5E+00 | 2.5E-01 | 1.4E+01 | 3.5E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 2| +5.08E+05 | -2.8E+06 | +8.9E-01 | 2.5E-01 | 1.5E+07 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 32| +1.48E+02 | +5.0E-03 | -1.8E-01 | 1.5E-02 | 2.7E+00 | 2.6E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 55| +1.48E+02 | -5.0E-06 | +4.1E-01 | 4.8E-03 | 3.3E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 184| +1.38E+02 | -1.1E-05 | +7.4E-01 | 3.3E-03 | 6.7E-02 | 4.5E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 49| +1.48E+02 | -9.9E-05 | +2.9E-01 | 5.4E-02 | 3.3E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 45| +1.54E+02 | -2.4E-05 | +2.8E-01 | 2.6E-03 | 4.7E-02 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 8| +1.76E+02 | -6.8E+00 | +9.1E-01 | 3.4E-01 | 1.4E+02 | 6.9E-01 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 33| +1.48E+02 | -9.9E-02 | +5.2E-01 | 6.2E-02 | 1.4E+01 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 56| +1.48E+02 | -8.0E-06 | +1.0E+00 | 4.8E-03 | 2.4E-02 | 9.2E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 50| +1.48E+02 | +6.2E-04 | -6.9E-01 | 5.4E-02 | 3.7E-01 | 1.5E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 33| +1.48E+02 | -1.1E-02 | +7.8E-01 | 3.7E-03 | 2.7E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 185| +1.38E+02 | -1.0E-05 | +7.5E-01 | 3.3E-03 | 5.9E-02 | 4.3E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 46| +1.54E+02 | +7.5E-06 | -1.5E-01 | 2.6E-03 | 3.9E-02 | 5.2E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 34| +1.48E+02 | -2.1E-02 | +9.4E-01 | 6.2E-02 | 6.9E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 51| +1.48E+02 | -1.5E-04 | +5.0E-01 | 1.3E-02 | 3.7E-01 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 57| +1.48E+02 | -5.0E-06 | +2.9E-01 | 9.5E-03 | 1.2E-01 | 2.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 34| +1.48E+02 | -1.4E-03 | +9.6E-01 | 7.3E-03 | 2.8E+00 | 6.0E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 9| +1.74E+02 | -1.6E+00 | +7.8E-01 | 3.4E-01 | 5.5E+01 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 3| +7.83E+04 | -4.3E+05 | +9.0E-01 | 5.0E-01 | 2.4E+06 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 186| +1.38E+02 | -1.1E-05 | +3.9E-01 | 6.7E-03 | 6.3E-02 | 8.3E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 35| +1.48E+02 | -8.4E-03 | +5.5E-01 | 1.2E-01 | 6.1E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 47| +1.54E+02 | -1.1E-05 | +7.6E-01 | 6.5E-04 | 3.9E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 35| +1.48E+02 | -2.5E-03 | +6.0E-01 | 1.5E-02 | 1.2E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:29.462 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.596 and h = 3.12958e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.463 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.596: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 52| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.3E-02 | 6.4E-01 | 3.5E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 58| +1.48E+02 | +1.8E-04 | -3.9E+00 | 9.5E-03 | 4.7E-02 | 2.1E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 10| +1.73E+02 | -7.7E-01 | +9.5E-01 | 6.9E-01 | 4.2E+01 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 187| +1.38E+02 | +5.3E-05 | -6.2E-01 | 6.7E-03 | 7.1E-02 | 1.9E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 36| +1.48E+02 | -2.4E-03 | +9.5E-01 | 1.5E-02 | 4.4E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 36| +1.48E+02 | +6.4E-02 | -1.6E+00 | 1.2E-01 | 2.7E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 48| +1.54E+02 | -5.0E-06 | +4.5E-01 | 1.3E-03 | 3.3E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 59| +1.48E+02 | +1.4E-04 | -3.5E+00 | 2.4E-03 | 4.7E-02 | 1.7E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 53| +1.48E+02 | -5.8E-05 | +1.0E+00 | 3.4E-03 | 6.4E-01 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 4| +1.05E+04 | -6.8E+04 | +9.2E-01 | 1.0E+00 | 3.6E+05 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 11| +1.73E+02 | +1.0E+00 | -1.1E+01 | 1.4E+00 | 3.5E+01 | 4.2E+00 | trr |0\n", + "2023-02-17 16:05:29 fides(INFO) 37| +1.48E+02 | -9.3E-04 | +9.9E-01 | 2.9E-02 | 5.3E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 37| +1.48E+02 | -2.3E-03 | +1.3E-01 | 3.1E-02 | 2.7E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 188| +1.38E+02 | -1.2E-05 | +5.2E-01 | 1.7E-03 | 7.1E-02 | 4.9E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 60| +1.48E+02 | +7.4E-05 | -2.1E+00 | 6.0E-04 | 4.7E-02 | 1.4E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 49| +1.54E+02 | -3.5E-06 | +2.4E-01 | 1.3E-03 | 1.9E-02 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 54| +1.48E+02 | -6.1E-05 | +8.6E-01 | 6.7E-03 | 1.6E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 38| +1.48E+02 | -1.1E-03 | +8.8E-01 | 5.9E-02 | 1.4E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 12| +1.73E+02 | -3.5E-01 | +8.9E-01 | 3.4E-01 | 3.5E+01 | 3.5E-01 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 38| +1.48E+02 | -5.6E-03 | +8.4E-01 | 7.8E-03 | 5.9E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 61| +1.48E+02 | -9.7E-06 | +7.4E-01 | 1.5E-04 | 4.7E-02 | 3.4E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 55| +1.48E+02 | -3.7E-05 | +1.0E+00 | 1.3E-02 | 3.6E-01 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 50| +1.54E+02 | -3.9E-06 | +8.2E-01 | 3.2E-04 | 3.4E-02 | 6.5E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 189| +1.38E+02 | -6.8E-06 | +1.4E+00 | 1.7E-03 | 1.0E-01 | 1.4E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 5| +1.58E+03 | -8.9E+03 | +9.1E-01 | 1.0E+00 | 5.1E+04 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 39| +1.48E+02 | -1.4E-03 | +7.7E-01 | 1.2E-01 | 3.9E-01 | 8.9E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 62| +1.48E+02 | -1.4E-06 | +2.5E+00 | 1.5E-04 | 4.0E-02 | 4.1E-05 | 2d |1\n", + "2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 1.39E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:29 fides(INFO) 39| +1.48E+02 | -6.2E-04 | +5.2E-01 | 1.6E-02 | 9.1E-01 | 7.7E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 13| +1.72E+02 | -5.0E-01 | +9.4E-01 | 3.4E-01 | 3.3E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 56| +1.48E+02 | -3.2E-05 | +8.2E-01 | 2.7E-02 | 8.1E-02 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 51| +1.54E+02 | -2.7E-06 | +5.6E-01 | 6.5E-04 | 1.7E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 190| +1.38E+02 | -8.2E-06 | +9.3E-01 | 3.3E-03 | 5.6E-02 | 2.7E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 40| +1.48E+02 | +4.2E-03 | -8.8E-01 | 2.3E-01 | 1.3E+00 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 40| +1.48E+02 | -2.9E-04 | +8.9E-01 | 1.6E-02 | 1.1E+00 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 57| +1.48E+02 | -2.9E-06 | +4.1E-02 | 5.4E-02 | 2.0E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 6| +3.68E+02 | -1.2E+03 | +9.1E-01 | 1.0E+00 | 7.7E+03 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 14| +1.72E+02 | -5.4E-01 | +8.9E-01 | 6.9E-01 | 2.5E+01 | 2.3E-01 | trr |1\n", + "2023-02-17 16:05:29.645 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2931 and h = 1.46524e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.646 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2931: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 191| +1.38E+02 | -1.7E-05 | +9.7E-01 | 6.7E-03 | 5.7E-02 | 5.4E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 41| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 5.5E-01 | 6.7E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 41| +1.48E+02 | -9.1E-04 | +5.9E-01 | 5.9E-02 | 1.3E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 52| +1.54E+02 | -3.4E-06 | +7.2E-01 | 6.5E-04 | 1.3E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 58| +1.48E+02 | +1.1E-04 | -6.7E-01 | 1.3E-02 | 1.3E-01 | 3.6E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 42| +1.48E+02 | -2.0E-04 | +9.3E-01 | 7.8E-03 | 5.5E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 42| +1.48E+02 | -4.5E-04 | +7.8E-01 | 5.9E-02 | 3.3E-01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 15| +1.71E+02 | -4.7E-01 | +6.5E-01 | 6.9E-01 | 3.4E+01 | 4.7E-01 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 192| +1.38E+02 | -3.2E-05 | +9.5E-01 | 1.3E-02 | 5.6E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 53| +1.54E+02 | -1.3E-06 | +3.1E-01 | 6.5E-04 | 3.5E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 59| +1.48E+02 | +3.1E-05 | -3.2E-01 | 3.4E-03 | 1.3E-01 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 1.26E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:29 fides(INFO) 7| +1.81E+02 | -1.9E+02 | +1.1E+00 | 1.0E+00 | 1.1E+03 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 0| +4.31E+02 | NaN | NaN | 1.0E+00 | 6.4E+01 | NaN | NaN |1\n", + "2023-02-17 16:05:29 fides(INFO) 43| +1.48E+02 | -6.0E-04 | +7.4E-01 | 1.2E-01 | 5.4E-01 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 16| +1.71E+02 | -8.5E-02 | +3.1E-01 | 6.9E-01 | 2.2E+01 | 1.6E-01 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 43| +1.48E+02 | -1.5E-04 | +9.8E-01 | 1.6E-02 | 9.1E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:29.722 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.674 and h = 2.5308e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.722 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.674: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 60| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.4E-04 | 1.3E-01 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 193| +1.38E+02 | -5.4E-05 | +8.1E-01 | 2.7E-02 | 5.6E-02 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 1| +2.68E+02 | -1.6E+02 | +8.8E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 44| +1.48E+02 | +1.2E-04 | -1.3E-01 | 1.2E-01 | 2.9E-01 | 6.7E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 44| +1.48E+02 | -9.5E-05 | +9.2E-01 | 3.1E-02 | 3.0E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 61| +1.48E+02 | -3.1E-05 | +6.7E-01 | 2.1E-04 | 1.3E-01 | 4.5E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 2| +2.68E+02 | +6.4E+00 | -4.0E-01 | 2.0E+00 | 6.9E+01 | 5.3E+00 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 17| +1.71E+02 | -6.9E-03 | +3.4E-02 | 6.9E-01 | 8.4E+00 | 2.1E-01 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 194| +1.38E+02 | +1.7E-02 | -2.5E+01 | 5.3E-02 | 7.3E-02 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 45| +1.48E+02 | -1.5E-04 | +4.0E-01 | 2.9E-02 | 2.9E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 3| +2.56E+02 | -1.2E+01 | +3.6E-01 | 5.0E-01 | 6.9E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 45| +1.48E+02 | -4.2E-05 | +4.1E-01 | 6.2E-02 | 3.9E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 62| +1.48E+02 | -7.6E-06 | +1.0E+00 | 2.1E-04 | 2.4E-01 | 7.2E-05 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 18| +1.71E+02 | -6.8E-02 | +6.9E-01 | 5.3E-02 | 1.1E+01 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:29.791 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.178 and h = 3.56278e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.792 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.178: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 46| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.9E-02 | 1.0E+00 | 1.7E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 4| +2.56E+02 | -7.5E-01 | -8.6E-03 | 5.0E-01 | 5.0E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 195| +1.38E+02 | +9.0E-04 | -3.9E+00 | 1.3E-02 | 7.3E-02 | 5.1E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 63| +1.48E+02 | -1.3E-06 | +7.7E-02 | 4.2E-04 | 6.3E-02 | 5.6E-04 | 2d |1\n", + "2023-02-17 16:05:29.809 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2503 and h = 4.35246e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.810 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2503: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 46| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 1.7E-01 | 2.7E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 0| +1.96E+13 | NaN | NaN | 1.0E+00 | 9.0E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:29 fides(INFO) 19| +1.71E+02 | -6.8E-03 | +8.7E-01 | 5.3E-02 | 4.4E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 5| +2.50E+02 | -6.6E+00 | +7.1E-01 | 1.2E-01 | 5.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 47| +1.48E+02 | -1.6E-04 | +9.5E-01 | 7.3E-03 | 1.0E+00 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:29.840 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.3921 and h = 2.28356e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.840 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.3921: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 47| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 1.7E-01 | 7.1E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 196| +1.38E+02 | +1.2E-05 | -2.0E-01 | 3.3E-03 | 7.3E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 1| +6.60E+10 | -2.0E+13 | +8.5E-02 | 1.0E+00 | 9.0E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 64| +1.48E+02 | -1.3E-05 | +8.6E-01 | 1.1E-04 | 3.5E-01 | 8.5E-05 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 6| +2.50E+02 | +9.0E-03 | -1.0E-01 | 1.2E-01 | 3.9E+00 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 48| +1.48E+02 | -6.7E-05 | +9.9E-01 | 1.5E-02 | 8.9E-02 | 8.3E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 20| +1.71E+02 | -7.8E-05 | +1.6E-01 | 1.1E-01 | 3.3E-01 | 2.2E-02 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 48| +1.48E+02 | +7.9E-05 | -5.5E-01 | 3.9E-03 | 1.7E-01 | 2.5E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 197| +1.38E+02 | -1.0E-05 | +6.2E-01 | 8.3E-04 | 7.3E-02 | 3.5E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 8| +1.81E+02 | +1.4E+03 | -5.6E+01 | 1.0E+00 | 6.2E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 65| +1.48E+02 | +6.1E-07 | -2.6E+00 | 2.1E-04 | 2.3E-02 | 4.3E-05 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 7| +2.50E+02 | +9.1E-03 | -1.1E-01 | 3.1E-02 | 3.9E+00 | 7.9E-02 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 2| +9.84E+09 | -5.6E+10 | +8.9E-01 | 2.5E-01 | 3.0E+11 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 49| +1.48E+02 | -1.0E-04 | +9.3E-01 | 2.9E-02 | 1.1E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 49| +1.48E+02 | +3.9E-05 | -3.4E-01 | 9.8E-04 | 1.7E-01 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 8| +2.50E+02 | -4.4E-02 | +7.3E-01 | 7.8E-03 | 3.9E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:29.904 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.594 and h = 2.06348e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.904 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.594: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 66| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.3E-05 | 2.3E-02 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 198| +1.38E+02 | -3.1E-06 | +8.4E-01 | 8.3E-04 | 1.1E-01 | 1.1E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 21| +1.71E+02 | -7.4E-06 | +1.8E-02 | 7.8E-03 | 2.4E-01 | 1.5E-02 | trr |1\n", + "2023-02-17 16:05:29 fides(INFO) 3| +1.47E+09 | -8.4E+09 | +8.9E-01 | 5.0E-01 | 4.5E+10 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 50| +1.48E+02 | -1.7E-04 | +9.9E-01 | 5.9E-02 | 1.1E-01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 9| +2.50E+02 | -1.5E-05 | +2.5E-03 | 7.8E-03 | 8.8E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 50| +1.48E+02 | -4.0E-05 | +7.2E-01 | 2.4E-04 | 1.7E-01 | 5.0E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 67| +1.48E+02 | -8.0E-07 | +7.1E+00 | 1.3E-05 | 2.3E-02 | 9.6E-06 | 2d |1\n", + "2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 7.96E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:29.943 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.796 and h = 9.16043e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:29.943 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.796: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:29 fides(INFO) 9| +1.81E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 6.2E+01 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:29 fides(INFO) 199| +1.38E+02 | -3.5E-06 | +9.6E-01 | 1.7E-03 | 5.6E-02 | 1.2E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 22| +1.71E+02 | -1.0E-04 | +8.5E-01 | 1.4E-03 | 2.6E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 10| +2.50E+02 | -2.0E-03 | +7.4E-01 | 2.0E-03 | 8.8E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 51| +1.48E+02 | -2.4E-04 | +9.6E-01 | 1.2E-01 | 1.6E-01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 4| +2.21E+08 | -1.3E+09 | +8.9E-01 | 5.0E-01 | 6.8E+09 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 51| +1.48E+02 | -3.7E-06 | +1.4E+00 | 2.4E-04 | 1.2E-01 | 7.4E-05 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 11| +2.50E+02 | -4.5E-06 | +7.9E-03 | 2.0E-03 | 3.0E-01 | 3.6E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:29 fides(INFO) 200| +1.38E+02 | -6.0E-06 | +8.9E-01 | 3.3E-03 | 5.7E-02 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 23| +1.71E+02 | -8.5E-05 | +7.9E-01 | 2.8E-03 | 2.5E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 5| +3.34E+07 | -1.9E+08 | +8.9E-01 | 5.0E-01 | 1.0E+09 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 52| +1.48E+02 | -1.7E-04 | +6.7E-01 | 2.3E-01 | 1.1E-01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:29 fides(INFO) 52| +1.48E+02 | -4.6E-06 | +7.7E-01 | 4.9E-04 | 5.9E-02 | 2.5E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.50E+02 | -2.4E-04 | +7.8E-01 | 4.9E-04 | 3.0E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 53| +1.48E+02 | +6.6E-03 | -7.8E+00 | 2.3E-01 | 1.1E-01 | 8.2E-02 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 201| +1.38E+02 | -1.2E-05 | +9.3E-01 | 6.7E-03 | 5.6E-02 | 4.4E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 53| +1.48E+02 | -3.2E-06 | +7.1E-01 | 9.8E-04 | 1.7E-01 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 6| +5.07E+06 | -2.8E+07 | +8.9E-01 | 5.0E-01 | 1.5E+08 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +2.50E+02 | +7.8E-08 | -1.9E-03 | 9.8E-04 | 8.6E-02 | 2.5E-03 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +1.74E+02 | -6.7E+00 | +1.0E+00 | 6.2E-02 | 6.2E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 24| +1.71E+02 | +2.2E-07 | -2.3E-02 | 5.6E-03 | 5.8E-02 | 2.9E-03 | trr |0\n", + "2023-02-17 16:05:30 fides(INFO) 54| +1.48E+02 | +1.6E-04 | -5.2E-01 | 5.9E-02 | 1.1E-01 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 0| +2.28E+12 | NaN | NaN | 1.0E+00 | 1.0E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:30 fides(INFO) 14| +2.50E+02 | -2.0E-05 | +5.5E-01 | 2.4E-04 | 8.6E-02 | 6.3E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 54| +1.48E+02 | -1.5E-06 | +3.4E-01 | 9.8E-04 | 2.9E-02 | 4.2E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +7.72E+05 | -4.3E+06 | +8.9E-01 | 5.0E-01 | 2.3E+07 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 202| +1.38E+02 | +8.6E-05 | -2.1E+00 | 1.3E-02 | 5.8E-02 | 1.9E-03 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 25| +1.71E+02 | -2.5E-06 | +5.2E-01 | 5.4E-04 | 5.8E-02 | 7.3E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 55| +1.48E+02 | -5.5E-05 | +6.3E-01 | 1.5E-02 | 1.1E-01 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 15| +2.50E+02 | -1.5E-09 | +5.4E-04 | 2.4E-04 | 2.1E-02 | 5.7E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 1| +1.65E+06 | -2.3E+12 | +8.4E-02 | 1.0E+00 | 1.0E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 55| +1.48E+02 | -2.0E-06 | +2.7E+00 | 9.8E-04 | 1.6E-02 | 1.7E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 8| +1.17E+05 | -6.5E+05 | +9.0E-01 | 5.0E-01 | 3.5E+06 | 7.8E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 203| +1.38E+02 | -3.9E-07 | +2.2E-02 | 3.3E-03 | 5.8E-02 | 5.5E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 26| +1.71E+02 | -1.8E-06 | +1.2E+00 | 5.4E-04 | 2.4E-02 | 7.2E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 16| +2.50E+02 | -1.2E-06 | +5.3E-01 | 6.1E-05 | 2.1E-02 | 1.6E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 1.18E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:30 fides(INFO) 56| +1.48E+02 | -9.7E-06 | +9.7E-01 | 1.5E-02 | 1.6E-01 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 2| +2.54E+05 | -1.4E+06 | +8.9E-01 | 2.5E-01 | 7.6E+06 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 56| +1.48E+02 | -1.7E-06 | +1.4E+00 | 2.0E-03 | 3.8E-02 | 3.2E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 11| +1.64E+02 | -1.1E+01 | +1.0E+00 | 1.2E-01 | 7.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 9| +1.73E+04 | -1.0E+05 | +9.0E-01 | 5.0E-01 | 5.4E+05 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 3| +4.01E+04 | -2.1E+05 | +9.0E-01 | 5.0E-01 | 1.2E+06 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 204| +1.38E+02 | -8.3E-06 | +7.3E-01 | 8.3E-04 | 1.1E-01 | 2.8E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 57| +1.48E+02 | -7.1E-06 | +8.7E-01 | 2.9E-02 | 2.3E-02 | 8.4E-03 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 57| +1.48E+02 | +1.9E-06 | -1.0E+00 | 3.9E-03 | 1.5E-02 | 6.1E-04 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 27| +1.71E+02 | -1.8E-07 | +2.2E+00 | 1.1E-03 | 7.0E-03 | 1.4E-04 | trr |1\n", + "2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 1.82E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:30 fides(INFO) 58| +1.48E+02 | -1.0E-05 | +8.7E-01 | 5.9E-02 | 5.2E-02 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 4| +6.41E+03 | -3.4E+04 | +9.0E-01 | 1.0E+00 | 1.8E+05 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.55E+03 | -1.5E+04 | +9.1E-01 | 5.0E-01 | 7.9E+04 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 58| +1.48E+02 | -6.8E-07 | +1.3E+00 | 9.8E-04 | 1.5E-02 | 1.5E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 6.84E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:30 fides(INFO) 205| +1.38E+02 | +2.7E-07 | -1.3E-01 | 8.3E-04 | 5.9E-02 | 9.0E-05 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 59| +1.48E+02 | -7.1E-07 | +4.5E-02 | 1.2E-01 | 1.8E-02 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 5| +1.18E+03 | -5.2E+03 | +9.0E-01 | 1.0E+00 | 2.8E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 0| +1.58E+05 | NaN | NaN | 1.0E+00 | 7.3E+05 | NaN | NaN |1\n", + "2023-02-17 16:05:30 fides(INFO) 11| +4.97E+02 | -2.1E+03 | +9.2E-01 | 5.0E-01 | 1.1E+04 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 206| +1.38E+02 | -4.1E-07 | +6.9E-01 | 2.1E-04 | 5.9E-02 | 2.4E-05 | 2d |1\n", + "2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 4.10E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:30 fides(INFO) 6| +3.76E+02 | -8.1E+02 | +9.0E-01 | 1.0E+00 | 4.5E+03 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 60| +1.48E+02 | +3.6E-05 | -6.2E-01 | 2.9E-02 | 6.8E-02 | 5.8E-03 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 1| +4.19E+02 | -1.6E+05 | +1.2E-01 | 1.0E+00 | 7.3E+05 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +2.56E+02 | -1.2E+02 | +8.9E-01 | 2.0E+00 | 6.9E+02 | 2.8E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 0| +2.21E+05 | NaN | NaN | 1.0E+00 | 1.0E+06 | NaN | NaN |1\n", + "2023-02-17 16:05:30 fides(INFO) 61| +1.48E+02 | +2.9E-06 | -1.4E-01 | 7.3E-03 | 6.8E-02 | 1.5E-03 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 8| +2.27E+02 | -2.9E+01 | +1.5E+00 | 2.0E+00 | 8.4E+01 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +1.56E+02 | -7.7E+00 | +9.1E-01 | 2.5E-01 | 4.1E+01 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 2| +3.80E+02 | -3.9E+01 | +9.6E-01 | 2.5E-01 | 5.6E+01 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 1| +6.40E+02 | -2.2E+05 | +1.2E-01 | 1.0E+00 | 1.0E+06 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.28E+02 | -2.7E+02 | +9.4E-01 | 5.0E-01 | 1.7E+03 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 62| +1.48E+02 | -2.5E-06 | +2.5E-01 | 1.8E-03 | 6.8E-02 | 4.4E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 0| +3.65E+13 | NaN | NaN | 1.0E+00 | 1.7E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:30 fides(INFO) 3| +3.05E+02 | -7.6E+01 | +1.0E+00 | 5.0E-01 | 5.3E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 2| +2.99E+02 | -3.4E+02 | +9.0E-01 | 2.5E-01 | 1.9E+03 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 9| +2.27E+02 | +1.7E+02 | -1.3E+01 | 2.0E+00 | 2.9E+01 | 5.1E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 1| +2.37E+07 | -3.7E+13 | +8.4E-02 | 1.0E+00 | 1.7E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:30.345 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1296 and h = 1.64695e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:30.345 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1296: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:30 fides(INFO) 63| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.6E-04 | 2.1E-01 | 9.3E-05 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 2| +3.64E+06 | -2.0E+07 | +8.9E-01 | 2.5E-01 | 1.1E+08 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 3| +2.52E+02 | -4.6E+01 | +8.5E-01 | 5.0E-01 | 2.9E+02 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.27E+02 | +9.6E+00 | -1.1E+00 | 5.0E-01 | 2.9E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 4| +3.05E+02 | +1.3E+03 | -2.5E+01 | 1.0E+00 | 5.2E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 64| +1.48E+02 | -9.4E-06 | +1.7E+00 | 1.1E-04 | 2.1E-01 | 5.4E-05 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 3| +5.63E+05 | -3.1E+06 | +9.0E-01 | 5.0E-01 | 1.7E+07 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 4| +2.50E+02 | -1.8E+00 | +4.6E-01 | 1.0E+00 | 3.3E+01 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +1.90E+02 | -3.8E+01 | +1.1E+00 | 5.0E-01 | 3.0E+02 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 11| +2.24E+02 | -3.8E+00 | +5.5E-01 | 1.2E-01 | 2.9E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 4| +8.80E+04 | -4.7E+05 | +9.0E-01 | 1.0E+00 | 2.6E+06 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 5| +2.71E+02 | -3.4E+01 | +9.7E-01 | 2.5E-01 | 5.2E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 65| +1.48E+02 | -1.7E-06 | +1.0E+00 | 2.3E-04 | 2.7E-02 | 1.3E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 5| +2.49E+02 | -8.0E-01 | +3.2E-01 | 1.0E+00 | 1.2E+01 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.21E+02 | -2.6E+00 | +7.8E-01 | 1.2E-01 | 2.8E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 0| +3.47E+09 | NaN | NaN | 1.0E+00 | 1.6E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:30 fides(INFO) 5| +1.40E+04 | -7.4E+04 | +9.0E-01 | 2.0E+00 | 4.0E+05 | 4.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 6| +2.41E+03 | -1.2E+04 | +9.0E-01 | 4.0E+00 | 6.4E+04 | 1.6E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +2.20E+02 | -1.0E+00 | +1.8E-01 | 2.5E-01 | 2.0E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 6| +2.71E+02 | +6.3E+01 | -2.0E+00 | 5.0E-01 | 4.7E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 6| +2.31E+02 | -1.8E+01 | +3.1E+00 | 1.0E+00 | 1.8E+01 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 66| +1.48E+02 | +6.5E-07 | -4.6E-01 | 4.6E-04 | 1.1E-01 | 8.1E-05 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 1| +9.62E+04 | -3.5E+09 | +9.3E-02 | 1.0E+00 | 1.6E+10 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +5.71E+02 | -1.8E+03 | +9.0E-01 | 4.0E+00 | 1.0E+04 | 1.3E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +1.52E+02 | -4.1E+00 | +8.1E-01 | 5.0E-01 | 6.9E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 14| +1.83E+02 | -7.2E+00 | +1.3E-01 | 1.0E+00 | 6.8E+01 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +2.57E+02 | -1.4E+01 | +9.3E-01 | 1.2E-01 | 4.7E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 67| +1.48E+02 | -1.1E-06 | +7.9E-01 | 1.1E-04 | 1.1E-01 | 3.2E-05 | 2d |1\n", + "2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 1.10E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:30 fides(INFO) 14| +2.17E+02 | -3.4E+00 | +8.3E-01 | 6.2E-02 | 4.6E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 8| +2.87E+02 | -2.8E+02 | +9.0E-01 | 4.0E+00 | 1.6E+03 | 1.7E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +2.31E+02 | +4.8E+02 | -2.3E+01 | 2.0E+00 | 4.2E+01 | 3.3E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 2| +2.00E+04 | -7.6E+04 | +9.0E-01 | 2.5E-01 | 4.1E+05 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 15| +2.14E+02 | -2.4E+00 | +8.0E-01 | 1.2E-01 | 2.2E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 8| +2.57E+02 | +4.1E+00 | -3.7E-01 | 2.5E-01 | 3.5E+01 | 6.5E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 9| +2.36E+02 | -5.1E+01 | +1.0E+00 | 4.0E+00 | 2.4E+02 | 3.6E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) 14| +1.51E+02 | -7.1E-01 | +9.7E-01 | 1.0E+00 | 3.9E+01 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 8| +2.31E+02 | +4.3E+01 | -2.0E+00 | 5.0E-01 | 4.2E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 16| +2.13E+02 | -1.5E+00 | +2.6E-01 | 2.5E-01 | 1.9E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 3| +4.16E+03 | -1.6E+04 | +9.1E-01 | 5.0E-01 | 7.0E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 9| +2.52E+02 | -4.9E+00 | +9.1E-01 | 6.2E-02 | 3.5E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.36E+02 | +1.2E+02 | -1.1E+01 | 4.0E+00 | 2.7E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 17| +2.06E+02 | -6.8E+00 | +7.3E-01 | 2.5E-01 | 4.5E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 9| +2.21E+02 | -9.8E+00 | +8.4E-01 | 1.2E-01 | 4.2E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 15| +1.51E+02 | +2.3E+02 | -1.3E+02 | 2.0E+00 | 2.1E+01 | 5.0E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 4| +4.16E+03 | +2.1E+04 | -1.9E+01 | 1.0E+00 | 1.3E+04 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 18| +2.02E+02 | -3.6E+00 | +4.2E-01 | 2.5E-01 | 2.3E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 11| +2.36E+02 | +1.1E+01 | -1.6E+00 | 1.0E+00 | 2.7E+01 | 3.0E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 15| +1.74E+02 | -9.1E+00 | +1.1E+00 | 2.5E-01 | 1.1E+02 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.51E+02 | -5.6E-01 | +8.0E-02 | 1.2E-01 | 2.4E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 0| +4.48E+11 | NaN | NaN | 1.0E+00 | 2.1E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.08E+02 | -1.3E+01 | +9.7E-01 | 2.5E-01 | 3.5E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 1| +6.61E+05 | -4.5E+11 | +9.0E-02 | 1.0E+00 | 2.1E+12 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 16| +1.51E+02 | +2.5E+00 | -7.2E+00 | 5.0E-01 | 2.1E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 2| +1.04E+05 | -5.6E+05 | +9.0E-01 | 2.5E-01 | 3.0E+06 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 19| +1.91E+02 | -1.1E+01 | +9.8E-01 | 2.5E-01 | 5.1E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 5| +9.03E+02 | -3.3E+03 | +8.9E-01 | 2.5E-01 | 1.3E+04 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.36E+02 | +1.2E+01 | -1.7E+00 | 2.5E-01 | 2.7E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 11| +2.50E+02 | -1.3E+00 | +8.7E-01 | 3.1E-02 | 2.9E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 11| +1.96E+02 | -1.2E+01 | +1.1E+00 | 5.0E-01 | 4.4E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 17| +1.51E+02 | -2.6E-01 | +1.1E+00 | 1.2E-01 | 2.1E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 3| +1.66E+04 | -8.7E+04 | +9.0E-01 | 5.0E-01 | 4.8E+05 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 20| +1.60E+02 | -3.1E+01 | +1.1E+00 | 5.0E-01 | 3.8E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 4| +2.84E+03 | -1.4E+04 | +9.0E-01 | 1.0E+00 | 7.5E+04 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +2.33E+02 | -3.0E+00 | +8.3E-01 | 6.2E-02 | 2.7E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.49E+02 | -5.2E-01 | +5.0E-01 | 6.2E-02 | 1.5E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 6| +3.44E+02 | -5.6E+02 | +8.3E-01 | 5.0E-01 | 2.3E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +1.96E+02 | +5.5E+02 | -3.7E+01 | 1.0E+00 | 2.8E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 5| +6.37E+02 | -2.2E+03 | +9.0E-01 | 2.0E+00 | 1.2E+04 | 3.6E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 21| +1.60E+02 | +1.1E+01 | -1.4E+00 | 1.0E+00 | 7.4E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 6| +2.97E+02 | -3.4E+02 | +9.0E-01 | 4.0E+00 | 1.9E+03 | 1.2E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) 14| +2.31E+02 | -1.5E+00 | +5.1E-01 | 1.2E-01 | 1.7E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 18| +1.51E+02 | -3.1E-01 | +4.8E-01 | 2.5E-01 | 2.3E+01 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +2.49E+02 | -8.7E-02 | +3.0E-01 | 6.2E-02 | 5.5E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +2.51E+02 | -4.5E+01 | +8.5E-01 | 4.0E+00 | 3.0E+02 | 1.9E+00 | trr |1\n", + "2023-02-17 16:05:30 fides(INFO) 7| +2.52E+02 | -9.2E+01 | +8.4E-01 | 1.0E+00 | 3.8E+02 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +1.90E+02 | -6.9E+00 | +7.1E-01 | 2.5E-01 | 2.8E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 22| +1.53E+02 | -6.1E+00 | +8.1E-01 | 2.1E-01 | 7.4E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 8| +2.36E+02 | -1.5E+01 | +2.5E+00 | 4.0E+00 | 3.1E+01 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 15| +2.29E+02 | -2.5E+00 | +6.4E-01 | 1.2E-01 | 3.3E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 8| +2.50E+02 | -1.7E+00 | +4.4E-01 | 2.0E+00 | 3.2E+01 | 4.8E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 14| +2.49E+02 | -1.5E-01 | +5.0E-01 | 6.2E-02 | 6.3E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 19| +1.50E+02 | -5.3E-01 | +6.8E-01 | 2.5E-01 | 3.6E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 16| +1.61E+02 | -1.3E+01 | +7.9E-01 | 5.0E-01 | 1.8E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 9| +2.50E+02 | +1.4E-01 | -6.4E-01 | 2.0E+00 | 1.3E+01 | 4.5E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 14| +1.78E+02 | -1.2E+01 | +7.8E-01 | 2.5E-01 | 4.4E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 23| +1.49E+02 | -4.1E+00 | +1.0E+00 | 4.1E-01 | 8.8E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 16| +2.29E+02 | -6.7E-03 | -6.1E-02 | 1.2E-01 | 1.9E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 9| +2.36E+02 | +5.5E+02 | -2.5E+01 | 4.0E+00 | 4.0E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.50E+02 | +4.2E-01 | -3.8E-01 | 5.0E-01 | 1.3E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 24| +1.49E+02 | +4.1E+00 | -2.1E+00 | 8.2E-01 | 3.2E+01 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 15| +2.49E+02 | -1.2E-01 | +4.8E-01 | 6.2E-02 | 4.7E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 17| +2.28E+02 | -9.9E-01 | +8.9E-01 | 3.1E-02 | 1.9E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 20| +1.50E+02 | -2.7E-01 | +8.7E-01 | 2.5E-01 | 2.2E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 10| +2.36E+02 | +1.1E+02 | -5.7E+00 | 1.0E+00 | 4.0E+01 | 3.0E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 11| +2.50E+02 | +4.2E-01 | -3.8E-01 | 1.2E-01 | 1.3E+01 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 15| +1.78E+02 | +1.8E+01 | -1.4E+00 | 5.0E-01 | 1.4E+02 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 25| +1.49E+02 | -7.4E-01 | +7.0E-01 | 1.3E-01 | 3.2E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 11| +2.35E+02 | -1.8E+00 | +3.1E-02 | 2.5E-01 | 4.0E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 18| +2.26E+02 | -1.3E+00 | +9.6E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 16| +2.49E+02 | -1.6E-01 | +5.9E-01 | 6.2E-02 | 5.5E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.50E+02 | -5.6E-01 | +6.9E-01 | 3.1E-02 | 1.3E+01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 21| +1.50E+02 | -1.7E-01 | +8.5E-01 | 5.0E-01 | 1.8E+01 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 16| +1.65E+02 | -1.2E+01 | +9.1E-01 | 1.2E-01 | 1.4E+02 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 12| +2.28E+02 | -6.2E+00 | +8.7E-01 | 6.2E-02 | 7.4E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 26| +1.49E+02 | +1.0E+00 | -1.1E+00 | 1.3E-01 | 2.6E+01 | 2.1E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 19| +2.24E+02 | -2.0E+00 | +1.0E+00 | 1.2E-01 | 1.7E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +2.50E+02 | +1.7E-04 | -3.3E-02 | 3.1E-02 | 9.4E-01 | 7.1E-02 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 17| +2.49E+02 | -1.4E-01 | +5.4E-01 | 6.2E-02 | 4.6E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 13| +2.25E+02 | -3.4E+00 | +6.6E-01 | 1.2E-01 | 3.9E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 27| +1.48E+02 | -2.0E-01 | +6.3E-01 | 3.4E-02 | 2.6E+01 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 22| +1.50E+02 | -2.2E-02 | +6.3E-01 | 1.0E+00 | 7.7E+00 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 17| +1.59E+02 | -1.6E+00 | +1.2E-01 | 1.0E+00 | 9.8E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 17| +1.58E+02 | -7.5E+00 | +6.2E-01 | 2.5E-01 | 4.3E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 20| +2.24E+02 | +7.3E-01 | -3.6E-01 | 2.5E-01 | 1.8E+01 | 7.2E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 14| +2.50E+02 | +1.7E-04 | -3.3E-02 | 7.8E-03 | 9.4E-01 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 14| +2.25E+02 | -5.0E-02 | -4.1E-02 | 1.2E-01 | 1.9E+01 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 18| +2.49E+02 | -1.8E-01 | +6.1E-01 | 6.2E-02 | 5.9E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 15| +2.50E+02 | -2.6E-03 | +7.2E-01 | 2.0E-03 | 9.4E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 28| +1.48E+02 | -2.4E-01 | +9.2E-01 | 3.4E-02 | 1.9E+01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 15| +2.24E+02 | -9.3E-01 | +8.8E-01 | 3.1E-02 | 1.9E+01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 21| +2.23E+02 | -1.1E+00 | +6.2E-01 | 6.2E-02 | 1.8E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 23| +1.50E+02 | +3.1E-01 | -5.5E+00 | 1.0E+00 | 8.4E-01 | 6.0E-01 | trr |0\n", + "2023-02-17 16:05:30 fides(INFO) 16| +2.50E+02 | +3.7E-07 | -4.0E-03 | 2.0E-03 | 1.3E-01 | 4.5E-03 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 16| +2.23E+02 | -1.5E+00 | +1.0E+00 | 6.2E-02 | 1.7E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 29| +1.48E+02 | -1.7E-01 | +8.2E-01 | 6.7E-02 | 2.4E+01 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 18| +1.54E+02 | -4.1E+00 | +8.4E-01 | 2.5E-01 | 1.0E+02 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 22| +2.22E+02 | -1.1E+00 | +8.6E-01 | 6.2E-02 | 1.7E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 19| +2.48E+02 | -1.6E-01 | +5.0E-01 | 6.2E-02 | 5.4E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 17| +2.50E+02 | -3.4E-05 | +3.6E-01 | 4.9E-04 | 1.3E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 17| +2.20E+02 | -2.5E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 24| +1.50E+02 | -9.6E-03 | +7.0E-01 | 1.5E-01 | 8.4E-01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 23| +2.22E+02 | -4.0E-01 | +2.1E-01 | 1.2E-01 | 1.3E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 30| +1.48E+02 | -1.7E-01 | +5.7E-01 | 1.3E-01 | 8.5E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 18| +2.20E+02 | +3.6E-01 | -2.5E-01 | 2.5E-01 | 1.7E+01 | 7.3E-01 | 2d |0\n", + "2023-02-17 16:05:30 fides(INFO) 18| +2.50E+02 | -1.3E-07 | +3.4E-03 | 4.9E-04 | 7.7E-02 | 9.5E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 19| +1.53E+02 | -9.0E-01 | +1.1E+00 | 5.0E-01 | 2.3E+01 | 7.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 18| +1.57E+02 | -2.5E+00 | +9.3E-01 | 1.0E-01 | 9.0E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:30 fides(INFO) 20| +2.48E+02 | -2.3E-01 | +5.8E-01 | 6.2E-02 | 7.3E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 24| +2.21E+02 | -1.2E+00 | +8.7E-01 | 3.1E-02 | 2.9E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 19| +2.50E+02 | -1.6E-05 | +8.0E-01 | 1.2E-04 | 7.7E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 19| +2.19E+02 | -9.3E-01 | +6.1E-01 | 6.2E-02 | 1.7E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 25| +1.50E+02 | -1.6E-03 | +6.7E-01 | 1.5E-01 | 1.6E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:30 fides(INFO) 31| +1.48E+02 | +7.5E-01 | -1.3E+00 | 1.3E-01 | 1.8E+01 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 20| +2.50E+02 | +1.2E-09 | -3.8E-04 | 2.4E-04 | 2.5E-02 | 5.7E-04 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 25| +2.20E+02 | -8.9E-01 | +7.1E-01 | 6.2E-02 | 1.7E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 20| +2.18E+02 | -1.1E+00 | +8.1E-01 | 6.2E-02 | 2.0E+01 | 9.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 20| +1.52E+02 | -4.3E-01 | +9.7E-01 | 1.0E+00 | 1.7E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 32| +1.48E+02 | -1.1E-01 | +5.7E-01 | 3.4E-02 | 1.8E+01 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 21| +2.48E+02 | -1.7E-01 | +4.1E-01 | 6.2E-02 | 6.5E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 26| +1.50E+02 | -5.0E-04 | +1.0E+00 | 1.5E-01 | 6.9E-01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 21| +2.50E+02 | -1.9E-06 | +6.5E-01 | 6.1E-05 | 2.5E-02 | 1.5E-04 | 2d |1\n", + "2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 1.86E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:31 fides(INFO) 21| +2.18E+02 | -1.1E-01 | -1.6E-02 | 1.2E-01 | 1.4E+01 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 26| +2.19E+02 | -4.6E-01 | +4.8E-01 | 6.2E-02 | 1.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 21| +1.52E+02 | +1.4E+02 | -2.2E+02 | 2.0E+00 | 1.4E+01 | 5.2E+00 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 33| +1.48E+02 | -3.9E-02 | +9.1E-01 | 3.4E-02 | 4.2E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 27| +1.50E+02 | -6.0E-04 | +1.1E+00 | 2.9E-01 | 4.8E-01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 22| +2.18E+02 | -5.6E-01 | +8.8E-01 | 3.1E-02 | 1.4E+01 | 6.2E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 19| +1.55E+02 | -1.4E+00 | +9.8E-01 | 2.0E-01 | 8.1E+01 | 3.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 27| +2.19E+02 | -7.9E-01 | +6.5E-01 | 6.2E-02 | 1.7E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 22| +1.52E+02 | -1.5E-01 | +3.0E-01 | 5.0E-01 | 1.4E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 22| +2.48E+02 | -3.1E-01 | +5.6E-01 | 6.2E-02 | 9.4E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 23| +2.16E+02 | -1.1E+00 | +1.0E+00 | 6.2E-02 | 1.4E+01 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 34| +1.48E+02 | -4.8E-02 | +8.4E-01 | 6.7E-02 | 1.0E+01 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 28| +1.50E+02 | -1.5E-04 | +8.2E-01 | 5.9E-01 | 2.9E-01 | 2.6E-01 | trr |1\n", + "2023-02-17 16:05:31 fides(INFO) 23| +1.52E+02 | -6.4E-01 | +5.2E-01 | 5.0E-01 | 2.3E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 28| +2.18E+02 | -3.0E-01 | +3.4E-01 | 6.2E-02 | 1.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 24| +2.16E+02 | -3.9E-01 | +2.1E-01 | 1.2E-01 | 1.3E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 35| +1.48E+02 | -4.7E-02 | +6.4E-01 | 1.3E-01 | 2.3E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 29| +1.50E+02 | +4.7E-04 | -3.2E+00 | 5.9E-01 | 3.3E-01 | 1.5E-02 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 23| +2.48E+02 | -1.9E-01 | +3.4E-01 | 6.2E-02 | 7.7E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 29| +2.17E+02 | -7.2E-01 | +6.0E-01 | 6.2E-02 | 1.7E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 25| +2.15E+02 | -1.1E+00 | +8.5E-01 | 3.1E-02 | 2.8E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 24| +1.51E+02 | -1.1E+00 | +8.7E-01 | 5.0E-01 | 2.0E+01 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 20| +1.55E+02 | +4.0E-01 | -7.4E-01 | 4.0E-01 | 2.1E+01 | 8.1E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 0| +2.59E+04 | NaN | NaN | 1.0E+00 | 9.1E+04 | NaN | NaN |1\n", + "2023-02-17 16:05:31 fides(INFO) 36| +1.48E+02 | +1.9E-01 | -1.3E+00 | 1.3E-01 | 3.7E+00 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 30| +2.17E+02 | -1.7E-01 | +2.0E-01 | 6.2E-02 | 1.0E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 26| +2.14E+02 | -5.0E-01 | +5.4E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 30| +1.50E+02 | -3.1E-05 | +4.5E-01 | 1.9E-02 | 3.3E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 24| +2.47E+02 | -4.2E-01 | +5.7E-01 | 6.2E-02 | 1.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 25| +1.51E+02 | +2.8E+00 | -1.7E+00 | 1.0E+00 | 9.0E+00 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 31| +2.17E+02 | -3.9E-01 | +9.0E-01 | 1.6E-02 | 1.7E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 37| +1.48E+02 | -2.1E-02 | +5.1E-01 | 3.4E-02 | 3.7E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 27| +2.14E+02 | +3.1E-03 | -3.1E-02 | 6.2E-02 | 1.1E+01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 1| +3.75E+02 | -2.6E+04 | +1.6E-01 | 1.0E+00 | 9.1E+04 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 31| +1.50E+02 | -6.2E-06 | +2.9E-01 | 1.9E-02 | 8.7E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 26| +1.50E+02 | -4.1E-01 | +6.1E-01 | 2.5E-01 | 9.0E+00 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 32| +2.17E+02 | -3.9E-01 | +7.9E-01 | 3.1E-02 | 1.2E+01 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 28| +2.14E+02 | -2.7E-01 | +8.7E-01 | 1.6E-02 | 1.1E+01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 38| +1.48E+02 | -9.7E-03 | +9.2E-01 | 3.4E-02 | 1.6E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 2| +2.83E+02 | -9.2E+01 | +8.9E-01 | 2.5E-01 | 5.4E+02 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 25| +2.47E+02 | -2.2E-01 | +3.1E-01 | 6.2E-02 | 9.0E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 21| +1.55E+02 | -5.6E-01 | +8.6E-01 | 1.0E-01 | 2.1E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 29| +2.14E+02 | -2.7E-01 | +7.9E-01 | 3.1E-02 | 9.4E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 33| +2.16E+02 | -5.8E-01 | +8.9E-01 | 6.2E-02 | 7.8E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 32| +1.50E+02 | +4.8E-08 | -4.0E-03 | 1.9E-02 | 5.6E-02 | 2.3E-03 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 3| +2.58E+02 | -2.5E+01 | +7.7E-01 | 5.0E-01 | 8.1E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 39| +1.48E+02 | -1.4E-02 | +9.3E-01 | 6.7E-02 | 2.1E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 27| +1.50E+02 | -1.8E-01 | +7.7E-01 | 2.5E-01 | 1.2E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 34| +2.16E+02 | -3.3E-01 | +5.0E-01 | 1.2E-01 | 9.8E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 30| +2.14E+02 | -3.0E-01 | +5.8E-01 | 6.2E-02 | 1.1E+01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 26| +2.46E+02 | -5.9E-01 | +6.0E-01 | 6.2E-02 | 1.5E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 4| +2.58E+02 | +1.1E+02 | -6.5E+00 | 1.0E+00 | 4.0E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 35| +2.16E+02 | +1.9E-01 | -2.3E-01 | 1.2E-01 | 1.1E+01 | 3.5E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 33| +1.50E+02 | -3.2E-06 | +7.8E-01 | 4.7E-03 | 5.6E-02 | 5.8E-04 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 40| +1.48E+02 | -1.6E-02 | +7.7E-01 | 1.3E-01 | 1.0E+00 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 28| +1.50E+02 | -2.1E-01 | +6.2E-01 | 5.0E-01 | 4.7E+00 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 31| +2.14E+02 | +1.2E-01 | -1.9E-01 | 6.2E-02 | 1.1E+01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 22| +1.54E+02 | -4.5E-01 | +6.0E-01 | 2.0E-01 | 4.9E+01 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 36| +2.15E+02 | -4.1E-01 | +6.8E-01 | 3.1E-02 | 1.1E+01 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 5| +2.57E+02 | -1.5E+00 | +1.0E-02 | 2.5E-01 | 4.0E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 41| +1.48E+02 | +3.6E-01 | -7.2E+00 | 2.7E-01 | 1.4E+00 | 2.6E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 32| +2.13E+02 | -2.7E-01 | +8.5E-01 | 1.6E-02 | 1.1E+01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 34| +1.50E+02 | -7.5E-07 | +3.3E-01 | 9.5E-03 | 1.0E-02 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 7.48E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:31 fides(INFO) 27| +2.46E+02 | -3.1E-01 | +3.6E-01 | 6.2E-02 | 1.0E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 29| +1.50E+02 | -1.2E-01 | +6.6E-01 | 5.0E-01 | 4.0E+00 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 37| +2.15E+02 | -2.6E-01 | +9.4E-01 | 3.1E-02 | 6.6E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 6| +2.52E+02 | -5.5E+00 | +8.5E-01 | 6.2E-02 | 6.6E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 33| +2.13E+02 | -1.5E-01 | +5.5E-01 | 3.1E-02 | 7.8E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 42| +1.48E+02 | +6.2E-03 | -3.4E-01 | 6.7E-02 | 1.4E+00 | 6.6E-02 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 23| +1.54E+02 | -2.0E-01 | +8.9E-01 | 2.0E-01 | 2.7E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 38| +2.15E+02 | -1.4E-01 | +3.4E-01 | 6.2E-02 | 6.1E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 7| +2.50E+02 | -1.2E+00 | +4.0E-01 | 1.2E-01 | 2.8E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 30| +1.50E+02 | -6.3E-02 | +7.3E-01 | 5.0E-01 | 7.0E+00 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 34| +2.13E+02 | -2.0E-01 | +6.4E-01 | 3.1E-02 | 9.9E+00 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 43| +1.48E+02 | -3.6E-03 | +6.9E-01 | 1.7E-02 | 1.4E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 28| +2.45E+02 | -7.9E-01 | +6.6E-01 | 6.2E-02 | 1.8E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 39| +2.15E+02 | -3.2E-01 | +4.3E-01 | 6.2E-02 | 1.3E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 35| +2.13E+02 | -9.1E-02 | +3.8E-01 | 3.1E-02 | 7.1E+00 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 8| +2.50E+02 | +3.4E-01 | -3.3E-01 | 1.2E-01 | 1.3E+01 | 2.8E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 24| +1.54E+02 | -2.9E-02 | +9.1E-01 | 4.0E-01 | 5.9E+00 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 44| +1.48E+02 | -1.3E-03 | +9.1E-01 | 1.7E-02 | 5.8E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 40| +2.15E+02 | +1.3E-02 | -5.0E-02 | 6.2E-02 | 8.2E+00 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 31| +1.50E+02 | -1.4E-02 | +7.5E-01 | 5.0E-01 | 2.7E+00 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 36| +2.13E+02 | -1.7E-01 | +5.7E-01 | 3.1E-02 | 9.8E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 0| +1.98E+12 | NaN | NaN | 1.0E+00 | 9.2E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:31 fides(INFO) 29| +2.45E+02 | -5.1E-01 | +5.1E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 9| +2.50E+02 | -5.2E-01 | +6.9E-01 | 3.1E-02 | 1.3E+01 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 41| +2.14E+02 | -2.0E-01 | +8.1E-01 | 1.6E-02 | 8.2E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 45| +1.48E+02 | -2.2E-03 | +9.8E-01 | 3.4E-02 | 7.0E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 37| +2.13E+02 | -4.2E-02 | +1.9E-01 | 3.1E-02 | 6.4E+00 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 25| +1.54E+02 | -7.2E-03 | +5.1E-01 | 8.0E-01 | 4.4E+00 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 1| +1.26E+06 | -2.0E+12 | +8.4E-02 | 1.0E+00 | 9.2E+12 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 32| +1.50E+02 | -3.6E-03 | +7.3E-01 | 1.0E+00 | 1.0E+00 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 10| +2.50E+02 | -3.9E-03 | +9.2E-02 | 3.1E-02 | 2.7E+00 | 6.2E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 42| +2.14E+02 | -1.4E-01 | +7.0E-01 | 3.1E-02 | 5.2E+00 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 38| +2.13E+02 | -1.0E-01 | +9.1E-01 | 7.8E-03 | 9.6E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 46| +1.48E+02 | -3.1E-03 | +9.4E-01 | 6.7E-02 | 5.8E-01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 30| +2.44E+02 | -9.4E-01 | +7.3E-01 | 6.2E-02 | 2.0E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 2| +1.83E+05 | -1.1E+06 | +9.0E-01 | 2.5E-01 | 6.0E+06 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 39| +2.12E+02 | -9.9E-02 | +7.8E-01 | 1.6E-02 | 7.3E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 43| +2.14E+02 | -1.5E-01 | +5.9E-01 | 3.1E-02 | 7.3E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 26| +1.54E+02 | +3.7E-01 | -1.2E+01 | 8.0E-01 | 1.1E+00 | 5.0E-01 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 33| +1.50E+02 | +1.0E-04 | -2.0E-01 | 1.0E+00 | 5.6E-01 | 7.4E-01 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 11| +2.50E+02 | -1.3E-02 | +4.3E-01 | 7.8E-03 | 2.3E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 3| +2.56E+04 | -1.6E+05 | +9.0E-01 | 5.0E-01 | 9.0E+05 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 47| +1.48E+02 | -2.5E-03 | +8.0E-01 | 1.3E-01 | 5.2E-01 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 40| +2.12E+02 | -1.4E-01 | +8.8E-01 | 3.1E-02 | 5.2E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 44| +2.14E+02 | -7.0E-02 | +3.1E-01 | 3.1E-02 | 5.7E+00 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 31| +2.43E+02 | -7.3E-01 | +6.4E-01 | 6.2E-02 | 1.3E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 27| +1.54E+02 | -5.4E-03 | +7.0E-01 | 1.3E-01 | 1.1E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 12| +2.50E+02 | -3.1E-04 | +4.0E-02 | 7.8E-03 | 1.1E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 4| +3.89E+03 | -2.2E+04 | +9.0E-01 | 5.0E-01 | 1.4E+05 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 48| +1.48E+02 | +8.2E-02 | -1.4E+01 | 2.7E-01 | 2.9E-01 | 1.4E-01 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 41| +2.12E+02 | -4.7E-02 | +3.2E-01 | 6.2E-02 | 5.9E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 45| +2.14E+02 | -1.6E-01 | +5.6E-01 | 3.1E-02 | 8.2E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 34| +1.50E+02 | -2.0E-04 | +7.7E-01 | 2.2E-01 | 5.6E-01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 5| +7.42E+02 | -3.1E+03 | +9.0E-01 | 5.0E-01 | 2.2E+04 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 13| +2.50E+02 | -3.1E-03 | +7.4E-01 | 2.0E-03 | 1.0E+00 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 49| +1.48E+02 | +3.1E-03 | -1.1E+00 | 3.9E-02 | 2.9E-01 | 3.4E-02 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 46| +2.14E+02 | -5.6E-02 | +2.8E-01 | 3.1E-02 | 5.3E+00 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 32| +2.42E+02 | -9.5E-01 | +7.7E-01 | 6.2E-02 | 2.0E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 42| +2.12E+02 | +3.4E-02 | -1.5E-01 | 6.2E-02 | 6.3E+00 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 28| +1.54E+02 | -5.8E-04 | +6.8E-01 | 1.3E-01 | 3.7E-01 | 9.3E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 35| +1.50E+02 | -7.7E-05 | +9.2E-01 | 4.3E-01 | 2.5E-01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 6| +2.75E+02 | -4.7E+02 | +9.0E-01 | 5.0E-01 | 3.5E+03 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 14| +2.50E+02 | +1.1E-06 | -6.0E-03 | 2.0E-03 | 1.8E-01 | 4.2E-03 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 47| +2.14E+02 | -1.5E-01 | +5.3E-01 | 3.1E-02 | 8.0E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 43| +2.12E+02 | -1.2E-01 | +6.9E-01 | 1.6E-02 | 6.3E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 50| +1.48E+02 | -3.3E-04 | +4.1E-01 | 9.8E-03 | 2.9E-01 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 7| +2.05E+02 | -7.0E+01 | +9.3E-01 | 5.0E-01 | 5.4E+02 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 29| +1.54E+02 | -2.3E-04 | +1.1E+00 | 1.3E-01 | 4.2E-01 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 33| +2.41E+02 | -8.7E-01 | +4.6E-01 | 1.2E-01 | 1.3E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 15| +2.50E+02 | -9.7E-05 | +5.8E-01 | 4.9E-04 | 1.8E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 44| +2.12E+02 | -6.4E-02 | +9.8E-01 | 1.6E-02 | 4.1E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 48| +2.14E+02 | -4.6E-02 | +2.4E-01 | 3.1E-02 | 5.2E+00 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 36| +1.50E+02 | -2.2E-05 | +8.7E-01 | 8.7E-01 | 1.9E-01 | 2.4E-01 | trr |1\n", + "2023-02-17 16:05:31 fides(INFO) 51| +1.48E+02 | -1.3E-04 | +8.5E-01 | 9.8E-03 | 8.1E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 45| +2.12E+02 | -6.6E-02 | +6.7E-01 | 3.1E-02 | 3.7E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 16| +2.50E+02 | -8.5E-09 | +1.2E-03 | 4.9E-04 | 3.3E-02 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 49| +2.13E+02 | -8.7E-02 | +9.0E-01 | 7.8E-03 | 7.8E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 30| +1.54E+02 | -3.4E-04 | +1.1E+00 | 2.5E-01 | 1.7E-01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 37| +1.50E+02 | +6.1E-06 | -4.5E-01 | 8.7E-01 | 5.5E-02 | 6.1E-03 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 8| +2.05E+02 | +1.8E+02 | -1.8E+01 | 1.0E+00 | 9.1E+01 | 2.9E+00 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 34| +2.39E+02 | -1.9E+00 | +9.3E-01 | 1.2E-01 | 1.2E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 52| +1.48E+02 | -8.1E-05 | +8.2E-01 | 2.0E-02 | 1.1E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 46| +2.12E+02 | -2.9E-02 | +2.3E-01 | 3.1E-02 | 5.5E+00 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 50| +2.13E+02 | -8.5E-02 | +7.7E-01 | 1.6E-02 | 5.5E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 9| +1.94E+02 | -1.0E+01 | +1.1E+00 | 2.5E-01 | 9.1E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 17| +2.50E+02 | -1.7E-06 | +2.8E-01 | 1.2E-04 | 3.2E-02 | 3.2E-04 | 2d |1\n", + "2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 1.72E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:31 fides(INFO) 38| +1.50E+02 | -5.2E-06 | +8.5E-01 | 1.9E-02 | 5.5E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 53| +1.48E+02 | +6.9E-05 | -3.9E-01 | 3.9E-02 | 1.6E-01 | 5.4E-03 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 31| +1.54E+02 | -5.0E-04 | +1.6E+00 | 5.1E-01 | 1.7E-01 | 2.1E-01 | trr |1\n", + "2023-02-17 16:05:31 fides(INFO) 47| +2.12E+02 | -5.5E-02 | +8.1E-01 | 7.8E-03 | 4.7E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 51| +2.13E+02 | -1.0E-01 | +7.1E-01 | 3.1E-02 | 3.9E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 10| +1.94E+02 | +1.3E+01 | -2.6E+00 | 5.0E-01 | 3.1E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 39| +1.50E+02 | -1.3E-06 | +6.0E-01 | 3.7E-02 | 2.5E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 1.28E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:31 fides(INFO) 54| +1.48E+02 | -3.9E-05 | +7.0E-01 | 9.8E-03 | 1.6E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 48| +2.12E+02 | -1.1E-02 | +2.9E-01 | 1.6E-02 | 3.0E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 35| +2.39E+02 | +2.7E+00 | -6.9E-01 | 2.5E-01 | 1.2E+01 | 6.0E-01 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 32| +1.54E+02 | -1.9E-04 | +1.5E+00 | 5.1E-01 | 1.0E-01 | 5.0E-03 | trr |1\n", + "2023-02-17 16:05:31 fides(INFO) 52| +2.13E+02 | -7.9E-02 | +4.2E-01 | 3.1E-02 | 6.2E+00 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 11| +1.89E+02 | -5.4E+00 | +1.0E+00 | 1.2E-01 | 3.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 55| +1.48E+02 | -2.8E-05 | +7.7E-01 | 9.8E-03 | 1.4E-01 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 49| +2.12E+02 | -3.4E-02 | +4.8E-01 | 1.6E-02 | 4.5E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 53| +2.13E+02 | -2.6E-02 | +1.3E-01 | 3.1E-02 | 5.3E+00 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 36| +2.38E+02 | -9.4E-01 | +7.2E-01 | 6.2E-02 | 1.2E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 33| +1.54E+02 | +3.4E-04 | -2.4E+00 | 5.1E-01 | 7.8E-02 | 1.6E-02 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 12| +1.76E+02 | -1.3E+01 | +1.4E+00 | 2.5E-01 | 1.9E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 50| +2.12E+02 | -4.7E-03 | +1.0E-01 | 1.6E-02 | 3.1E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 0| +1.57E+13 | NaN | NaN | 1.0E+00 | 5.8E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:31 fides(INFO) 56| +1.48E+02 | -3.1E-05 | +6.2E-01 | 2.0E-02 | 8.4E-02 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 54| +2.13E+02 | -8.6E-02 | +8.9E-01 | 7.8E-03 | 7.6E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 1| +4.16E+10 | -1.6E+13 | +1.0E-01 | 1.0E+00 | 5.8E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 51| +2.12E+02 | -2.2E-02 | +9.0E-01 | 3.9E-03 | 4.3E+00 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 13| +1.63E+02 | -1.2E+01 | +4.7E-01 | 5.0E-01 | 6.1E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 57| +1.48E+02 | +4.0E-05 | -4.4E-01 | 2.0E-02 | 1.7E-01 | 7.6E-03 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 55| +2.13E+02 | -7.2E-02 | +7.1E-01 | 1.6E-02 | 5.2E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 34| +1.54E+02 | -3.3E-05 | +5.3E-01 | 1.8E-03 | 7.8E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 37| +2.37E+02 | -9.8E-01 | +8.0E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 2| +6.23E+09 | -3.5E+10 | +8.9E-01 | 2.5E-01 | 1.9E+11 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 52| +2.12E+02 | -2.0E-02 | +7.2E-01 | 7.8E-03 | 3.2E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 0| +6.30E+11 | NaN | NaN | 1.0E+00 | 2.6E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:31 fides(INFO) 56| +2.13E+02 | -5.4E-02 | +7.6E-01 | 1.6E-02 | 3.5E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 3| +9.33E+08 | -5.3E+09 | +8.9E-01 | 5.0E-01 | 2.9E+10 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 14| +1.63E+02 | -2.2E+00 | -6.9E-02 | 5.0E-01 | 1.4E+02 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 58| +1.48E+02 | -1.9E-05 | +6.9E-01 | 4.9E-03 | 1.7E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 4| +1.41E+08 | -7.9E+08 | +8.9E-01 | 5.0E-01 | 4.3E+09 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 35| +1.54E+02 | -2.2E-05 | +4.6E-01 | 1.8E-03 | 4.6E-02 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 53| +2.12E+02 | -1.5E-02 | +8.3E-01 | 7.8E-03 | 2.4E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 1| +9.99E+09 | -6.2E+11 | +9.9E-02 | 1.0E+00 | 2.6E+12 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 38| +2.35E+02 | -2.1E+00 | +1.0E+00 | 1.2E-01 | 1.5E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 5| +2.13E+07 | -1.2E+08 | +8.9E-01 | 5.0E-01 | 6.4E+08 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 57| +2.13E+02 | -4.7E-02 | +4.1E-01 | 3.1E-02 | 4.3E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 15| +1.58E+02 | -4.9E+00 | +9.8E-01 | 1.2E-01 | 1.4E+02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 59| +1.48E+02 | -7.7E-06 | +1.2E+00 | 4.9E-03 | 4.8E-02 | 8.9E-04 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 2| +1.49E+09 | -8.5E+09 | +8.9E-01 | 2.5E-01 | 4.6E+10 | 7.5E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 54| +2.12E+02 | -1.2E-02 | +4.2E-01 | 1.6E-02 | 2.6E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 6| +3.24E+06 | -1.8E+07 | +8.9E-01 | 5.0E-01 | 9.7E+07 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 58| +2.13E+02 | +1.6E-02 | -1.0E-01 | 3.1E-02 | 5.3E+00 | 7.5E-02 | trr |0\n", + "2023-02-17 16:05:31 fides(INFO) 36| +1.54E+02 | -2.1E-05 | +4.1E-01 | 1.8E-03 | 5.1E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 16| +1.57E+02 | -1.5E+00 | +3.8E-01 | 2.5E-01 | 6.9E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 7| +4.97E+05 | -2.7E+06 | +8.9E-01 | 5.0E-01 | 1.5E+07 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 3| +2.25E+08 | -1.3E+09 | +8.9E-01 | 5.0E-01 | 6.9E+09 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 60| +1.48E+02 | -9.4E-06 | +9.5E-01 | 9.8E-03 | 6.0E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 55| +2.12E+02 | -2.9E-03 | +5.7E-02 | 1.6E-02 | 2.9E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 59| +2.13E+02 | -7.0E-02 | +8.5E-01 | 7.8E-03 | 5.3E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 8| +7.70E+04 | -4.2E+05 | +9.0E-01 | 5.0E-01 | 2.3E+06 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 4| +3.41E+07 | -1.9E+08 | +8.9E-01 | 1.0E+00 | 1.0E+09 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 17| +1.52E+02 | -4.8E+00 | +8.1E-01 | 2.5E-01 | 7.9E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 39| +2.34E+02 | -1.3E+00 | +2.5E-01 | 2.5E-01 | 1.3E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 37| +1.54E+02 | -1.1E-05 | +2.7E-01 | 1.8E-03 | 3.5E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 61| +1.48E+02 | -1.1E-05 | +8.1E-01 | 2.0E-02 | 3.6E-02 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 56| +2.12E+02 | -2.0E-02 | +8.9E-01 | 3.9E-03 | 3.8E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 9| +1.21E+04 | -6.5E+04 | +9.0E-01 | 5.0E-01 | 3.5E+05 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 60| +2.13E+02 | -3.8E-02 | +5.5E-01 | 1.6E-02 | 3.5E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 5| +5.17E+06 | -2.9E+07 | +8.9E-01 | 2.0E+00 | 1.6E+08 | 8.0E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:31 fides(INFO) 10| +2.08E+03 | -1.0E+04 | +9.0E-01 | 1.0E+00 | 5.5E+04 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 57| +2.12E+02 | -1.4E-02 | +6.3E-01 | 7.8E-03 | 2.7E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 38| +1.54E+02 | -1.4E-05 | +3.0E-01 | 1.8E-03 | 4.1E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 18| +1.50E+02 | -2.0E+00 | +7.7E-01 | 5.0E-01 | 3.8E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 62| +1.48E+02 | +2.3E-05 | -1.4E+00 | 3.9E-02 | 4.1E-02 | 7.0E-03 | 2d |0\n", + "2023-02-17 16:05:31 fides(INFO) 11| +5.14E+02 | -1.6E+03 | +9.0E-01 | 1.0E+00 | 8.6E+03 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 6| +7.88E+05 | -4.4E+06 | +8.9E-01 | 2.0E+00 | 2.4E+07 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 61| +2.13E+02 | -5.5E-02 | +6.7E-01 | 1.6E-02 | 4.4E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:31 fides(INFO) 58| +2.12E+02 | -6.6E-03 | +4.9E-01 | 7.8E-03 | 1.9E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 12| +2.76E+02 | -2.4E+02 | +9.0E-01 | 2.0E+00 | 1.3E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 40| +2.29E+02 | -4.7E+00 | +9.8E-01 | 2.5E-01 | 3.4E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 63| +1.48E+02 | -6.0E-06 | +1.1E+00 | 9.8E-03 | 4.1E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 7| +1.21E+05 | -6.7E+05 | +9.0E-01 | 2.0E+00 | 3.6E+06 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 62| +2.13E+02 | -3.4E-02 | +5.3E-01 | 1.6E-02 | 3.3E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 39| +1.54E+02 | -5.5E-06 | +1.5E-01 | 1.8E-03 | 2.8E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 59| +2.12E+02 | -1.1E-02 | +5.8E-01 | 7.8E-03 | 2.4E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 13| +2.29E+02 | -4.7E+01 | +1.2E+00 | 2.0E+00 | 1.9E+02 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 19| +1.50E+02 | -2.3E-01 | +2.2E-01 | 1.0E+00 | 3.0E+01 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 8| +1.88E+04 | -1.0E+05 | +9.0E-01 | 2.0E+00 | 5.5E+05 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 64| +1.48E+02 | +2.3E-05 | -1.7E+00 | 2.0E-02 | 3.1E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 63| +2.13E+02 | -5.2E-02 | +6.4E-01 | 1.6E-02 | 4.4E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 41| +2.23E+02 | -6.6E+00 | +7.2E-01 | 5.0E-01 | 2.8E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 60| +2.12E+02 | -4.4E-03 | +3.3E-01 | 7.8E-03 | 1.9E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 9| +3.09E+03 | -1.6E+04 | +9.0E-01 | 2.0E+00 | 8.5E+04 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 40| +1.54E+02 | -9.6E-06 | +8.3E-01 | 4.5E-04 | 3.4E-02 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 64| +2.13E+02 | -2.9E-02 | +4.7E-01 | 1.6E-02 | 3.2E+00 | 3.3E-02 | trr |1\n", + "2023-02-17 16:05:32 fides(INFO) 65| +1.48E+02 | -1.8E-07 | +3.5E-02 | 4.9E-03 | 3.1E-02 | 3.8E-04 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 14| +2.29E+02 | +1.4E+02 | -1.6E+01 | 2.0E+00 | 3.1E+01 | 6.1E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 61| +2.12E+02 | -1.0E-02 | +5.5E-01 | 7.8E-03 | 2.4E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 20| +1.50E+02 | -1.9E-01 | +5.3E-01 | 1.1E-01 | 6.9E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 10| +6.63E+02 | -2.4E+03 | +9.0E-01 | 2.0E+00 | 1.3E+04 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 42| +2.23E+02 | +8.6E+01 | -6.9E+00 | 5.0E-01 | 3.5E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 15| +2.29E+02 | +1.4E+01 | -1.6E+00 | 5.0E-01 | 3.1E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 41| +1.54E+02 | -6.5E-06 | +4.4E-01 | 9.0E-04 | 2.3E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 65| +2.13E+02 | -5.0E-02 | +6.2E-01 | 1.6E-02 | 4.4E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 62| +2.12E+02 | -3.3E-03 | +2.7E-01 | 7.8E-03 | 1.7E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 11| +2.93E+02 | -3.7E+02 | +9.0E-01 | 2.0E+00 | 2.1E+03 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 66| +1.48E+02 | -5.5E-06 | +2.3E+00 | 1.2E-03 | 1.0E-01 | 2.7E-04 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 66| +2.13E+02 | -2.5E-02 | +4.2E-01 | 1.6E-02 | 3.1E+00 | 3.4E-02 | trr |1\n", + "2023-02-17 16:05:32 fides(INFO) 16| +2.25E+02 | -3.9E+00 | +5.3E-01 | 1.2E-01 | 3.1E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 43| +2.23E+02 | +2.0E+00 | -3.7E-01 | 1.2E-01 | 3.5E+01 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 12| +2.43E+02 | -5.0E+01 | +8.8E-01 | 2.0E+00 | 3.1E+02 | 5.0E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 42| +1.54E+02 | -4.7E-06 | +4.2E-01 | 9.0E-04 | 1.7E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 17| +2.23E+02 | -2.1E+00 | +7.1E-01 | 1.2E-01 | 2.6E+01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 67| +1.48E+02 | +3.7E-06 | -3.2E+00 | 2.4E-03 | 1.2E-02 | 4.0E-04 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 63| +2.12E+02 | -9.0E-03 | +5.1E-01 | 7.8E-03 | 2.3E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 67| +2.12E+02 | -5.1E-02 | +6.3E-01 | 1.6E-02 | 4.4E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 18| +2.23E+02 | +1.0E-01 | -8.0E-02 | 1.2E-01 | 2.1E+01 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 68| +1.48E+02 | +3.3E-06 | -9.3E+00 | 6.1E-04 | 1.2E-02 | 1.0E-04 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 43| +1.54E+02 | -3.0E-06 | +2.6E-01 | 9.0E-04 | 2.0E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 64| +2.12E+02 | -2.6E-03 | +2.3E-01 | 7.8E-03 | 1.6E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 68| +2.12E+02 | -2.2E-02 | +3.9E-01 | 1.6E-02 | 3.0E+00 | 3.4E-02 | trr |1\n", + "2023-02-17 16:05:32 fides(INFO) 21| +1.50E+02 | -1.3E-01 | +8.2E-01 | 1.1E-01 | 1.7E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 44| +2.21E+02 | -1.6E+00 | +8.1E-01 | 3.1E-02 | 3.5E+01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 13| +2.38E+02 | -5.3E+00 | +7.2E-01 | 4.0E+00 | 3.5E+01 | 4.4E+00 | trr |1\n", + "2023-02-17 16:05:32 fides(INFO) 19| +2.22E+02 | -1.1E+00 | +8.8E-01 | 3.1E-02 | 2.1E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 65| +2.12E+02 | -5.3E-03 | +9.0E-01 | 2.0E-03 | 2.1E+00 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 69| +1.48E+02 | +4.7E-06 | -3.2E+01 | 1.5E-04 | 1.2E-02 | 3.0E-05 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 69| +2.12E+02 | -5.1E-02 | +6.3E-01 | 1.6E-02 | 4.3E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 44| +1.54E+02 | -3.8E-06 | +3.3E-01 | 9.0E-04 | 1.4E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 14| +2.38E+02 | +7.8E+01 | -6.4E+00 | 4.0E+00 | 2.2E+01 | 9.9E+00 | trr |0\n", + "2023-02-17 16:05:32 fides(INFO) 66| +2.12E+02 | -5.2E-03 | +7.6E-01 | 3.9E-03 | 1.7E+00 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 20| +2.20E+02 | -1.2E+00 | +8.6E-01 | 6.2E-02 | 1.7E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 45| +2.18E+02 | -2.6E+00 | +7.3E-01 | 6.2E-02 | 4.6E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 22| +1.50E+02 | -5.4E-02 | +5.6E-01 | 2.2E-01 | 5.4E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 70| +1.48E+02 | +5.5E-06 | -5.8E+01 | 3.8E-05 | 1.2E-02 | 1.6E-05 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 70| +2.12E+02 | -2.0E-02 | +3.8E-01 | 1.6E-02 | 2.8E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 67| +2.12E+02 | -6.3E-03 | +7.2E-01 | 7.8E-03 | 1.3E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 21| +2.19E+02 | -1.8E+00 | +8.4E-01 | 1.2E-01 | 2.0E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 45| +1.54E+02 | -4.9E-07 | +5.4E-02 | 9.0E-04 | 1.6E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 46| +2.16E+02 | -1.9E+00 | +8.6E-01 | 6.2E-02 | 4.8E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 71| +2.12E+02 | -5.0E-02 | +6.2E-01 | 1.6E-02 | 4.3E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:32.264 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.574 and h = 2.93244e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:32.264 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.574: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:32 fides(INFO) 71| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.6E-06 | 1.2E-02 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 68| +2.12E+02 | -3.9E-03 | +3.5E-01 | 7.8E-03 | 1.7E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 22| +2.19E+02 | +8.3E-01 | -3.6E-01 | 2.5E-01 | 1.9E+01 | 7.2E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 23| +1.50E+02 | -1.1E-02 | +8.8E-01 | 2.2E-01 | 4.1E+00 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 46| +1.54E+02 | -2.9E-06 | +8.7E-01 | 2.2E-04 | 1.1E-02 | 4.9E-04 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 72| +2.12E+02 | -2.8E-02 | +5.4E-01 | 1.6E-02 | 2.8E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 15| +2.38E+02 | +2.5E+01 | -5.3E+00 | 9.2E-01 | 2.2E+01 | 2.5E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 69| +2.12E+02 | -2.3E-03 | +1.9E-01 | 7.8E-03 | 1.6E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 23| +2.17E+02 | -1.2E+00 | +6.1E-01 | 6.2E-02 | 1.9E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 47| +2.14E+02 | -2.2E+00 | +9.6E-01 | 1.2E-01 | 3.1E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 72| +1.48E+02 | +2.8E-06 | -6.0E+01 | 2.4E-06 | 1.2E-02 | 5.2E-06 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 73| +2.12E+02 | -4.1E-02 | +6.2E-01 | 1.6E-02 | 3.7E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 24| +1.50E+02 | -8.9E-03 | +9.2E-01 | 4.5E-01 | 3.6E+00 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 47| +1.54E+02 | -2.3E-06 | +5.4E-01 | 4.5E-04 | 2.7E-02 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 24| +2.16E+02 | -1.0E+00 | +8.6E-01 | 6.2E-02 | 1.8E+01 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 70| +2.12E+02 | -4.8E-03 | +8.9E-01 | 2.0E-03 | 1.9E+00 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 48| +2.11E+02 | -3.0E+00 | +8.7E-01 | 2.5E-01 | 3.3E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 73| +1.48E+02 | +6.7E-06 | -4.9E+02 | 6.0E-07 | 1.2E-02 | 1.3E-06 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 74| +2.12E+02 | -2.8E-02 | +5.2E-01 | 1.6E-02 | 2.8E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 16| +2.38E+02 | +3.1E+00 | -8.3E-01 | 2.3E-01 | 2.2E+01 | 5.6E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 25| +2.16E+02 | -1.4E-01 | +3.3E-02 | 1.2E-01 | 1.4E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 71| +2.12E+02 | -3.8E-03 | +6.9E-01 | 3.9E-03 | 1.4E+00 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 25| +1.50E+02 | -3.7E-03 | +5.2E-01 | 9.0E-01 | 7.0E-01 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 48| +1.54E+02 | -1.2E-06 | +4.9E-01 | 4.5E-04 | 9.6E-03 | 9.5E-04 | 2d |1\n", + "2023-02-17 16:05:32 fides(WARNING) Stopping as function difference 1.19E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:32 fides(INFO) 75| +2.12E+02 | -4.0E-02 | +6.2E-01 | 1.6E-02 | 3.6E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 74| +1.48E+02 | +1.4E-05 | -4.0E+03 | 1.5E-07 | 1.2E-02 | 3.2E-07 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 49| +2.11E+02 | +1.6E+01 | -5.2E+00 | 5.0E-01 | 4.0E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 26| +2.15E+02 | -1.2E+00 | +8.7E-01 | 3.1E-02 | 3.1E+01 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 72| +2.12E+02 | -2.6E-03 | +6.5E-01 | 3.9E-03 | 1.1E+00 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 17| +2.36E+02 | -1.9E+00 | +8.2E-01 | 5.8E-02 | 2.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 76| +2.12E+02 | -2.7E-02 | +5.2E-01 | 1.6E-02 | 2.7E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 26| +1.50E+02 | +8.2E-03 | -2.7E+00 | 9.0E-01 | 1.5E+00 | 1.2E-01 | trr |0\n", + "2023-02-17 16:05:32 fides(INFO) 73| +2.12E+02 | -3.2E-03 | +6.7E-01 | 3.9E-03 | 1.3E+00 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 27| +2.14E+02 | -8.0E-01 | +6.6E-01 | 6.2E-02 | 1.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 75| +1.48E+02 | +1.5E-05 | -1.6E+04 | 3.7E-08 | 1.2E-02 | 8.1E-08 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 50| +2.09E+02 | -1.9E+00 | +1.1E+00 | 1.2E-01 | 4.0E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 77| +2.12E+02 | -3.9E-02 | +6.2E-01 | 1.6E-02 | 3.5E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 28| +2.14E+02 | -2.5E-01 | +2.8E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 74| +2.12E+02 | -2.0E-03 | +5.4E-01 | 3.9E-03 | 1.0E+00 | 8.1E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 18| +2.33E+02 | -2.9E+00 | +1.2E+00 | 1.2E-01 | 1.6E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 76| +1.48E+02 | +8.1E-06 | -3.6E+04 | 9.3E-09 | 1.2E-02 | 2.0E-08 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 27| +1.50E+02 | -8.3E-04 | +5.5E-01 | 7.9E-02 | 1.5E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 51| +2.05E+02 | -4.8E+00 | +8.5E-01 | 2.5E-01 | 3.2E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 78| +2.12E+02 | -2.8E-02 | +5.3E-01 | 1.6E-02 | 2.7E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 75| +2.12E+02 | -3.0E-03 | +6.3E-01 | 3.9E-03 | 1.2E+00 | 7.2E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 29| +2.13E+02 | -7.1E-01 | +5.8E-01 | 6.2E-02 | 1.9E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 79| +2.12E+02 | -3.9E-02 | +6.3E-01 | 1.6E-02 | 3.4E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 77| +1.48E+02 | +4.7E-06 | -8.4E+04 | 2.3E-09 | 1.2E-02 | 5.0E-09 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 28| +1.50E+02 | -1.7E-04 | +3.6E-01 | 7.9E-02 | 4.4E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 52| +1.90E+02 | -1.5E+01 | +6.2E-01 | 5.0E-01 | 1.1E+02 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 30| +2.13E+02 | -6.8E-02 | +6.2E-02 | 6.2E-02 | 1.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 76| +2.12E+02 | -1.7E-03 | +4.8E-01 | 3.9E-03 | 9.9E-01 | 8.5E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 0| +7.90E+12 | NaN | NaN | 1.0E+00 | 3.6E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 80| +2.12E+02 | -2.8E-02 | +5.5E-01 | 1.6E-02 | 2.6E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 78| +1.48E+02 | +7.0E-06 | -5.0E+05 | 5.8E-10 | 1.2E-02 | 1.3E-09 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 31| +2.13E+02 | -4.1E-01 | +9.0E-01 | 1.6E-02 | 2.0E+01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 19| +2.30E+02 | -2.6E+00 | +9.5E-01 | 2.3E-01 | 1.6E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 29| +1.50E+02 | -2.5E-05 | +8.4E-02 | 7.9E-02 | 4.0E-01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 77| +2.12E+02 | -2.7E-03 | +6.0E-01 | 3.9E-03 | 1.2E+00 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 53| +1.90E+02 | +6.1E+01 | -4.4E+00 | 5.0E-01 | 5.1E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 81| +2.12E+02 | -5.6E-02 | +1.0E+00 | 1.6E-02 | 3.3E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 32| +2.12E+02 | -3.7E-01 | +7.5E-01 | 3.1E-02 | 1.4E+01 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 1| +3.35E+08 | -7.9E+12 | +8.5E-02 | 1.0E+00 | 3.6E+13 | 3.0E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 79| +1.48E+02 | +3.2E-06 | -9.2E+05 | 1.5E-10 | 1.2E-02 | 3.2E-10 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 78| +2.12E+02 | -1.5E-03 | +4.4E-01 | 3.9E-03 | 9.3E-01 | 8.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 30| +1.50E+02 | -8.0E-05 | +7.1E-01 | 2.0E-02 | 9.9E-02 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 54| +1.87E+02 | -2.3E+00 | +3.4E-01 | 1.2E-01 | 5.1E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 82| +2.12E+02 | -8.3E-02 | +7.8E-01 | 3.1E-02 | 2.2E+00 | 6.6E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 33| +2.12E+02 | -4.2E-01 | +7.5E-01 | 6.2E-02 | 8.8E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 20| +2.25E+02 | -5.8E+00 | +1.0E+00 | 4.6E-01 | 2.8E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 79| +2.12E+02 | -2.5E-03 | +5.7E-01 | 3.9E-03 | 1.1E+00 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 2| +5.08E+07 | -2.8E+08 | +8.9E-01 | 2.5E-01 | 1.5E+09 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 34| +2.12E+02 | -2.1E-01 | +3.8E-01 | 6.2E-02 | 1.3E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 83| +2.12E+02 | -1.8E-01 | +1.0E+00 | 6.2E-02 | 3.2E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 31| +1.50E+02 | -1.2E-05 | +7.5E-01 | 2.0E-02 | 1.7E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 55| +1.85E+02 | -2.3E+00 | +6.9E-01 | 1.2E-01 | 3.8E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 80| +1.48E+02 | +3.5E-06 | -4.0E+06 | 3.6E-11 | 1.2E-02 | 7.9E-11 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 80| +2.12E+02 | -1.3E-03 | +4.1E-01 | 3.9E-03 | 8.9E-01 | 9.3E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 3| +7.21E+06 | -4.4E+07 | +9.0E-01 | 5.0E-01 | 2.3E+08 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 21| +2.20E+02 | -4.1E+00 | +2.9E-01 | 9.2E-01 | 2.3E+01 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 35| +2.12E+02 | +1.1E-01 | -2.1E-01 | 6.2E-02 | 9.5E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 84| +2.11E+02 | -2.7E-01 | +9.6E-01 | 1.2E-01 | 2.2E+00 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 32| +1.50E+02 | -2.2E-06 | +8.6E-01 | 2.0E-02 | 3.6E-02 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 81| +2.12E+02 | -2.2E-03 | +5.4E-01 | 3.9E-03 | 1.1E+00 | 7.7E-03 | 2d |1\n", + "2023-02-17 16:05:32.617 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.317 and h = 3.91293e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:32.617 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.317: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:32 fides(INFO) 81| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.1E-12 | 1.2E-02 | 2.0E-11 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 56| +1.77E+02 | -8.4E+00 | +6.6E-01 | 1.2E-01 | 5.5E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 36| +2.12E+02 | -2.3E-01 | +8.4E-01 | 1.6E-02 | 9.5E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 85| +2.10E+02 | -1.2E+00 | +1.4E+00 | 2.5E-01 | 4.8E+00 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 82| +2.12E+02 | -1.2E-03 | +3.9E-01 | 3.9E-03 | 8.5E-01 | 9.6E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 4| +1.01E+06 | -6.2E+06 | +9.0E-01 | 5.0E-01 | 3.3E+07 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 22| +2.20E+02 | -5.1E+00 | -4.0E-01 | 9.2E-01 | 6.9E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 33| +1.50E+02 | -1.8E-06 | +8.9E-01 | 3.9E-02 | 4.4E-02 | 6.3E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 82| +1.48E+02 | +5.5E-06 | -1.0E+08 | 2.3E-12 | 1.2E-02 | 4.9E-12 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 37| +2.11E+02 | -1.4E-01 | +5.8E-01 | 3.1E-02 | 7.1E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 57| +1.73E+02 | -3.1E+00 | +5.8E-01 | 1.2E-01 | 4.6E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 86| +2.10E+02 | +2.5E+01 | -1.0E+01 | 5.0E-01 | 8.4E+00 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 83| +2.12E+02 | -2.0E-03 | +5.2E-01 | 3.9E-03 | 1.0E+00 | 7.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 38| +2.11E+02 | -1.6E-01 | +5.7E-01 | 3.1E-02 | 9.6E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 5| +1.44E+05 | -8.7E+05 | +9.0E-01 | 5.0E-01 | 4.9E+06 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 87| +2.10E+02 | -6.9E-01 | +8.2E-01 | 1.2E-01 | 8.4E+00 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 34| +1.50E+02 | -1.8E-06 | +1.1E+00 | 7.9E-02 | 3.4E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 84| +2.12E+02 | -1.1E-03 | +3.8E-01 | 3.9E-03 | 8.2E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 58| +1.71E+02 | -2.9E+00 | +4.1E-01 | 1.2E-01 | 4.3E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 23| +2.07E+02 | -1.3E+01 | +8.3E-01 | 2.3E-01 | 6.9E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 39| +2.11E+02 | -6.7E-02 | +2.8E-01 | 3.1E-02 | 6.8E+00 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 83| +1.48E+02 | +1.4E-05 | -9.9E+08 | 5.7E-13 | 1.2E-02 | 1.2E-12 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 85| +2.12E+02 | -1.8E-03 | +5.0E-01 | 3.9E-03 | 9.7E-01 | 8.1E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 88| +2.10E+02 | +8.6E+00 | -4.0E+00 | 2.5E-01 | 6.7E+00 | 4.7E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 59| +1.71E+02 | +2.7E+01 | -2.7E+00 | 1.2E-01 | 4.9E+01 | 3.3E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 6| +2.12E+04 | -1.2E+05 | +9.0E-01 | 5.0E-01 | 7.5E+05 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 35| +1.50E+02 | +2.5E-06 | -2.2E+00 | 1.6E-01 | 1.5E-02 | 8.4E-03 | trr |0\n", + "2023-02-17 16:05:32 fides(INFO) 40| +2.11E+02 | -1.6E-01 | +5.3E-01 | 3.1E-02 | 9.8E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 86| +2.12E+02 | -1.1E-03 | +3.7E-01 | 3.9E-03 | 7.8E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 24| +1.83E+02 | -2.4E+01 | +1.0E+00 | 4.6E-01 | 3.3E+01 | 9.6E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 89| +2.10E+02 | +3.0E-01 | -4.3E-01 | 6.2E-02 | 6.7E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 84| +1.48E+02 | +5.3E-06 | -1.6E+09 | 1.4E-13 | 1.2E-02 | 3.1E-13 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 87| +2.12E+02 | -1.7E-03 | +4.8E-01 | 3.9E-03 | 9.2E-01 | 8.3E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 41| +2.11E+02 | -3.4E-02 | +1.6E-01 | 3.1E-02 | 6.2E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 60| +1.70E+02 | -3.8E-01 | +1.0E-01 | 3.1E-02 | 4.9E+01 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 7| +3.31E+03 | -1.8E+04 | +9.0E-01 | 5.0E-01 | 1.2E+05 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 90| +2.09E+02 | -1.3E-01 | +6.3E-01 | 1.6E-02 | 6.7E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 36| +1.50E+02 | -1.7E-07 | +3.1E-01 | 2.3E-02 | 1.5E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(WARNING) Stopping as function difference 1.68E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:32 fides(INFO) 25| +1.83E+02 | +3.9E+02 | -1.7E+01 | 9.2E-01 | 1.2E+02 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 85| +1.48E+02 | +4.3E-06 | -5.0E+09 | 3.6E-14 | 1.2E-02 | 7.7E-14 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 88| +2.12E+02 | -1.0E-03 | +3.7E-01 | 3.9E-03 | 7.5E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 42| +2.11E+02 | -9.6E-02 | +9.0E-01 | 7.8E-03 | 9.5E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 91| +2.09E+02 | -5.5E-02 | +1.0E+00 | 1.6E-02 | 1.9E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 61| +1.69E+02 | -8.6E-01 | +1.0E+00 | 7.8E-03 | 6.9E+01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 8| +6.40E+02 | -2.7E+03 | +9.0E-01 | 5.0E-01 | 1.9E+04 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 89| +2.12E+02 | -1.5E-03 | +4.7E-01 | 3.9E-03 | 8.8E-01 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 26| +1.70E+02 | -1.3E+01 | +8.7E-01 | 2.3E-01 | 1.2E+02 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 86| +1.48E+02 | +2.5E-06 | -1.1E+10 | 8.9E-15 | 1.2E-02 | 1.9E-14 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 43| +2.11E+02 | -9.0E-02 | +7.5E-01 | 1.6E-02 | 7.2E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 92| +2.09E+02 | -1.1E-01 | +1.1E+00 | 3.1E-02 | 1.4E+00 | 8.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 62| +1.68E+02 | -1.1E+00 | +1.0E+00 | 1.6E-02 | 5.1E+01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 27| +1.56E+02 | -1.4E+01 | +1.0E+00 | 4.6E-01 | 8.3E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 44| +2.11E+02 | -1.1E-01 | +7.6E-01 | 3.1E-02 | 5.0E+00 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 9| +2.48E+02 | -3.9E+02 | +8.9E-01 | 5.0E-01 | 3.0E+03 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 90| +2.12E+02 | -1.0E-03 | +3.8E-01 | 3.9E-03 | 7.3E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 93| +2.09E+02 | -2.0E-01 | +1.1E+00 | 6.2E-02 | 1.6E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 45| +2.11E+02 | -6.0E-02 | +3.5E-01 | 6.2E-02 | 6.6E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 0| +6.35E+09 | NaN | NaN | 1.0E+00 | 2.9E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:32 fides(INFO) 87| +1.48E+02 | +1.1E-05 | -2.0E+11 | 2.2E-15 | 1.2E-02 | 4.8E-15 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 91| +2.12E+02 | -1.4E-03 | +4.6E-01 | 3.9E-03 | 8.4E-01 | 8.8E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 28| +1.56E+02 | +1.8E+01 | -2.7E+00 | 9.2E-01 | 9.3E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 63| +1.67E+02 | -1.1E+00 | +9.9E-01 | 3.1E-02 | 2.6E+01 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 94| +2.09E+02 | -5.6E-01 | +1.3E+00 | 1.2E-01 | 3.5E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 10| +1.84E+02 | -6.4E+01 | +9.0E-01 | 5.0E-01 | 5.2E+02 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 1| +1.83E+04 | -6.4E+09 | +9.6E-02 | 1.0E+00 | 2.9E+10 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 46| +2.11E+02 | +4.8E-03 | -3.8E-02 | 6.2E-02 | 6.0E+00 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 92| +2.12E+02 | -2.2E-03 | +1.0E+00 | 3.9E-03 | 7.0E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 88| +1.48E+02 | +6.8E-06 | -5.1E+11 | 5.6E-16 | 1.2E-02 | 1.2E-15 | 2d |0\n", + "2023-02-17 16:05:32 fides(WARNING) Stopping as trust region radius 1.39E-16 is smaller than machine precision.\n", + "2023-02-17 16:05:32 fides(INFO) 2| +3.15E+03 | -1.5E+04 | +9.0E-01 | 2.5E-01 | 8.3E+04 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 29| +1.51E+02 | -4.4E+00 | +8.7E-01 | 2.1E-01 | 9.3E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 95| +2.06E+02 | -2.5E+00 | +1.9E+00 | 2.5E-01 | 7.4E+00 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 64| +1.66E+02 | -1.5E+00 | +9.8E-01 | 6.2E-02 | 2.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 47| +2.11E+02 | -1.0E-01 | +6.7E-01 | 1.6E-02 | 6.0E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 93| +2.12E+02 | -3.6E-03 | +9.0E-01 | 7.8E-03 | 5.2E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 3| +7.50E+02 | -2.4E+03 | +9.0E-01 | 5.0E-01 | 1.3E+04 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 11| +1.69E+02 | -1.5E+01 | +1.0E+00 | 5.0E-01 | 2.0E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 96| +1.98E+02 | -8.5E+00 | +6.2E-01 | 5.0E-01 | 1.4E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:32 fides(INFO) 30| +1.51E+02 | +4.7E-01 | -1.9E-01 | 4.2E-01 | 5.9E+01 | 5.4E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 4| +3.61E+02 | -3.9E+02 | +9.0E-01 | 1.0E+00 | 2.1E+03 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 48| +2.11E+02 | -6.1E-02 | +9.3E-01 | 1.6E-02 | 4.3E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 94| +2.12E+02 | -1.3E-03 | +5.8E-01 | 1.6E-02 | 6.0E-01 | 8.8E-03 | trr |1\n", + "2023-02-17 16:05:32 fides(INFO) 65| +1.62E+02 | -3.3E+00 | +7.9E-01 | 1.2E-01 | 2.3E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 97| +1.98E+02 | +5.1E-01 | -1.2E-01 | 5.0E-01 | 6.8E+01 | 9.2E-01 | 2d |0\n", + "2023-02-17 16:05:32 fides(INFO) 5| +2.64E+02 | -9.7E+01 | +9.2E-01 | 2.0E+00 | 3.3E+02 | 4.8E+00 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 49| +2.10E+02 | -2.6E-02 | +3.1E-01 | 3.1E-02 | 3.8E+00 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 31| +1.50E+02 | -1.1E+00 | +8.4E-01 | 1.1E-01 | 5.9E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:32 fides(INFO) 95| +2.12E+02 | -3.1E-03 | +8.9E-01 | 1.6E-02 | 7.0E-01 | 1.4E-02 | trr |1\n", + "2023-02-17 16:05:32 fides(INFO) 66| +1.60E+02 | -2.1E+00 | +1.2E-01 | 2.5E-01 | 5.4E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 6| +2.64E+02 | +1.6E+03 | -1.1E+02 | 4.0E+00 | 4.8E+01 | 9.8E+00 | trr |0\n", + "2023-02-17 16:05:33.009 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 193.843 and h = 3.10514e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:33 fides(INFO) 12| +1.66E+02 | -3.1E+00 | +6.3E-01 | 1.0E+00 | 5.1E+01 | 4.0E-01 | trr |1\n", + "2023-02-17 16:05:33.009 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 193.843: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 50| +2.10E+02 | -5.4E-02 | +3.1E-01 | 3.1E-02 | 6.7E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 98| +1.98E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 6.8E+01 | 2.4E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 32| +1.49E+02 | -1.1E+00 | +6.4E-01 | 2.1E-01 | 4.0E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 0| +3.27E+09 | NaN | NaN | 1.0E+00 | 1.5E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:33 fides(INFO) 7| +2.64E+02 | +1.7E+02 | -8.1E+00 | 1.0E+00 | 4.8E+01 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 96| +2.12E+02 | -3.0E-03 | +8.3E-01 | 1.6E-02 | 6.4E-01 | 1.7E-02 | trr |1\n", + "2023-02-17 16:05:33 fides(INFO) 67| +1.57E+02 | -3.6E+00 | +7.7E-01 | 6.2E-02 | 1.2E+02 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 8| +2.52E+02 | -1.2E+01 | +5.7E-01 | 2.5E-01 | 4.8E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 51| +2.10E+02 | -5.6E-03 | +2.7E-02 | 3.1E-02 | 4.9E+00 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 99| +1.94E+02 | -3.6E+00 | +1.0E+00 | 3.1E-02 | 6.8E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 1| +1.38E+04 | -3.3E+09 | +9.8E-02 | 1.0E+00 | 1.5E+10 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 33| +1.49E+02 | +2.8E-01 | -2.0E-01 | 2.1E-01 | 5.9E+01 | 2.8E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 97| +2.12E+02 | -3.2E-03 | +9.8E-01 | 1.6E-02 | 7.1E-01 | 1.5E-02 | trr |1\n", + "2023-02-17 16:05:33 fides(INFO) 9| +2.51E+02 | -5.9E-01 | +1.5E-01 | 2.5E-01 | 2.7E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 68| +1.57E+02 | +2.0E-01 | -2.9E-01 | 1.2E-01 | 2.8E+01 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 52| +2.10E+02 | -7.1E-02 | +8.6E-01 | 7.8E-03 | 6.9E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:33.067 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 57.1283 and h = 7.30369e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:33.067 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 57.1283: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 100| +1.94E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 6.4E+01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 98| +2.12E+02 | -2.4E-03 | +8.6E-01 | 1.6E-02 | 4.5E-01 | 2.3E-02 | trr |1\n", + "2023-02-17 16:05:33 fides(INFO) 10| +2.50E+02 | -1.2E+00 | +6.1E-01 | 6.2E-02 | 2.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 2| +2.98E+03 | -1.1E+04 | +8.9E-01 | 2.5E-01 | 5.4E+04 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 13| +1.59E+02 | -6.5E+00 | +1.0E+00 | 1.0E+00 | 1.5E+02 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 34| +1.48E+02 | -6.5E-01 | +8.4E-01 | 5.3E-02 | 5.9E+01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 11| +2.50E+02 | -1.4E-02 | +1.5E-01 | 6.2E-02 | 4.0E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 53| +2.10E+02 | -3.3E-02 | +5.1E-01 | 1.6E-02 | 4.4E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 101| +1.92E+02 | -1.7E+00 | +1.0E+00 | 1.6E-02 | 6.4E+01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 99| +2.12E+02 | -3.5E-03 | +8.7E-01 | 3.1E-02 | 6.8E-01 | 2.9E-02 | trr |1\n", + "2023-02-17 16:05:33 fides(INFO) 69| +1.56E+02 | -3.2E-01 | +7.2E-01 | 3.1E-02 | 2.8E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 12| +2.50E+02 | +9.1E-05 | -7.4E-03 | 1.6E-02 | 3.2E+00 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 35| +1.48E+02 | -2.7E-01 | +7.1E-01 | 1.1E-01 | 1.7E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 3| +6.53E+02 | -2.3E+03 | +9.0E-01 | 5.0E-01 | 9.7E+03 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 54| +2.10E+02 | -1.5E-02 | +2.9E-01 | 1.6E-02 | 3.3E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 13| +2.50E+02 | -2.4E-02 | +8.6E-01 | 3.9E-03 | 3.2E+00 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 102| +1.89E+02 | -3.4E+00 | +9.9E-01 | 3.1E-02 | 6.3E+01 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 100| +2.12E+02 | -2.3E-03 | +6.3E-01 | 3.1E-02 | 7.1E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 36| +1.48E+02 | -2.0E-01 | +8.9E-01 | 1.1E-01 | 2.2E+01 | 9.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 70| +1.56E+02 | -2.7E-01 | +7.6E-01 | 3.1E-02 | 1.5E+01 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 55| +2.10E+02 | -3.2E-02 | +4.9E-01 | 1.6E-02 | 4.4E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 101| +2.12E+02 | -7.8E-05 | +1.3E-02 | 3.1E-02 | 4.8E-01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 14| +2.50E+02 | -9.3E-04 | +5.2E-02 | 7.8E-03 | 1.7E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 4| +2.90E+02 | -3.6E+02 | +8.9E-01 | 1.0E+00 | 1.6E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 103| +1.82E+02 | -6.4E+00 | +9.9E-01 | 6.2E-02 | 6.0E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 15| +2.50E+02 | -4.8E-03 | +8.9E-01 | 2.0E-03 | 1.6E+00 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 37| +1.48E+02 | -1.6E-01 | +8.1E-01 | 2.1E-01 | 5.7E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 5| +2.49E+02 | -4.1E+01 | +8.3E-01 | 1.0E+00 | 2.3E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 56| +2.10E+02 | -1.3E-02 | +2.7E-01 | 1.6E-02 | 3.1E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 102| +2.12E+02 | -4.0E-03 | +8.9E-01 | 7.8E-03 | 1.1E+00 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 71| +1.56E+02 | +1.4E-01 | -5.0E-01 | 6.2E-02 | 6.1E+00 | 1.3E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 16| +2.50E+02 | -2.4E-03 | +5.0E-01 | 3.9E-03 | 9.6E-01 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 104| +1.72E+02 | -1.0E+01 | +1.0E+00 | 1.2E-01 | 5.4E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 17| +2.50E+02 | -1.6E-04 | +2.1E-01 | 3.9E-03 | 3.2E-01 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 6| +2.35E+02 | -1.5E+01 | +3.9E+00 | 2.0E+00 | 1.2E+01 | 3.9E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 57| +2.10E+02 | -2.7E-02 | +4.5E-01 | 1.6E-02 | 4.1E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 103| +2.12E+02 | -4.4E-03 | +8.0E-01 | 1.6E-02 | 3.7E-01 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 38| +1.48E+02 | +4.2E+00 | -8.7E+00 | 4.2E-01 | 3.2E+00 | 4.8E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 72| +1.56E+02 | -1.1E-01 | +8.6E-01 | 1.6E-02 | 6.1E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 18| +2.50E+02 | -3.1E-04 | +6.8E-01 | 9.8E-04 | 3.2E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 105| +1.65E+02 | -7.2E+00 | +4.9E-01 | 2.5E-01 | 4.9E+01 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 104| +2.12E+02 | -8.0E-03 | +1.1E+00 | 3.1E-02 | 5.8E-01 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 58| +2.10E+02 | -1.2E-02 | +2.6E-01 | 1.6E-02 | 3.0E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 19| +2.50E+02 | -6.7E-05 | +9.8E-01 | 9.8E-04 | 3.0E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 14| +1.59E+02 | -1.8E+00 | -4.6E-01 | 2.0E+00 | 3.8E+01 | 2.5E+00 | trr |0\n", + "2023-02-17 16:05:33 fides(INFO) 39| +1.48E+02 | +5.4E-02 | -3.5E-01 | 1.1E-01 | 3.2E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 73| +1.56E+02 | -5.4E-02 | +6.5E-01 | 3.1E-02 | 3.4E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 7| +2.35E+02 | +4.0E+02 | -1.8E+01 | 4.0E+00 | 3.5E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:33.259 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 68.9213 and h = 1.14762e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:33.259 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 68.9213: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:33 fides(INFO) 106| +1.65E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 1.3E+02 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 20| +2.50E+02 | -7.7E-05 | +8.7E-01 | 2.0E-03 | 4.1E-02 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 105| +2.12E+02 | -2.0E-02 | +1.1E+00 | 6.2E-02 | 3.6E-01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 59| +2.10E+02 | -2.4E-02 | +4.3E-01 | 1.6E-02 | 3.9E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 8| +2.35E+02 | +3.4E+01 | -3.0E+00 | 1.0E+00 | 3.5E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 21| +2.50E+02 | -1.6E-04 | +8.3E-01 | 3.9E-03 | 6.9E-02 | 9.1E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 40| +1.48E+02 | -3.1E-02 | +6.8E-01 | 2.6E-02 | 3.2E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 106| +2.12E+02 | -7.4E-02 | +1.4E+00 | 1.2E-01 | 6.9E-01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 60| +2.10E+02 | -1.1E-02 | +2.6E-01 | 1.6E-02 | 2.9E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 22| +2.50E+02 | -3.1E-04 | +8.6E-01 | 7.8E-03 | 9.6E-02 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 74| +1.56E+02 | -8.2E-02 | +1.1E+00 | 3.1E-02 | 3.8E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 107| +1.61E+02 | -4.2E+00 | +3.4E-01 | 6.2E-02 | 1.3E+02 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 9| +2.35E+02 | +5.7E+00 | -5.3E-01 | 2.5E-01 | 3.5E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 41| +1.48E+02 | -1.2E-02 | +9.6E-01 | 2.6E-02 | 3.4E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 23| +2.50E+02 | -6.5E-04 | +9.2E-01 | 1.6E-02 | 1.1E-01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 107| +2.11E+02 | -4.3E-01 | +2.1E+00 | 2.5E-01 | 1.7E+00 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 10| +2.30E+02 | -4.4E+00 | +8.8E-01 | 6.2E-02 | 3.5E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 61| +2.10E+02 | -2.1E-02 | +4.2E-01 | 1.6E-02 | 3.6E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 24| +2.50E+02 | -1.4E-03 | +9.8E-01 | 3.1E-02 | 1.3E-01 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 108| +1.54E+02 | -7.0E+00 | +9.0E-01 | 6.2E-02 | 1.5E+02 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 75| +1.56E+02 | -1.7E-01 | +1.2E+00 | 6.2E-02 | 2.6E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 42| +1.48E+02 | -1.9E-02 | +9.5E-01 | 5.3E-02 | 1.5E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 108| +2.11E+02 | +8.4E+00 | -8.0E+00 | 5.0E-01 | 4.3E+00 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 25| +2.50E+02 | -3.2E-03 | +1.1E+00 | 6.2E-02 | 1.4E-01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 11| +2.29E+02 | -1.1E+00 | +2.1E-01 | 1.2E-01 | 2.3E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 62| +2.10E+02 | -1.1E-02 | +2.7E-01 | 1.6E-02 | 2.7E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 109| +1.52E+02 | -2.0E+00 | +3.1E-01 | 1.2E-01 | 5.2E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 26| +2.50E+02 | -8.3E-03 | +1.2E+00 | 1.2E-01 | 1.6E-01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 12| +2.28E+02 | -1.7E+00 | +9.2E-01 | 3.1E-02 | 3.9E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 76| +1.55E+02 | -3.3E-01 | +1.0E+00 | 1.2E-01 | 5.5E+00 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 109| +2.11E+02 | -6.0E-01 | +1.4E+00 | 1.2E-01 | 4.3E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 63| +2.10E+02 | -1.9E-02 | +4.1E-01 | 1.6E-02 | 3.4E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 43| +1.48E+02 | -3.2E-02 | +9.6E-01 | 1.1E-01 | 2.1E+00 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 15| +1.56E+02 | -3.0E+00 | +1.0E+00 | 5.0E-01 | 3.8E+01 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 27| +2.50E+02 | -2.8E-02 | +1.4E+00 | 2.5E-01 | 1.8E-01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 13| +2.26E+02 | -1.9E+00 | +8.6E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 110| +1.52E+02 | +9.5E-01 | -2.4E-01 | 1.2E-01 | 7.2E+01 | 2.8E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 110| +2.11E+02 | +1.5E+00 | -1.5E+00 | 2.5E-01 | 3.6E+00 | 6.7E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 28| +2.50E+02 | -1.6E-01 | +2.0E+00 | 5.0E-01 | 2.7E-01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 64| +2.10E+02 | -1.1E-02 | +2.9E-01 | 1.6E-02 | 2.6E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 44| +1.48E+02 | -3.8E-02 | +8.5E-01 | 2.1E-01 | 1.1E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 14| +2.23E+02 | -3.2E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 77| +1.55E+02 | -5.7E-01 | +6.7E-01 | 2.5E-01 | 2.2E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 29| +2.47E+02 | -2.1E+00 | +3.2E+00 | 1.0E+00 | 5.1E-01 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 111| +1.50E+02 | -1.5E+00 | +5.5E-01 | 3.1E-02 | 7.2E+01 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 65| +2.10E+02 | -1.8E-02 | +4.2E-01 | 1.6E-02 | 3.2E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 111| +2.10E+02 | -3.6E-01 | +1.0E+00 | 6.2E-02 | 3.6E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 45| +1.48E+02 | +2.0E-01 | -3.7E+00 | 4.2E-01 | 1.7E+00 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 15| +2.20E+02 | -3.0E+00 | +1.0E+00 | 2.5E-01 | 1.9E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 30| +2.29E+02 | -1.8E+01 | +3.6E+00 | 2.0E+00 | 6.4E+00 | 3.7E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 112| +2.10E+02 | +2.5E-01 | -5.3E-01 | 1.2E-01 | 2.0E+00 | 3.3E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 66| +2.10E+02 | -1.2E-02 | +3.2E-01 | 1.6E-02 | 2.4E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 112| +1.49E+02 | -1.0E+00 | +5.1E-01 | 3.1E-02 | 7.3E+01 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 46| +1.48E+02 | -6.6E-03 | +2.8E-01 | 1.1E-01 | 1.7E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 16| +2.19E+02 | -9.4E-01 | +1.1E-04 | 5.0E-01 | 2.0E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 78| +1.54E+02 | -9.4E-01 | +1.4E+00 | 2.5E-01 | 3.1E+01 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 31| +2.29E+02 | +1.9E+02 | -1.3E+01 | 4.0E+00 | 2.7E+01 | 1.2E+01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 113| +2.10E+02 | -1.2E-01 | +8.6E-01 | 3.1E-02 | 2.0E+00 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 17| +2.12E+02 | -6.7E+00 | +7.7E-01 | 1.2E-01 | 6.3E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 67| +2.10E+02 | -1.7E-02 | +4.3E-01 | 1.6E-02 | 3.0E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 47| +1.48E+02 | +4.7E-02 | -7.8E-01 | 1.1E-01 | 2.3E+00 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 113| +1.49E+02 | -4.6E-01 | +6.7E-01 | 3.1E-02 | 3.7E+01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 32| +2.29E+02 | +5.4E+00 | -1.3E+00 | 1.0E+00 | 2.7E+01 | 2.9E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 114| +2.10E+02 | +1.7E-01 | -1.4E+00 | 6.2E-02 | 1.2E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 18| +2.03E+02 | -8.4E+00 | +1.3E+00 | 2.5E-01 | 1.6E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 68| +2.10E+02 | -1.2E-02 | +3.6E-01 | 1.6E-02 | 2.3E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 114| +1.48E+02 | -2.7E-01 | +6.1E-01 | 3.1E-02 | 2.5E+01 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 33| +2.29E+02 | +6.5E+00 | -9.9E-01 | 2.5E-01 | 2.7E+01 | 6.5E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 48| +1.48E+02 | -9.9E-03 | +5.8E-01 | 2.6E-02 | 2.3E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 115| +2.10E+02 | -3.1E-02 | +7.8E-01 | 1.6E-02 | 1.2E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 69| +2.10E+02 | -1.7E-02 | +4.6E-01 | 1.6E-02 | 2.8E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 19| +1.77E+02 | -2.6E+01 | +8.4E-01 | 5.0E-01 | 3.1E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 34| +2.26E+02 | -2.9E+00 | +8.2E-01 | 6.2E-02 | 2.7E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 16| +1.52E+02 | -4.3E+00 | +9.0E-01 | 1.0E+00 | 6.9E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 115| +1.48E+02 | -2.6E-01 | +4.1E-01 | 3.1E-02 | 2.4E+01 | 6.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 49| +1.48E+02 | -2.2E-03 | +9.7E-01 | 2.6E-02 | 1.0E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 116| +2.10E+02 | -3.2E-03 | +5.8E-02 | 3.1E-02 | 1.4E+00 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 35| +2.25E+02 | -1.6E+00 | +5.6E-01 | 1.2E-01 | 1.8E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 79| +1.52E+02 | -2.0E+00 | +1.2E+00 | 2.5E-01 | 4.5E+01 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 20| +1.77E+02 | +1.3E+02 | -6.6E+00 | 1.0E+00 | 1.2E+02 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 70| +2.10E+02 | -1.3E-02 | +4.0E-01 | 1.6E-02 | 2.1E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 50| +1.48E+02 | -3.6E-03 | +9.6E-01 | 5.3E-02 | 4.1E-01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 116| +1.48E+02 | -1.2E-01 | +3.0E-01 | 3.1E-02 | 2.0E+01 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 36| +2.22E+02 | -2.3E+00 | +6.6E-01 | 1.2E-01 | 3.3E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 17| +1.52E+02 | +1.8E+02 | -7.2E+02 | 2.0E+00 | 3.9E+01 | 5.7E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 117| +2.10E+02 | -3.4E-02 | +1.0E+00 | 7.8E-03 | 3.4E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 21| +1.61E+02 | -1.6E+01 | +8.7E-01 | 2.5E-01 | 1.2E+02 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 71| +2.10E+02 | -1.6E-02 | +5.0E-01 | 1.6E-02 | 2.5E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 117| +1.48E+02 | -1.9E-01 | +4.4E-01 | 3.1E-02 | 3.2E+01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 37| +2.22E+02 | -2.2E-01 | +6.1E-03 | 1.2E-01 | 1.8E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 118| +2.10E+02 | -1.7E-02 | +1.1E+00 | 1.6E-02 | 9.4E-01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 51| +1.48E+02 | -5.1E-03 | +9.5E-01 | 1.1E-01 | 7.8E-01 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 72| +2.10E+02 | -1.3E-02 | +4.6E-01 | 1.6E-02 | 2.0E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 38| +2.20E+02 | -1.7E+00 | +8.8E-01 | 3.1E-02 | 4.1E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 119| +2.10E+02 | -3.2E-02 | +1.1E+00 | 3.1E-02 | 4.9E-01 | 8.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 22| +1.58E+02 | -3.4E+00 | +9.4E-01 | 5.0E-01 | 8.1E+01 | 2.5E-01 | trr |1\n", + "2023-02-17 16:05:33 fides(INFO) 118| +1.48E+02 | -1.5E-01 | +6.8E-01 | 3.1E-02 | 2.3E+01 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 52| +1.48E+02 | -4.2E-03 | +8.8E-01 | 2.1E-01 | 2.5E-01 | 9.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 73| +2.10E+02 | -1.7E-02 | +5.4E-01 | 1.6E-02 | 2.3E+00 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 39| +2.19E+02 | -1.4E+00 | +7.6E-01 | 6.2E-02 | 2.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 120| +2.10E+02 | -7.6E-02 | +1.2E+00 | 6.2E-02 | 7.9E-01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 23| +1.58E+02 | +2.3E+01 | -2.0E+00 | 5.0E-01 | 6.3E+01 | 9.2E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 119| +1.48E+02 | -1.3E-02 | +9.6E-02 | 3.1E-02 | 9.5E+00 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 74| +2.10E+02 | -2.2E-02 | +8.2E-01 | 1.6E-02 | 1.8E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 53| +1.48E+02 | +5.1E-03 | -5.4E+00 | 4.2E-01 | 6.0E-01 | 3.2E-02 | trr |0\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 40| +2.18E+02 | -1.3E+00 | +6.3E-01 | 1.2E-01 | 1.5E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 80| +1.52E+02 | +2.0E+00 | -2.0E+00 | 5.0E-01 | 1.3E+01 | 4.0E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 121| +2.10E+02 | -2.1E-01 | +1.4E+00 | 1.2E-01 | 1.5E+00 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 18| +1.51E+02 | -2.5E-01 | +1.0E+00 | 5.0E-01 | 3.9E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 75| +2.10E+02 | +5.0E-04 | -1.5E-02 | 3.1E-02 | 1.8E+00 | 8.5E-02 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 24| +1.53E+02 | -5.5E+00 | +7.9E-01 | 1.2E-01 | 6.3E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 120| +1.48E+02 | -5.1E-02 | +7.8E-01 | 7.8E-03 | 1.5E+01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 41| +2.16E+02 | -1.4E+00 | +5.9E-01 | 1.2E-01 | 2.7E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 54| +1.48E+02 | -3.6E-05 | +8.2E-02 | 4.3E-02 | 6.0E-01 | 8.1E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 122| +2.10E+02 | -1.2E-01 | +9.6E-02 | 2.5E-01 | 2.9E+00 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 76| +2.10E+02 | -1.2E-02 | +6.1E-01 | 7.8E-03 | 1.8E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 25| +1.49E+02 | -3.1E+00 | +9.8E-01 | 2.5E-01 | 7.7E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 42| +2.16E+02 | +1.5E-01 | -1.5E-01 | 1.2E-01 | 1.4E+01 | 3.2E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 19| +1.51E+02 | +3.2E+00 | -2.2E+01 | 1.0E+00 | 3.2E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 123| +2.09E+02 | -7.1E-01 | +1.0E+00 | 6.2E-02 | 6.6E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 121| +1.48E+02 | -1.2E-02 | +4.5E-01 | 1.6E-02 | 3.9E+00 | 4.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 55| +1.48E+02 | -2.5E-04 | +5.2E-01 | 1.1E-02 | 2.8E-01 | 7.2E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 77| +2.10E+02 | -9.6E-03 | +1.0E+00 | 7.8E-03 | 1.4E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 43| +2.16E+02 | -6.4E-01 | +8.1E-01 | 3.1E-02 | 1.4E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 26| +1.49E+02 | +1.0E+01 | -3.8E+00 | 5.0E-01 | 4.1E+01 | 5.4E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 124| +2.08E+02 | -6.2E-01 | +1.2E+00 | 1.2E-01 | 4.4E+00 | 3.0E-01 | trr |1\n", + "2023-02-17 16:05:33 fides(INFO) 122| +1.48E+02 | +2.6E-03 | -4.2E-01 | 1.6E-02 | 4.5E+00 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 56| +1.48E+02 | -3.8E-05 | +9.3E-01 | 1.1E-02 | 2.9E-01 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 81| +1.51E+02 | -3.0E-01 | +5.1E-01 | 4.2E-02 | 1.3E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 78| +2.10E+02 | -1.9E-02 | +9.2E-01 | 1.6E-02 | 1.2E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 44| +2.15E+02 | -9.0E-01 | +1.0E+00 | 6.2E-02 | 1.2E+01 | 9.3E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 27| +1.49E+02 | -9.2E-01 | +6.2E-01 | 1.2E-01 | 4.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 125| +2.07E+02 | -7.8E-01 | +4.3E-01 | 2.5E-01 | 5.8E+00 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:33.825 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.2839 and h = 1.60631e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:33.825 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.2839: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:33 fides(INFO) 123| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.0E-03 | 4.5E+00 | 5.4E-03 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 79| +2.10E+02 | -4.0E-02 | +1.0E+00 | 3.1E-02 | 1.3E+00 | 8.9E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 57| +1.48E+02 | -5.9E-05 | +1.1E+00 | 2.1E-02 | 8.0E-02 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 20| +1.51E+02 | -3.6E-01 | +1.0E+00 | 2.5E-01 | 3.2E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 45| +2.14E+02 | -9.4E-01 | +8.3E-01 | 1.2E-01 | 1.2E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:33.840 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.3559 and h = 3.61223e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:33.840 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.3559: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:33 fides(INFO) 28| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 4.1E+01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 80| +2.10E+02 | -8.6E-02 | +1.1E+00 | 6.2E-02 | 1.2E+00 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 46| +2.14E+02 | -3.7E-01 | +1.4E-01 | 2.5E-01 | 1.3E+01 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 126| +2.05E+02 | -2.3E+00 | +8.8E-01 | 2.5E-01 | 3.5E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 124| +1.48E+02 | -2.3E-03 | +7.2E-01 | 4.9E-04 | 4.5E+00 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 21| +1.51E+02 | +8.5E-01 | -3.0E+00 | 5.0E-01 | 3.0E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 29| +1.48E+02 | -3.0E-01 | +8.8E-01 | 3.1E-02 | 4.1E+01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 81| +2.10E+02 | -2.1E-01 | +1.2E+00 | 1.2E-01 | 1.5E+00 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 47| +2.12E+02 | -1.5E+00 | +6.9E-01 | 6.2E-02 | 2.8E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 127| +2.05E+02 | +4.3E+00 | -5.9E-01 | 5.0E-01 | 3.1E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 125| +1.48E+02 | -4.1E-04 | +9.8E-01 | 4.9E-04 | 1.2E+00 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 48| +2.11E+02 | -5.6E-01 | +9.0E-01 | 6.2E-02 | 7.2E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 82| +2.09E+02 | -5.2E-01 | +1.1E+00 | 2.5E-01 | 2.9E+00 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 82| +1.51E+02 | -3.2E-01 | +8.7E-01 | 4.2E-02 | 1.6E+01 | 9.5E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 30| +1.48E+02 | -2.3E-01 | +8.7E-01 | 6.2E-02 | 2.4E+01 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 128| +2.04E+02 | -1.4E+00 | +2.6E-01 | 1.2E-01 | 3.1E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 49| +2.10E+02 | -1.2E+00 | +1.0E+00 | 1.2E-01 | 1.0E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 126| +1.48E+02 | -4.1E-04 | +9.0E-01 | 9.8E-04 | 7.5E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 22| +1.51E+02 | -2.5E-01 | +1.1E+00 | 1.2E-01 | 3.0E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 83| +2.09E+02 | +1.6E+00 | -4.9E+00 | 5.0E-01 | 7.9E+00 | 8.8E-01 | 2d |0\n", + "2023-02-17 16:05:33 fides(INFO) 129| +2.01E+02 | -2.9E+00 | +1.4E+00 | 1.2E-01 | 2.3E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 31| +1.48E+02 | -2.1E-01 | +9.6E-01 | 1.2E-01 | 2.6E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 127| +1.48E+02 | -5.3E-04 | +1.0E+00 | 2.0E-03 | 8.9E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 50| +2.06E+02 | -4.3E+00 | +1.3E+00 | 2.5E-01 | 9.8E+00 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 84| +2.09E+02 | -3.8E-01 | +1.3E+00 | 1.2E-01 | 7.9E+00 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:33 fides(INFO) 130| +1.93E+02 | -7.4E+00 | +1.2E+00 | 2.5E-01 | 1.8E+01 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 58| +1.48E+02 | -5.7E-05 | +8.0E-01 | 4.3E-02 | 1.2E-01 | 8.0E-03 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 23| +1.50E+02 | -6.3E-01 | +1.3E+00 | 2.5E-01 | 1.6E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:33 fides(INFO) 32| +1.48E+02 | -1.6E-01 | +8.7E-01 | 2.5E-01 | 1.3E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:33.989 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.0831 and h = 2.15215e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:33.989 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.0831: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:33 fides(INFO) 128| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 5.3E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 85| +2.09E+02 | +5.0E+00 | -2.1E+00 | 2.5E-01 | 6.4E+00 | 6.7E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 51| +1.84E+02 | -2.2E+01 | +1.4E+00 | 5.0E-01 | 2.4E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 59| +1.48E+02 | +2.4E-04 | -3.0E+00 | 8.5E-02 | 4.8E-02 | 1.9E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 83| +1.51E+02 | -2.7E-01 | +1.1E+00 | 8.5E-02 | 2.0E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 131| +1.93E+02 | +9.2E+01 | -6.7E+00 | 5.0E-01 | 5.0E+01 | 1.3E+00 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 129| +1.48E+02 | -2.6E-04 | +1.0E+00 | 9.8E-04 | 5.3E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 33| +1.48E+02 | +8.8E-01 | -5.0E+00 | 5.0E-01 | 8.7E+00 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 86| +2.08E+02 | -3.4E-01 | +3.6E-01 | 6.2E-02 | 6.4E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 24| +1.50E+02 | +4.2E-01 | -1.1E+00 | 5.0E-01 | 2.0E+01 | 9.8E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 52| +1.84E+02 | +3.1E+02 | -1.3E+01 | 1.0E+00 | 3.1E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 60| +1.48E+02 | -1.5E-05 | +4.8E-01 | 2.1E-02 | 4.8E-02 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 130| +1.48E+02 | -4.7E-04 | +1.0E+00 | 2.0E-03 | 4.8E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 34| +1.48E+02 | -2.2E-02 | +2.7E-01 | 1.2E-01 | 8.7E+00 | 6.9E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 87| +2.08E+02 | -7.9E-01 | +1.3E+00 | 6.2E-02 | 1.0E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 132| +1.88E+02 | -4.9E+00 | +8.5E-01 | 1.2E-01 | 5.0E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 53| +1.68E+02 | -1.6E+01 | +1.3E+00 | 2.5E-01 | 3.1E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 61| +1.48E+02 | +4.6E-05 | -6.0E-01 | 2.1E-02 | 9.3E-02 | 3.1E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 88| +2.06E+02 | -1.5E+00 | +1.0E+00 | 1.2E-01 | 5.4E+00 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 25| +1.50E+02 | -1.9E-01 | +8.9E-01 | 1.2E-01 | 2.0E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 131| +1.48E+02 | -6.7E-04 | +1.0E+00 | 3.9E-03 | 4.8E-01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 133| +1.77E+02 | -1.1E+01 | +5.5E-01 | 2.5E-01 | 7.0E+01 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 35| +1.48E+02 | +1.5E-01 | -8.7E-01 | 1.2E-01 | 4.8E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 84| +1.51E+02 | +5.3E-03 | -8.8E-02 | 1.7E-01 | 4.7E+00 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 89| +2.03E+02 | -3.1E+00 | +1.0E+00 | 2.5E-01 | 1.2E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 54| +1.68E+02 | +1.4E+01 | -1.4E+00 | 5.0E-01 | 4.5E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 62| +1.48E+02 | -1.5E-05 | +6.2E-01 | 5.3E-03 | 9.3E-02 | 8.1E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 132| +1.48E+02 | -1.2E-03 | +7.6E-01 | 7.8E-03 | 3.1E-01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 134| +1.71E+02 | -6.0E+00 | +4.0E-01 | 2.5E-01 | 7.0E+01 | 3.7E-01 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 36| +1.48E+02 | -2.7E-02 | +5.4E-01 | 2.9E-02 | 4.8E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 26| +1.50E+02 | -1.8E-01 | +6.7E-01 | 2.5E-01 | 1.3E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 90| +2.03E+02 | +2.6E+01 | -5.3E+00 | 5.0E-01 | 4.2E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 55| +1.59E+02 | -8.5E+00 | +1.0E+00 | 1.2E-01 | 4.5E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 63| +1.48E+02 | -3.2E-06 | +6.1E-01 | 5.3E-03 | 1.4E-01 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 37| +1.48E+02 | -9.3E-03 | +9.8E-01 | 2.9E-02 | 7.3E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 135| +1.58E+02 | -1.3E+01 | +1.1E+00 | 2.5E-01 | 1.1E+02 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 133| +1.48E+02 | -2.4E-03 | +1.1E+00 | 1.6E-02 | 1.6E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 91| +2.01E+02 | -1.8E+00 | +1.1E+00 | 1.2E-01 | 4.2E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 64| +1.48E+02 | -4.0E-06 | +1.0E+00 | 5.3E-03 | 2.9E-02 | 6.8E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 27| +1.50E+02 | -1.6E-01 | +8.2E-01 | 2.5E-01 | 1.8E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 38| +1.48E+02 | -8.7E-03 | +9.5E-01 | 5.9E-02 | 3.6E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 134| +1.48E+02 | -2.7E-03 | +9.5E-01 | 3.1E-02 | 6.9E-01 | 9.1E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 56| +1.52E+02 | -7.3E+00 | +4.1E-01 | 2.5E-01 | 7.5E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 136| +1.58E+02 | +3.0E+02 | -1.7E+01 | 5.0E-01 | 5.6E+01 | 1.3E+00 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 85| +1.51E+02 | -5.1E-02 | +9.5E-01 | 1.1E-02 | 4.7E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 92| +2.01E+02 | +4.2E-01 | -1.6E-01 | 2.5E-01 | 5.3E+01 | 6.7E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 65| +1.48E+02 | -6.0E-06 | +1.2E+00 | 1.1E-02 | 8.5E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:34.214 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.9354 and h = 3.13883e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.215 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.9354: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 135| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.3E-02 | 3.9E-01 | 2.4E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 39| +1.48E+02 | -1.1E-02 | +9.2E-01 | 1.2E-01 | 3.9E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 57| +1.49E+02 | -3.2E+00 | +9.6E-01 | 2.5E-01 | 1.8E+02 | 3.3E-01 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 137| +1.51E+02 | -7.0E+00 | +8.7E-01 | 1.2E-01 | 5.6E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:34.229 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 171.577 and h = 4.79171e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.229 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 171.577: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 28| +1.50E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 1.3E+01 | 7.9E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 66| +1.48E+02 | -2.5E-06 | +3.6E-01 | 2.1E-02 | 2.2E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 93| +1.98E+02 | -3.1E+00 | +1.4E+00 | 6.2E-02 | 5.3E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:34.243 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.485 and h = 3.02269e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.243 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.485: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 136| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.0E-03 | 3.9E-01 | 5.9E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 40| +1.48E+02 | +3.8E-02 | -2.4E+00 | 2.4E-01 | 2.1E+00 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 58| +1.49E+02 | +2.5E-02 | -6.7E-02 | 2.5E-01 | 3.6E+01 | 2.6E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 138| +1.51E+02 | +2.6E+01 | -4.4E+00 | 2.5E-01 | 2.9E+01 | 5.4E-01 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 137| +1.48E+02 | -2.2E-04 | +1.3E+00 | 5.1E-04 | 3.9E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 94| +1.85E+02 | -1.3E+01 | +8.7E-01 | 1.2E-01 | 5.3E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 41| +1.48E+02 | -2.2E-03 | +3.7E-01 | 5.9E-02 | 2.1E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 67| +1.48E+02 | +2.4E-05 | -1.2E+00 | 2.1E-02 | 6.1E-02 | 4.2E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 59| +1.48E+02 | -9.4E-01 | +6.2E-01 | 6.2E-02 | 3.6E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 139| +1.51E+02 | +2.2E+00 | -7.1E-01 | 6.2E-02 | 2.9E+01 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 29| +1.50E+02 | -4.7E-02 | +1.1E+00 | 1.2E-01 | 1.3E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 138| +1.48E+02 | -1.4E-04 | +9.0E-01 | 1.0E-03 | 3.1E-01 | 2.9E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 42| +1.48E+02 | +7.8E-04 | -8.4E-02 | 5.9E-02 | 2.1E+00 | 2.5E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 68| +1.48E+02 | -5.0E-06 | +8.5E-01 | 5.3E-03 | 6.1E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 95| +1.85E+02 | +1.1E+01 | -5.7E-01 | 2.5E-01 | 4.4E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 140| +1.50E+02 | -7.8E-01 | +7.2E-01 | 1.6E-02 | 2.9E+01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 60| +1.48E+02 | -1.2E-01 | +5.3E-01 | 6.2E-02 | 2.1E+01 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 86| +1.51E+02 | -3.4E-02 | +8.2E-01 | 2.2E-02 | 4.0E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 139| +1.48E+02 | -1.4E-04 | +9.4E-01 | 2.0E-03 | 6.3E-01 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 43| +1.48E+02 | -2.4E-03 | +6.7E-01 | 1.5E-02 | 2.1E+00 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 69| +1.48E+02 | +2.7E-06 | -1.5E+00 | 1.1E-02 | 2.0E-02 | 8.0E-04 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 96| +1.78E+02 | -6.7E+00 | +9.9E-01 | 6.2E-02 | 4.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 141| +1.49E+02 | -6.6E-01 | +7.9E-01 | 1.6E-02 | 3.9E+01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 61| +1.48E+02 | -4.4E-02 | +3.7E-01 | 6.2E-02 | 4.7E+00 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 30| +1.50E+02 | -8.0E-02 | +1.1E+00 | 2.5E-01 | 9.0E+00 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 140| +1.48E+02 | -7.6E-05 | +9.2E-01 | 4.1E-03 | 1.6E-01 | 8.2E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 70| +1.48E+02 | -1.8E-07 | +3.3E-01 | 2.7E-03 | 2.0E-02 | 2.0E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(WARNING) Stopping as function difference 1.75E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:34 fides(INFO) 44| +1.48E+02 | -1.3E-03 | +9.7E-01 | 1.5E-02 | 2.6E+00 | 5.7E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 97| +1.68E+02 | -1.0E+01 | +7.8E-01 | 1.2E-01 | 4.6E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 62| +1.48E+02 | -2.8E-02 | +6.4E-01 | 6.2E-02 | 9.5E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 142| +1.49E+02 | -5.3E-01 | +8.5E-01 | 3.1E-02 | 2.9E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 141| +1.48E+02 | -2.0E-06 | +2.8E-01 | 4.1E-03 | 4.6E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 31| +1.50E+02 | -9.7E-03 | +8.3E-01 | 5.0E-01 | 1.7E+00 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 98| +1.68E+02 | +5.6E+00 | -6.0E-01 | 2.5E-01 | 8.1E+01 | 5.1E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 45| +1.48E+02 | -1.4E-03 | +9.5E-01 | 2.9E-02 | 1.2E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 143| +1.48E+02 | -4.9E-01 | +5.0E-01 | 6.2E-02 | 2.6E+01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 63| +1.48E+02 | -1.1E-02 | +8.1E-01 | 6.2E-02 | 3.5E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 142| +1.48E+02 | -3.4E-06 | +1.7E+00 | 4.1E-03 | 2.9E-02 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 32| +1.50E+02 | -3.3E-03 | +8.7E-01 | 1.0E+00 | 1.4E+00 | 1.1E+00 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 46| +1.48E+02 | -1.2E-03 | +7.6E-01 | 5.9E-02 | 1.8E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 87| +1.51E+02 | +3.9E-03 | -4.8E-01 | 4.4E-02 | 5.0E+00 | 1.6E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 99| +1.63E+02 | -4.6E+00 | +9.4E-01 | 6.2E-02 | 8.1E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 144| +1.48E+02 | -2.2E-02 | +1.2E-02 | 6.2E-02 | 5.3E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 64| +1.48E+02 | -1.2E-02 | +8.5E-01 | 1.2E-01 | 4.7E+00 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 143| +1.48E+02 | +4.7E-07 | -8.7E+00 | 4.1E-03 | 5.6E-03 | 4.0E-04 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 100| +1.59E+02 | -4.3E+00 | +6.8E-01 | 1.2E-01 | 5.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 0| +3.57E+10 | NaN | NaN | 1.0E+00 | 1.6E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:34 fides(INFO) 33| +1.50E+02 | -3.0E-04 | +2.6E-01 | 2.0E+00 | 1.8E+00 | 2.2E-01 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 47| +1.48E+02 | +4.6E-03 | -1.6E+00 | 1.2E-01 | 7.2E-01 | 3.2E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 65| +1.48E+02 | +4.4E-03 | -3.2E-01 | 2.5E-01 | 1.6E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 145| +1.48E+02 | -2.3E-01 | +7.6E-01 | 1.6E-02 | 2.7E+01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 144| +1.48E+02 | -2.7E-06 | +1.0E+02 | 3.5E-05 | 5.6E-03 | 9.9E-05 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 1| +9.25E+07 | -3.6E+10 | +9.0E-02 | 1.0E+00 | 1.6E+11 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 48| +1.48E+02 | -3.9E-04 | +3.5E-01 | 2.9E-02 | 7.2E-01 | 8.2E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 101| +1.54E+02 | -5.0E+00 | +6.0E-01 | 1.2E-01 | 7.3E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 34| +1.50E+02 | -2.1E-05 | +2.1E-02 | 2.0E+00 | 6.3E-01 | 7.8E-03 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 66| +1.48E+02 | -3.3E-03 | +6.8E-01 | 6.2E-02 | 1.6E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 146| +1.48E+02 | -2.9E-01 | +7.0E-01 | 3.1E-02 | 2.6E+01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 2| +1.42E+07 | -7.8E+07 | +8.9E-01 | 2.5E-01 | 4.3E+08 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 145| +1.48E+02 | +4.4E-06 | -2.5E+02 | 7.0E-05 | 2.1E-03 | 1.9E-04 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 3| +2.21E+06 | -1.2E+07 | +8.9E-01 | 5.0E-01 | 6.5E+07 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 49| +1.48E+02 | -4.3E-04 | +3.5E-01 | 2.9E-02 | 1.3E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 88| +1.51E+02 | -3.1E-03 | +5.4E-01 | 2.1E-03 | 5.0E+00 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 67| +1.48E+02 | -2.3E-03 | +7.4E-01 | 6.2E-02 | 2.1E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 102| +1.54E+02 | +3.8E+01 | -3.4E+00 | 1.2E-01 | 6.3E+01 | 2.3E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 35| +1.50E+02 | +1.6E-05 | -1.7E-02 | 1.7E-02 | 1.0E+00 | 6.4E-03 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 146| +1.48E+02 | +2.9E-06 | -3.8E+02 | 1.7E-05 | 2.1E-03 | 4.7E-05 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 147| +1.48E+02 | +2.9E-02 | -1.3E-01 | 3.1E-02 | 1.9E+01 | 3.7E-02 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 68| +1.48E+02 | -1.4E-03 | +6.5E-01 | 6.2E-02 | 8.2E-01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 4| +3.72E+05 | -1.8E+06 | +8.7E-01 | 1.0E+00 | 1.0E+07 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 103| +1.53E+02 | -5.3E-01 | +1.6E-01 | 3.1E-02 | 6.3E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 50| +1.48E+02 | +1.6E-05 | -1.7E-02 | 2.9E-02 | 5.0E-01 | 8.3E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 36| +1.50E+02 | -3.8E-04 | +7.9E-01 | 1.9E-03 | 1.0E+00 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 148| +1.48E+02 | -5.6E-02 | +6.9E-01 | 7.2E-03 | 1.9E+01 | 7.9E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 147| +1.48E+02 | +4.4E-06 | -1.7E+03 | 4.4E-06 | 2.1E-03 | 1.2E-05 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 5| +5.76E+04 | -3.1E+05 | +9.0E-01 | 2.0E+00 | 1.6E+06 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 69| +1.48E+02 | -1.1E-03 | +5.8E-01 | 6.2E-02 | 1.5E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 51| +1.48E+02 | -2.3E-04 | +5.3E-01 | 7.3E-03 | 5.0E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 104| +1.52E+02 | -1.0E+00 | +9.8E-01 | 7.8E-03 | 7.3E+01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 37| +1.50E+02 | -8.4E-05 | +7.0E-01 | 3.7E-03 | 4.0E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 148| +1.48E+02 | +3.9E-06 | -3.1E+03 | 1.1E-06 | 2.1E-03 | 2.9E-06 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 149| +1.48E+02 | -3.8E-02 | +9.5E-01 | 7.2E-03 | 1.3E+01 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 6| +8.73E+03 | -4.9E+04 | +9.1E-01 | 2.0E+00 | 2.4E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 7| +1.35E+03 | -7.4E+03 | +9.2E-01 | 2.0E+00 | 3.6E+04 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 52| +1.48E+02 | -2.0E-04 | +9.5E-01 | 7.3E-03 | 1.2E+00 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 70| +1.48E+02 | +2.4E-04 | -1.2E-01 | 6.2E-02 | 5.1E-01 | 2.8E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 89| +1.51E+02 | -1.1E-03 | +9.9E-01 | 2.1E-03 | 2.5E+00 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 150| +1.48E+02 | -4.4E-02 | +7.2E-01 | 1.4E-02 | 9.4E+00 | 1.5E-02 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 105| +1.52E+02 | -5.8E-01 | +9.3E-01 | 1.6E-02 | 3.5E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 149| +1.48E+02 | +1.5E-06 | -1.8E+03 | 2.7E-07 | 2.1E-03 | 7.0E-07 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 38| +1.50E+02 | -6.5E-07 | +9.2E-02 | 3.7E-03 | 1.4E-01 | 8.8E-04 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 8| +3.49E+02 | -1.0E+03 | +9.2E-01 | 2.0E+00 | 5.1E+03 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 53| +1.48E+02 | -1.6E-04 | +9.0E-01 | 1.5E-02 | 2.1E-01 | 4.3E-03 | 2d |1\n", + "2023-02-17 16:05:34.687 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.782 and h = 3.80467e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.687 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.782: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 71| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 5.1E-01 | 7.7E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 151| +1.48E+02 | -5.6E-02 | +8.8E-01 | 1.4E-02 | 2.0E+01 | 6.5E-03 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 106| +1.51E+02 | -9.8E-01 | +8.8E-01 | 3.1E-02 | 3.1E+01 | 6.2E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 9| +2.27E+02 | -1.2E+02 | +9.2E-01 | 2.0E+00 | 7.5E+02 | 1.9E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 150| +1.48E+02 | +3.1E-06 | -9.7E+03 | 6.8E-08 | 2.1E-03 | 1.7E-07 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 39| +1.50E+02 | +1.8E-06 | -2.3E-01 | 9.3E-04 | 3.1E-02 | 1.2E-03 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 54| +1.48E+02 | -9.1E-05 | +5.3E-01 | 2.9E-02 | 4.0E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 72| +1.48E+02 | -1.6E-04 | +2.2E-01 | 3.9E-03 | 5.1E-01 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 10| +2.27E+02 | +5.9E+01 | -4.5E+00 | 2.0E+00 | 1.2E+02 | 3.0E+00 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 152| +1.48E+02 | -2.0E-02 | +9.5E-01 | 1.4E-02 | 7.9E+00 | 6.2E-03 | trr |1\n", + "2023-02-17 16:05:34.726 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.665 and h = 2.87681e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.726 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.665: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 151| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.7E-08 | 2.1E-03 | 4.3E-08 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 107| +1.51E+02 | -8.2E-02 | +4.8E-02 | 6.2E-02 | 3.8E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 40| +1.50E+02 | -3.0E-06 | +7.7E-01 | 1.6E-04 | 3.1E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 11| +2.00E+02 | -2.7E+01 | +1.0E+00 | 5.0E-01 | 1.2E+02 | 7.9E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 55| +1.48E+02 | +5.0E-05 | -2.5E-01 | 2.9E-02 | 1.6E-01 | 6.0E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 73| +1.48E+02 | -4.7E-04 | +9.6E-01 | 9.8E-04 | 2.0E+00 | 6.7E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 153| +1.48E+02 | -1.9E-02 | +9.3E-01 | 1.4E-02 | 9.5E+00 | 5.4E-03 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 152| +1.48E+02 | +5.5E-06 | -2.4E+05 | 4.3E-09 | 2.1E-03 | 1.1E-08 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 12| +2.00E+02 | +7.4E+02 | -2.4E+01 | 1.0E+00 | 5.5E+01 | 2.0E+00 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 108| +1.50E+02 | -5.9E-01 | +9.1E-01 | 1.6E-02 | 4.8E+01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 41| +1.50E+02 | -6.4E-08 | +5.8E-02 | 3.1E-04 | 6.1E-02 | 4.8E-04 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 56| +1.48E+02 | -1.9E-05 | +2.0E-01 | 7.3E-03 | 1.6E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 74| +1.48E+02 | -4.6E-05 | +1.0E+00 | 2.0E-03 | 2.3E-01 | 9.9E-04 | 2d |1\n", + "2023-02-17 16:05:34.794 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 81.0378 and h = 4.97343e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.794 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 81.0378: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 154| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.4E-02 | 7.2E+00 | 7.4E-03 | trr |0\n", + "2023-02-17 16:05:34 fides(INFO) 13| +1.81E+02 | -1.9E+01 | +8.5E-01 | 2.5E-01 | 5.5E+01 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 153| +1.48E+02 | +3.0E-06 | -5.3E+05 | 1.1E-09 | 2.1E-03 | 2.7E-09 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 109| +1.49E+02 | -7.0E-01 | +6.7E-01 | 3.1E-02 | 3.2E+01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 90| +1.51E+02 | -8.2E-04 | +1.4E+00 | 4.3E-03 | 3.5E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 42| +1.50E+02 | -2.9E-07 | +5.0E-01 | 7.8E-05 | 6.1E-03 | 1.7E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 57| +1.48E+02 | -4.8E-05 | +1.0E+00 | 1.8E-03 | 5.9E-01 | 5.7E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(WARNING) Stopping as function difference 2.88E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:34.819 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.558 and h = 2.71512e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.819 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.558: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 75| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 2.5E-01 | 1.9E-03 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 155| +1.48E+02 | -8.0E-03 | +9.9E-01 | 1.0E-03 | 7.2E+00 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 14| +1.70E+02 | -1.2E+01 | +7.0E-02 | 5.0E-01 | 5.3E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 154| +1.48E+02 | +4.5E-06 | -3.2E+06 | 2.7E-10 | 2.1E-03 | 6.7E-10 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 110| +1.49E+02 | -8.1E-02 | +8.5E-02 | 3.1E-02 | 3.5E+01 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 15| +1.53E+02 | -1.7E+01 | +7.8E-01 | 1.2E-01 | 3.3E+02 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 76| +1.48E+02 | -2.6E-05 | +9.5E-01 | 9.8E-04 | 2.5E-01 | 5.0E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 58| +1.48E+02 | -1.4E-05 | +1.2E+00 | 3.7E-03 | 4.6E-02 | 1.0E-03 | 2d |1\n", + "2023-02-17 16:05:34.854 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0766 and h = 1.15392e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.854 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0766: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 155| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.7E-11 | 2.1E-03 | 1.7E-10 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 156| +1.48E+02 | -8.1E-03 | +9.7E-01 | 2.0E-03 | 4.3E+00 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 111| +1.49E+02 | -4.0E-01 | +8.0E-01 | 7.8E-03 | 5.3E+01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 16| +1.51E+02 | -2.4E+00 | +4.9E-01 | 2.5E-01 | 1.2E+02 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 77| +1.48E+02 | -3.2E-05 | +9.4E-01 | 2.0E-03 | 2.0E-01 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 59| +1.48E+02 | -1.3E-05 | +7.5E-01 | 7.3E-03 | 5.0E-02 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 156| +1.48E+02 | +1.5E-06 | -1.7E+07 | 1.7E-11 | 2.1E-03 | 4.2E-11 | 2d |0\n", + "2023-02-17 16:05:34.885 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 224.204 and h = 2.042e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:34.885 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 224.204: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:34 fides(INFO) 91| +1.51E+02 | +0.0E+00 | +0.0E+00 | 8.6E-03 | 3.0E-01 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 157| +1.48E+02 | -1.0E-02 | +9.7E-01 | 4.1E-03 | 7.7E+00 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 17| +1.49E+02 | -1.7E+00 | +6.7E-01 | 2.5E-01 | 4.6E+01 | 5.0E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 78| +1.48E+02 | -5.7E-05 | +9.2E-01 | 3.9E-03 | 1.5E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 112| +1.49E+02 | -2.4E-01 | +8.9E-01 | 1.6E-02 | 1.2E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 60| +1.48E+02 | -2.2E-05 | +9.2E-01 | 1.5E-02 | 3.7E-02 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 157| +1.48E+02 | +5.0E-06 | -2.3E+08 | 4.2E-12 | 2.1E-03 | 1.1E-11 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 0| +8.21E+10 | NaN | NaN | 1.0E+00 | 3.8E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:34 fides(INFO) 18| +1.49E+02 | -4.0E-01 | +4.2E-01 | 2.5E-01 | 3.5E+01 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 158| +1.48E+02 | -6.8E-03 | +9.8E-01 | 8.1E-03 | 4.1E+00 | 4.9E-03 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) 79| +1.48E+02 | -9.5E-05 | +9.7E-01 | 7.8E-03 | 2.4E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 113| +1.49E+02 | -1.6E-01 | +6.4E-01 | 3.1E-02 | 1.7E+01 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 1| +1.49E+05 | -8.2E+10 | +9.2E-02 | 1.0E+00 | 3.8E+11 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 19| +1.49E+02 | +5.7E-01 | -4.4E-01 | 2.5E-01 | 2.0E+01 | 4.3E-01 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 158| +1.48E+02 | +2.6E-06 | -4.8E+08 | 1.0E-12 | 2.1E-03 | 2.6E-12 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 61| +1.48E+02 | -3.6E-05 | +1.0E+00 | 2.9E-02 | 7.3E-02 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 159| +1.48E+02 | -9.2E-03 | +9.8E-01 | 8.1E-03 | 6.5E+00 | 4.6E-03 | trr |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 20| +1.48E+02 | -3.8E-01 | +7.3E-01 | 6.2E-02 | 2.0E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 2| +2.36E+04 | -1.2E+05 | +9.0E-01 | 2.5E-01 | 6.8E+05 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 62| +1.48E+02 | -4.2E-05 | +9.5E-01 | 5.9E-02 | 4.2E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 114| +1.49E+02 | +4.0E+00 | -6.2E+00 | 3.1E-02 | 9.9E+00 | 8.1E-02 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 80| +1.48E+02 | -1.6E-04 | +9.7E-01 | 1.6E-02 | 1.1E-01 | 7.3E-03 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) 159| +1.48E+02 | +5.8E-06 | -4.2E+09 | 2.6E-13 | 2.1E-03 | 6.6E-13 | 2d |0\n", + "2023-02-17 16:05:34 fides(INFO) 21| +1.48E+02 | -1.1E-01 | +7.5E-01 | 6.2E-02 | 1.8E+01 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:34 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:34 fides(INFO) 160| +1.48E+02 | -6.5E-03 | +9.9E-01 | 8.1E-03 | 4.8E+00 | 5.4E-03 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 3| +3.99E+03 | -2.0E+04 | +9.0E-01 | 5.0E-01 | 1.1E+05 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 63| +1.48E+02 | +3.0E-04 | -5.9E+00 | 1.2E-01 | 3.1E-02 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 22| +1.48E+02 | -6.1E-02 | +8.7E-01 | 6.2E-02 | 1.2E+01 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 115| +1.49E+02 | +9.3E-02 | -5.0E-01 | 7.8E-03 | 9.9E+00 | 2.1E-02 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 81| +1.48E+02 | -2.5E-04 | +9.5E-01 | 3.1E-02 | 2.6E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 92| +1.51E+02 | -3.7E-04 | +1.0E+00 | 2.1E-03 | 3.0E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 4| +8.79E+02 | -3.1E+03 | +9.0E-01 | 1.0E+00 | 1.7E+04 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 161| +1.48E+02 | -8.2E-03 | +9.9E-01 | 8.1E-03 | 4.9E+00 | 7.2E-03 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 23| +1.48E+02 | -1.1E-01 | +9.5E-01 | 1.2E-01 | 1.1E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 64| +1.48E+02 | +2.6E-06 | -1.2E-01 | 2.9E-02 | 3.1E-02 | 5.4E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 160| +1.48E+02 | +1.3E-06 | -3.9E+09 | 6.5E-14 | 2.1E-03 | 1.6E-13 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 5| +3.46E+02 | -5.3E+02 | +9.2E-01 | 2.0E+00 | 2.7E+03 | 1.9E+00 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 82| +1.48E+02 | -3.9E-04 | +9.3E-01 | 6.2E-02 | 1.5E-01 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 162| +1.48E+02 | -8.6E-03 | +1.0E+00 | 8.1E-03 | 5.3E+00 | 9.9E-03 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 116| +1.49E+02 | -3.1E-02 | +6.4E-01 | 2.0E-03 | 9.9E+00 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 24| +1.48E+02 | -9.6E-02 | +6.6E-01 | 2.5E-01 | 1.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 6| +2.60E+02 | -8.6E+01 | +8.9E-01 | 2.0E+00 | 4.0E+02 | 5.5E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 65| +1.48E+02 | -2.7E-06 | +4.7E-01 | 7.3E-03 | 3.1E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 161| +1.48E+02 | +2.2E-06 | -2.6E+10 | 1.6E-14 | 2.1E-03 | 4.1E-14 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 83| +1.48E+02 | -1.5E-04 | +2.1E-01 | 1.2E-01 | 4.3E-01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 25| +1.48E+02 | +2.4E-01 | -7.0E-01 | 2.5E-01 | 7.1E+00 | 2.9E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 163| +1.48E+02 | -8.3E-03 | +1.0E+00 | 8.1E-03 | 4.7E+00 | 8.9E-03 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 117| +1.49E+02 | -3.0E-02 | +9.2E-01 | 2.0E-03 | 9.7E+00 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 7| +2.25E+02 | -3.5E+01 | +5.1E-01 | 4.0E+00 | 5.5E+01 | 8.5E+00 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 66| +1.48E+02 | -6.6E-07 | +2.7E-01 | 7.3E-03 | 2.2E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 6.59E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:35 fides(INFO) 84| +1.48E+02 | +6.5E-04 | -4.5E-01 | 3.1E-02 | 4.0E-01 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 26| +1.48E+02 | -6.0E-02 | +3.7E-01 | 6.2E-02 | 7.1E+00 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 162| +1.48E+02 | +1.3E-06 | -5.8E+10 | 4.1E-15 | 2.1E-03 | 1.0E-14 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 8| +2.25E+02 | +4.9E+02 | -3.4E+01 | 4.0E+00 | 3.9E+01 | 9.4E+00 | trr |0\n", + "2023-02-17 16:05:35 fides(INFO) 164| +1.48E+02 | -1.6E-02 | +1.0E+00 | 1.6E-02 | 3.1E+00 | 3.0E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 27| +1.48E+02 | -7.2E-02 | +8.4E-01 | 6.2E-02 | 1.9E+01 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 118| +1.48E+02 | -4.0E-02 | +8.7E-01 | 3.9E-03 | 7.1E+00 | 8.9E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 85| +1.48E+02 | -2.2E-06 | +8.4E-04 | 7.8E-03 | 4.0E-01 | 4.3E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 163| +1.48E+02 | +1.7E-06 | -3.1E+11 | 1.0E-15 | 2.1E-03 | 2.6E-15 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 28| +1.48E+02 | -7.0E-02 | +1.0E+00 | 1.2E-01 | 3.1E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 93| +1.51E+02 | -6.9E-04 | +1.0E+00 | 4.3E-03 | 3.7E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 9| +2.25E+02 | +1.9E+01 | -1.7E+00 | 8.0E-01 | 3.9E+01 | 1.9E+00 | trr |0\n", + "2023-02-17 16:05:35 fides(INFO) 165| +1.48E+02 | -1.1E-02 | +9.8E-01 | 3.3E-02 | 2.5E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 119| +1.48E+02 | -5.0E-02 | +9.3E-01 | 7.8E-03 | 1.0E+01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 86| +1.48E+02 | -4.2E-04 | +9.5E-01 | 2.0E-03 | 1.9E+00 | 8.7E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 29| +1.47E+02 | -1.6E-01 | +1.2E+00 | 2.5E-01 | 7.0E+00 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 164| +1.48E+02 | +1.6E-07 | -1.2E+11 | 2.5E-16 | 2.1E-03 | 6.4E-16 | 2d |0\n", + "2023-02-17 16:05:35 fides(WARNING) Stopping as trust region radius 6.35E-17 is smaller than machine precision.\n", + "2023-02-17 16:05:35 fides(INFO) 166| +1.48E+02 | -1.7E-02 | +9.4E-01 | 6.5E-02 | 2.3E+00 | 8.8E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 10| +2.21E+02 | -4.6E+00 | +3.4E-01 | 2.0E-01 | 3.9E+01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 87| +1.48E+02 | -2.9E-05 | +8.6E-01 | 3.9E-03 | 1.6E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 30| +1.47E+02 | +2.7E-02 | -1.4E-01 | 5.0E-01 | 4.2E+00 | 3.8E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 120| +1.48E+02 | -5.9E-02 | +8.5E-01 | 1.6E-02 | 6.9E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 167| +1.48E+02 | +1.5E-02 | -1.8E+00 | 1.3E-01 | 9.2E-01 | 7.1E-02 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 31| +1.47E+02 | -8.3E-02 | +7.9E-01 | 1.2E-01 | 4.2E+00 | 9.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 0| +1.15E+13 | NaN | NaN | 1.0E+00 | 5.3E+13 | NaN | NaN |1\n", + "2023-02-17 16:05:35 fides(INFO) 11| +2.18E+02 | -2.9E+00 | +4.8E-01 | 2.0E-01 | 3.4E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 88| +1.48E+02 | -3.2E-05 | +8.7E-01 | 7.8E-03 | 1.9E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 121| +1.48E+02 | -1.8E-01 | +8.8E-01 | 3.1E-02 | 7.7E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 32| +1.47E+02 | -1.2E-01 | +3.1E-01 | 2.5E-01 | 7.4E+00 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 168| +1.48E+02 | -1.9E-03 | +5.3E-01 | 2.2E-02 | 9.2E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 1| +6.42E+06 | -1.2E+13 | +8.3E-02 | 1.0E+00 | 5.3E+13 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 12| +2.18E+02 | -2.4E-01 | +1.8E-02 | 2.0E-01 | 2.2E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 94| +1.51E+02 | -1.7E-03 | +1.1E+00 | 8.6E-03 | 2.1E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:35.268 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.52 and h = 3.50065e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:35.268 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.52: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:35 fides(INFO) 89| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 7.9E-02 | 4.9E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 33| +1.47E+02 | +8.0E+00 | -4.5E+00 | 2.5E-01 | 1.8E+01 | 3.5E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 122| +1.48E+02 | -3.2E-02 | +1.0E-01 | 6.2E-02 | 4.7E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 13| +2.15E+02 | -2.4E+00 | +8.3E-01 | 5.0E-02 | 3.4E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 169| +1.48E+02 | -9.4E-04 | +7.6E-01 | 2.2E-02 | 1.2E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 2| +9.82E+05 | -5.4E+06 | +8.9E-01 | 2.5E-01 | 3.0E+07 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 34| +1.47E+02 | -1.5E-01 | +2.6E-01 | 6.2E-02 | 1.8E+01 | 8.8E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 90| +1.48E+02 | -8.6E-06 | +8.2E-01 | 3.9E-03 | 7.9E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 123| +1.48E+02 | -2.3E-01 | +9.9E-01 | 1.6E-02 | 4.0E+01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 14| +2.15E+02 | -6.2E-01 | +4.3E-01 | 1.0E-01 | 1.4E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 35| +1.47E+02 | -1.4E-01 | +7.0E-01 | 6.2E-02 | 9.2E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 3| +1.52E+05 | -8.3E+05 | +8.9E-01 | 5.0E-01 | 4.5E+06 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 170| +1.48E+02 | +1.6E-03 | -1.8E+00 | 4.4E-02 | 2.6E-01 | 3.0E-02 | trr |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 0| +6.05E+13 | NaN | NaN | 1.0E+00 | 2.8E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:35 fides(INFO) 91| +1.48E+02 | -1.4E-05 | +9.9E-01 | 7.8E-03 | 1.0E-01 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 124| +1.48E+02 | -9.1E-02 | +9.3E-01 | 3.1E-02 | 3.9E+00 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 36| +1.47E+02 | -1.2E-01 | +8.4E-01 | 6.2E-02 | 1.3E+01 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 15| +2.15E+02 | -8.5E-02 | +3.3E-02 | 1.0E-01 | 1.6E+01 | 2.5E-01 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 4| +3.14E+04 | -1.2E+05 | +7.2E-01 | 1.0E+00 | 7.0E+05 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 1| +3.62E+07 | -6.0E+13 | +8.3E-02 | 1.0E+00 | 2.8E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 171| +1.48E+02 | +7.3E-05 | -1.6E-01 | 7.2E-03 | 2.6E-01 | 6.3E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 37| +1.47E+02 | -2.2E-01 | +9.7E-01 | 1.2E-01 | 9.1E+00 | 9.2E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 92| +1.48E+02 | -2.2E-05 | +1.1E+00 | 1.6E-02 | 5.0E-02 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 125| +1.48E+02 | -1.1E-01 | +8.6E-01 | 6.2E-02 | 4.3E+00 | 9.4E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 2| +5.55E+06 | -3.1E+07 | +8.9E-01 | 2.5E-01 | 1.7E+08 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 16| +2.14E+02 | -7.3E-01 | +8.6E-01 | 2.5E-02 | 2.0E+01 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 5| +5.08E+03 | -2.6E+04 | +9.0E-01 | 1.0E+00 | 1.1E+05 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 172| +1.48E+02 | +4.1E-05 | -1.4E-01 | 1.8E-03 | 2.6E-01 | 2.3E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 38| +1.47E+02 | +3.5E+00 | -5.9E+00 | 2.5E-01 | 7.2E+00 | 2.4E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 6| +9.65E+02 | -4.1E+03 | +9.0E-01 | 1.0E+00 | 1.8E+04 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 17| +2.14E+02 | -2.7E-01 | +4.7E-01 | 5.0E-02 | 1.0E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 126| +1.48E+02 | -1.7E-02 | +7.5E-02 | 1.2E-01 | 4.0E+00 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 3| +8.57E+05 | -4.7E+06 | +9.0E-01 | 5.0E-01 | 2.6E+07 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 93| +1.48E+02 | -2.7E-05 | +8.9E-01 | 3.1E-02 | 9.1E-02 | 8.9E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 39| +1.47E+02 | -9.7E-02 | +3.6E-01 | 6.2E-02 | 7.2E+00 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 7| +3.34E+02 | -6.3E+02 | +9.0E-01 | 1.0E+00 | 2.8E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 173| +1.48E+02 | -9.0E-05 | +4.9E-01 | 4.5E-04 | 2.6E-01 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 4| +1.34E+05 | -7.2E+05 | +9.0E-01 | 1.0E+00 | 3.9E+06 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 18| +2.14E+02 | -8.5E-02 | +1.9E-01 | 5.0E-02 | 8.3E+00 | 1.2E-01 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 127| +1.48E+02 | -8.9E-02 | +8.5E-01 | 3.1E-02 | 6.1E+00 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 95| +1.51E+02 | -3.0E-03 | +1.0E+00 | 1.7E-02 | 5.7E-01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 40| +1.46E+02 | -1.7E-01 | +4.8E-01 | 6.2E-02 | 1.4E+01 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 94| +1.48E+02 | -4.4E-05 | +1.0E+00 | 6.2E-02 | 4.6E-02 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 5| +1.34E+05 | +1.0E+09 | -7.0E+04 | 2.0E+00 | 6.1E+05 | 5.5E+00 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 8| +2.52E+02 | -8.2E+01 | +8.6E-01 | 1.0E+00 | 4.3E+02 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 41| +1.46E+02 | -9.1E-02 | +5.9E-01 | 6.2E-02 | 1.5E+01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 19| +2.13E+02 | -1.9E-01 | +8.8E-01 | 1.3E-02 | 9.9E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 174| +1.48E+02 | -5.7E-05 | +7.7E-01 | 4.5E-04 | 7.2E-01 | 5.3E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 6| +2.12E+04 | -1.1E+05 | +9.0E-01 | 5.0E-01 | 6.1E+05 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 128| +1.48E+02 | -4.6E-02 | +9.8E-01 | 6.2E-02 | 9.7E+00 | 6.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 42| +1.46E+02 | -6.1E-02 | +2.8E-01 | 6.2E-02 | 6.9E+00 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 95| +1.48E+02 | +3.0E-05 | -5.7E-01 | 1.2E-01 | 6.7E-02 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 9| +2.29E+02 | -2.4E+01 | +2.0E+00 | 2.0E+00 | 4.6E+01 | 4.7E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 20| +2.13E+02 | -1.5E-01 | +6.9E-01 | 2.5E-02 | 6.1E+00 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 7| +3.53E+03 | -1.8E+04 | +9.0E-01 | 1.0E+00 | 9.7E+04 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 129| +1.48E+02 | -9.9E-03 | +1.1E+00 | 6.2E-02 | 1.1E+00 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 175| +1.48E+02 | -3.2E-05 | +1.4E+00 | 8.9E-04 | 1.3E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 43| +1.46E+02 | +2.9E-01 | -8.8E-01 | 6.2E-02 | 7.6E+00 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 8| +7.48E+02 | -2.8E+03 | +9.0E-01 | 2.0E+00 | 1.5E+04 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 96| +1.48E+02 | -9.6E-06 | +5.5E-01 | 3.1E-02 | 6.7E-02 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 21| +2.13E+02 | -9.9E-02 | +6.4E-01 | 2.5E-02 | 4.7E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 10| +2.29E+02 | +6.1E+03 | -1.7E+02 | 4.0E+00 | 4.3E+01 | 1.1E+01 | trr |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 130| +1.48E+02 | -3.1E-03 | +3.2E-01 | 6.2E-02 | 1.1E+00 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 44| +1.46E+02 | -9.1E-02 | +7.1E-01 | 1.6E-02 | 7.6E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 9| +3.13E+02 | -4.3E+02 | +9.0E-01 | 2.0E+00 | 2.4E+03 | 1.9E+00 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 176| +1.48E+02 | -3.3E-05 | +9.8E-01 | 1.8E-03 | 1.0E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 22| +2.13E+02 | -1.1E-01 | +6.0E-01 | 2.5E-02 | 5.2E+00 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 97| +1.48E+02 | -1.9E-06 | +1.1E-01 | 3.1E-02 | 4.4E-02 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 11| +2.29E+02 | +8.1E+01 | -4.2E+00 | 1.0E+00 | 4.3E+01 | 2.7E+00 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 10| +2.53E+02 | -6.0E+01 | +8.6E-01 | 2.0E+00 | 3.8E+02 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 45| +1.46E+02 | -4.7E-02 | +9.3E-01 | 1.6E-02 | 1.6E+01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:35.557 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0211 and h = 1.41573e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:35.558 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0211: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:35 fides(INFO) 131| +1.48E+02 | -5.1E-03 | +1.0E+00 | 6.2E-02 | 3.1E+00 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 177| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.6E-03 | 8.1E-02 | 4.6E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 11| +2.50E+02 | -2.9E+00 | +5.6E-01 | 2.0E+00 | 4.4E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 12| +2.21E+02 | -7.8E+00 | +3.3E-01 | 2.5E-01 | 4.3E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 23| +2.13E+02 | -8.3E-02 | +5.3E-01 | 2.5E-02 | 5.2E+00 | 5.1E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 98| +1.48E+02 | -9.3E-06 | +8.2E-01 | 7.8E-03 | 1.3E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 96| +1.51E+02 | -5.7E-03 | +1.0E+00 | 3.4E-02 | 4.4E-01 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 46| +1.46E+02 | -7.3E-02 | +1.0E+00 | 3.1E-02 | 4.9E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 132| +1.48E+02 | -4.2E-04 | +9.5E-01 | 6.2E-02 | 3.6E-01 | 9.4E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 12| +2.50E+02 | +2.0E-02 | -4.4E-02 | 2.0E+00 | 1.3E+01 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 178| +1.48E+02 | -1.5E-05 | +1.0E+00 | 8.9E-04 | 8.1E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 24| +2.13E+02 | -8.0E-02 | +4.7E-01 | 2.5E-02 | 5.0E+00 | 5.5E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 13| +2.15E+02 | -6.1E+00 | +6.8E-01 | 2.5E-01 | 4.7E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 47| +1.46E+02 | -8.9E-02 | +1.0E+00 | 6.2E-02 | 1.4E+01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 99| +1.48E+02 | -4.1E-06 | +8.8E-01 | 1.6E-02 | 2.3E-02 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 13| +2.50E+02 | -3.3E-01 | +8.5E-01 | 1.7E-02 | 1.3E+01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 133| +1.48E+02 | -7.9E-05 | +1.2E+00 | 6.2E-02 | 1.1E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 48| +1.46E+02 | -8.9E-02 | +8.7E-01 | 1.2E-01 | 3.2E+00 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 25| +2.13E+02 | -8.4E-02 | +5.0E-01 | 2.5E-02 | 5.6E+00 | 5.1E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 14| +2.10E+02 | -4.9E+00 | +9.9E-01 | 2.5E-01 | 1.6E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 14| +2.50E+02 | -5.2E-02 | +2.2E-01 | 3.3E-02 | 6.6E+00 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 179| +1.48E+02 | -2.1E-05 | +9.1E-01 | 1.8E-03 | 5.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 100| +1.48E+02 | -3.7E-06 | +6.9E-01 | 3.1E-02 | 1.7E-02 | 5.7E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 49| +1.46E+02 | +2.2E+01 | -5.4E+01 | 2.5E-01 | 3.0E+00 | 4.8E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 15| +2.50E+02 | -5.9E-02 | +7.9E-01 | 8.3E-03 | 4.8E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 134| +1.48E+02 | -1.3E-05 | +1.3E+00 | 6.2E-02 | 2.3E-02 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 15| +1.91E+02 | -1.9E+01 | +1.2E+00 | 5.0E-01 | 2.3E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 26| +2.13E+02 | -5.5E-02 | +3.6E-01 | 2.5E-02 | 4.7E+00 | 5.7E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 180| +1.48E+02 | -3.3E-05 | +1.0E+00 | 3.6E-03 | 4.0E-02 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 16| +2.50E+02 | -9.4E-04 | +4.7E-02 | 1.7E-02 | 1.8E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 50| +1.46E+02 | +4.5E-01 | -2.9E+00 | 6.2E-02 | 3.0E+00 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 101| +1.48E+02 | +4.8E-06 | -9.0E-01 | 3.1E-02 | 4.7E-02 | 5.3E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 135| +1.48E+02 | +2.4E-06 | -2.5E+01 | 6.2E-02 | 7.1E-03 | 3.0E-04 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 27| +2.13E+02 | -9.0E-02 | +5.1E-01 | 2.5E-02 | 6.0E+00 | 5.1E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 17| +2.50E+02 | -7.3E-03 | +7.9E-01 | 2.7E-03 | 1.7E+00 | 6.7E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 16| +1.91E+02 | +4.3E+03 | -9.5E+01 | 1.0E+00 | 5.8E+01 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 51| +1.46E+02 | -1.0E-02 | +2.3E-01 | 1.6E-02 | 3.0E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:35.696 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.9877 and h = 3.2767e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:35.696 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.9877: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:35 fides(INFO) 181| +1.48E+02 | -1.5E-05 | +5.8E-01 | 7.2E-03 | 3.6E-02 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 102| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.8E-03 | 4.7E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 97| +1.51E+02 | -9.5E-03 | +1.1E+00 | 6.8E-02 | 4.7E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 18| +2.50E+02 | -4.5E-06 | +9.3E-04 | 5.4E-03 | 6.0E-01 | 7.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 136| +1.48E+02 | +1.8E-06 | -3.7E+01 | 5.8E-05 | 7.1E-03 | 7.4E-05 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 28| +2.13E+02 | -4.0E-02 | +2.9E-01 | 2.5E-02 | 4.3E+00 | 5.9E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 52| +1.46E+02 | -5.1E-03 | +8.4E-01 | 3.9E-03 | 3.3E+00 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 17| +1.68E+02 | -2.3E+01 | +9.4E-01 | 2.5E-01 | 5.8E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 103| +1.48E+02 | -9.8E-07 | +1.6E+00 | 2.0E-03 | 4.7E-02 | 3.3E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 9.82E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:35 fides(INFO) 19| +2.50E+02 | -8.2E-04 | +8.3E-01 | 8.6E-04 | 6.0E-01 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 182| +1.48E+02 | -2.8E-07 | +2.0E-02 | 7.2E-03 | 5.3E-02 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 29| +2.13E+02 | -9.0E-02 | +5.0E-01 | 2.5E-02 | 6.1E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 53| +1.46E+02 | -4.9E-03 | +8.0E-01 | 7.8E-03 | 3.3E+00 | 8.0E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 137| +1.48E+02 | +9.8E-07 | -4.8E+01 | 1.4E-05 | 7.1E-03 | 1.9E-05 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 20| +2.50E+02 | -4.6E-05 | +9.2E-02 | 1.7E-03 | 2.9E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 183| +1.48E+02 | -6.0E-06 | +8.3E-01 | 1.2E-03 | 5.0E-02 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 18| +1.68E+02 | +1.1E+00 | -2.2E-01 | 5.0E-01 | 5.4E+01 | 8.6E-01 | trr |0\n", + "2023-02-17 16:05:35 fides(INFO) 54| +1.46E+02 | -7.7E-03 | +9.1E-01 | 1.6E-02 | 2.2E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 30| +2.13E+02 | -2.3E-02 | +1.6E-01 | 2.5E-02 | 4.2E+00 | 5.9E-02 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 21| +2.50E+02 | -1.8E-04 | +7.9E-01 | 4.3E-04 | 2.6E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 138| +1.48E+02 | +7.6E-07 | -6.1E+01 | 3.6E-06 | 7.1E-03 | 5.3E-06 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 22| +2.50E+02 | -5.3E-08 | +8.2E-04 | 8.6E-04 | 9.4E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 55| +1.46E+02 | -1.1E-03 | +7.2E-02 | 3.1E-02 | 3.7E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 184| +1.48E+02 | -3.7E-06 | +3.3E+00 | 2.4E-03 | 4.0E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 19| +1.64E+02 | -4.1E+00 | +8.8E-01 | 7.5E-02 | 5.4E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 31| +2.12E+02 | -6.4E-02 | +9.1E-01 | 6.3E-03 | 6.5E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 98| +1.51E+02 | -1.1E-02 | +1.4E+00 | 1.4E-01 | 6.9E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 23| +2.50E+02 | -2.1E-05 | +8.2E-01 | 1.4E-04 | 9.4E-02 | 3.3E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 139| +1.48E+02 | -6.1E-07 | +7.1E+01 | 9.0E-07 | 7.1E-03 | 1.8E-06 | 2d |1\n", + "2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 6.06E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:35 fides(INFO) 56| +1.46E+02 | -8.6E-03 | +5.1E-01 | 7.8E-03 | 2.0E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 32| +2.12E+02 | -6.5E-02 | +7.8E-01 | 1.3E-02 | 4.6E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 24| +2.50E+02 | -1.0E-08 | +8.5E-04 | 2.8E-04 | 4.2E-02 | 5.0E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 185| +1.48E+02 | +2.3E-06 | -1.4E+01 | 2.4E-03 | 7.6E-03 | 1.1E-04 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 20| +1.54E+02 | -9.2E+00 | +7.7E-01 | 1.5E-01 | 7.6E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 57| +1.46E+02 | -2.8E-03 | +9.7E-01 | 7.8E-03 | 2.7E+00 | 3.0E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 0| +2.95E+13 | NaN | NaN | 1.0E+00 | 1.4E+14 | NaN | NaN |1\n", + "2023-02-17 16:05:35 fides(INFO) 33| +2.12E+02 | -1.1E-01 | +9.3E-01 | 2.5E-02 | 2.9E+00 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 25| +2.50E+02 | -4.4E-06 | +8.1E-01 | 6.4E-05 | 4.2E-02 | 1.6E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 186| +1.48E+02 | +2.4E-06 | -2.7E+01 | 1.2E-04 | 7.6E-03 | 3.1E-05 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 58| +1.46E+02 | -3.5E-03 | +9.5E-01 | 1.6E-02 | 1.5E+00 | 7.2E-03 | 2d |1\n", + "2023-02-17 16:05:35.868 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 143.128 and h = 1.38416e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:35.868 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 143.128: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:35 fides(INFO) 21| +1.54E+02 | +0.0E+00 | +0.0E+00 | 3.0E-01 | 8.2E+01 | 3.2E-01 | trr |0\n", + "2023-02-17 16:05:35 fides(INFO) 26| +2.50E+02 | -3.3E-10 | +1.6E-04 | 1.3E-04 | 1.7E-02 | 2.0E-04 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 59| +1.46E+02 | +8.1E-03 | -1.1E+00 | 3.1E-02 | 1.3E+00 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:35 fides(INFO) 34| +2.12E+02 | -2.6E-02 | +1.9E-01 | 5.0E-02 | 3.7E+00 | 1.2E-01 | trr |1\n", + "2023-02-17 16:05:35 fides(INFO) 187| +1.48E+02 | -1.4E-06 | +2.7E+01 | 2.9E-05 | 7.6E-03 | 1.3E-05 | 2d |1\n", + "2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 1.37E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:35 fides(INFO) 27| +2.50E+02 | -6.9E-07 | +8.2E-01 | 2.5E-05 | 1.7E-02 | 6.0E-05 | 2d |1\n", + "2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 6.87E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:35 fides(INFO) 22| +1.53E+02 | -1.9E+00 | +9.5E-01 | 2.6E-02 | 8.2E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 60| +1.46E+02 | -1.4E-03 | +6.0E-01 | 7.8E-03 | 1.3E+00 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 1| +2.16E+07 | -2.9E+13 | +8.5E-02 | 1.0E+00 | 1.4E+14 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 35| +2.12E+02 | -1.3E-01 | +8.2E-01 | 1.2E-02 | 6.7E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 61| +1.46E+02 | -1.0E-03 | +3.6E-01 | 7.8E-03 | 1.7E+00 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 2| +3.33E+06 | -1.8E+07 | +8.9E-01 | 2.5E-01 | 9.9E+07 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 23| +1.50E+02 | -2.1E+00 | +8.4E-01 | 5.2E-02 | 4.6E+01 | 9.9E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 36| +2.12E+02 | -3.0E-02 | +2.9E-01 | 2.4E-02 | 3.3E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 62| +1.46E+02 | -2.5E-03 | +3.8E-01 | 7.8E-03 | 9.7E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 99| +1.51E+02 | -9.1E-03 | +1.6E+00 | 1.4E-01 | 1.2E+00 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:35 fides(INFO) 0| +5.21E+07 | NaN | NaN | 1.0E+00 | 2.4E+08 | NaN | NaN |1\n", + "2023-02-17 16:05:35 fides(INFO) 3| +5.18E+05 | -2.8E+06 | +9.0E-01 | 5.0E-01 | 1.5E+07 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 24| +1.49E+02 | -1.3E+00 | +9.6E-01 | 1.0E-01 | 4.8E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 37| +2.12E+02 | -1.1E-01 | +6.0E-01 | 2.4E-02 | 6.1E+00 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 63| +1.46E+02 | -1.2E-03 | +1.7E-01 | 7.8E-03 | 1.9E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 1| +2.41E+04 | -5.2E+07 | +1.1E-01 | 1.0E+00 | 2.4E+08 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:35 fides(INFO) 4| +8.27E+04 | -4.4E+05 | +8.9E-01 | 1.0E+00 | 2.4E+06 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 64| +1.46E+02 | -1.1E-03 | +7.3E-01 | 2.0E-03 | 8.2E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 0| +2.15E+10 | NaN | NaN | 1.0E+00 | 9.9E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:36 fides(INFO) 25| +1.49E+02 | -1.1E-01 | -3.1E-02 | 2.1E-01 | 3.0E+01 | 2.3E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 5| +1.32E+04 | -6.9E+04 | +9.0E-01 | 2.0E+00 | 3.7E+05 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 38| +2.12E+02 | -5.4E-02 | +4.5E-01 | 2.4E-02 | 3.5E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 2| +4.83E+03 | -1.9E+04 | +8.9E-01 | 2.5E-01 | 1.0E+05 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 65| +1.46E+02 | -3.9E-04 | +7.8E-01 | 2.0E-03 | 9.7E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 1| +3.42E+04 | -2.2E+10 | +9.0E-02 | 1.0E+00 | 9.9E+10 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 6| +2.26E+03 | -1.1E+04 | +9.0E-01 | 2.0E+00 | 5.9E+04 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 3| +9.58E+02 | -3.9E+03 | +8.9E-01 | 5.0E-01 | 1.7E+04 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 39| +2.12E+02 | -1.1E-01 | +6.4E-01 | 2.4E-02 | 5.5E+00 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 26| +1.49E+02 | -6.0E-01 | +7.5E-01 | 5.2E-02 | 3.0E+01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 2| +5.57E+03 | -2.9E+04 | +9.0E-01 | 2.5E-01 | 1.6E+05 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 66| +1.46E+02 | -2.4E-04 | +8.1E-01 | 3.9E-03 | 4.6E-01 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 7| +5.46E+02 | -1.7E+03 | +9.0E-01 | 2.0E+00 | 9.4E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 4| +3.30E+02 | -6.3E+02 | +8.9E-01 | 1.0E+00 | 2.7E+03 | 1.6E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 0| +2.85E+08 | NaN | NaN | 1.0E+00 | 1.2E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 40| +2.12E+02 | -8.0E-02 | +6.0E-01 | 2.4E-02 | 3.6E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 3| +1.06E+03 | -4.5E+03 | +9.0E-01 | 5.0E-01 | 2.4E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 8| +2.84E+02 | -2.6E+02 | +9.0E-01 | 2.0E+00 | 1.5E+03 | 1.7E+00 | trr |1\n", + "2023-02-17 16:05:36 fides(INFO) 67| +1.46E+02 | -3.6E-04 | +7.3E-01 | 7.8E-03 | 4.5E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 27| +1.48E+02 | -3.5E-01 | +9.6E-01 | 5.2E-02 | 4.2E+01 | 4.4E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 5| +2.53E+02 | -7.7E+01 | +8.5E-01 | 1.0E+00 | 4.0E+02 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 1| +6.78E+06 | -2.8E+08 | +1.1E-01 | 1.0E+00 | 1.2E+09 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 4| +3.57E+02 | -7.0E+02 | +9.0E-01 | 1.0E+00 | 3.9E+03 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 41| +2.12E+02 | -1.2E-01 | +7.1E-01 | 2.4E-02 | 5.0E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 68| +1.46E+02 | +6.4E-05 | -8.7E-02 | 7.8E-03 | 5.6E-01 | 4.7E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 100| +1.51E+02 | -1.5E-02 | +1.4E+00 | 1.4E-01 | 1.2E+00 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 6| +2.42E+02 | -1.1E+01 | +9.0E-01 | 2.0E+00 | 4.3E+01 | 4.0E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 9| +2.48E+02 | -3.5E+01 | +8.7E-01 | 2.0E+00 | 2.3E+02 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 28| +1.48E+02 | -3.3E-01 | +8.4E-01 | 1.0E-01 | 1.9E+01 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 5| +2.57E+02 | -9.9E+01 | +8.8E-01 | 1.0E+00 | 6.0E+02 | 2.6E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 42| +2.12E+02 | -1.1E-01 | +7.0E-01 | 2.4E-02 | 3.7E+00 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 2| +1.04E+06 | -5.7E+06 | +8.9E-01 | 2.5E-01 | 3.1E+07 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 69| +1.46E+02 | -1.6E-04 | +7.5E-01 | 2.0E-03 | 5.6E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 10| +2.29E+02 | -1.9E+01 | +3.0E+00 | 2.0E+00 | 1.6E+01 | 3.4E+00 | trr |1\n", + "2023-02-17 16:05:36 fides(INFO) 7| +2.42E+02 | +3.2E+01 | -6.3E+00 | 4.0E+00 | 2.8E+01 | 9.0E+00 | trr |0\n", + "2023-02-17 16:05:36 fides(INFO) 6| +2.47E+02 | -1.1E+01 | +7.1E-01 | 2.0E+00 | 7.7E+01 | 4.3E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 29| +1.48E+02 | -1.6E-01 | +5.6E-01 | 2.1E-01 | 3.0E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 43| +2.11E+02 | -1.4E-01 | +7.8E-01 | 2.4E-02 | 4.9E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 8| +2.42E+02 | +9.1E+00 | -1.2E+00 | 8.5E-01 | 2.8E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 70| +1.46E+02 | -1.9E-04 | +9.7E-01 | 3.9E-03 | 3.4E-01 | 9.2E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 3| +1.61E+05 | -8.8E+05 | +8.9E-01 | 5.0E-01 | 4.8E+06 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 7| +2.35E+02 | -1.1E+01 | +1.6E+00 | 2.0E+00 | 1.2E+01 | 3.1E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 71| +1.46E+02 | -2.9E-04 | +1.0E+00 | 7.8E-03 | 5.7E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 44| +2.11E+02 | -2.1E-01 | +7.2E-01 | 4.8E-02 | 3.9E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 9| +2.42E+02 | +7.0E+00 | -1.0E+00 | 2.1E-01 | 2.8E+01 | 5.4E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 30| +1.48E+02 | +4.6E-01 | -1.0E+00 | 2.1E-01 | 9.8E+00 | 2.1E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 4| +2.51E+04 | -1.4E+05 | +9.0E-01 | 1.0E+00 | 7.4E+05 | 9.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 45| +2.11E+02 | -3.2E-01 | +6.7E-01 | 4.8E-02 | 7.9E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 10| +2.40E+02 | -2.8E+00 | +8.5E-01 | 5.3E-02 | 2.8E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 11| +2.29E+02 | +1.7E+02 | -2.0E+01 | 2.0E+00 | 3.1E+01 | 6.1E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 8| +2.35E+02 | +2.0E+01 | -3.9E+00 | 4.0E+00 | 1.9E+01 | 6.9E+00 | trr |0\n", + "2023-02-17 16:05:36 fides(INFO) 72| +1.46E+02 | -4.4E-04 | +8.1E-01 | 1.6E-02 | 2.4E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 101| +1.51E+02 | -1.8E-02 | +1.3E+00 | 2.7E-01 | 7.5E-01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 11| +2.39E+02 | -5.3E-01 | +1.9E-01 | 1.1E-01 | 1.6E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 73| +1.46E+02 | +1.8E-02 | -8.2E+00 | 3.1E-02 | 9.4E-01 | 2.8E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 31| +1.48E+02 | -9.8E-02 | +3.4E-01 | 5.2E-02 | 9.8E+00 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 12| +2.29E+02 | +1.6E+01 | -1.7E+00 | 5.0E-01 | 3.1E+01 | 1.4E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 46| +2.11E+02 | -3.0E-01 | +5.8E-01 | 4.8E-02 | 6.4E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 9| +2.30E+02 | -5.3E+00 | +1.3E+00 | 5.8E-01 | 1.9E+01 | 1.7E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 5| +4.09E+03 | -2.1E+04 | +9.0E-01 | 1.0E+00 | 1.1E+05 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 12| +2.38E+02 | -1.3E+00 | +9.3E-01 | 2.7E-02 | 3.3E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 74| +1.46E+02 | +5.1E-04 | -6.9E-01 | 7.8E-03 | 9.4E-01 | 7.0E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 13| +2.25E+02 | -4.0E+00 | +5.4E-01 | 1.2E-01 | 3.1E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 32| +1.48E+02 | -8.1E-02 | +5.7E-01 | 5.2E-02 | 1.4E+01 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 47| +2.10E+02 | -4.7E-01 | +7.3E-01 | 4.8E-02 | 9.3E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 13| +2.36E+02 | -1.6E+00 | +8.8E-01 | 5.3E-02 | 2.4E+01 | 9.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 10| +2.30E+02 | +1.0E+02 | -1.0E+01 | 1.2E+00 | 2.6E+01 | 3.2E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 75| +1.46E+02 | -1.7E-04 | +6.9E-01 | 2.0E-03 | 9.4E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 14| +2.22E+02 | -2.3E+00 | +7.6E-01 | 1.2E-01 | 2.6E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 6| +8.23E+02 | -3.3E+03 | +9.0E-01 | 1.0E+00 | 1.8E+04 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 14| +2.33E+02 | -2.9E+00 | +1.2E+00 | 1.1E-01 | 1.6E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 48| +2.10E+02 | -4.7E-01 | +7.2E-01 | 4.8E-02 | 7.1E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 33| +1.48E+02 | -5.8E-03 | +9.3E-01 | 5.2E-02 | 3.2E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 76| +1.46E+02 | -3.1E-05 | +9.7E-01 | 2.0E-03 | 1.2E-01 | 3.6E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 15| +2.22E+02 | -5.6E-02 | -5.7E-02 | 2.5E-01 | 2.0E+01 | 7.0E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 11| +2.30E+02 | +2.6E+00 | -4.7E-01 | 2.9E-01 | 2.6E+01 | 7.4E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 15| +2.30E+02 | -3.5E+00 | +8.4E-01 | 2.1E-01 | 1.7E+01 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 77| +1.46E+02 | -4.6E-05 | +9.4E-01 | 3.9E-03 | 2.3E-01 | 6.8E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 49| +2.09E+02 | -5.9E-01 | +8.2E-01 | 4.8E-02 | 9.3E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36.303 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.9015 and h = 7.61275e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:36.304 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.9015: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:36 fides(INFO) 34| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.0E-01 | 1.7E+00 | 5.2E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 16| +2.21E+02 | -1.4E+00 | +6.8E-01 | 6.2E-02 | 2.0E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 12| +2.27E+02 | -2.9E+00 | +7.8E-01 | 7.2E-02 | 2.6E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 7| +3.14E+02 | -5.1E+02 | +9.1E-01 | 1.0E+00 | 2.8E+03 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 16| +2.25E+02 | -4.4E+00 | +7.3E-01 | 4.3E-01 | 3.9E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 78| +1.46E+02 | -6.6E-05 | +8.2E-01 | 7.8E-03 | 1.3E-01 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 50| +2.08E+02 | -6.4E-01 | +6.0E-01 | 9.6E-02 | 7.2E+00 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 17| +2.20E+02 | -1.4E+00 | +9.6E-01 | 6.2E-02 | 2.0E+01 | 9.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 102| +1.51E+02 | -2.4E-03 | +1.0E+00 | 2.7E-01 | 5.9E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 35| +1.48E+02 | -4.0E-03 | +9.1E-01 | 2.6E-02 | 1.7E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 13| +2.23E+02 | -4.2E+00 | +1.2E+00 | 1.4E-01 | 2.0E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 79| +1.46E+02 | +9.6E-04 | -3.1E+00 | 1.6E-02 | 1.3E-01 | 7.5E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 17| +2.22E+02 | -3.2E+00 | +3.5E-01 | 4.3E-01 | 2.3E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 18| +2.18E+02 | -1.7E+00 | +7.2E-01 | 1.2E-01 | 1.6E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 51| +2.07E+02 | -1.0E+00 | +7.3E-01 | 9.6E-02 | 1.4E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 80| +1.46E+02 | -7.0E-06 | +7.6E-02 | 3.9E-03 | 1.3E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 36| +1.48E+02 | -3.5E-03 | +9.6E-01 | 5.2E-02 | 3.8E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 14| +2.17E+02 | -5.5E+00 | +1.1E+00 | 2.9E-01 | 1.9E+01 | 6.9E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 18| +2.14E+02 | -8.1E+00 | +7.4E-01 | 4.3E-01 | 5.5E+01 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 19| +2.16E+02 | -1.6E+00 | +5.9E-01 | 1.2E-01 | 2.6E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 8| +2.20E+02 | -9.4E+01 | +1.1E+00 | 1.0E+00 | 4.0E+02 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 52| +2.07E+02 | -7.1E-01 | +7.6E-01 | 9.6E-02 | 7.0E+00 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 81| +1.46E+02 | -3.8E-05 | +6.6E-01 | 9.8E-04 | 1.7E-01 | 7.2E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 19| +1.99E+02 | -1.5E+01 | +1.1E+00 | 4.3E-01 | 2.5E+01 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 20| +2.16E+02 | -2.7E-01 | +7.9E-02 | 1.2E-01 | 1.7E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 37| +1.48E+02 | -3.9E-03 | +9.0E-01 | 1.0E-01 | 9.8E-01 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 15| +2.02E+02 | -1.6E+01 | +1.0E+00 | 5.8E-01 | 2.8E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 82| +1.46E+02 | -1.1E-05 | +9.3E-01 | 9.8E-04 | 1.4E-01 | 1.9E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 53| +2.05E+02 | -2.0E+00 | +1.1E+00 | 1.9E-01 | 9.8E+00 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 103| +1.51E+02 | -3.1E-04 | +1.7E+00 | 2.7E-01 | 3.0E-01 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 21| +2.15E+02 | -1.3E+00 | +8.8E-01 | 3.1E-02 | 3.2E+01 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 16| +2.02E+02 | +3.0E+03 | -1.0E+02 | 1.2E+00 | 6.6E+01 | 2.2E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 20| +1.99E+02 | +1.6E+02 | -7.8E+00 | 8.5E-01 | 4.6E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 83| +1.46E+02 | -1.5E-05 | +1.1E+00 | 2.0E-03 | 9.8E-02 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 38| +1.48E+02 | +7.4E-03 | -1.9E+00 | 2.1E-01 | 2.5E+00 | 9.8E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 54| +1.93E+02 | -1.2E+01 | +2.2E+00 | 3.9E-01 | 1.1E+01 | 9.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 22| +2.14E+02 | -1.0E+00 | +7.3E-01 | 6.2E-02 | 2.0E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 21| +1.85E+02 | -1.3E+01 | +1.1E+00 | 2.1E-01 | 4.6E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 84| +1.46E+02 | -2.4E-05 | +9.5E-01 | 3.9E-03 | 9.2E-02 | 5.2E-04 | 2d |1\n", + "2023-02-17 16:05:36.482 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 115.442 and h = 1.5043e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:36.482 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 115.442: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:36 fides(INFO) 17| +2.02E+02 | +0.0E+00 | +0.0E+00 | 2.9E-01 | 6.6E+01 | 5.9E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 39| +1.48E+02 | -9.4E-04 | +5.3E-01 | 5.2E-02 | 2.5E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 23| +2.13E+02 | -6.4E-01 | +6.7E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 55| +1.93E+02 | +1.3E+03 | -3.9E+01 | 7.7E-01 | 4.3E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 9| +2.20E+02 | +8.5E+00 | -1.0E+00 | 1.0E+00 | 2.8E+01 | 1.9E+00 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 85| +1.46E+02 | -3.4E-05 | +7.8E-01 | 7.8E-03 | 1.1E-01 | 7.7E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 18| +1.94E+02 | -8.0E+00 | +9.8E-01 | 7.2E-02 | 6.6E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 40| +1.48E+02 | +6.4E-04 | -3.5E-01 | 5.2E-02 | 6.1E-01 | 1.9E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 22| +1.62E+02 | -2.3E+01 | +5.2E-01 | 4.3E-01 | 4.7E+01 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 24| +2.12E+02 | -7.7E-01 | +7.2E-01 | 6.2E-02 | 1.6E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 86| +1.46E+02 | +1.1E-03 | -5.3E+00 | 1.6E-02 | 6.9E-02 | 7.5E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 56| +1.73E+02 | -2.0E+01 | +1.1E+00 | 1.9E-01 | 4.3E+01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 19| +1.81E+02 | -1.3E+01 | +9.6E-01 | 1.4E-01 | 5.7E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 87| +1.46E+02 | +2.5E-05 | -3.9E-01 | 3.9E-03 | 6.9E-02 | 1.9E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 25| +2.12E+02 | -5.1E-01 | +5.7E-01 | 6.2E-02 | 1.1E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 41| +1.48E+02 | -3.0E-04 | +3.2E-01 | 1.3E-02 | 6.1E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 23| +1.49E+02 | -1.3E+01 | +9.4E-01 | 4.3E-01 | 2.8E+02 | 5.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 57| +1.73E+02 | -2.0E+00 | -1.8E-01 | 3.9E-01 | 4.8E+01 | 8.7E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 104| +1.51E+02 | -7.1E-04 | +1.4E+00 | 2.7E-01 | 1.3E-01 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 88| +1.46E+02 | -1.2E-05 | +6.5E-01 | 9.8E-04 | 6.9E-02 | 5.2E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 26| +2.11E+02 | -6.9E-01 | +6.8E-01 | 6.2E-02 | 1.6E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36.568 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 100.881 and h = 9.40868e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:36.568 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 100.881: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:36 fides(INFO) 42| +1.48E+02 | -5.0E-04 | +8.8E-01 | 1.3E-02 | 1.9E+00 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 10| +2.20E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 2.8E+01 | 6.0E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 20| +1.72E+02 | -8.7E+00 | +3.1E-01 | 2.9E-01 | 5.3E+01 | 5.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 24| +1.48E+02 | -7.3E-01 | +4.7E-01 | 8.5E-01 | 8.0E+01 | 8.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 58| +1.64E+02 | -8.9E+00 | +9.9E-01 | 9.6E-02 | 4.8E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 89| +1.46E+02 | -4.6E-06 | +8.3E-01 | 9.8E-04 | 1.4E-01 | 1.0E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 27| +2.11E+02 | -4.5E-01 | +5.4E-01 | 6.2E-02 | 9.8E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 21| +1.72E+02 | -1.8E+00 | -7.1E-02 | 2.9E-01 | 2.4E+02 | 4.7E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 43| +1.48E+02 | -1.1E-04 | +9.0E-01 | 2.6E-02 | 2.1E-01 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 25| +1.48E+02 | +8.2E+00 | -5.3E+00 | 8.5E-01 | 1.7E+01 | 4.4E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 90| +1.46E+02 | -1.8E-05 | +7.8E-01 | 2.0E-03 | 5.1E-02 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 28| +2.10E+02 | -6.3E-01 | +6.5E-01 | 6.2E-02 | 1.5E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 59| +1.54E+02 | -1.0E+01 | +7.2E-01 | 1.9E-01 | 5.2E+01 | 4.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 26| +1.48E+02 | -4.9E-01 | +5.8E-01 | 8.3E-02 | 1.7E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 91| +1.46E+02 | +1.4E-05 | -3.1E-01 | 3.9E-03 | 2.1E-01 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 44| +1.48E+02 | -1.4E-04 | +9.9E-01 | 5.2E-02 | 3.7E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 22| +1.56E+02 | -1.6E+01 | +9.7E-01 | 7.2E-02 | 2.4E+02 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 29| +2.10E+02 | -3.8E-01 | +4.6E-01 | 6.2E-02 | 9.0E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 60| +1.50E+02 | -3.9E+00 | +6.4E-01 | 1.9E-01 | 1.1E+02 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 92| +1.46E+02 | -1.2E-05 | +7.8E-01 | 9.8E-04 | 2.1E-01 | 4.0E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 27| +1.48E+02 | -7.2E-02 | +8.4E-01 | 8.3E-02 | 7.9E+00 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 45| +1.48E+02 | -1.5E-04 | +9.1E-01 | 1.0E-01 | 1.3E-01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 23| +1.51E+02 | -4.9E+00 | +8.6E-01 | 1.4E-01 | 6.7E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 30| +2.09E+02 | -5.9E-01 | +6.1E-01 | 6.2E-02 | 1.4E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 105| +1.51E+02 | -5.2E-04 | +1.5E+00 | 2.7E-01 | 4.6E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 93| +1.46E+02 | -6.2E-06 | +9.8E-01 | 2.0E-03 | 6.2E-02 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 61| +1.50E+02 | +1.2E+00 | -5.5E-01 | 1.9E-01 | 4.1E+01 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 28| +1.48E+02 | -2.9E-02 | +8.3E-01 | 1.7E-01 | 5.7E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 11| +2.17E+02 | -3.3E+00 | +8.6E-01 | 6.2E-02 | 2.8E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 24| +1.49E+02 | -2.3E+00 | +9.2E-01 | 2.9E-01 | 8.5E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 31| +2.09E+02 | -2.9E-01 | +3.5E-01 | 6.2E-02 | 8.5E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 46| +1.48E+02 | +1.1E-03 | -6.5E+00 | 2.1E-01 | 1.4E-01 | 4.4E-02 | trr |0\n", + "2023-02-17 16:05:36 fides(INFO) 94| +1.46E+02 | -8.5E-06 | +1.0E+00 | 3.9E-03 | 4.7E-02 | 2.5E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 62| +1.49E+02 | -1.0E+00 | +8.2E-01 | 4.8E-02 | 4.1E+01 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:36.723 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0685 and h = 1.43602e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:36.724 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0685: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:36 fides(INFO) 47| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.0E-02 | 1.4E-01 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 29| +1.48E+02 | +1.5E-02 | -2.0E+00 | 3.3E-01 | 1.3E+00 | 1.4E-01 | trr |0\n", + "2023-02-17 16:05:36 fides(INFO) 95| +1.46E+02 | -6.0E-06 | +3.4E-01 | 7.8E-03 | 5.4E-02 | 9.0E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 32| +2.08E+02 | -5.8E-01 | +5.7E-01 | 6.2E-02 | 1.5E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 25| +1.49E+02 | +2.7E+00 | -1.4E+00 | 5.8E-01 | 4.4E+01 | 5.4E-01 | 2d |0\n", + "2023-02-17 16:05:36.750 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.9736 and h = 9.3318e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:36.751 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.9736: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 30| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.5E-02 | 1.3E+00 | 3.4E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 48| +1.48E+02 | -1.6E-05 | +7.3E-01 | 1.3E-02 | 1.4E-01 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 96| +1.46E+02 | +5.3E-04 | -3.8E+00 | 7.8E-03 | 5.6E-02 | 4.6E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 63| +1.48E+02 | -5.9E-01 | +8.9E-01 | 9.6E-02 | 3.7E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 106| +1.51E+02 | -4.1E-04 | +1.4E+00 | 2.7E-01 | 3.9E-01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 33| +2.08E+02 | -2.1E-01 | +2.5E-01 | 6.2E-02 | 8.4E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 26| +1.48E+02 | -8.5E-01 | +7.3E-01 | 1.4E-01 | 4.4E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 97| +1.46E+02 | +5.1E-06 | -1.3E-01 | 2.0E-03 | 5.6E-02 | 1.2E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 31| +1.48E+02 | -1.1E-03 | +9.2E-01 | 1.1E-02 | 1.3E+00 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 49| +1.48E+02 | -8.1E-06 | +8.5E-01 | 1.3E-02 | 8.1E-02 | 2.8E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 34| +2.08E+02 | -3.7E-01 | +8.9E-01 | 1.6E-02 | 1.5E+01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 64| +1.48E+02 | +1.1E+00 | -2.2E+00 | 1.9E-01 | 1.7E+01 | 3.0E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 27| +1.48E+02 | -2.4E-01 | +4.3E-01 | 1.4E-01 | 3.8E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 98| +1.46E+02 | -8.5E-06 | +7.8E-01 | 4.9E-04 | 5.6E-02 | 3.2E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 35| +2.07E+02 | -3.5E-01 | +7.8E-01 | 3.1E-02 | 8.6E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 32| +1.48E+02 | -1.3E-03 | +9.6E-01 | 2.3E-02 | 8.0E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 99| +1.46E+02 | -2.1E-06 | +4.7E-01 | 9.8E-04 | 1.2E-01 | 1.9E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 50| +1.48E+02 | -1.3E-05 | +8.9E-01 | 2.5E-02 | 8.6E-02 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 12| +2.13E+02 | -4.1E+00 | +8.7E-01 | 1.2E-01 | 2.1E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 65| +1.48E+02 | -7.9E-02 | +4.5E-01 | 4.8E-02 | 1.7E+01 | 7.4E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 28| +1.48E+02 | -3.4E-01 | +4.6E-01 | 1.4E-01 | 2.4E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 36| +2.07E+02 | -4.3E-01 | +7.5E-01 | 6.2E-02 | 5.2E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 100| +1.46E+02 | -1.6E-06 | +1.1E+00 | 9.8E-04 | 3.4E-02 | 8.0E-05 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 51| +1.48E+02 | -2.1E-05 | +1.1E+00 | 5.0E-02 | 5.5E-02 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 66| +1.48E+02 | -9.3E-02 | +3.0E-01 | 4.8E-02 | 1.5E+01 | 6.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 33| +1.48E+02 | -1.8E-03 | +9.3E-01 | 4.5E-02 | 7.7E-01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 29| +1.48E+02 | +5.7E-02 | -1.4E-01 | 1.4E-01 | 8.4E+00 | 2.0E-01 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 101| +1.46E+02 | -3.4E-06 | +1.3E+00 | 2.0E-03 | 5.1E-02 | 1.0E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 37| +2.07E+02 | -2.2E-01 | +2.3E-01 | 1.2E-01 | 1.2E+01 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 107| +1.51E+02 | -1.8E-04 | +1.4E+00 | 2.7E-01 | 1.4E-01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 52| +1.48E+02 | +8.1E-06 | -3.6E-01 | 1.0E-01 | 5.7E-02 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 67| +1.48E+02 | -1.2E-01 | +4.4E-01 | 4.8E-02 | 2.2E+01 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 34| +1.48E+02 | +3.4E-03 | -1.6E+00 | 9.0E-02 | 5.1E-01 | 6.3E-02 | 2d |0\n", + "2023-02-17 16:05:36.908 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 92.147 and h = 1.45023e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:36.908 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 92.147: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:36 fides(INFO) 102| +1.46E+02 | -4.4E-06 | +9.2E-01 | 3.9E-03 | 3.3E-02 | 1.8E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 30| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.6E-02 | 8.4E+00 | 5.1E-02 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 38| +2.06E+02 | -7.6E-01 | +8.4E-01 | 3.1E-02 | 1.5E+01 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 103| +1.46E+02 | -6.4E-06 | +7.2E-01 | 7.8E-03 | 3.7E-02 | 5.6E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 53| +1.48E+02 | -5.4E-06 | +7.0E-01 | 2.5E-02 | 5.7E-02 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 68| +1.48E+02 | -4.2E-03 | +3.1E-02 | 4.8E-02 | 6.7E+00 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 35| +1.48E+02 | -3.8E-04 | +5.0E-01 | 2.3E-02 | 5.1E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 39| +2.05E+02 | -7.9E-01 | +1.3E+00 | 6.2E-02 | 6.2E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 31| +1.48E+02 | -6.6E-02 | +8.6E-01 | 9.0E-03 | 8.4E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 13| +2.07E+02 | -6.6E+00 | +9.3E-01 | 2.5E-01 | 3.4E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 104| +1.46E+02 | +3.6E-04 | -6.0E+00 | 7.8E-03 | 4.1E-02 | 3.6E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 54| +1.48E+02 | -3.0E-06 | +3.6E-01 | 2.5E-02 | 3.8E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 40| +2.05E+02 | -3.2E-01 | +2.5E-01 | 1.2E-01 | 9.9E+00 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 69| +1.48E+02 | -4.3E-02 | +7.4E-01 | 1.2E-02 | 5.4E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 36| +1.48E+02 | +2.3E-04 | -1.9E-01 | 2.3E-02 | 4.6E-01 | 6.1E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 32| +1.48E+02 | -7.1E-02 | +8.8E-01 | 1.8E-02 | 1.4E+01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 105| +1.46E+02 | +1.0E-05 | -5.9E-01 | 2.0E-03 | 4.1E-02 | 9.1E-04 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 106| +1.46E+02 | -2.5E-06 | +5.3E-01 | 4.9E-04 | 4.1E-02 | 2.4E-04 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 55| +1.48E+02 | +1.3E-06 | -7.4E-02 | 2.5E-02 | 8.9E-02 | 4.4E-03 | 2d |0\n", + "2023-02-17 16:05:36 fides(INFO) 41| +2.03E+02 | -1.5E+00 | +8.0E-01 | 1.2E-01 | 2.2E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:36 fides(INFO) 70| +1.48E+02 | -2.3E-02 | +8.2E-01 | 1.2E-02 | 8.6E+00 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 33| +1.48E+02 | -5.4E-02 | +6.1E-01 | 3.6E-02 | 5.4E+00 | 4.7E-02 | 2d |1\n", + "2023-02-17 16:05:36 fides(INFO) 37| +1.48E+02 | -2.9E-04 | +6.6E-01 | 5.6E-03 | 4.6E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 108| +1.51E+02 | -7.8E-05 | +1.4E+00 | 2.7E-01 | 3.0E-02 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 107| +1.46E+02 | -5.4E-07 | +8.7E-01 | 4.9E-04 | 5.0E-02 | 3.3E-05 | 2d |1\n", + "2023-02-17 16:05:37 fides(WARNING) Stopping as function difference 5.41E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:37 fides(INFO) 42| +2.01E+02 | -2.1E+00 | +1.0E+00 | 2.5E-01 | 1.1E+01 | 7.3E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 34| +1.48E+02 | -1.5E-02 | +7.8E-01 | 3.6E-02 | 9.3E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 56| +1.48E+02 | -1.0E-06 | +1.8E-01 | 6.3E-03 | 8.9E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 71| +1.48E+02 | -9.8E-03 | +5.5E-01 | 2.4E-02 | 2.6E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 38| +1.48E+02 | -1.6E-04 | +9.8E-01 | 5.6E-03 | 7.9E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 14| +1.96E+02 | -1.0E+01 | +3.0E-01 | 5.0E-01 | 2.9E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:37.056 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.455 and h = 1.39738e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.056 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.455: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 35| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.2E-02 | 2.6E+00 | 4.1E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 43| +1.89E+02 | -1.2E+01 | +1.8E+00 | 5.0E-01 | 1.8E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 57| +1.48E+02 | -2.3E-06 | +6.4E+00 | 1.6E-03 | 2.0E-02 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 39| +1.48E+02 | -2.4E-04 | +9.3E-01 | 1.1E-02 | 2.2E-01 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:37.066 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.258 and h = 3.96555e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.066 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.258: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 72| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-02 | 2.4E+00 | 2.5E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 36| +1.48E+02 | -4.0E-03 | +9.2E-01 | 1.8E-02 | 2.6E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 58| +1.48E+02 | -3.9E-06 | +7.9E+00 | 3.1E-03 | 2.2E-02 | 4.5E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 44| +1.89E+02 | +1.7E+03 | -6.6E+01 | 1.0E+00 | 3.0E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 40| +1.48E+02 | -1.6E-04 | +5.7E-01 | 2.3E-02 | 5.8E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 109| +1.51E+02 | -4.8E-05 | +1.4E+00 | 2.7E-01 | 7.1E-02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 73| +1.48E+02 | -3.4E-03 | +9.5E-01 | 6.0E-03 | 2.4E+00 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 59| +1.48E+02 | +2.5E-06 | -3.2E+00 | 6.3E-03 | 1.5E-02 | 8.9E-04 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 37| +1.48E+02 | -3.4E-03 | +9.6E-01 | 3.6E-02 | 4.5E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 41| +1.48E+02 | +6.4E-04 | -1.2E+00 | 2.3E-02 | 2.1E-01 | 5.7E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 45| +1.73E+02 | -1.6E+01 | +1.1E+00 | 2.5E-01 | 3.0E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 74| +1.48E+02 | -4.7E-03 | +9.6E-01 | 1.2E-02 | 2.3E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 15| +1.96E+02 | +4.8E+00 | -5.1E-01 | 5.0E-01 | 1.9E+02 | 9.2E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 0| +1.22E+10 | NaN | NaN | 1.0E+00 | 4.7E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 60| +1.48E+02 | +1.3E-06 | -4.3E+00 | 1.6E-03 | 1.5E-02 | 2.2E-04 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 38| +1.48E+02 | -2.8E-03 | +9.2E-01 | 7.2E-02 | 1.8E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 42| +1.48E+02 | -1.9E-05 | +8.4E-02 | 5.6E-03 | 2.1E-01 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 75| +1.48E+02 | -6.1E-03 | +9.4E-01 | 2.4E-02 | 1.8E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 1| +1.13E+08 | -1.2E+10 | +1.1E-01 | 1.0E+00 | 4.7E+10 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 46| +1.73E+02 | +7.8E-01 | -5.9E-01 | 5.0E-01 | 1.1E+02 | 9.2E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 61| +1.48E+02 | +2.9E-07 | -1.6E+00 | 3.9E-04 | 1.5E-02 | 5.9E-05 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 43| +1.48E+02 | -9.0E-05 | +9.2E-01 | 1.4E-03 | 7.8E-01 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 2| +1.71E+07 | -9.6E+07 | +8.9E-01 | 2.5E-01 | 5.2E+08 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 39| +1.48E+02 | -1.9E-03 | +7.9E-01 | 1.4E-01 | 2.8E+00 | 7.3E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 76| +1.48E+02 | -8.8E-03 | +8.6E-01 | 4.8E-02 | 1.5E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 3| +2.61E+06 | -1.4E+07 | +8.9E-01 | 5.0E-01 | 7.9E+07 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 62| +1.48E+02 | +3.0E-06 | -2.0E+01 | 9.8E-05 | 1.5E-02 | 2.5E-05 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 44| +1.48E+02 | -2.9E-05 | +7.9E-01 | 2.8E-03 | 8.0E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 40| +1.48E+02 | +2.2E-02 | -4.4E+00 | 2.9E-01 | 9.5E-01 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 110| +1.51E+02 | -1.6E-05 | +1.1E+00 | 2.7E-01 | 5.2E-02 | 1.4E-01 | trr |1\n", + "2023-02-17 16:05:37 fides(INFO) 47| +1.62E+02 | -1.1E+01 | +9.3E-01 | 1.2E-01 | 1.1E+02 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 77| +1.48E+02 | +2.9E-02 | -2.2E+00 | 9.6E-02 | 9.2E-01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 16| +1.77E+02 | -1.9E+01 | +1.0E+00 | 1.2E-01 | 1.9E+02 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 4| +4.00E+05 | -2.2E+06 | +8.9E-01 | 5.0E-01 | 1.2E+07 | 9.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 63| +1.48E+02 | +2.7E-06 | -1.9E+01 | 2.5E-05 | 1.5E-02 | 2.1E-05 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 45| +1.48E+02 | -2.5E-05 | +7.8E-01 | 5.6E-03 | 1.0E-01 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 41| +1.48E+02 | +1.9E-04 | -9.1E-02 | 7.2E-02 | 9.5E-01 | 3.6E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 5| +6.19E+04 | -3.4E+05 | +9.0E-01 | 5.0E-01 | 1.8E+06 | 9.0E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 78| +1.48E+02 | -1.5E-03 | +3.4E-01 | 2.4E-02 | 9.2E-01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 48| +1.52E+02 | -1.0E+01 | +8.2E-01 | 2.5E-01 | 5.7E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 6| +9.77E+03 | -5.2E+04 | +9.0E-01 | 5.0E-01 | 2.8E+05 | 9.3E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 46| +1.48E+02 | -2.9E-05 | +7.8E-01 | 1.1E-02 | 5.4E-02 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 64| +1.48E+02 | +1.6E-06 | -1.4E+01 | 6.1E-06 | 1.5E-02 | 1.3E-05 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 42| +1.48E+02 | -6.2E-04 | +6.2E-01 | 1.8E-02 | 9.5E-01 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:37.289 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 125.179 and h = 9.55388e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.289 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 125.179: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 49| +1.52E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 9.7E+01 | 6.9E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 7| +1.68E+03 | -8.1E+03 | +9.0E-01 | 1.0E+00 | 4.4E+04 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 79| +1.48E+02 | +1.1E-02 | -1.2E+00 | 2.4E-02 | 9.5E-01 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 47| +1.48E+02 | -3.3E-05 | +5.7E-01 | 2.3E-02 | 1.4E-01 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 65| +1.48E+02 | +3.2E-06 | -7.9E+01 | 1.5E-06 | 1.5E-02 | 3.3E-06 | 2d |0\n", + "2023-02-17 16:05:37.307 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.78 and h = 2.75474e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.307 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.78: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 43| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.8E-02 | 1.8E+00 | 7.5E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 17| +1.68E+02 | -9.1E+00 | +4.9E-01 | 2.5E-01 | 6.8E+01 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 8| +4.19E+02 | -1.3E+03 | +9.2E-01 | 2.0E+00 | 6.8E+03 | 9.3E-01 | trr |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 80| +1.48E+02 | -4.9E-04 | +1.3E-01 | 6.0E-03 | 9.5E-01 | 7.2E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 50| +1.50E+02 | -2.0E+00 | +9.0E-01 | 1.2E-01 | 9.7E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 48| +1.48E+02 | +5.2E-04 | -2.5E+00 | 2.3E-02 | 1.0E-01 | 6.4E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 9| +2.28E+02 | -1.9E+02 | +9.8E-01 | 2.0E+00 | 9.6E+02 | 8.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 111| +1.51E+02 | +7.4E-08 | -6.8E-01 | 2.7E-01 | 3.3E-02 | 8.2E-06 | g |0\n", + "2023-02-17 16:05:37 fides(INFO) 44| +1.48E+02 | -3.8E-04 | +9.6E-01 | 4.5E-03 | 1.8E+00 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 66| +1.48E+02 | +5.5E-06 | -5.2E+02 | 3.8E-07 | 1.5E-02 | 8.2E-07 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 10| +2.15E+02 | -1.2E+01 | +8.0E-01 | 2.0E+00 | 9.8E+01 | 5.8E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 81| +1.48E+02 | -1.2E-03 | +9.4E-01 | 1.5E-03 | 3.0E+00 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 49| +1.48E+02 | +1.3E-05 | -1.7E-01 | 5.6E-03 | 1.0E-01 | 1.8E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 51| +1.49E+02 | -1.0E+00 | +8.9E-01 | 2.5E-01 | 4.2E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 45| +1.48E+02 | -2.4E-04 | +9.3E-01 | 9.0E-03 | 4.9E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 67| +1.48E+02 | +1.8E-06 | -6.8E+02 | 9.6E-08 | 1.5E-02 | 2.1E-07 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 82| +1.48E+02 | -4.5E-04 | +8.2E-01 | 3.0E-03 | 3.5E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 50| +1.48E+02 | -9.8E-06 | +2.6E-01 | 1.4E-03 | 1.0E-01 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 52| +1.49E+02 | +1.5E-01 | -1.6E-01 | 5.0E-01 | 3.8E+01 | 5.8E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 46| +1.48E+02 | -1.4E-04 | +9.7E-01 | 1.8E-02 | 1.0E+00 | 7.4E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 68| +1.48E+02 | +3.0E-06 | -4.4E+03 | 2.4E-08 | 1.5E-02 | 5.1E-08 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 83| +1.48E+02 | -5.2E-04 | +8.1E-01 | 6.0E-03 | 6.5E-01 | 7.0E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 51| +1.48E+02 | -1.8E-05 | +7.9E-01 | 1.4E-03 | 4.2E-01 | 4.0E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 11| +2.15E+02 | +3.2E+02 | -1.9E+01 | 4.0E+00 | 2.5E+01 | 1.1E+01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 53| +1.48E+02 | -5.3E-01 | +7.7E-01 | 1.2E-01 | 3.8E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 47| +1.48E+02 | -7.6E-05 | +9.3E-01 | 3.6E-02 | 2.6E-01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 69| +1.48E+02 | +2.5E-06 | -1.5E+04 | 6.0E-09 | 1.5E-02 | 1.3E-08 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 84| +1.48E+02 | -6.6E-04 | +9.1E-01 | 1.2E-02 | 1.9E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 52| +1.48E+02 | -4.5E-06 | +1.7E+00 | 2.8E-03 | 3.0E-02 | 5.8E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 54| +1.48E+02 | -3.7E-01 | +7.3E-01 | 2.5E-01 | 3.4E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:37.474 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 159.303 and h = 7.75438e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.474 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 159.303: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 12| +2.00E+02 | -1.6E+01 | +1.4E+00 | 1.0E+00 | 2.5E+01 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 112| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.1E-06 | 3.3E-02 | 2.0E-06 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 18| +1.57E+02 | -1.1E+01 | +9.8E-01 | 2.5E-01 | 1.6E+02 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 48| +1.48E+02 | -5.7E-05 | +9.4E-01 | 7.2E-02 | 4.9E-01 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 85| +1.48E+02 | -1.0E-03 | +8.6E-01 | 2.4E-02 | 2.6E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 53| +1.48E+02 | -4.1E-06 | +1.0E+00 | 5.6E-03 | 2.6E-02 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 55| +1.48E+02 | +2.4E-02 | -7.7E-02 | 2.5E-01 | 2.1E+01 | 2.5E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 70| +1.48E+02 | +2.6E-06 | -6.0E+04 | 1.5E-09 | 1.5E-02 | 3.2E-09 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 13| +2.00E+02 | +1.0E+03 | -3.7E+01 | 2.0E+00 | 6.8E+01 | 5.4E+00 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 49| +1.48E+02 | +7.9E-06 | -1.4E-01 | 1.4E-01 | 1.3E-01 | 5.0E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 86| +1.48E+02 | +2.8E-03 | -1.7E+00 | 4.8E-02 | 2.2E-01 | 5.1E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 54| +1.48E+02 | -5.6E-06 | +9.8E-01 | 1.1E-02 | 2.3E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 71| +1.48E+02 | +2.3E-06 | -2.2E+05 | 3.7E-10 | 1.5E-02 | 8.0E-10 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 56| +1.48E+02 | -2.2E-01 | +5.8E-01 | 6.2E-02 | 2.1E+01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:37.540 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.636 and h = 2.24351e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.540 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.636: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 50| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.6E-02 | 1.3E-01 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 87| +1.48E+02 | -2.4E-04 | +4.6E-01 | 1.2E-02 | 2.2E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 14| +1.80E+02 | -2.0E+01 | +1.0E+00 | 5.0E-01 | 6.8E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 55| +1.48E+02 | -5.4E-06 | +8.2E-01 | 2.3E-02 | 1.8E-02 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 72| +1.48E+02 | +1.3E-06 | -4.9E+05 | 9.4E-11 | 1.5E-02 | 2.0E-10 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 57| +1.48E+02 | -1.5E-01 | +8.9E-01 | 6.2E-02 | 3.3E+01 | 6.4E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 51| +1.48E+02 | -1.2E-05 | +1.0E+00 | 9.0E-03 | 1.3E-01 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 113| +1.51E+02 | -3.4E-08 | +2.6E+00 | 2.8E-07 | 3.3E-02 | 5.1E-07 | 2d |1\n", + "2023-02-17 16:05:37 fides(WARNING) Stopping as function difference 3.41E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:37 fides(INFO) 88| +1.48E+02 | +4.4E-03 | -3.4E+00 | 1.2E-02 | 2.3E-01 | 1.0E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 73| +1.48E+02 | +2.3E-06 | -3.5E+06 | 2.3E-11 | 1.5E-02 | 5.0E-11 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 56| +1.48E+02 | +4.5E-04 | -1.3E+01 | 4.5E-02 | 3.3E-02 | 7.0E-03 | trr |0\n", + "2023-02-17 16:05:37 fides(INFO) 15| +1.80E+02 | +3.8E+01 | -2.6E+00 | 1.0E+00 | 6.9E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 58| +1.48E+02 | -5.0E-02 | +9.0E-01 | 1.2E-01 | 6.5E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 52| +1.48E+02 | -9.2E-06 | +8.9E-01 | 1.8E-02 | 2.2E-01 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 89| +1.48E+02 | +1.6E-03 | -1.8E+00 | 3.0E-03 | 2.3E-01 | 6.7E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 57| +1.48E+02 | +2.1E-05 | -1.3E+00 | 8.4E-03 | 3.3E-02 | 1.8E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 16| +1.77E+02 | -2.5E+00 | +1.5E-01 | 2.5E-01 | 6.9E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 59| +1.48E+02 | -3.1E-02 | +7.5E-01 | 2.5E-01 | 1.0E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 53| +1.48E+02 | -1.5E-05 | +1.2E+00 | 3.6E-02 | 8.0E-02 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 74| +1.48E+02 | -5.7E-07 | +3.5E+06 | 5.8E-12 | 1.5E-02 | 1.3E-11 | 2d |1\n", + "2023-02-17 16:05:37 fides(WARNING) Stopping as function difference 5.75E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:37 fides(INFO) 19| +1.55E+02 | -1.5E+00 | +9.5E-01 | 5.0E-01 | 3.9E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 58| +1.48E+02 | +6.4E-06 | -1.2E+00 | 2.1E-03 | 3.3E-02 | 4.7E-04 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 90| +1.48E+02 | -1.7E-04 | +5.1E-01 | 7.5E-04 | 2.3E-01 | 1.7E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 17| +1.68E+02 | -9.1E+00 | +9.2E-01 | 6.2E-02 | 1.4E+02 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 54| +1.48E+02 | -6.6E-06 | +5.9E-01 | 7.2E-02 | 1.5E-01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 60| +1.48E+02 | +6.0E-02 | -1.3E+00 | 2.5E-01 | 2.7E+00 | 1.7E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 59| +1.48E+02 | +1.0E-06 | -4.7E-01 | 5.3E-04 | 3.3E-02 | 1.5E-04 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 91| +1.48E+02 | -2.9E-05 | +9.3E-01 | 7.5E-04 | 3.0E-01 | 7.1E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 61| +1.48E+02 | -4.7E-03 | +2.4E-01 | 6.2E-02 | 2.7E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 55| +1.48E+02 | -6.9E-06 | +1.1E+00 | 7.2E-02 | 3.7E-02 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 18| +1.66E+02 | -2.4E+00 | +5.5E-01 | 1.2E-01 | 5.0E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 0| +2.13E+11 | NaN | NaN | 1.0E+00 | 8.4E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:37 fides(INFO) 92| +1.48E+02 | -3.3E-05 | +8.2E-01 | 1.5E-03 | 1.2E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 60| +1.48E+02 | +2.5E-06 | -1.9E+00 | 1.3E-04 | 3.3E-02 | 7.8E-05 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 62| +1.48E+02 | -6.6E-03 | +9.0E-01 | 1.6E-02 | 6.3E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 1| +2.64E+09 | -2.1E+11 | +1.0E-01 | 1.0E+00 | 8.4E+11 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 56| +1.48E+02 | +1.7E-05 | -2.5E+00 | 1.4E-01 | 6.0E-02 | 3.4E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 61| +1.48E+02 | +7.0E-07 | -6.6E-01 | 3.3E-05 | 3.3E-02 | 6.1E-05 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 93| +1.48E+02 | -6.3E-05 | +1.0E+00 | 3.0E-03 | 1.5E-01 | 2.6E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 0| +4.07E+10 | NaN | NaN | 1.0E+00 | 1.9E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:37 fides(INFO) 19| +1.62E+02 | -3.3E+00 | +9.2E-01 | 1.2E-01 | 1.0E+02 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 2| +3.98E+08 | -2.2E+09 | +8.9E-01 | 2.5E-01 | 1.2E+10 | 6.7E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 57| +1.48E+02 | -2.3E-06 | +9.2E-01 | 3.6E-02 | 6.0E-02 | 8.5E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 63| +1.48E+02 | -2.2E-03 | +7.7E-01 | 3.1E-02 | 8.7E-01 | 2.3E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 1| +8.32E+04 | -4.1E+10 | +9.3E-02 | 1.0E+00 | 1.9E+11 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 62| +1.48E+02 | -4.2E-08 | +8.9E-02 | 8.2E-06 | 3.3E-02 | 1.7E-05 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 94| +1.48E+02 | -9.4E-05 | +9.4E-01 | 6.0E-03 | 8.3E-02 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 20| +1.61E+02 | -1.2E+00 | +7.5E-01 | 2.5E-01 | 3.9E+01 | 5.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 2| +1.33E+04 | -7.0E+04 | +9.0E-01 | 2.5E-01 | 3.8E+05 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 64| +1.48E+02 | -2.2E-03 | +9.3E-01 | 6.2E-02 | 9.4E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 58| +1.48E+02 | +5.7E-06 | -1.1E+00 | 7.2E-02 | 1.4E-02 | 1.6E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 63| +1.48E+02 | +1.5E-06 | -1.2E+01 | 2.1E-06 | 2.6E-02 | 5.3E-06 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 95| +1.48E+02 | -1.5E-04 | +9.7E-01 | 1.2E-02 | 1.3E-01 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 3| +6.02E+07 | -3.4E+08 | +8.9E-01 | 5.0E-01 | 1.8E+09 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 21| +1.59E+02 | -2.1E+00 | +1.2E+00 | 5.0E-01 | 5.6E+01 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 3| +2.29E+03 | -1.1E+04 | +9.0E-01 | 5.0E-01 | 6.0E+04 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 65| +1.48E+02 | -3.2E-03 | +9.0E-01 | 1.2E-01 | 7.4E-01 | 7.8E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 59| +1.48E+02 | -1.4E-06 | +9.4E-01 | 1.8E-02 | 1.4E-02 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(WARNING) Stopping as function difference 1.40E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:37 fides(INFO) 4| +9.00E+06 | -5.1E+07 | +8.9E-01 | 1.0E+00 | 2.8E+08 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 64| +1.48E+02 | +1.0E-07 | -3.0E+00 | 5.1E-07 | 2.6E-02 | 1.3E-06 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 4| +5.52E+02 | -1.7E+03 | +9.0E-01 | 5.0E-01 | 9.6E+03 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 96| +1.48E+02 | -7.9E-05 | +4.5E-01 | 2.4E-02 | 5.5E-02 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:37.842 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 182.65 and h = 3.35302e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.842 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 182.65: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 22| +1.59E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 2.4E+01 | 1.8E+00 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 5| +1.28E+06 | -7.7E+06 | +9.0E-01 | 1.0E+00 | 4.1E+07 | 9.2E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 66| +1.48E+02 | +2.0E-03 | -4.1E-01 | 2.5E-01 | 7.8E-01 | 1.5E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 5| +2.84E+02 | -2.7E+02 | +9.0E-01 | 1.0E+00 | 1.5E+03 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 97| +1.48E+02 | +4.4E-03 | -5.0E+00 | 2.4E-02 | 1.8E-01 | 2.3E-02 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 65| +1.48E+02 | +1.6E-06 | -1.9E+02 | 1.3E-07 | 2.6E-02 | 3.3E-07 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 23| +1.57E+02 | -2.0E+00 | +1.1E+00 | 2.5E-01 | 2.4E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 6| +1.59E+05 | -1.1E+06 | +9.2E-01 | 1.0E+00 | 5.9E+06 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 20| +1.53E+02 | -2.1E+00 | +4.9E-01 | 1.0E+00 | 3.8E+01 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 67| +1.48E+02 | -1.1E-03 | +7.0E-01 | 6.2E-02 | 7.8E-01 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 6| +2.51E+02 | -3.3E+01 | +8.5E-01 | 2.0E+00 | 2.3E+02 | 4.7E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 98| +1.48E+02 | +8.5E-05 | -2.8E-01 | 6.0E-03 | 1.8E-01 | 5.8E-03 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 66| +1.48E+02 | +1.6E-06 | -7.3E+02 | 3.2E-08 | 2.6E-02 | 8.3E-08 | 2d |0\n", + "2023-02-17 16:05:37.902 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 99.1786 and h = 1.85395e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:37.902 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 99.1786: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:37 fides(INFO) 24| +1.57E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 3.9E+01 | 7.0E-01 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 7| +1.73E+04 | -1.4E+05 | +9.4E-01 | 1.0E+00 | 7.7E+05 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 68| +1.48E+02 | -5.4E-04 | +3.6E-01 | 6.2E-02 | 4.7E-01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 7| +2.33E+02 | -1.7E+01 | +8.8E+00 | 4.0E+00 | 1.9E+01 | 6.8E+00 | trr |1\n", + "2023-02-17 16:05:37 fides(INFO) 99| +1.48E+02 | -5.8E-05 | +5.8E-01 | 1.5E-03 | 1.8E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 25| +1.56E+02 | -1.3E+00 | +1.1E+00 | 1.2E-01 | 3.9E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 8| +2.36E+03 | -1.5E+04 | +9.1E-01 | 1.0E+00 | 1.0E+05 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 0| +4.92E+02 | NaN | NaN | 1.0E+00 | 5.7E+02 | NaN | NaN |1\n", + "2023-02-17 16:05:37 fides(INFO) 69| +1.48E+02 | -6.5E-04 | +2.4E-01 | 6.2E-02 | 1.5E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 67| +1.48E+02 | +3.5E-07 | -6.5E+02 | 8.0E-09 | 2.6E-02 | 2.1E-08 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 8| +2.33E+02 | +4.2E+04 | -1.5E+03 | 4.0E+00 | 4.9E+01 | 1.2E+01 | trr |0\n", + "2023-02-17 16:05:37 fides(INFO) 100| +1.48E+02 | -1.8E-05 | +7.8E-01 | 1.5E-03 | 3.8E-01 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 9| +4.73E+02 | -1.9E+03 | +9.0E-01 | 1.0E+00 | 1.7E+04 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 26| +1.53E+02 | -2.9E+00 | +1.1E+00 | 2.5E-01 | 1.7E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 1| +3.93E+02 | -9.9E+01 | +9.5E-02 | 1.0E+00 | 5.7E+02 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 70| +1.48E+02 | -2.9E-04 | +2.1E-01 | 1.6E-02 | 5.8E-01 | 8.0E-03 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 68| +1.48E+02 | +6.4E-06 | -4.8E+04 | 2.0E-09 | 2.6E-02 | 5.2E-09 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 9| +2.33E+02 | +1.7E+03 | -5.1E+01 | 9.5E-01 | 4.9E+01 | 2.5E+00 | 2d |0\n", + "2023-02-17 16:05:37 fides(INFO) 101| +1.48E+02 | -7.5E-06 | +1.2E+00 | 3.0E-03 | 3.4E-02 | 7.8E-04 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 2| +3.48E+02 | -4.5E+01 | +9.9E-01 | 2.5E-01 | 6.3E+01 | 7.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) 27| +1.49E+02 | -3.5E+00 | +1.0E+00 | 5.0E-01 | 4.1E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:37 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:37 fides(INFO) 10| +2.06E+02 | -2.7E+02 | +9.0E-01 | 1.0E+00 | 2.8E+03 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 71| +1.48E+02 | -6.4E-04 | +9.5E-01 | 3.9E-03 | 2.3E+00 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 10| +2.15E+02 | -1.9E+01 | +7.0E-01 | 2.4E-01 | 4.9E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 69| +1.48E+02 | +3.9E-06 | -1.2E+05 | 5.0E-10 | 2.6E-02 | 1.3E-09 | 2d |0\n", + "2023-02-17 16:05:38.015 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 86.6153 and h = 1.31e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:38.015 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 86.6153: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:38 fides(INFO) 102| +1.48E+02 | -6.9E-06 | +7.3E-01 | 6.0E-03 | 6.1E-02 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 28| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 1.3E+01 | 6.3E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 11| +1.69E+02 | -3.6E+01 | +8.7E-01 | 1.0E+00 | 4.8E+02 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 3| +2.89E+02 | -5.9E+01 | +7.0E-01 | 5.0E-01 | 6.1E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 11| +2.15E+02 | +2.0E+00 | -4.5E-01 | 2.4E-01 | 2.8E+01 | 6.3E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 21| +1.52E+02 | -7.1E-01 | +9.7E-01 | 1.0E+00 | 7.1E+01 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 72| +1.48E+02 | -7.3E-05 | +9.1E-01 | 7.8E-03 | 1.5E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 70| +1.48E+02 | +2.3E-06 | -2.8E+05 | 1.3E-10 | 2.6E-02 | 3.2E-10 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 12| +1.61E+02 | -8.0E+00 | +1.2E+00 | 1.0E+00 | 9.2E+01 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 103| +1.48E+02 | +1.4E-05 | -8.5E-01 | 6.0E-03 | 3.6E-02 | 7.7E-04 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 29| +1.49E+02 | -6.6E-01 | +6.7E-01 | 1.4E-01 | 1.3E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 4| +2.66E+02 | -2.3E+01 | +8.8E-01 | 5.0E-01 | 8.8E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 12| +2.12E+02 | -2.5E+00 | +8.1E-01 | 5.9E-02 | 2.8E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 13| +1.61E+02 | +1.6E+01 | -2.8E+00 | 2.0E+00 | 2.8E+01 | 2.3E+00 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 22| +1.52E+02 | +3.8E+01 | -2.1E+02 | 2.0E+00 | 8.5E+00 | 5.0E+00 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 73| +1.48E+02 | -1.1E-04 | +9.2E-01 | 1.6E-02 | 1.2E-01 | 7.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 71| +1.48E+02 | +1.9E-06 | -9.3E+05 | 3.1E-11 | 2.6E-02 | 8.1E-11 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 30| +1.49E+02 | +1.7E+00 | -1.5E+00 | 1.4E-01 | 1.5E+01 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 104| +1.48E+02 | +1.3E-06 | -2.2E-01 | 1.5E-03 | 3.6E-02 | 2.6E-04 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 14| +1.57E+02 | -4.8E+00 | +1.1E+00 | 3.0E-01 | 2.8E+01 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 13| +2.12E+02 | +1.4E-01 | -2.4E-01 | 1.2E-01 | 9.4E+00 | 3.5E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 5| +2.66E+02 | +3.3E+03 | -1.7E+02 | 1.0E+00 | 3.9E+01 | 2.6E+00 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 74| +1.48E+02 | -1.7E-04 | +9.6E-01 | 3.1E-02 | 1.1E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 72| +1.48E+02 | +1.0E-07 | -1.9E+05 | 7.9E-12 | 2.6E-02 | 2.0E-11 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 31| +1.48E+02 | -2.1E-01 | +5.9E-01 | 3.5E-02 | 1.5E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 15| +1.50E+02 | -6.1E+00 | +6.9E-01 | 6.0E-01 | 3.6E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 6| +2.53E+02 | -1.3E+01 | +6.0E-01 | 2.5E-01 | 3.9E+01 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 105| +1.48E+02 | -6.5E-07 | +2.4E-01 | 3.8E-04 | 3.6E-02 | 1.3E-04 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 14| +2.12E+02 | -3.2E-01 | +6.4E-01 | 3.0E-02 | 9.4E+00 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 16| +1.50E+02 | +1.2E+01 | -3.4E+00 | 6.0E-01 | 1.0E+02 | 8.8E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 75| +1.48E+02 | -2.6E-04 | +9.7E-01 | 6.2E-02 | 1.4E-01 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 23| +1.52E+02 | +6.7E-03 | -5.3E-01 | 5.0E-01 | 8.5E+00 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 73| +1.48E+02 | +1.5E-06 | -1.2E+07 | 2.0E-12 | 2.6E-02 | 5.1E-12 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 32| +1.48E+02 | -1.1E-01 | +9.5E-01 | 3.5E-02 | 9.5E+00 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 15| +2.12E+02 | -6.5E-02 | +5.8E-01 | 3.0E-02 | 2.6E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 7| +2.50E+02 | -2.6E+00 | +5.9E-01 | 2.5E-01 | 4.0E+01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 106| +1.48E+02 | -2.5E-06 | +1.7E+00 | 9.4E-05 | 1.1E-01 | 3.3E-05 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 17| +1.49E+02 | -1.7E+00 | +6.7E-01 | 1.5E-01 | 1.0E+02 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 76| +1.48E+02 | -3.3E-04 | +9.6E-01 | 1.2E-01 | 1.3E-01 | 4.8E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 74| +1.48E+02 | +1.2E-05 | -3.7E+08 | 4.9E-13 | 2.6E-02 | 1.3E-12 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 33| +1.48E+02 | -1.9E-01 | +9.8E-01 | 7.1E-02 | 9.3E+00 | 6.6E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 16| +2.12E+02 | +7.9E-03 | -7.3E-02 | 3.0E-02 | 4.1E+00 | 8.2E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 18| +1.48E+02 | -6.2E-01 | +9.1E-01 | 1.5E-01 | 3.1E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 8| +2.50E+02 | +1.9E-01 | -3.9E-01 | 2.5E-01 | 8.6E+00 | 6.6E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 107| +1.48E+02 | +2.9E-06 | -3.5E+00 | 1.9E-04 | 1.6E-02 | 1.0E-04 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 17| +2.12E+02 | -5.2E-02 | +8.2E-01 | 7.4E-03 | 4.1E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 19| +1.48E+02 | -3.4E-01 | +4.3E-01 | 3.0E-01 | 2.2E+01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 77| +1.48E+02 | -1.9E-04 | +8.5E-01 | 2.5E-01 | 5.8E-02 | 7.7E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 34| +1.48E+02 | -2.3E-01 | +8.7E-01 | 1.4E-01 | 8.7E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 9| +2.50E+02 | +1.9E-01 | -3.9E-01 | 6.2E-02 | 8.6E+00 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 75| +1.48E+02 | -9.9E-07 | +1.2E+08 | 1.2E-13 | 2.6E-02 | 3.2E-13 | 2d |1\n", + "2023-02-17 16:05:38 fides(WARNING) Stopping as function difference 9.94E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 20| +1.47E+02 | -3.5E-01 | +2.9E-01 | 3.0E-01 | 2.8E+01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 18| +2.12E+02 | -7.5E-03 | +2.3E-01 | 1.5E-02 | 1.6E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 108| +1.48E+02 | +1.8E-06 | -2.5E+00 | 4.7E-05 | 1.6E-02 | 8.8E-05 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 78| +1.48E+02 | +5.4E-05 | -6.7E+00 | 5.0E-01 | 9.4E-02 | 1.4E-02 | trr |0\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 10| +2.50E+02 | -2.3E-01 | +7.9E-01 | 1.6E-02 | 8.6E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 35| +1.48E+02 | +1.5E-01 | -4.3E-01 | 2.8E-01 | 6.8E+00 | 2.3E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 21| +1.47E+02 | +8.2E+00 | -4.5E+00 | 3.0E-01 | 1.9E+01 | 4.1E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 19| +2.12E+02 | -1.9E-02 | +8.9E-01 | 3.7E-03 | 3.0E+00 | 7.9E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 109| +1.48E+02 | -1.3E-07 | +4.1E-01 | 1.2E-05 | 1.6E-02 | 2.5E-05 | 2d |1\n", + "2023-02-17 16:05:38 fides(WARNING) Stopping as function difference 1.33E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:38 fides(INFO) 22| +1.47E+02 | -1.2E-01 | +2.0E-01 | 7.6E-02 | 1.9E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 79| +1.48E+02 | -2.9E-06 | +6.9E-01 | 2.9E-02 | 9.4E-02 | 3.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 36| +1.48E+02 | -1.0E-01 | +7.1E-01 | 7.1E-02 | 6.8E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 11| +2.50E+02 | +3.2E-03 | -7.4E-02 | 3.1E-02 | 2.9E+00 | 8.1E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 24| +1.52E+02 | -7.9E-02 | +1.1E+00 | 1.2E-01 | 8.5E+00 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 20| +2.12E+02 | -1.3E-02 | +6.4E-01 | 7.4E-03 | 1.8E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 23| +1.47E+02 | -2.2E-01 | +8.8E-01 | 1.9E-02 | 1.9E+01 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 12| +2.50E+02 | -2.2E-02 | +5.9E-01 | 7.8E-03 | 2.9E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 80| +1.48E+02 | +2.3E-05 | -1.3E+00 | 2.9E-02 | 3.1E-02 | 3.8E-03 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 37| +1.48E+02 | -2.9E-02 | +2.2E-01 | 7.1E-02 | 9.0E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 21| +2.12E+02 | -2.8E-03 | +3.3E-01 | 7.4E-03 | 8.1E-01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 24| +1.47E+02 | -1.4E-01 | +9.8E-01 | 3.8E-02 | 3.3E+01 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 81| +1.48E+02 | -2.9E-06 | +5.4E-01 | 7.3E-03 | 3.1E-02 | 9.7E-04 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 13| +2.50E+02 | -1.2E-04 | +2.3E-02 | 7.8E-03 | 9.0E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 38| +1.48E+02 | -6.1E-02 | +6.2E-01 | 1.8E-02 | 5.7E+00 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 22| +2.12E+02 | -4.2E-03 | +3.3E-01 | 7.4E-03 | 1.4E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 25| +1.47E+02 | -1.7E-01 | +9.8E-01 | 7.6E-02 | 1.0E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 25| +1.52E+02 | -1.3E-01 | +1.1E+00 | 2.5E-01 | 1.6E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 82| +1.48E+02 | +1.2E-06 | -2.3E+00 | 7.3E-03 | 4.7E-02 | 7.2E-04 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 23| +2.12E+02 | -8.3E-04 | +9.7E-02 | 7.4E-03 | 1.1E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 39| +1.48E+02 | -4.0E-02 | +9.7E-01 | 1.8E-02 | 1.6E+01 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 14| +2.50E+02 | -2.3E-03 | +6.8E-01 | 2.0E-03 | 8.7E-01 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 26| +1.47E+02 | -1.9E-01 | +9.4E-01 | 1.5E-01 | 2.4E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 24| +2.12E+02 | -3.5E-03 | +8.5E-01 | 1.9E-03 | 1.2E+00 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 83| +1.48E+02 | +2.3E-06 | -6.7E+00 | 1.8E-03 | 4.7E-02 | 1.8E-04 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 27| +1.46E+02 | -2.1E-01 | +5.4E-01 | 3.0E-01 | 7.1E+00 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 15| +2.50E+02 | +8.3E-09 | -1.2E-03 | 2.0E-03 | 3.6E-02 | 5.1E-03 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 40| +1.48E+02 | -2.2E-02 | +9.3E-01 | 3.5E-02 | 2.2E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 26| +1.52E+02 | +7.5E-01 | -4.8E+00 | 5.0E-01 | 8.2E+00 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 0| +1.34E+03 | NaN | NaN | 1.0E+00 | 5.1E+03 | NaN | NaN |1\n", + "2023-02-17 16:05:38 fides(INFO) 28| +1.46E+02 | +1.8E+01 | -1.1E+01 | 3.0E-01 | 1.1E+01 | 4.6E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 25| +2.12E+02 | -8.2E-04 | +3.2E-01 | 3.7E-03 | 5.9E-01 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 84| +1.48E+02 | +6.4E-07 | -2.2E+00 | 4.5E-04 | 4.7E-02 | 4.7E-05 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 16| +2.50E+02 | +8.3E-09 | -1.2E-03 | 4.9E-04 | 3.6E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 41| +1.48E+02 | -3.6E-02 | +9.6E-01 | 7.1E-02 | 4.3E+00 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 1| +3.07E+02 | -1.0E+03 | +1.2E-01 | 1.0E+00 | 5.1E+03 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 29| +1.46E+02 | +6.2E-02 | -1.5E-01 | 7.6E-02 | 1.1E+01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 26| +2.12E+02 | -4.3E-04 | +2.0E-01 | 3.7E-03 | 5.5E-01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 85| +1.48E+02 | +9.7E-07 | -3.5E+00 | 1.1E-04 | 4.7E-02 | 1.6E-05 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 17| +2.50E+02 | -3.0E-06 | +4.3E-01 | 1.2E-04 | 3.6E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 42| +1.48E+02 | -3.5E-02 | +7.2E-01 | 1.4E-01 | 1.8E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 30| +1.46E+02 | -1.2E-01 | +7.6E-01 | 1.9E-02 | 1.1E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 27| +2.12E+02 | -8.1E-04 | +8.5E-01 | 9.3E-04 | 5.8E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 2| +2.71E+02 | -3.6E+01 | +9.2E-01 | 2.5E-01 | 6.0E+01 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 27| +1.52E+02 | -9.8E-02 | +1.1E+00 | 1.2E-01 | 8.2E+00 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 86| +1.48E+02 | +2.9E-06 | -1.0E+01 | 2.8E-05 | 4.7E-02 | 1.2E-05 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 31| +1.46E+02 | -5.6E-02 | +3.6E-01 | 3.8E-02 | 1.1E+01 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 18| +2.50E+02 | -1.0E-09 | +6.2E-04 | 1.2E-04 | 1.6E-02 | 2.7E-04 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 43| +1.48E+02 | +1.3E-01 | -1.6E+00 | 1.4E-01 | 3.0E+00 | 7.4E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 28| +2.12E+02 | -2.7E-04 | +4.4E-01 | 1.9E-03 | 2.7E-01 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 3| +2.71E+02 | +5.8E+01 | -2.0E+00 | 5.0E-01 | 4.4E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 32| +1.46E+02 | -1.2E-01 | +9.1E-01 | 3.8E-02 | 6.3E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 87| +1.48E+02 | +1.3E-06 | -4.8E+00 | 7.1E-06 | 4.7E-02 | 1.2E-05 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 44| +1.48E+02 | -1.2E-02 | +4.6E-01 | 3.5E-02 | 3.0E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 29| +2.12E+02 | -1.9E-04 | +3.6E-01 | 1.9E-03 | 2.5E-01 | 5.3E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 19| +2.50E+02 | -7.5E-07 | +7.5E-01 | 3.1E-05 | 1.6E-02 | 7.7E-05 | 2d |1\n", + "2023-02-17 16:05:38 fides(WARNING) Stopping as function difference 7.52E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:38 fides(INFO) 28| +1.52E+02 | -1.7E-01 | +7.3E-01 | 2.5E-01 | 1.4E+01 | 5.4E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 4| +2.59E+02 | -1.2E+01 | +9.0E-01 | 1.2E-01 | 4.4E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 33| +1.46E+02 | -5.1E-02 | +5.2E-01 | 7.6E-02 | 1.3E+01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 88| +1.48E+02 | +5.7E-07 | -4.4E+00 | 1.8E-06 | 4.7E-02 | 3.2E-06 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 30| +2.12E+02 | -1.9E-04 | +4.0E-01 | 1.9E-03 | 2.5E-01 | 4.9E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 45| +1.48E+02 | -6.6E-03 | +4.9E-01 | 3.5E-02 | 2.9E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 34| +1.46E+02 | -2.7E-02 | +2.1E-01 | 7.6E-02 | 3.9E+00 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 31| +2.12E+02 | -1.6E-04 | +4.1E-01 | 1.9E-03 | 2.1E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 35| +1.46E+02 | -3.7E-02 | +5.5E-01 | 1.9E-02 | 4.7E+00 | 2.8E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 5| +2.56E+02 | -3.2E+00 | +7.9E-02 | 2.5E-01 | 3.2E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 89| +1.48E+02 | -1.2E-06 | +3.2E+01 | 4.4E-07 | 4.7E-02 | 8.1E-07 | 2d |1\n", + "2023-02-17 16:05:38 fides(WARNING) Stopping as function difference 1.15E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:38 fides(INFO) 29| +1.52E+02 | -1.9E-01 | +9.5E-01 | 2.5E-01 | 1.7E+01 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 46| +1.48E+02 | -4.5E-03 | +3.6E-01 | 3.5E-02 | 1.4E+00 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 32| +2.12E+02 | -1.6E-04 | +4.5E-01 | 1.9E-03 | 2.0E-01 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 36| +1.46E+02 | -2.1E-02 | +9.8E-01 | 1.9E-02 | 1.1E+01 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 6| +2.51E+02 | -4.8E+00 | +8.2E-01 | 6.2E-02 | 6.2E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 37| +1.46E+02 | -1.9E-02 | +1.0E+00 | 3.8E-02 | 3.3E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 33| +2.12E+02 | -1.5E-04 | +4.8E-01 | 1.9E-03 | 1.8E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 47| +1.48E+02 | -6.2E-03 | +4.0E-01 | 3.5E-02 | 4.7E+00 | 3.8E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 38| +1.46E+02 | -3.3E-02 | +9.9E-01 | 7.6E-02 | 4.0E+00 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 7| +2.50E+02 | -6.8E-01 | +4.1E-01 | 1.2E-01 | 2.0E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 34| +2.12E+02 | -1.5E-04 | +5.2E-01 | 1.9E-03 | 1.7E-01 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 30| +1.52E+02 | -1.1E-01 | +5.6E-01 | 5.0E-01 | 1.5E+01 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 48| +1.48E+02 | +2.8E-03 | -2.5E-01 | 3.5E-02 | 1.2E+00 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 39| +1.46E+02 | -4.2E-02 | +9.3E-01 | 1.5E-01 | 3.9E+00 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 35| +2.12E+02 | -1.5E-04 | +5.4E-01 | 1.9E-03 | 1.5E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 8| +2.50E+02 | +2.2E-01 | -4.2E-01 | 1.2E-01 | 8.6E+00 | 3.1E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 49| +1.48E+02 | -1.2E-03 | +2.1E-01 | 8.8E-03 | 1.2E+00 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 40| +1.46E+02 | +2.2E+00 | -2.2E+01 | 3.0E-01 | 2.3E+00 | 2.6E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 36| +2.12E+02 | -1.5E-04 | +5.7E-01 | 1.9E-03 | 1.5E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 9| +2.50E+02 | -2.2E-01 | +4.6E-01 | 3.1E-02 | 8.6E+00 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 41| +1.46E+02 | +5.6E-02 | -1.3E+00 | 7.6E-02 | 2.3E+00 | 6.4E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 31| +1.51E+02 | -1.5E-01 | +1.1E+00 | 5.0E-01 | 1.3E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 50| +1.48E+02 | -2.8E-03 | +9.5E-01 | 2.2E-03 | 4.8E+00 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 37| +2.12E+02 | -1.5E-04 | +5.9E-01 | 1.9E-03 | 1.4E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 42| +1.46E+02 | -6.3E-03 | +5.0E-01 | 1.9E-02 | 2.3E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 10| +2.50E+02 | -1.0E-02 | +1.3E-01 | 3.1E-02 | 3.8E+00 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 38| +2.12E+02 | -1.5E-04 | +6.1E-01 | 1.9E-03 | 1.4E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 51| +1.48E+02 | -6.1E-04 | +9.1E-01 | 4.4E-03 | 4.3E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 43| +1.46E+02 | -4.6E-03 | +7.4E-01 | 1.9E-02 | 2.4E+00 | 8.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 32| +1.51E+02 | -2.2E-01 | +1.5E+00 | 1.0E+00 | 1.2E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 39| +2.12E+02 | -1.5E-04 | +6.1E-01 | 1.9E-03 | 1.3E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 11| +2.50E+02 | -2.9E-02 | +6.5E-01 | 7.8E-03 | 3.1E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 44| +1.46E+02 | -4.1E-03 | +8.6E-01 | 1.9E-02 | 2.6E+00 | 8.9E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 52| +1.48E+02 | -8.0E-04 | +9.0E-01 | 8.8E-03 | 7.9E-01 | 6.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 40| +2.12E+02 | -1.5E-04 | +6.3E-01 | 1.9E-03 | 1.3E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 45| +1.46E+02 | -6.0E-03 | +7.8E-01 | 3.8E-02 | 1.7E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 33| +1.51E+02 | -4.8E-01 | +1.7E+00 | 2.0E+00 | 7.4E+00 | 8.4E-01 | trr |1\n", + "2023-02-17 16:05:38 fides(INFO) 53| +1.48E+02 | -1.2E-03 | +9.6E-01 | 1.8E-02 | 3.0E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 12| +2.50E+02 | -1.2E-04 | +4.4E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 46| +1.46E+02 | +2.2E-02 | -1.2E+00 | 7.6E-02 | 3.3E+00 | 4.7E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 41| +2.12E+02 | -1.5E-04 | +6.2E-01 | 1.9E-03 | 1.3E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 54| +1.48E+02 | -1.8E-03 | +9.4E-01 | 3.5E-02 | 7.2E-01 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 34| +1.51E+02 | +3.7E+00 | -3.8E+00 | 2.0E+00 | 2.9E+01 | 6.4E-01 | trr |0\n", + "2023-02-17 16:05:38 fides(INFO) 47| +1.46E+02 | -3.5E-03 | +5.8E-01 | 1.9E-02 | 3.3E+00 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 42| +2.12E+02 | -1.5E-04 | +6.4E-01 | 1.9E-03 | 1.3E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 13| +2.50E+02 | -1.2E-04 | +4.5E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 48| +1.46E+02 | -3.5E-03 | +5.0E-01 | 1.9E-02 | 1.2E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 43| +2.12E+02 | -1.5E-04 | +6.3E-01 | 1.9E-03 | 1.3E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 55| +1.48E+02 | -2.2E-03 | +8.2E-01 | 7.1E-02 | 3.4E-01 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 35| +1.50E+02 | -4.4E-01 | +1.0E+00 | 1.6E-01 | 2.9E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 14| +2.50E+02 | -1.3E-04 | +4.7E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 49| +1.46E+02 | -3.8E-03 | +4.4E-01 | 1.9E-02 | 4.2E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 44| +2.12E+02 | -1.6E-04 | +6.4E-01 | 1.9E-03 | 1.3E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 56| +1.48E+02 | +2.8E-02 | -4.9E+00 | 1.4E-01 | 5.2E-01 | 1.1E-01 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 50| +1.46E+02 | -4.1E-04 | +9.3E-02 | 1.9E-02 | 1.2E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 36| +1.50E+02 | -5.2E-01 | +8.3E-01 | 3.2E-01 | 9.2E+00 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 15| +2.50E+02 | -1.3E-04 | +4.8E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 45| +2.12E+02 | -1.5E-04 | +6.3E-01 | 1.9E-03 | 1.3E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 57| +1.48E+02 | +1.2E-04 | -6.6E-02 | 3.5E-02 | 5.2E-01 | 2.8E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 51| +1.46E+02 | -1.5E-03 | +7.5E-01 | 4.7E-03 | 9.2E-01 | 4.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 46| +2.12E+02 | -1.6E-04 | +6.4E-01 | 1.9E-03 | 1.3E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 16| +2.50E+02 | -1.4E-04 | +5.0E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 37| +1.50E+02 | -1.0E-02 | +1.2E-02 | 6.3E-01 | 1.0E+01 | 2.8E-01 | trr |1\n", + "2023-02-17 16:05:38 fides(INFO) 52| +1.46E+02 | -1.0E-03 | +7.5E-01 | 9.4E-03 | 1.5E+00 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 58| +1.48E+02 | -4.1E-04 | +7.3E-01 | 8.8E-03 | 5.2E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 47| +2.12E+02 | -1.6E-04 | +6.3E-01 | 1.9E-03 | 1.3E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 17| +2.50E+02 | -1.4E-04 | +5.0E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 53| +1.46E+02 | -2.0E-03 | +9.4E-01 | 9.4E-03 | 6.3E-01 | 6.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 38| +1.50E+02 | -5.3E-02 | +2.7E-01 | 1.1E-01 | 7.8E+00 | 1.6E-01 | trr |1\n", + "2023-02-17 16:05:38 fides(INFO) 48| +2.12E+02 | -1.6E-04 | +6.4E-01 | 1.9E-03 | 1.3E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 59| +1.48E+02 | -1.9E-04 | +9.8E-01 | 8.8E-03 | 1.8E-01 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 54| +1.46E+02 | -1.3E-03 | +7.1E-01 | 1.9E-02 | 2.8E+00 | 7.0E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 18| +2.50E+02 | -1.5E-04 | +5.2E-01 | 7.8E-03 | 1.6E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 49| +2.12E+02 | -2.3E-04 | +1.0E+00 | 1.9E-03 | 1.3E-01 | 5.5E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 39| +1.50E+02 | -3.6E-02 | +6.0E-01 | 1.1E-01 | 4.2E+00 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 60| +1.48E+02 | -2.9E-04 | +9.6E-01 | 1.8E-02 | 1.4E-01 | 8.0E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 55| +1.46E+02 | +2.2E-05 | -1.7E-02 | 1.9E-02 | 4.3E-01 | 7.8E-03 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 19| +2.50E+02 | -1.5E-04 | +5.3E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 50| +2.12E+02 | -2.9E-04 | +6.7E-01 | 3.7E-03 | 4.4E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 56| +1.46E+02 | -3.5E-04 | +7.1E-01 | 4.7E-03 | 4.3E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 61| +1.48E+02 | -4.4E-04 | +9.7E-01 | 3.5E-02 | 2.2E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 40| +1.50E+02 | -8.0E-03 | +4.8E-01 | 1.1E-01 | 7.4E+00 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 20| +2.50E+02 | -1.6E-04 | +5.5E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 51| +2.12E+02 | -3.5E-04 | +1.0E+00 | 3.7E-03 | 2.5E-01 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 57| +1.46E+02 | -2.4E-04 | +9.8E-01 | 4.7E-03 | 9.6E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 62| +1.48E+02 | -2.8E-04 | +5.6E-01 | 7.1E-02 | 9.4E-02 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 41| +1.50E+02 | +1.7E-03 | -4.2E-01 | 1.1E-01 | 1.9E+00 | 4.2E-02 | trr |0\n", + "2023-02-17 16:05:38 fides(INFO) 58| +1.46E+02 | -3.1E-04 | +1.0E+00 | 9.4E-03 | 3.4E-01 | 2.2E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 52| +2.12E+02 | -4.9E-04 | +9.4E-01 | 7.4E-03 | 9.2E-02 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 21| +2.50E+02 | -1.7E-04 | +5.6E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 63| +1.48E+02 | +1.4E-02 | -6.8E+00 | 7.1E-02 | 2.9E-01 | 3.9E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 59| +1.46E+02 | -5.5E-04 | +9.8E-01 | 1.9E-02 | 4.5E-01 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 53| +2.12E+02 | -6.4E-04 | +8.5E-01 | 1.5E-02 | 1.0E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 42| +1.50E+02 | -1.5E-03 | +7.5E-01 | 2.0E-02 | 1.9E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 22| +2.50E+02 | -1.7E-04 | +5.7E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 54| +2.12E+02 | -2.3E-03 | +5.8E-01 | 3.0E-02 | 1.8E-01 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:38 fides(INFO) 60| +1.46E+02 | -8.3E-04 | +9.0E-01 | 3.8E-02 | 3.7E-01 | 8.0E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 64| +1.48E+02 | +3.5E-04 | -4.5E-01 | 1.8E-02 | 2.9E-01 | 9.8E-03 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 43| +1.50E+02 | -1.8E-04 | +9.0E-01 | 2.0E-02 | 5.2E-01 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 61| +1.46E+02 | +1.1E-02 | -4.2E+00 | 7.6E-02 | 2.4E-01 | 2.8E-02 | 2d |0\n", + "2023-02-17 16:05:38 fides(INFO) 23| +2.50E+02 | -1.8E-04 | +5.8E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 55| +2.12E+02 | -5.7E-03 | +1.2E+00 | 3.0E-02 | 7.0E-01 | 8.5E-02 | 2d |1\n", + "2023-02-17 16:05:38 fides(INFO) 65| +1.48E+02 | -1.4E-04 | +5.8E-01 | 4.4E-03 | 2.9E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 62| +1.46E+02 | +6.0E-05 | -8.3E-02 | 1.9E-02 | 2.4E-01 | 7.1E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 44| +1.50E+02 | -4.4E-05 | +6.5E-01 | 4.0E-02 | 1.8E-01 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 56| +2.12E+02 | -6.3E-03 | +5.1E-01 | 5.9E-02 | 4.3E-01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 24| +2.50E+02 | -1.9E-04 | +6.0E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 66| +1.48E+02 | -3.8E-05 | +9.7E-01 | 4.4E-03 | 4.8E-01 | 6.1E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 63| +1.46E+02 | -1.7E-04 | +7.3E-01 | 4.7E-03 | 2.4E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 57| +2.12E+02 | -2.1E-02 | +1.4E+00 | 5.9E-02 | 1.5E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 45| +1.50E+02 | -1.5E-06 | +1.0E-01 | 4.0E-02 | 1.9E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 64| +1.46E+02 | -1.0E-04 | +1.0E+00 | 4.7E-03 | 4.9E-01 | 9.3E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 25| +2.50E+02 | -1.9E-04 | +6.0E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 67| +1.48E+02 | -1.5E-05 | +7.8E-01 | 8.8E-03 | 5.7E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 58| +2.12E+02 | -5.7E-02 | +1.5E+00 | 1.2E-01 | 1.2E+00 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 65| +1.46E+02 | -2.8E-04 | +9.3E-01 | 9.4E-03 | 2.0E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 46| +1.50E+02 | +2.1E-06 | -1.1E-01 | 1.0E-02 | 3.4E-02 | 2.7E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 26| +2.50E+02 | -2.0E-04 | +6.2E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 59| +2.11E+02 | -3.5E-01 | +2.2E+00 | 2.4E-01 | 1.9E+00 | 6.8E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 68| +1.48E+02 | -1.8E-05 | +6.3E-01 | 1.8E-02 | 1.4E-01 | 4.3E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 66| +1.46E+02 | -2.4E-04 | +5.5E-01 | 1.9E-02 | 1.0E+00 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 47| +1.50E+02 | -6.1E-06 | +8.0E-01 | 2.5E-03 | 3.4E-02 | 6.8E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 67| +1.46E+02 | +9.1E-04 | -8.5E-01 | 1.9E-02 | 2.3E-01 | 8.1E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 60| +2.11E+02 | +2.7E+00 | -4.0E+00 | 4.7E-01 | 4.4E+00 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 27| +2.50E+02 | -2.1E-04 | +6.3E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 69| +1.48E+02 | +3.4E-05 | -7.1E-01 | 1.8E-02 | 6.2E-02 | 1.8E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 68| +1.46E+02 | -1.5E-04 | +5.2E-01 | 4.7E-03 | 2.3E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 61| +2.11E+02 | -4.6E-01 | +1.4E+00 | 1.2E-01 | 4.4E+00 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 48| +1.50E+02 | -1.9E-06 | +6.3E-01 | 5.0E-03 | 3.1E-02 | 6.8E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 70| +1.48E+02 | -8.7E-06 | +5.0E-01 | 4.4E-03 | 6.2E-02 | 5.5E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 28| +2.50E+02 | -2.2E-04 | +6.4E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 69| +1.46E+02 | -7.2E-05 | +9.6E-01 | 4.7E-03 | 4.5E-01 | 9.2E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 62| +2.10E+02 | -3.7E-01 | +2.5E-01 | 2.4E-01 | 5.1E+00 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 49| +1.50E+02 | -2.3E-07 | +8.0E-01 | 5.0E-03 | 2.7E-02 | 1.4E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(WARNING) Stopping as function difference 2.33E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:39 fides(INFO) 71| +1.48E+02 | -8.1E-06 | +7.6E-01 | 4.4E-03 | 2.0E-01 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 70| +1.46E+02 | -1.0E-04 | +9.9E-01 | 9.4E-03 | 1.3E-01 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 29| +2.50E+02 | -2.2E-04 | +6.5E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 63| +2.10E+02 | +3.0E-01 | -4.3E-01 | 5.9E-02 | 7.4E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 71| +1.46E+02 | -1.8E-04 | +9.6E-01 | 1.9E-02 | 2.0E-01 | 3.1E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 72| +1.48E+02 | -3.2E-06 | +6.3E-01 | 8.8E-03 | 2.7E-02 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 30| +2.50E+02 | -2.4E-04 | +6.6E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 64| +2.10E+02 | -1.6E-01 | +7.2E-01 | 1.5E-02 | 7.4E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 72| +1.46E+02 | -2.7E-05 | +2.0E-02 | 3.8E-02 | 1.3E-01 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 73| +1.48E+02 | -2.1E-06 | +5.3E-01 | 8.8E-03 | 2.9E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 31| +2.50E+02 | -2.4E-04 | +6.7E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 73| +1.46E+02 | +1.2E-03 | -7.7E-01 | 9.4E-03 | 2.3E-01 | 9.2E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 65| +2.10E+02 | -1.1E-01 | +9.5E-01 | 1.5E-02 | 4.7E+00 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 74| +1.48E+02 | -5.4E-06 | +1.8E+00 | 8.8E-03 | 2.0E-02 | 8.6E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 74| +1.46E+02 | -1.2E-04 | +2.3E-01 | 2.4E-03 | 2.3E-01 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 32| +2.50E+02 | -3.0E-04 | +9.6E-01 | 7.8E-03 | 1.5E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 66| +2.10E+02 | -1.7E-01 | +9.6E-01 | 3.0E-02 | 3.9E+00 | 6.2E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 75| +1.46E+02 | -9.9E-05 | +9.7E-01 | 5.9E-04 | 1.0E+00 | 2.3E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 75| +1.48E+02 | +2.5E-06 | -4.7E-01 | 1.8E-02 | 3.1E-02 | 2.6E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 67| +2.10E+02 | -1.4E-01 | +7.0E-01 | 5.9E-02 | 3.0E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 33| +2.50E+02 | +1.8E-04 | -2.4E-01 | 1.6E-02 | 9.8E-02 | 3.8E-02 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 76| +1.46E+02 | -3.6E-05 | +9.3E-01 | 1.2E-03 | 2.3E-01 | 3.4E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 68| +2.10E+02 | -1.8E-01 | +9.7E-01 | 5.9E-02 | 4.4E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 76| +1.48E+02 | +1.1E-07 | -6.7E-02 | 4.4E-03 | 3.1E-02 | 6.5E-04 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 77| +1.46E+02 | -2.4E-05 | +8.3E-01 | 2.4E-03 | 1.1E-01 | 4.7E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 34| +2.50E+02 | +8.1E-05 | -3.2E-01 | 3.9E-03 | 9.8E-02 | 9.6E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 69| +2.09E+02 | -2.6E-01 | +1.0E+00 | 1.2E-01 | 2.6E+00 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 78| +1.46E+02 | -3.8E-05 | +9.7E-01 | 4.7E-03 | 3.6E-01 | 6.5E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 77| +1.48E+02 | +2.3E-07 | -4.7E-01 | 1.1E-03 | 3.1E-02 | 1.6E-04 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 70| +2.09E+02 | +7.3E-01 | -2.3E+00 | 2.4E-01 | 2.2E+00 | 6.3E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 79| +1.46E+02 | -5.3E-05 | +9.6E-01 | 9.4E-03 | 8.1E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 35| +2.50E+02 | +5.2E-05 | -4.6E-01 | 9.8E-04 | 9.8E-02 | 2.4E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 78| +1.48E+02 | +2.2E-08 | -1.0E-01 | 2.8E-04 | 3.1E-02 | 4.2E-05 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 80| +1.46E+02 | -6.1E-05 | +5.4E-01 | 1.9E-02 | 1.3E-01 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 71| +2.09E+02 | -1.3E-01 | +1.1E+00 | 5.9E-02 | 2.2E+00 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 36| +2.50E+02 | -2.7E-05 | +5.8E-01 | 2.4E-04 | 9.8E-02 | 5.8E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 79| +1.48E+02 | +2.0E-06 | -1.4E+01 | 6.9E-05 | 3.1E-02 | 1.3E-05 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 81| +1.46E+02 | +1.2E-03 | -2.3E+00 | 1.9E-02 | 1.2E-01 | 7.4E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 72| +2.09E+02 | -4.1E-01 | +1.2E+00 | 1.2E-01 | 2.7E+00 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 37| +2.50E+02 | -9.9E-06 | +6.0E-01 | 2.4E-04 | 4.0E-02 | 5.6E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 82| +1.46E+02 | -3.1E-05 | +2.2E-01 | 4.7E-03 | 1.2E-01 | 1.9E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 80| +1.48E+02 | +4.8E-07 | -3.9E+00 | 1.7E-05 | 3.1E-02 | 8.0E-06 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 73| +2.08E+02 | -3.8E-01 | +3.3E-01 | 2.4E-01 | 3.5E+00 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 83| +1.46E+02 | -2.2E-05 | +7.7E-01 | 1.2E-03 | 1.9E-01 | 4.4E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 38| +2.50E+02 | -1.0E-05 | +1.0E+00 | 2.4E-04 | 3.1E-02 | 6.1E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 81| +1.48E+02 | +2.0E-06 | -1.7E+01 | 4.3E-06 | 3.1E-02 | 7.5E-06 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 74| +2.07E+02 | -1.3E+00 | +6.8E-01 | 2.4E-01 | 1.3E+01 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 84| +1.46E+02 | -1.6E-05 | +7.2E-01 | 2.4E-03 | 6.8E-02 | 5.4E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 39| +2.50E+02 | -2.2E-05 | +1.0E+00 | 4.9E-04 | 2.3E-02 | 1.3E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 82| +1.48E+02 | +2.0E-06 | -2.8E+01 | 1.1E-06 | 3.1E-02 | 2.8E-06 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 85| +1.46E+02 | -9.7E-06 | +9.4E-01 | 2.4E-03 | 6.8E-02 | 2.6E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 75| +2.03E+02 | -3.9E+00 | +1.3E+00 | 2.4E-01 | 1.7E+01 | 6.5E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 86| +1.46E+02 | -2.0E-05 | +1.1E+00 | 4.7E-03 | 9.1E-02 | 4.7E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 40| +2.50E+02 | -3.8E-05 | +1.0E+00 | 9.8E-04 | 2.9E-02 | 2.4E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 76| +2.03E+02 | +2.0E+01 | -3.6E+00 | 4.7E-01 | 1.8E+01 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 87| +1.46E+02 | -3.6E-05 | +9.9E-01 | 9.4E-03 | 5.7E-02 | 9.4E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 83| +1.48E+02 | +9.3E-08 | -4.5E+00 | 2.7E-07 | 3.1E-02 | 7.1E-07 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 77| +2.01E+02 | -2.5E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 41| +2.50E+02 | -8.7E-05 | +1.0E+00 | 2.0E-03 | 2.3E-02 | 5.2E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 88| +1.46E+02 | -5.8E-05 | +9.4E-01 | 1.9E-02 | 1.4E-01 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 84| +1.48E+02 | +2.8E-07 | -5.2E+01 | 6.7E-08 | 3.1E-02 | 1.8E-07 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 78| +2.01E+02 | +7.4E+00 | -9.2E-01 | 2.4E-01 | 1.9E+01 | 5.8E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 89| +1.46E+02 | +7.9E-04 | -5.4E+00 | 3.8E-02 | 5.1E-02 | 5.9E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 42| +2.50E+02 | -1.7E-04 | +1.0E+00 | 3.9E-03 | 3.9E-02 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 79| +1.99E+02 | -1.7E+00 | +7.2E-01 | 5.9E-02 | 1.9E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 90| +1.46E+02 | +1.4E-05 | -3.2E-01 | 9.4E-03 | 5.1E-02 | 1.5E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 85| +1.48E+02 | +1.5E-07 | -1.1E+02 | 1.7E-08 | 3.1E-02 | 4.5E-08 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 43| +2.50E+02 | -3.4E-04 | +1.0E+00 | 7.8E-03 | 3.1E-02 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 91| +1.46E+02 | -8.3E-06 | +6.2E-01 | 2.4E-03 | 5.1E-02 | 3.9E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 80| +1.98E+02 | -1.1E+00 | +8.2E-01 | 5.9E-02 | 1.4E+01 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 86| +1.48E+02 | +4.8E-07 | -1.4E+03 | 4.2E-09 | 3.1E-02 | 1.1E-08 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 92| +1.46E+02 | -8.6E-06 | +1.1E+00 | 2.4E-03 | 1.1E-01 | 2.4E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 44| +2.50E+02 | -7.2E-04 | +1.1E+00 | 1.6E-02 | 3.8E-02 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 81| +1.96E+02 | -1.8E+00 | +9.3E-01 | 1.2E-01 | 1.2E+01 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 93| +1.46E+02 | -1.1E-05 | +9.3E-01 | 4.7E-03 | 4.1E-02 | 3.5E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 87| +1.48E+02 | +6.8E-07 | -7.9E+03 | 1.1E-09 | 3.1E-02 | 2.8E-09 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 45| +2.50E+02 | -1.6E-03 | +1.1E+00 | 3.1E-02 | 6.3E-02 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 82| +1.93E+02 | -3.0E+00 | +7.0E-01 | 2.4E-01 | 1.6E+01 | 5.8E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 94| +1.46E+02 | -2.0E-05 | +8.7E-01 | 9.4E-03 | 5.5E-02 | 7.7E-04 | 2d |1\n", + "2023-02-17 16:05:39.482 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0965 and h = 4.6875e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:39.482 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0965: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:39 fides(INFO) 88| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.6E-10 | 3.1E-02 | 7.0E-10 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 46| +2.50E+02 | -4.3E-03 | +1.2E+00 | 6.2E-02 | 1.2E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 95| +1.46E+02 | +7.0E-05 | -1.4E+00 | 1.9E-02 | 4.4E-02 | 2.3E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 83| +1.84E+02 | -9.3E+00 | +1.9E+00 | 2.4E-01 | 2.0E+01 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 89| +1.48E+02 | +2.6E-07 | -4.8E+04 | 6.6E-11 | 3.1E-02 | 1.7E-10 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 96| +1.46E+02 | -8.8E-06 | +5.4E-01 | 4.7E-03 | 4.4E-02 | 5.7E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 47| +2.50E+02 | -1.5E-02 | +1.5E+00 | 1.2E-01 | 2.4E-01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 84| +1.84E+02 | +8.0E+01 | -4.0E+00 | 4.7E-01 | 3.5E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 97| +1.46E+02 | -4.7E-07 | +5.4E-03 | 4.7E-03 | 5.9E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 90| +1.48E+02 | +3.6E-07 | -2.7E+05 | 1.6E-11 | 3.1E-02 | 4.3E-11 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 48| +2.50E+02 | -9.1E-02 | +2.2E+00 | 2.5E-01 | 4.8E-01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 98| +1.46E+02 | -1.4E-05 | +6.8E-01 | 1.2E-03 | 6.9E-02 | 4.8E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 85| +1.76E+02 | -8.3E+00 | +1.1E+00 | 1.2E-01 | 3.5E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 91| +1.48E+02 | +1.2E-07 | -3.7E+05 | 4.1E-12 | 3.1E-02 | 1.1E-11 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 99| +1.46E+02 | -4.0E-06 | +1.1E+00 | 1.2E-03 | 8.8E-02 | 1.2E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 49| +2.48E+02 | -1.5E+00 | +4.2E+00 | 5.0E-01 | 1.1E+00 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 86| +1.76E+02 | +8.7E+00 | -8.3E-01 | 2.4E-01 | 5.1E+01 | 5.6E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 100| +1.46E+02 | -4.3E-06 | +9.3E-01 | 2.4E-03 | 3.5E-02 | 1.5E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 92| +1.48E+02 | +4.8E-07 | -5.7E+06 | 1.0E-12 | 3.1E-02 | 2.7E-12 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 50| +2.26E+02 | -2.2E+01 | +3.4E+00 | 1.0E+00 | 7.4E+00 | 2.2E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 101| +1.46E+02 | -8.4E-06 | +9.5E-01 | 4.7E-03 | 4.6E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 93| +1.48E+02 | +4.5E-08 | -2.2E+06 | 2.6E-13 | 3.1E-02 | 6.8E-13 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 87| +1.71E+02 | -4.7E+00 | +1.1E+00 | 5.9E-02 | 5.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 51| +2.26E+02 | +1.6E+02 | -5.5E+00 | 2.0E+00 | 5.0E+01 | 3.9E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 102| +1.46E+02 | -1.2E-05 | +6.8E-01 | 9.4E-03 | 3.4E-02 | 6.1E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 94| +1.48E+02 | +1.9E-08 | -3.6E+06 | 6.4E-14 | 3.1E-02 | 1.7E-13 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 52| +2.12E+02 | -1.4E+01 | +3.7E-01 | 5.0E-01 | 5.0E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 103| +1.46E+02 | +1.1E-04 | -1.9E+00 | 9.4E-03 | 4.5E-02 | 2.5E-03 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 88| +1.62E+02 | -9.0E+00 | +9.6E-01 | 1.2E-01 | 4.4E+01 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 104| +1.46E+02 | -5.5E-06 | +3.6E-01 | 2.4E-03 | 4.5E-02 | 6.2E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 53| +2.12E+02 | +3.3E+02 | -5.8E+00 | 5.0E-01 | 1.3E+02 | 1.3E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 95| +1.48E+02 | -4.2E-08 | +3.2E+07 | 1.6E-14 | 3.1E-02 | 4.2E-14 | 2d |1\n", + "2023-02-17 16:05:39 fides(WARNING) Stopping as function difference 4.16E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:39 fides(INFO) 89| +1.62E+02 | +1.3E+01 | -1.2E+00 | 2.4E-01 | 4.3E+01 | 4.5E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 105| +1.46E+02 | -3.5E-06 | +3.0E-01 | 2.4E-03 | 5.0E-02 | 4.8E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 54| +1.96E+02 | -1.6E+01 | +5.0E-01 | 1.2E-01 | 1.3E+02 | 3.4E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 90| +1.59E+02 | -3.0E+00 | +7.8E-01 | 5.9E-02 | 4.3E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 55| +1.90E+02 | -5.4E+00 | +4.8E-01 | 1.2E-01 | 5.5E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 106| +1.46E+02 | -4.1E-06 | +4.4E-01 | 2.4E-03 | 4.3E-02 | 4.6E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 107| +1.46E+02 | -2.7E-06 | +3.3E-01 | 2.4E-03 | 3.9E-02 | 3.9E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 56| +1.82E+02 | -8.4E+00 | +9.9E-01 | 1.2E-01 | 3.0E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 91| +1.57E+02 | -1.8E+00 | +3.5E-01 | 1.2E-01 | 4.6E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 108| +1.46E+02 | -3.9E-06 | +5.0E-01 | 2.4E-03 | 4.3E-02 | 4.2E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 57| +1.71E+02 | -1.1E+01 | +7.8E-01 | 2.5E-01 | 2.8E+01 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 92| +1.56E+02 | -1.4E+00 | +2.7E-01 | 1.2E-01 | 1.0E+02 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 109| +1.46E+02 | -2.0E-06 | +2.5E-01 | 2.4E-03 | 3.7E-02 | 4.0E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 0| +7.05E+09 | NaN | NaN | 1.0E+00 | 3.2E+10 | NaN | NaN |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 110| +1.46E+02 | -2.5E-06 | +2.8E-01 | 2.4E-03 | 4.4E-02 | 4.7E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 58| +1.71E+02 | +7.6E+02 | -4.2E+01 | 5.0E-01 | 8.6E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 93| +1.54E+02 | -2.0E+00 | +3.0E-01 | 1.2E-01 | 1.1E+02 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 1| +1.37E+04 | -7.0E+09 | +9.2E-02 | 1.0E+00 | 3.2E+10 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 111| +1.46E+02 | -4.3E-06 | +4.3E-01 | 2.4E-03 | 3.9E-02 | 5.1E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 59| +1.70E+02 | -1.3E+00 | +1.0E-01 | 1.2E-01 | 8.6E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:39.776 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 38.3134 and h = 1.45372e-06, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:39.776 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 38.3134: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:39 fides(INFO) 94| +1.54E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 2.4E+01 | 2.1E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 2| +2.35E+03 | -1.1E+04 | +9.0E-01 | 2.5E-01 | 6.2E+04 | 6.3E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 112| +1.46E+02 | +8.4E-07 | -7.0E-02 | 2.4E-03 | 4.8E-02 | 6.5E-04 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 3| +5.66E+02 | -1.8E+03 | +9.0E-01 | 5.0E-01 | 9.8E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 60| +1.64E+02 | -5.7E+00 | +8.9E-01 | 3.1E-02 | 1.2E+02 | 8.4E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 113| +1.46E+02 | -1.6E-06 | +4.4E-01 | 5.9E-04 | 4.8E-02 | 1.7E-04 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 95| +1.53E+02 | -8.4E-01 | +9.9E-01 | 3.0E-02 | 2.4E+01 | 5.6E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 114| +1.46E+02 | -1.3E-06 | +1.1E+00 | 5.9E-04 | 3.3E-02 | 7.7E-05 | 2d |1\n", + "2023-02-17 16:05:39 fides(WARNING) Stopping as function difference 1.28E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:39 fides(INFO) 4| +2.86E+02 | -2.8E+02 | +8.9E-01 | 1.0E+00 | 1.5E+03 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 61| +1.60E+02 | -3.8E+00 | +7.7E-01 | 6.2E-02 | 4.6E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 96| +1.52E+02 | -6.3E-01 | +5.6E-01 | 5.9E-02 | 1.5E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 5| +2.41E+02 | -4.5E+01 | +9.6E-01 | 2.0E+00 | 2.3E+02 | 4.4E+00 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 62| +1.58E+02 | -2.2E+00 | +2.6E-01 | 1.2E-01 | 4.2E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 97| +1.51E+02 | -9.1E-01 | +8.4E-01 | 5.9E-02 | 5.1E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 6| +2.41E+02 | +7.7E+02 | -3.0E+01 | 4.0E+00 | 3.5E+01 | 1.1E+01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 98| +1.50E+02 | -1.3E+00 | +1.1E+00 | 1.2E-01 | 2.0E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 63| +1.53E+02 | -5.3E+00 | +6.5E-01 | 1.2E-01 | 5.5E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 7| +2.41E+02 | +6.3E+01 | -5.5E+00 | 1.0E+00 | 3.5E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 99| +1.50E+02 | +8.1E-01 | -4.9E-01 | 2.4E-01 | 1.4E+01 | 4.2E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 64| +1.53E+02 | +3.7E+00 | -5.1E-01 | 1.2E-01 | 9.3E+01 | 2.4E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 8| +2.41E+02 | +5.7E+00 | -5.6E-01 | 2.5E-01 | 3.5E+01 | 6.4E-01 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 100| +1.49E+02 | -7.2E-01 | +8.7E-01 | 5.9E-02 | 1.4E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 65| +1.51E+02 | -1.9E+00 | +5.6E-01 | 3.1E-02 | 9.3E+01 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 9| +2.36E+02 | -4.3E+00 | +8.8E-01 | 6.2E-02 | 3.5E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 101| +1.48E+02 | -6.8E-01 | +6.4E-01 | 1.2E-01 | 7.6E+00 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 66| +1.50E+02 | -1.4E+00 | +8.9E-01 | 3.1E-02 | 4.7E+01 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 10| +2.36E+02 | -3.2E-01 | +5.3E-02 | 1.2E-01 | 2.0E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 102| +1.48E+02 | -3.2E-01 | +4.4E-01 | 1.2E-01 | 1.7E+01 | 1.9E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 67| +1.49E+02 | -1.6E-01 | +4.7E-02 | 6.2E-02 | 2.6E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 11| +2.35E+02 | -1.4E+00 | +8.9E-01 | 3.1E-02 | 3.3E+01 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 103| +1.48E+02 | -3.9E-01 | +5.5E-01 | 1.2E-01 | 4.8E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 68| +1.48E+02 | -1.2E+00 | +6.0E-01 | 1.6E-02 | 1.1E+02 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 12| +2.34E+02 | -1.2E+00 | +7.6E-01 | 6.2E-02 | 2.0E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 104| +1.48E+02 | -4.4E-02 | +1.7E-01 | 1.2E-01 | 2.2E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 69| +1.48E+02 | -2.4E-01 | +8.0E-01 | 1.6E-02 | 3.8E+01 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 13| +2.32E+02 | -1.4E+00 | +8.9E-01 | 1.2E-01 | 1.1E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) 105| +1.48E+02 | -1.1E-01 | +8.6E-01 | 2.2E-02 | 7.1E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:39 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:39 fides(INFO) 70| +1.48E+02 | +1.1E-01 | -6.8E-01 | 3.1E-02 | 8.6E+00 | 5.5E-02 | 2d |0\n", + "2023-02-17 16:05:39 fides(INFO) 14| +2.29E+02 | -3.4E+00 | +9.5E-01 | 2.5E-01 | 1.9E+01 | 6.0E-01 | 2d |1\n", + "2023-02-17 16:05:39.998 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.601 and h = 3.69658e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:39.998 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.601: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:39 fides(INFO) 106| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.4E-02 | 6.3E+00 | 3.7E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 71| +1.48E+02 | -4.8E-02 | +7.4E-01 | 7.8E-03 | 8.6E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 15| +2.18E+02 | -1.1E+01 | +1.1E+00 | 5.0E-01 | 1.8E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 107| +1.48E+02 | -1.5E-02 | +7.3E-01 | 3.8E-03 | 6.3E+00 | 9.2E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 72| +1.48E+02 | -6.0E-02 | +7.5E-01 | 7.8E-03 | 1.6E+01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 16| +2.02E+02 | -1.6E+01 | +4.2E-01 | 1.0E+00 | 4.2E+01 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 108| +1.48E+02 | -5.3E-03 | +1.1E+00 | 3.8E-03 | 3.7E+00 | 5.3E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 17| +2.02E+02 | +7.0E+02 | -2.2E+01 | 1.0E+00 | 9.6E+01 | 1.7E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 73| +1.48E+02 | +1.9E-02 | -2.4E-01 | 1.6E-02 | 9.7E+00 | 2.3E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 109| +1.48E+02 | -7.6E-03 | +1.1E+00 | 7.5E-03 | 1.4E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 18| +1.84E+02 | -1.8E+01 | +8.6E-01 | 2.5E-01 | 9.6E+01 | 4.3E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 74| +1.48E+02 | -2.1E-02 | +6.2E-01 | 3.9E-03 | 9.7E+00 | 6.8E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 110| +1.48E+02 | -1.0E-02 | +1.0E+00 | 1.5E-02 | 1.8E+00 | 2.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 19| +1.78E+02 | -6.2E+00 | +6.2E-01 | 5.0E-01 | 4.1E+01 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 75| +1.48E+02 | -2.8E-02 | +7.6E-01 | 3.9E-03 | 1.0E+01 | 7.8E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 111| +1.48E+02 | -1.2E-02 | +1.0E+00 | 3.0E-02 | 8.1E-01 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 20| +1.67E+02 | -1.1E+01 | +1.4E+00 | 5.0E-01 | 7.6E+01 | 7.7E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 112| +1.48E+02 | -1.4E-02 | +1.2E+00 | 6.0E-02 | 5.6E-01 | 8.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 76| +1.48E+02 | +6.3E-03 | -1.5E-01 | 7.8E-03 | 6.7E+00 | 2.0E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 21| +1.67E+02 | +8.1E+02 | -3.3E+01 | 1.0E+00 | 9.4E+01 | 1.9E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 113| +1.48E+02 | -4.5E-03 | +1.1E+00 | 1.2E-01 | 3.0E-01 | 7.5E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 77| +1.48E+02 | -1.5E-02 | +8.1E-01 | 2.0E-03 | 6.7E+00 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 22| +1.53E+02 | -1.4E+01 | +1.0E+00 | 2.5E-01 | 9.4E+01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 114| +1.48E+02 | -1.2E-03 | +7.5E-01 | 1.2E-01 | 5.1E-01 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 78| +1.48E+02 | -2.5E-02 | +8.2E-01 | 3.9E-03 | 7.3E+00 | 9.0E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 23| +1.53E+02 | +1.1E+02 | -1.2E+01 | 5.0E-01 | 5.0E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 115| +1.48E+02 | -1.6E-04 | +1.0E+00 | 1.2E-01 | 4.1E-01 | 3.7E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 24| +1.49E+02 | -3.9E+00 | +8.2E-01 | 1.2E-01 | 5.0E+01 | 3.0E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 79| +1.48E+02 | -8.8E-03 | +3.4E-01 | 7.8E-03 | 6.3E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 116| +1.48E+02 | -7.5E-06 | +9.8E-01 | 1.2E-01 | 4.2E-02 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 25| +1.48E+02 | -7.0E-01 | +5.6E-01 | 2.5E-01 | 2.7E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 80| +1.48E+02 | -3.2E-02 | +9.0E-01 | 7.8E-03 | 7.2E+00 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 117| +1.48E+02 | +4.5E-06 | -3.1E+00 | 1.2E-01 | 3.5E-02 | 8.3E-04 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 26| +1.48E+02 | -4.2E-01 | +9.4E-01 | 2.5E-01 | 3.2E+01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 81| +1.48E+02 | +3.6E-01 | -5.1E+00 | 1.6E-02 | 4.2E+00 | 4.1E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 118| +1.48E+02 | -3.8E-07 | +4.2E-01 | 1.6E-04 | 3.5E-02 | 2.1E-04 | 2d |1\n", + "2023-02-17 16:05:40 fides(WARNING) Stopping as function difference 3.76E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:40.211 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.5253 and h = 1.64262e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:40.211 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.5253: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:40 fides(INFO) 27| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 2.0E+01 | 3.6E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 82| +1.48E+02 | +1.8E-02 | -7.8E-01 | 3.9E-03 | 4.2E+00 | 1.0E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 28| +1.48E+02 | -1.4E-01 | +9.6E-01 | 1.2E-01 | 2.0E+01 | 9.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 29| +1.48E+02 | -1.0E-01 | +7.2E-01 | 2.5E-01 | 1.5E+01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 83| +1.48E+02 | -4.3E-03 | +5.1E-01 | 9.8E-04 | 4.2E+00 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 30| +1.48E+02 | +3.2E-01 | -1.5E+00 | 2.5E-01 | 1.3E+01 | 2.8E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 84| +1.48E+02 | -5.8E-03 | +9.7E-01 | 9.8E-04 | 5.3E+00 | 2.0E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 0| +1.71E+03 | NaN | NaN | 1.0E+00 | 6.0E+03 | NaN | NaN |1\n", + "2023-02-17 16:05:40 fides(INFO) 31| +1.48E+02 | -4.1E-02 | +5.4E-01 | 6.2E-02 | 1.3E+01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 85| +1.48E+02 | -7.2E-03 | +9.3E-01 | 2.0E-03 | 3.0E+00 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 1| +4.70E+02 | -1.2E+03 | +1.3E-01 | 1.0E+00 | 6.0E+03 | 2.1E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 32| +1.48E+02 | -2.5E-02 | +7.6E-01 | 6.2E-02 | 8.2E+00 | 5.3E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 2| +4.23E+02 | -4.7E+01 | +1.0E+00 | 2.5E-01 | 6.4E+01 | 7.5E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 86| +1.48E+02 | -1.1E-02 | +7.6E-01 | 3.9E-03 | 5.2E+00 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 33| +1.48E+02 | -1.2E-02 | +3.5E-01 | 1.2E-01 | 9.1E+00 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 3| +3.42E+02 | -8.1E+01 | +9.0E-01 | 5.0E-01 | 6.3E+01 | 1.5E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 87| +1.48E+02 | -2.8E-03 | +1.2E-01 | 7.8E-03 | 2.9E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 34| +1.48E+02 | +4.8E-02 | -6.0E-01 | 1.2E-01 | 4.6E+00 | 1.4E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 4| +3.42E+02 | +3.9E+02 | -7.8E+00 | 1.0E+00 | 5.6E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 88| +1.48E+02 | -3.8E-03 | +6.2E-01 | 2.0E-03 | 3.2E+00 | 4.1E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 5| +3.06E+02 | -3.6E+01 | +9.8E-01 | 2.5E-01 | 5.6E+01 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 35| +1.48E+02 | -3.9E-03 | +6.5E-02 | 3.1E-02 | 4.6E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 89| +1.48E+02 | -3.4E-03 | +6.5E-01 | 2.0E-03 | 4.4E+00 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 6| +2.83E+02 | -2.3E+01 | +1.7E-01 | 5.0E-01 | 5.0E+01 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 36| +1.48E+02 | -1.4E-02 | +8.8E-01 | 7.8E-03 | 7.7E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 90| +1.48E+02 | -3.3E-03 | +8.6E-01 | 2.0E-03 | 2.5E+00 | 3.8E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 7| +2.58E+02 | -2.5E+01 | +8.3E-01 | 1.2E-01 | 1.9E+02 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 37| +1.48E+02 | -8.0E-03 | +7.2E-01 | 1.6E-02 | 2.9E+00 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 8| +2.53E+02 | -5.1E+00 | +3.2E-01 | 2.5E-01 | 5.0E+01 | 5.6E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 91| +1.48E+02 | -5.2E-03 | +8.1E-01 | 3.9E-03 | 1.5E+00 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 38| +1.48E+02 | -1.8E-03 | +8.9E-01 | 1.6E-02 | 3.0E+00 | 6.3E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 9| +2.52E+02 | -1.1E+00 | +1.5E-01 | 2.5E-01 | 3.5E+01 | 5.9E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 39| +1.48E+02 | -1.3E-03 | +8.1E-01 | 3.1E-02 | 7.1E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 92| +1.48E+02 | +5.4E-04 | -1.7E-01 | 7.8E-03 | 1.6E+00 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 10| +2.50E+02 | -2.2E+00 | +7.5E-01 | 6.2E-02 | 3.0E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 40| +1.48E+02 | -1.5E-03 | +9.1E-01 | 6.2E-02 | 1.7E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 93| +1.48E+02 | -3.9E-04 | +2.7E-01 | 2.0E-03 | 1.6E+00 | 4.5E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 11| +2.50E+02 | -1.9E-02 | +1.1E-01 | 6.2E-02 | 5.5E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 41| +1.48E+02 | -1.7E-04 | +8.4E-02 | 1.2E-01 | 3.6E-01 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 94| +1.48E+02 | -1.3E-03 | +7.0E-01 | 2.0E-03 | 2.6E+00 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 12| +2.50E+02 | -5.5E-02 | +4.8E-01 | 1.6E-02 | 4.8E+00 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 42| +1.48E+02 | -6.0E-04 | +1.4E-01 | 3.1E-02 | 7.5E-01 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 95| +1.48E+02 | -3.7E-04 | +8.8E-01 | 2.0E-03 | 6.0E-01 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 13| +2.50E+02 | -3.2E-03 | +1.2E-01 | 1.6E-02 | 2.1E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 43| +1.48E+02 | -7.6E-04 | +7.7E-01 | 7.8E-03 | 1.4E+00 | 4.8E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 14| +2.50E+02 | -9.8E-03 | +6.9E-01 | 3.9E-03 | 1.8E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 96| +1.48E+02 | -4.1E-04 | +9.8E-01 | 3.9E-03 | 4.8E-01 | 9.7E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 44| +1.48E+02 | -1.9E-04 | +5.7E-01 | 1.6E-02 | 4.1E-01 | 4.4E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 15| +2.50E+02 | -2.3E-04 | +7.7E-01 | 3.9E-03 | 1.1E-01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 97| +1.48E+02 | -5.5E-04 | +9.8E-01 | 7.8E-03 | 2.6E-01 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 45| +1.48E+02 | -6.1E-05 | +1.0E+00 | 1.6E-02 | 2.7E-01 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 16| +2.50E+02 | -4.6E-04 | +8.3E-01 | 7.8E-03 | 1.3E-01 | 1.9E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 98| +1.48E+02 | -9.2E-04 | +1.0E+00 | 1.6E-02 | 1.6E-01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 46| +1.48E+02 | -9.5E-05 | +9.5E-01 | 3.1E-02 | 1.7E-01 | 8.6E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 17| +2.50E+02 | -9.6E-04 | +9.0E-01 | 1.6E-02 | 1.5E-01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 99| +1.48E+02 | -1.7E-03 | +1.1E+00 | 3.1E-02 | 2.2E-01 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 47| +1.48E+02 | -1.0E-04 | +9.0E-01 | 6.2E-02 | 2.9E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 18| +2.50E+02 | -2.1E-03 | +9.7E-01 | 3.1E-02 | 1.7E-01 | 7.9E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 100| +1.48E+02 | -3.8E-03 | +1.1E+00 | 6.2E-02 | 4.1E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 48| +1.48E+02 | +4.3E-04 | -3.0E+00 | 1.2E-01 | 8.1E-02 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 19| +2.50E+02 | -4.9E-03 | +1.1E+00 | 6.2E-02 | 2.0E-01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 49| +1.48E+02 | -1.6E-05 | +3.0E-01 | 3.1E-02 | 8.1E-02 | 5.4E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 20| +2.50E+02 | -1.4E-02 | +1.2E+00 | 1.2E-01 | 2.2E-01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 101| +1.48E+02 | -1.0E-02 | +1.4E+00 | 1.2E-01 | 1.0E+00 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 21| +2.50E+02 | -5.3E-02 | +1.5E+00 | 2.5E-01 | 2.8E-01 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 50| +1.48E+02 | +4.5E-05 | -3.8E-01 | 3.1E-02 | 1.3E-01 | 9.3E-03 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 102| +1.48E+02 | -1.9E-02 | +7.9E-01 | 2.5E-01 | 1.3E+00 | 6.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 22| +2.49E+02 | -3.6E-01 | +2.3E+00 | 5.0E-01 | 3.6E-01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 51| +1.48E+02 | -2.0E-05 | +5.8E-01 | 7.8E-03 | 1.3E-01 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 23| +2.44E+02 | -4.8E+00 | +3.3E+00 | 1.0E+00 | 1.8E+00 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 103| +1.48E+02 | -1.3E-02 | +6.3E-01 | 5.0E-01 | 7.7E+00 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 52| +1.48E+02 | -8.4E-06 | +1.5E+00 | 7.8E-03 | 6.6E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 24| +2.20E+02 | -2.4E+01 | +1.9E+00 | 2.0E+00 | 1.3E+01 | 4.1E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 104| +1.48E+02 | -3.7E-03 | +3.5E-01 | 5.0E-01 | 2.2E+00 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 53| +1.48E+02 | -7.8E-06 | +7.2E-01 | 1.6E-02 | 4.5E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 54| +1.48E+02 | -8.2E-06 | +1.1E+00 | 1.6E-02 | 6.5E-02 | 2.7E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 25| +2.20E+02 | +4.5E+03 | -1.4E+02 | 4.0E+00 | 2.7E+01 | 7.7E+00 | trr |0\n", + "2023-02-17 16:05:40 fides(INFO) 105| +1.48E+02 | -4.6E-04 | +1.3E-02 | 5.0E-01 | 6.5E-01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 55| +1.48E+02 | -5.8E-06 | +5.9E-01 | 3.1E-02 | 2.3E-02 | 4.3E-03 | 2d |1\n", + "2023-02-17 16:05:40.669 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.415 and h = 1.50222e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:40.669 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.415: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:40 fides(INFO) 26| +2.20E+02 | +0.0E+00 | +0.0E+00 | 8.0E-01 | 2.7E+01 | 1.6E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 106| +1.48E+02 | -4.5E-03 | +8.4E-01 | 3.1E-02 | 1.5E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 56| +1.48E+02 | +1.5E-05 | -7.1E-01 | 3.1E-02 | 4.0E-02 | 5.5E-03 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 27| +2.17E+02 | -3.1E+00 | +3.3E-01 | 2.0E-01 | 2.7E+01 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 107| +1.48E+02 | -8.4E-04 | +1.1E+00 | 3.1E-02 | 8.0E-01 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 57| +1.48E+02 | -5.1E-06 | +8.4E-01 | 7.8E-03 | 4.0E-02 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 28| +2.07E+02 | -1.0E+01 | +9.2E-01 | 2.0E-01 | 5.8E+01 | 4.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 108| +1.48E+02 | -7.2E-05 | +1.5E+00 | 3.1E-02 | 1.7E-01 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 58| +1.48E+02 | +2.7E-06 | -1.2E+00 | 1.6E-02 | 2.1E-02 | 1.8E-03 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 29| +1.96E+02 | -1.1E+01 | +4.1E-01 | 4.0E-01 | 2.9E+01 | 8.7E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 59| +1.48E+02 | +7.2E-07 | -1.1E+00 | 3.9E-03 | 2.1E-02 | 4.5E-04 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 109| +1.48E+02 | -7.8E-05 | +1.2E+00 | 3.1E-02 | 8.2E-02 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 30| +1.66E+02 | -3.0E+01 | +9.6E-01 | 4.0E-01 | 1.4E+02 | 6.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 60| +1.48E+02 | +2.4E-06 | -1.2E+01 | 9.8E-04 | 2.1E-02 | 1.1E-04 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 110| +1.48E+02 | -1.7E-05 | +1.6E+00 | 3.1E-02 | 4.5E-02 | 8.0E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 31| +1.56E+02 | -9.8E+00 | +4.4E-01 | 8.0E-01 | 6.1E+01 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 61| +1.48E+02 | +8.6E-07 | -8.0E+00 | 2.4E-04 | 2.1E-02 | 3.0E-05 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 111| +1.48E+02 | -8.0E-05 | +1.6E+00 | 3.1E-02 | 4.4E-02 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 32| +1.51E+02 | -5.1E+00 | +5.1E-01 | 8.0E-01 | 2.4E+02 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 62| +1.48E+02 | +6.9E-08 | -8.7E-01 | 6.1E-05 | 2.1E-02 | 1.0E-05 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 112| +1.48E+02 | -8.8E-05 | +1.3E+00 | 3.1E-02 | 7.5E-02 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 33| +1.49E+02 | -2.2E+00 | +9.5E-01 | 8.0E-01 | 1.3E+02 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 63| +1.48E+02 | -1.0E-06 | +1.4E+01 | 1.5E-05 | 2.1E-02 | 7.1E-06 | 2d |1\n", + "2023-02-17 16:05:40 fides(WARNING) Stopping as function difference 9.98E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:40 fides(INFO) 113| +1.48E+02 | -1.7E-04 | +1.1E+00 | 6.2E-02 | 8.5E-02 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 34| +1.49E+02 | +2.6E+01 | -1.2E+01 | 1.6E+00 | 3.1E+01 | 4.8E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 35| +1.48E+02 | -5.8E-01 | +2.8E-01 | 4.0E-01 | 3.1E+01 | 1.2E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 114| +1.48E+02 | -2.7E-04 | +1.1E+00 | 1.2E-01 | 8.2E-02 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 36| +1.48E+02 | +1.9E+01 | -8.7E+00 | 4.0E-01 | 3.9E+01 | 6.3E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 115| +1.48E+02 | -2.4E-04 | +1.3E+00 | 2.5E-01 | 9.1E-02 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 0| +1.46E+07 | NaN | NaN | 1.0E+00 | 6.7E+07 | NaN | NaN |1\n", + "2023-02-17 16:05:40.850 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.3823 and h = 1.24949e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:40.850 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.3823: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:40 fides(INFO) 37| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.0E-01 | 3.9E+01 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 116| +1.48E+02 | -9.9E-05 | +1.5E+00 | 2.5E-01 | 1.9E-02 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 1| +3.72E+02 | -1.5E+07 | +1.1E-01 | 1.0E+00 | 6.7E+07 | 2.5E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 38| +1.48E+02 | -2.9E-01 | +8.5E-01 | 2.5E-02 | 3.9E+01 | 4.1E-02 | 2d |1\n", + "2023-02-17 16:05:40.874 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.9091 and h = 1.33625e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:40.874 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.9091: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:40 fides(INFO) 117| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 1.5E-02 | 2.4E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 2| +2.65E+02 | -1.1E+02 | +8.9E-01 | 2.5E-01 | 6.3E+02 | 5.3E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 39| +1.48E+02 | -9.9E-03 | +2.7E-02 | 5.0E-02 | 5.7E+00 | 7.6E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 3| +2.50E+02 | -1.5E+01 | +7.5E-01 | 5.0E-01 | 9.3E+01 | 1.1E+00 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 118| +1.48E+02 | -1.7E-05 | +1.1E+00 | 4.6E-02 | 1.5E-02 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 40| +1.48E+02 | -6.2E-02 | +9.3E-01 | 1.3E-02 | 1.7E+01 | 9.8E-03 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 4| +2.50E+02 | +8.8E-01 | -5.9E-01 | 1.0E+00 | 1.4E+01 | 2.8E+00 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 119| +1.48E+02 | -2.8E-05 | +1.1E+00 | 9.2E-02 | 1.2E-02 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 41| +1.48E+02 | -2.7E-02 | +2.8E-01 | 2.5E-02 | 6.2E+00 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 5| +2.50E+02 | +8.8E-01 | -5.9E-01 | 2.5E-01 | 1.4E+01 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 120| +1.48E+02 | -3.2E-05 | +1.1E+00 | 1.8E-01 | 1.5E-02 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 42| +1.48E+02 | -3.7E-02 | +8.1E-01 | 2.5E-02 | 1.6E+01 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 6| +2.50E+02 | -3.7E-01 | +2.4E-01 | 6.2E-02 | 1.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 121| +1.48E+02 | -2.0E-05 | +1.3E+00 | 3.7E-01 | 4.5E-03 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 43| +1.48E+02 | -9.4E-03 | +9.4E-01 | 5.0E-02 | 1.6E+00 | 3.5E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 7| +2.50E+02 | -2.6E-01 | +8.7E-01 | 1.6E-02 | 1.2E+01 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 122| +1.48E+02 | -1.5E-05 | +1.9E+00 | 3.7E-01 | 7.8E-04 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 44| +1.48E+02 | -1.2E-02 | +8.9E-01 | 1.0E-01 | 2.0E+00 | 5.9E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 8| +2.50E+02 | -6.9E-02 | +3.3E-01 | 3.1E-02 | 6.4E+00 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 123| +1.48E+02 | -4.1E-06 | +8.8E-01 | 3.7E-01 | 3.2E-03 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 45| +1.48E+02 | +3.5E-02 | -2.2E+00 | 2.0E-01 | 8.2E-01 | 1.6E-01 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 9| +2.50E+02 | +7.7E-03 | -9.9E-02 | 3.1E-02 | 3.6E+00 | 8.4E-02 | 2d |0\n", + "2023-02-17 16:05:40 fides(INFO) 124| +1.48E+02 | -7.2E-06 | +3.1E+00 | 3.7E-01 | 2.4E-03 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:40 fides(INFO) 10| +2.50E+02 | -4.0E-02 | +7.1E-01 | 7.8E-03 | 3.6E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:40 fides(INFO) 46| +1.48E+02 | -2.5E-03 | +4.2E-01 | 5.0E-02 | 8.2E-01 | 3.9E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 125| +1.48E+02 | +2.8E-07 | -5.5E-01 | 3.7E-01 | 1.1E-03 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 11| +2.50E+02 | +6.8E-06 | -9.8E-03 | 7.8E-03 | 3.5E-01 | 2.1E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 47| +1.48E+02 | +1.0E-03 | -1.0E-01 | 5.0E-02 | 1.0E+00 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 126| +1.48E+02 | +4.5E-06 | -9.3E+00 | 7.2E-02 | 1.1E-03 | 4.5E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 12| +2.50E+02 | +6.8E-06 | -9.8E-03 | 2.0E-03 | 3.5E-01 | 5.1E-03 | 2d |0\n", + "2023-02-17 16:05:41.025 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.328 and h = 3.65848e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:41.025 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.328: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:41 fides(INFO) 48| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.3E-02 | 1.0E+00 | 4.9E-03 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 13| +2.50E+02 | -3.0E-04 | +8.3E-01 | 4.9E-04 | 3.5E-01 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 127| +1.48E+02 | +3.0E-06 | -2.2E+01 | 1.8E-02 | 1.1E-03 | 1.1E-02 | 2d |0\n", + "2023-02-17 16:05:41.037 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.4913 and h = 1.14652e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:41.037 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.4913: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:41 fides(INFO) 49| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-03 | 1.0E+00 | 1.7E-03 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 128| +1.48E+02 | +5.1E-06 | -1.5E+02 | 4.5E-03 | 1.1E-03 | 2.8E-03 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 14| +2.50E+02 | +4.7E-07 | -4.1E-03 | 9.8E-04 | 1.4E-01 | 2.6E-03 | 2d |0\n", + "2023-02-17 16:05:41.053 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.1737 and h = 1.14938e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:41.053 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.1737: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 50| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.8E-04 | 1.0E+00 | 9.4E-04 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 15| +2.50E+02 | -5.6E-05 | +7.8E-01 | 2.4E-04 | 1.4E-01 | 6.2E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 129| +1.48E+02 | +3.9E-06 | -4.3E+02 | 1.1E-03 | 1.1E-03 | 7.1E-04 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 16| +2.50E+02 | +9.6E-09 | -1.2E-03 | 4.9E-04 | 3.8E-02 | 1.3E-03 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 51| +1.48E+02 | -3.5E-04 | +9.6E-01 | 2.0E-04 | 1.0E+00 | 5.0E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 130| +1.48E+02 | +2.7E-06 | -1.1E+03 | 2.8E-04 | 1.1E-03 | 1.8E-04 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 17| +2.50E+02 | -3.8E-06 | +4.9E-01 | 1.2E-04 | 3.8E-02 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 131| +1.48E+02 | +3.4E-06 | -4.1E+03 | 7.0E-05 | 1.1E-03 | 4.4E-05 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 52| +1.48E+02 | -5.3E-04 | +9.3E-01 | 3.9E-04 | 1.2E+00 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 18| +2.50E+02 | -5.7E-10 | +4.8E-04 | 1.2E-04 | 1.4E-02 | 2.9E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 132| +1.48E+02 | +5.2E-06 | -1.3E+04 | 1.8E-05 | 1.1E-03 | 1.1E-05 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 53| +1.48E+02 | -3.7E-04 | +9.5E-01 | 7.8E-04 | 1.1E+00 | 6.4E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 19| +2.50E+02 | -5.6E-07 | +6.9E-01 | 3.1E-05 | 1.4E-02 | 7.7E-05 | 2d |1\n", + "2023-02-17 16:05:41 fides(WARNING) Stopping as function difference 5.57E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:41 fides(INFO) 133| +1.48E+02 | +2.8E-06 | -9.2E+03 | 4.4E-06 | 1.1E-03 | 2.8E-06 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 54| +1.48E+02 | -4.3E-04 | +9.1E-01 | 1.6E-03 | 1.1E+00 | 8.6E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 134| +1.48E+02 | +4.9E-06 | -1.8E+04 | 1.1E-06 | 1.1E-03 | 8.5E-07 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 55| +1.48E+02 | -4.7E-04 | +9.5E-01 | 3.1E-03 | 1.0E+00 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 135| +1.48E+02 | +1.7E-06 | -6.4E+03 | 2.8E-07 | 1.1E-03 | 5.2E-07 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 56| +1.48E+02 | -6.2E-04 | +8.7E-01 | 6.3E-03 | 7.6E-01 | 2.5E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 136| +1.48E+02 | +2.8E-06 | -1.8E+04 | 6.9E-08 | 1.1E-03 | 1.8E-07 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 57| +1.48E+02 | -7.6E-04 | +9.5E-01 | 1.3E-02 | 1.0E+00 | 5.9E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 137| +1.48E+02 | +2.6E-06 | -5.8E+04 | 1.7E-08 | 1.1E-03 | 4.5E-08 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 58| +1.48E+02 | -1.2E-03 | +9.5E-01 | 2.5E-02 | 4.2E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 138| +1.48E+02 | +4.1E-06 | -3.5E+05 | 4.3E-09 | 1.1E-03 | 1.1E-08 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 59| +1.48E+02 | -1.3E-03 | +6.8E-01 | 5.0E-02 | 1.1E+00 | 3.0E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 139| +1.48E+02 | +4.5E-06 | -1.5E+06 | 1.1E-09 | 1.1E-03 | 2.8E-09 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 60| +1.48E+02 | +2.5E-03 | -8.0E-01 | 5.0E-02 | 4.9E-01 | 1.3E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 140| +1.48E+02 | +3.6E-06 | -4.9E+06 | 2.7E-10 | 1.1E-03 | 7.0E-10 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 61| +1.48E+02 | -2.4E-04 | +1.9E-01 | 1.3E-02 | 4.9E-01 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:41.250 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.431 and h = 4.24931e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:41.250 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.431: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:41 fides(INFO) 141| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.7E-11 | 1.1E-03 | 1.7E-10 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 62| +1.48E+02 | -5.3E-04 | +9.3E-01 | 3.1E-03 | 1.9E+00 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 142| +1.48E+02 | +4.7E-06 | -1.0E+08 | 1.7E-11 | 1.1E-03 | 4.4E-11 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 63| +1.48E+02 | -2.0E-04 | +8.5E-01 | 6.3E-03 | 1.8E-01 | 4.0E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 143| +1.48E+02 | +3.6E-06 | -3.1E+08 | 4.2E-12 | 1.1E-03 | 1.1E-11 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 64| +1.48E+02 | -2.2E-04 | +8.7E-01 | 1.3E-02 | 2.4E-01 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 144| +1.48E+02 | +5.3E-06 | -1.8E+09 | 1.1E-12 | 1.1E-03 | 2.7E-12 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 65| +1.48E+02 | -3.5E-04 | +9.5E-01 | 2.5E-02 | 1.6E-01 | 9.5E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 145| +1.48E+02 | +4.6E-06 | -6.4E+09 | 2.6E-13 | 1.1E-03 | 6.8E-13 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 66| +1.48E+02 | -2.7E-04 | +4.8E-01 | 5.0E-02 | 4.2E-01 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 146| +1.48E+02 | +3.9E-06 | -2.2E+10 | 6.6E-14 | 1.1E-03 | 1.7E-13 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 67| +1.48E+02 | +4.3E-03 | -2.3E+00 | 5.0E-02 | 3.1E-01 | 1.8E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 147| +1.48E+02 | +4.5E-06 | -1.0E+11 | 1.6E-14 | 1.1E-03 | 4.3E-14 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 68| +1.48E+02 | +9.9E-05 | -1.4E-01 | 1.3E-02 | 3.1E-01 | 5.1E-03 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 148| +1.48E+02 | +3.0E-06 | -2.7E+11 | 4.1E-15 | 1.1E-03 | 1.1E-14 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 69| +1.48E+02 | -8.9E-05 | +2.7E-01 | 3.1E-03 | 3.1E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 70| +1.48E+02 | -1.8E-04 | +9.4E-01 | 3.1E-03 | 1.2E+00 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 149| +1.48E+02 | +3.2E-06 | -1.1E+12 | 1.0E-15 | 1.1E-03 | 2.7E-15 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 71| +1.48E+02 | -3.2E-05 | +1.2E+00 | 6.3E-03 | 8.9E-02 | 1.8E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 150| +1.48E+02 | +5.3E-06 | -7.6E+12 | 2.6E-16 | 1.1E-03 | 6.6E-16 | 2d |0\n", + "2023-02-17 16:05:41 fides(WARNING) Stopping as trust region radius 6.41E-17 is smaller than machine precision.\n", + "2023-02-17 16:05:41 fides(INFO) 72| +1.48E+02 | -3.7E-05 | +8.6E-01 | 1.3E-02 | 8.6E-02 | 3.3E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 73| +1.48E+02 | -6.3E-05 | +9.8E-01 | 2.5E-02 | 7.2E-02 | 5.6E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 74| +1.48E+02 | -4.4E-05 | +6.1E-01 | 5.0E-02 | 5.9E-02 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 75| +1.48E+02 | +1.5E-03 | -5.8E+00 | 5.0E-02 | 9.9E-02 | 1.2E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 0| +9.34E+11 | NaN | NaN | 1.0E+00 | 4.2E+12 | NaN | NaN |1\n", + "2023-02-17 16:05:41 fides(INFO) 76| +1.48E+02 | +3.1E-05 | -3.4E-01 | 1.3E-02 | 9.9E-02 | 3.1E-03 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 1| +1.55E+10 | -9.2E+11 | +9.0E-02 | 1.0E+00 | 4.2E+12 | 2.9E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 77| +1.48E+02 | -1.9E-05 | +6.6E-01 | 3.1E-03 | 9.9E-02 | 8.3E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 2| +2.31E+09 | -1.3E+10 | +8.9E-01 | 2.5E-01 | 7.1E+10 | 6.2E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 78| +1.48E+02 | -3.1E-06 | +5.1E-01 | 3.1E-03 | 2.0E-01 | 3.1E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 3| +3.45E+08 | -2.0E+09 | +8.9E-01 | 5.0E-01 | 1.1E+10 | 8.8E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 79| +1.48E+02 | -7.2E-06 | +4.2E+00 | 3.1E-03 | 2.3E-02 | 3.3E-04 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 4| +5.14E+07 | -2.9E+08 | +8.9E-01 | 5.0E-01 | 1.6E+09 | 8.3E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 5| +7.57E+06 | -4.4E+07 | +9.0E-01 | 5.0E-01 | 2.4E+08 | 8.1E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 80| +1.48E+02 | +1.0E-06 | -4.2E-01 | 6.3E-03 | 5.3E-02 | 7.8E-04 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 6| +1.09E+06 | -6.5E+06 | +9.0E-01 | 5.0E-01 | 3.5E+07 | 8.6E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 81| +1.48E+02 | +4.3E-06 | -5.0E+00 | 1.6E-03 | 5.3E-02 | 2.0E-04 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 7| +1.53E+05 | -9.3E+05 | +9.0E-01 | 5.0E-01 | 5.1E+06 | 7.8E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 82| +1.48E+02 | +8.8E-07 | -1.8E+00 | 3.9E-04 | 5.3E-02 | 5.1E-05 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 83| +1.48E+02 | +4.2E-06 | -1.1E+01 | 9.8E-05 | 5.3E-02 | 1.8E-05 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 8| +2.17E+04 | -1.3E+05 | +9.0E-01 | 5.0E-01 | 7.4E+05 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 84| +1.48E+02 | +2.8E-06 | -7.9E+00 | 2.4E-05 | 5.3E-02 | 1.3E-05 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 9| +3.33E+03 | -1.8E+04 | +9.0E-01 | 5.0E-01 | 1.1E+05 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 85| +1.48E+02 | +5.6E-06 | -1.6E+01 | 6.1E-06 | 5.3E-02 | 1.3E-05 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 10| +6.49E+02 | -2.7E+03 | +9.0E-01 | 5.0E-01 | 1.7E+04 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 86| +1.48E+02 | +4.9E-06 | -2.7E+01 | 1.5E-06 | 5.3E-02 | 4.0E-06 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 11| +2.51E+02 | -4.0E+02 | +9.0E-01 | 5.0E-01 | 2.7E+03 | 4.6E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 87| +1.48E+02 | -4.1E-07 | +8.0E+00 | 3.8E-07 | 5.3E-02 | 1.0E-06 | 2d |1\n", + "2023-02-17 16:05:41 fides(WARNING) Stopping as function difference 4.13E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:41 fides(INFO) 12| +1.78E+02 | -7.3E+01 | +9.8E-01 | 5.0E-01 | 4.4E+02 | 1.0E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 13| +1.67E+02 | -1.1E+01 | +5.5E-02 | 1.0E+00 | 8.3E+01 | 2.0E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 14| +1.57E+02 | -1.0E+01 | +9.3E-01 | 2.5E-01 | 1.4E+02 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 0| +8.42E+08 | NaN | NaN | 1.0E+00 | 3.9E+09 | NaN | NaN |1\n", + "2023-02-17 16:05:41 fides(INFO) 15| +1.57E+02 | +1.3E+00 | -3.3E-01 | 5.0E-01 | 5.6E+01 | 7.4E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 1| +1.10E+04 | -8.4E+08 | +9.9E-02 | 1.0E+00 | 3.9E+09 | 2.7E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 16| +1.53E+02 | -4.2E+00 | +7.0E-01 | 1.2E-01 | 5.6E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 2| +2.54E+03 | -8.5E+03 | +9.1E-01 | 2.5E-01 | 3.8E+04 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 17| +1.51E+02 | -1.8E+00 | +9.4E-01 | 1.2E-01 | 9.4E+01 | 1.6E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 3| +6.03E+02 | -1.9E+03 | +8.9E-01 | 5.0E-01 | 7.7E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 18| +1.50E+02 | -1.3E+00 | +9.4E-01 | 2.5E-01 | 1.8E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 4| +2.82E+02 | -3.2E+02 | +8.9E-01 | 1.0E+00 | 1.3E+03 | 2.3E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 5| +2.50E+02 | -3.2E+01 | +8.0E-01 | 2.0E+00 | 1.8E+02 | 4.0E+00 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 19| +1.50E+02 | +3.5E-01 | -3.1E-01 | 5.0E-01 | 2.1E+01 | 5.6E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 6| +2.33E+02 | -1.7E+01 | +2.8E+01 | 4.0E+00 | 5.7E+00 | 7.6E+00 | trr |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 20| +1.49E+02 | -5.1E-01 | +7.8E-01 | 1.2E-01 | 2.1E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 7| +2.33E+02 | +9.0E+03 | -4.0E+02 | 8.0E+00 | 4.7E+01 | 7.1E+00 | trr |0\n", + "2023-02-17 16:05:41 fides(INFO) 21| +1.49E+02 | -6.7E-02 | +6.0E-02 | 2.5E-01 | 1.8E+01 | 2.9E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 8| +2.33E+02 | +1.5E+02 | -4.6E+00 | 5.8E-01 | 4.7E+01 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 22| +1.49E+02 | -5.2E-01 | +8.7E-01 | 6.2E-02 | 2.0E+01 | 6.9E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 9| +2.18E+02 | -1.4E+01 | +8.8E-01 | 1.4E-01 | 4.7E+01 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 23| +1.48E+02 | -3.8E-01 | +6.5E-01 | 1.2E-01 | 2.4E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 10| +2.18E+02 | +1.7E+01 | -1.6E+00 | 2.9E-01 | 3.1E+01 | 7.2E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 11| +2.14E+02 | -4.4E+00 | +8.7E-01 | 7.2E-02 | 3.1E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 24| +1.48E+02 | -1.3E-01 | +5.2E-01 | 1.2E-01 | 1.5E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 12| +2.14E+02 | +2.9E+00 | -9.6E-01 | 1.4E-01 | 1.8E+01 | 3.5E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 25| +1.48E+02 | -1.4E-01 | +3.7E-01 | 1.2E-01 | 8.7E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 13| +2.13E+02 | -1.2E+00 | +8.6E-01 | 3.6E-02 | 1.8E+01 | 8.8E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 26| +1.48E+02 | +4.6E-01 | -8.0E-01 | 1.2E-01 | 1.0E+01 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 14| +2.13E+02 | +2.7E-01 | -4.0E-01 | 7.2E-02 | 9.2E+00 | 1.9E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 27| +1.48E+02 | -1.2E-01 | +6.6E-01 | 3.1E-02 | 1.0E+01 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 15| +2.12E+02 | -3.0E-01 | +8.4E-01 | 1.8E-02 | 9.2E+00 | 4.5E-02 | 2d |1\n", + "2023-02-17 16:05:41.877 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 141.82 and h = 3.32306e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:41.877 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 141.82: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:41 fides(INFO) 28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 2.6E+00 | 3.0E-02 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 16| +2.12E+02 | -1.0E-01 | +4.0E-01 | 3.6E-02 | 4.1E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 29| +1.48E+02 | -8.7E-03 | +9.5E-01 | 7.8E-03 | 2.6E+00 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 17| +2.12E+02 | -2.0E-01 | +5.2E-01 | 3.6E-02 | 7.7E+00 | 8.3E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 30| +1.48E+02 | -1.5E-02 | +9.5E-01 | 1.6E-02 | 2.5E+00 | 1.5E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 18| +2.12E+02 | -2.3E-02 | +7.4E-02 | 3.6E-02 | 5.0E+00 | 9.6E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 19| +2.12E+02 | -1.3E-01 | +9.0E-01 | 9.0E-03 | 8.6E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 31| +1.48E+02 | -2.4E-02 | +9.4E-01 | 3.1E-02 | 2.8E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:41 fides(INFO) 20| +2.12E+02 | -1.1E-01 | +7.3E-01 | 1.8E-02 | 5.2E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 32| +1.48E+02 | -4.2E-02 | +9.7E-01 | 6.2E-02 | 2.4E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 21| +2.12E+02 | -7.5E-02 | +8.7E-01 | 1.8E-02 | 2.0E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 33| +1.48E+02 | -6.1E-02 | +9.1E-01 | 1.2E-01 | 3.7E+00 | 9.9E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 22| +2.12E+02 | -2.6E-02 | +3.2E-01 | 3.6E-02 | 2.5E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 34| +1.48E+02 | -3.0E-02 | +3.1E-01 | 2.5E-01 | 1.9E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 23| +2.12E+02 | +9.0E-03 | -8.2E-02 | 3.6E-02 | 4.2E+00 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 35| +1.48E+02 | +2.3E+00 | -4.2E+00 | 2.5E-01 | 6.9E+00 | 3.6E-01 | 2d |0\n", + "2023-02-17 16:05:41 fides(INFO) 24| +2.12E+02 | -5.8E-02 | +7.7E-01 | 9.0E-03 | 4.2E+00 | 2.2E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 36| +1.48E+02 | -2.0E-02 | +1.1E-01 | 6.2E-02 | 6.9E+00 | 9.0E-02 | 2d |1\n", + "2023-02-17 16:05:41 fides(INFO) 25| +2.12E+02 | -7.7E-03 | +3.5E-01 | 1.8E-02 | 1.2E+00 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 26| +2.12E+02 | -2.0E-03 | +5.5E-02 | 1.8E-02 | 2.4E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 37| +1.48E+02 | -2.4E-02 | +7.1E-01 | 1.6E-02 | 3.6E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 27| +2.12E+02 | -1.6E-02 | +8.1E-01 | 4.5E-03 | 2.5E+00 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 38| +1.48E+02 | -1.1E-02 | +8.5E-01 | 1.6E-02 | 7.5E+00 | 7.5E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 28| +2.12E+02 | -2.1E-03 | +2.6E-01 | 9.0E-03 | 1.0E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 39| +1.48E+02 | -4.4E-03 | +8.4E-01 | 3.1E-02 | 1.3E+00 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 29| +2.12E+02 | -4.7E-04 | +5.5E-02 | 9.0E-03 | 1.2E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 40| +1.48E+02 | -5.5E-03 | +8.9E-01 | 6.2E-02 | 9.8E-01 | 4.0E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 30| +2.12E+02 | -3.8E-03 | +8.3E-01 | 2.3E-03 | 1.2E+00 | 4.7E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 41| +1.48E+02 | -2.2E-03 | +2.4E-01 | 1.2E-01 | 5.8E-01 | 5.7E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 31| +2.12E+02 | -6.4E-04 | +3.1E-01 | 4.5E-03 | 5.1E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 42| +1.48E+02 | -4.0E-03 | +2.7E-01 | 3.1E-02 | 1.2E+00 | 3.6E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 32| +2.12E+02 | -3.0E-04 | +1.6E-01 | 4.5E-03 | 5.1E-01 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 43| +1.48E+02 | -9.5E-04 | +1.8E-01 | 3.1E-02 | 1.5E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 33| +2.12E+02 | -7.6E-04 | +8.1E-01 | 1.1E-03 | 5.2E-01 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 44| +1.48E+02 | -9.1E-04 | +6.6E-01 | 7.8E-03 | 4.3E-01 | 7.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 34| +2.12E+02 | -2.0E-04 | +5.3E-01 | 2.3E-03 | 1.8E-01 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 35| +2.12E+02 | -1.5E-04 | +4.4E-01 | 2.3E-03 | 1.9E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 45| +1.48E+02 | -4.2E-04 | +9.1E-01 | 7.8E-03 | 1.2E+00 | 5.0E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 36| +2.12E+02 | -1.8E-04 | +5.0E-01 | 2.3E-03 | 1.9E-01 | 6.5E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 46| +1.48E+02 | -3.1E-04 | +8.6E-01 | 1.6E-02 | 1.1E-01 | 8.3E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 37| +2.12E+02 | -1.6E-04 | +4.8E-01 | 2.3E-03 | 1.7E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 47| +1.48E+02 | -4.5E-04 | +9.6E-01 | 3.1E-02 | 3.1E-01 | 1.2E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 38| +2.12E+02 | -1.7E-04 | +5.3E-01 | 2.3E-03 | 1.7E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 48| +1.48E+02 | -4.7E-04 | +7.8E-01 | 6.2E-02 | 1.0E-01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 39| +2.12E+02 | -1.6E-04 | +5.3E-01 | 2.3E-03 | 1.6E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 49| +1.48E+02 | +1.2E-02 | -9.4E+00 | 1.2E-01 | 2.7E-01 | 2.4E-02 | trr |0\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 40| +2.12E+02 | -1.7E-04 | +5.6E-01 | 2.3E-03 | 1.6E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 41| +2.12E+02 | -1.6E-04 | +5.6E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 50| +1.48E+02 | +2.7E-04 | -4.9E-01 | 3.1E-02 | 2.7E-01 | 6.0E-03 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 42| +2.12E+02 | -1.7E-04 | +5.8E-01 | 2.3E-03 | 1.5E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 51| +1.48E+02 | -1.1E-04 | +6.3E-01 | 7.7E-03 | 2.7E-01 | 1.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 43| +2.12E+02 | -1.6E-04 | +5.7E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 52| +1.48E+02 | -4.0E-05 | +9.6E-01 | 7.7E-03 | 2.9E-01 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 44| +2.12E+02 | -1.7E-04 | +5.9E-01 | 2.3E-03 | 1.5E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 53| +1.48E+02 | -5.5E-05 | +9.2E-01 | 1.5E-02 | 6.6E-02 | 3.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 45| +2.12E+02 | -1.6E-04 | +5.7E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 54| +1.48E+02 | -5.8E-05 | +6.3E-01 | 3.1E-02 | 1.9E-01 | 9.0E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 46| +2.12E+02 | -1.8E-04 | +5.9E-01 | 2.3E-03 | 1.5E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 55| +1.48E+02 | +2.9E-04 | -1.5E+00 | 3.1E-02 | 1.1E-01 | 4.8E-03 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 47| +2.12E+02 | -1.7E-04 | +5.8E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 56| +1.48E+02 | -1.5E-05 | +2.1E-01 | 7.7E-03 | 1.1E-01 | 1.4E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 48| +2.12E+02 | -1.8E-04 | +5.9E-01 | 2.3E-03 | 1.5E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 57| +1.48E+02 | -1.8E-05 | +6.5E-01 | 1.9E-03 | 3.8E-01 | 7.5E-04 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 49| +2.12E+02 | -1.7E-04 | +5.7E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 50| +2.12E+02 | -1.8E-04 | +5.9E-01 | 2.3E-03 | 1.5E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 58| +1.48E+02 | -7.5E-06 | +1.3E+00 | 1.9E-03 | 3.9E-02 | 5.8E-04 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 51| +2.12E+02 | -1.7E-04 | +5.7E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 59| +1.48E+02 | -6.3E-06 | +8.7E-01 | 3.8E-03 | 3.4E-02 | 9.8E-04 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 52| +2.12E+02 | -1.9E-04 | +5.9E-01 | 2.3E-03 | 1.5E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 60| +1.48E+02 | -8.8E-06 | +1.1E+00 | 7.7E-03 | 2.4E-02 | 1.5E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 53| +2.12E+02 | -1.7E-04 | +5.7E-01 | 2.3E-03 | 1.5E-01 | 6.9E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 61| +1.48E+02 | -1.1E-05 | +9.2E-01 | 1.5E-02 | 3.1E-02 | 2.3E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 54| +2.12E+02 | -1.9E-04 | +5.9E-01 | 2.3E-03 | 1.6E-01 | 6.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 62| +1.48E+02 | -1.2E-05 | +8.7E-01 | 3.1E-02 | 2.7E-02 | 4.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 55| +2.12E+02 | -1.8E-04 | +9.9E-01 | 2.3E-03 | 1.6E-01 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 63| +1.48E+02 | +2.0E-04 | -9.4E+00 | 6.2E-02 | 2.6E-02 | 4.2E-03 | trr |0\n", + "2023-02-17 16:05:42 fides(INFO) 56| +2.12E+02 | -2.6E-04 | +8.5E-01 | 4.5E-03 | 5.1E-02 | 9.6E-03 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 64| +1.48E+02 | +8.0E-05 | -4.7E+00 | 1.5E-02 | 2.6E-02 | 1.6E-03 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 57| +2.12E+02 | -5.6E-04 | +9.6E-01 | 9.0E-03 | 2.1E-01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 58| +2.12E+02 | -8.4E-04 | +9.1E-01 | 1.8E-02 | 8.4E-02 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 65| +1.48E+02 | +6.1E-05 | -4.2E+00 | 3.7E-03 | 2.6E-02 | 1.2E-03 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 59| +2.12E+02 | -1.3E-03 | +6.2E-01 | 3.6E-02 | 2.1E-01 | 6.1E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 66| +1.48E+02 | +5.9E-05 | -4.2E+00 | 9.2E-04 | 2.6E-02 | 1.1E-03 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 60| +2.12E+02 | -4.4E-03 | +9.8E-01 | 3.6E-02 | 4.4E-01 | 9.1E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 67| +1.48E+02 | +1.5E-05 | -1.5E+00 | 2.3E-04 | 2.6E-02 | 5.1E-04 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 61| +2.12E+02 | -1.1E-02 | +1.3E+00 | 7.2E-02 | 5.4E-01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 68| +1.48E+02 | -1.4E-06 | +4.7E-01 | 5.8E-05 | 2.6E-02 | 1.3E-04 | 2d |1\n", + "2023-02-17 16:05:42 fides(WARNING) Stopping as function difference 1.38E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:42 fides(INFO) 62| +2.12E+02 | -3.6E-02 | +1.5E+00 | 1.4E-01 | 7.1E-01 | 3.6E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 63| +2.11E+02 | -2.5E-01 | +2.4E+00 | 2.9E-01 | 1.5E+00 | 7.4E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 64| +2.11E+02 | +2.4E+00 | -5.0E+00 | 5.8E-01 | 3.3E+00 | 1.5E+00 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 65| +2.11E+02 | -3.8E-01 | +1.5E+00 | 1.4E-01 | 3.3E+00 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 66| +2.10E+02 | -5.4E-01 | +4.7E-01 | 2.9E-01 | 3.4E+00 | 7.5E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 67| +2.10E+02 | +6.8E-01 | -7.8E-01 | 2.9E-01 | 4.7E+00 | 4.5E-01 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 68| +2.10E+02 | -4.3E-02 | +8.2E-02 | 7.2E-02 | 4.7E+00 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 69| +2.10E+02 | -2.4E-01 | +9.2E-01 | 1.8E-02 | 9.5E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 70| +2.10E+02 | -6.3E-02 | +9.4E-01 | 3.6E-02 | 3.3E+00 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 71| +2.10E+02 | -6.0E-02 | +8.9E-01 | 7.2E-02 | 1.8E+00 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 72| +2.10E+02 | -1.1E-01 | +9.6E-01 | 1.4E-01 | 2.1E+00 | 3.3E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 73| +2.10E+02 | -2.5E-01 | +1.3E+00 | 2.9E-01 | 1.2E+00 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 74| +2.10E+02 | +4.9E+00 | -1.4E+01 | 5.8E-01 | 2.4E+00 | 1.5E+00 | trr |0\n", + "2023-02-17 16:05:42 fides(INFO) 75| +2.10E+02 | -1.7E-01 | +1.1E+00 | 1.4E-01 | 2.4E+00 | 3.5E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 76| +2.09E+02 | -5.6E-01 | +9.5E-01 | 2.9E-01 | 3.0E+00 | 7.2E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 77| +2.01E+02 | -7.5E+00 | +4.2E+00 | 5.8E-01 | 9.0E+00 | 1.2E+00 | trr |1\n", + "2023-02-17 16:05:42 fides(INFO) 78| +2.01E+02 | +8.4E+00 | -6.4E-01 | 1.2E+00 | 2.8E+01 | 1.4E+00 | trr |0\n", + "2023-02-17 16:05:42 fides(INFO) 79| +1.89E+02 | -1.3E+01 | +1.5E+00 | 2.9E-01 | 2.8E+01 | 5.4E-01 | trr |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 80| +1.89E+02 | +2.6E+02 | -1.0E+01 | 5.8E-01 | 4.4E+01 | 1.3E+00 | trr |0\n", + "2023-02-17 16:05:42 fides(INFO) 81| +1.83E+02 | -5.8E+00 | +7.1E-01 | 1.4E-01 | 4.4E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 82| +1.70E+02 | -1.3E+01 | +8.3E-01 | 1.4E-01 | 7.0E+01 | 3.1E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 83| +1.70E+02 | +7.7E+00 | -5.5E-01 | 2.9E-01 | 4.8E+01 | 6.2E-01 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 84| +1.65E+02 | -5.3E+00 | +8.0E-01 | 7.2E-02 | 4.8E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 85| +1.58E+02 | -6.6E+00 | +8.3E-01 | 1.4E-01 | 7.3E+01 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:42.744 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 124.452 and h = 1.67549e-05, the error test failed repeatedly or with |h| = hmin. \n", + "2023-02-17 16:05:42.744 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 124.452: AMICI failed to integrate the forward problem\n", + "2023-02-17 16:05:42 fides(INFO) 86| +1.58E+02 | +0.0E+00 | +0.0E+00 | 2.9E-01 | 7.6E+01 | 5.5E-01 | trr |0\n", + "2023-02-17 16:05:42 fides(INFO) 87| +1.54E+02 | -4.1E+00 | +7.1E-01 | 7.2E-02 | 7.6E+01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 88| +1.51E+02 | -2.7E+00 | +8.3E-01 | 7.2E-02 | 8.1E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 89| +1.49E+02 | -2.5E+00 | +5.7E-01 | 1.4E-01 | 4.4E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 90| +1.49E+02 | +9.5E-01 | -4.4E-01 | 1.4E-01 | 5.9E+01 | 1.8E-01 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 91| +1.49E+02 | +1.7E-01 | -1.5E-01 | 3.6E-02 | 5.9E+01 | 5.1E-02 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 92| +1.48E+02 | -3.6E-01 | +5.3E-01 | 9.0E-03 | 5.9E+01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 93| +1.48E+02 | -8.1E-02 | +9.6E-01 | 9.0E-03 | 1.7E+01 | 1.0E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 94| +1.48E+02 | -1.1E-01 | +7.4E-01 | 1.8E-02 | 1.2E+01 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 95| +1.48E+02 | -1.1E-01 | +8.2E-01 | 1.8E-02 | 2.1E+01 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 96| +1.48E+02 | -1.3E-01 | +8.8E-01 | 3.6E-02 | 1.2E+01 | 5.2E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 97| +1.48E+02 | -1.6E-01 | +7.5E-01 | 7.2E-02 | 8.8E+00 | 9.5E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 98| +1.48E+02 | +3.0E+00 | -5.2E+00 | 1.4E-01 | 1.5E+01 | 2.3E-01 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) 99| +1.48E+02 | +6.0E-02 | -2.5E-01 | 3.6E-02 | 1.5E+01 | 5.6E-02 | 2d |0\n", + "2023-02-17 16:05:42 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:42 fides(INFO) 100| +1.48E+02 | -5.5E-02 | +6.6E-01 | 9.0E-03 | 1.5E+01 | 1.4E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 101| +1.48E+02 | -2.2E-02 | +8.1E-01 | 9.0E-03 | 5.3E+00 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 102| +1.48E+02 | -2.6E-02 | +5.8E-01 | 1.8E-02 | 5.6E+00 | 2.7E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 103| +1.48E+02 | -3.4E-02 | +9.3E-01 | 1.8E-02 | 8.4E+00 | 2.4E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 104| +1.48E+02 | -5.2E-02 | +8.2E-01 | 3.6E-02 | 4.3E+00 | 4.6E-02 | 2d |1\n", + "2023-02-17 16:05:42 fides(INFO) 105| +1.48E+02 | +5.5E-02 | -6.4E-01 | 7.2E-02 | 5.2E+00 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 106| +1.48E+02 | -1.9E-02 | +7.2E-01 | 1.8E-02 | 5.2E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 107| +1.48E+02 | +4.0E-02 | -1.0E+00 | 1.8E-02 | 2.5E+00 | 2.7E-02 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 108| +1.48E+02 | +2.1E-02 | -1.4E+00 | 4.5E-03 | 2.5E+00 | 8.4E-03 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 109| +1.48E+02 | +6.9E-04 | -1.2E-01 | 1.1E-03 | 2.5E+00 | 2.7E-03 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 110| +1.48E+02 | -1.2E-03 | +7.3E-01 | 2.8E-04 | 2.5E+00 | 6.9E-04 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 111| +1.48E+02 | -1.1E-03 | +9.9E-01 | 2.8E-04 | 2.2E+00 | 5.6E-04 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 112| +1.48E+02 | -2.0E-03 | +1.0E+00 | 5.6E-04 | 2.0E+00 | 1.2E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 113| +1.48E+02 | -3.3E-03 | +9.9E-01 | 1.1E-03 | 2.0E+00 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 114| +1.48E+02 | -3.2E-03 | +9.9E-01 | 2.3E-03 | 1.9E+00 | 3.2E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 115| +1.48E+02 | -5.6E-03 | +9.7E-01 | 4.5E-03 | 2.1E+00 | 6.4E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 116| +1.48E+02 | -1.0E-02 | +9.8E-01 | 9.0E-03 | 2.1E+00 | 1.3E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 117| +1.48E+02 | -2.0E-02 | +1.0E+00 | 1.8E-02 | 1.9E+00 | 2.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 118| +1.48E+02 | -2.3E-02 | +8.0E-01 | 3.6E-02 | 1.5E+00 | 5.0E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 119| +1.48E+02 | -2.5E-02 | +4.5E-01 | 7.2E-02 | 2.4E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 120| +1.48E+02 | +3.0E-02 | -6.7E-01 | 7.2E-02 | 3.0E+00 | 1.0E-01 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 121| +1.48E+02 | -1.6E-02 | +8.0E-01 | 1.8E-02 | 3.0E+00 | 2.5E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 122| +1.48E+02 | -1.4E-02 | +8.7E-01 | 3.6E-02 | 2.4E+00 | 4.9E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 123| +1.48E+02 | -4.8E-03 | +4.7E-01 | 7.2E-02 | 2.4E+00 | 8.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 124| +1.48E+02 | -5.4E-03 | +1.1E+00 | 7.2E-02 | 5.7E+00 | 3.3E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 125| +1.48E+02 | -2.8E-04 | +3.9E-01 | 7.2E-02 | 7.7E-01 | 1.8E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 126| +1.48E+02 | -3.6E-04 | +1.0E+00 | 7.2E-02 | 9.5E-01 | 8.8E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 127| +1.48E+02 | -1.4E-05 | +7.5E-01 | 7.2E-02 | 1.4E-01 | 5.1E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 128| +1.48E+02 | -3.9E-06 | +1.3E+00 | 7.2E-02 | 5.9E-02 | 1.1E-03 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 129| +1.48E+02 | +3.8E-06 | -1.5E+02 | 7.2E-02 | 1.1E-02 | 5.7E-05 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 130| +1.48E+02 | +1.3E-06 | -7.0E+01 | 1.2E-05 | 1.1E-02 | 1.4E-05 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 131| +1.48E+02 | +2.4E-06 | -1.7E+02 | 3.0E-06 | 1.1E-02 | 4.1E-06 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 132| +1.48E+02 | +1.2E-06 | -1.1E+02 | 7.4E-07 | 1.1E-02 | 1.4E-06 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 133| +1.48E+02 | -7.8E-07 | +2.3E+02 | 1.9E-07 | 1.1E-02 | 3.4E-07 | 2d |1\n", + "2023-02-17 16:05:43 fides(WARNING) Stopping as function difference 7.78E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 0| +2.42E+10 | NaN | NaN | 1.0E+00 | 1.1E+11 | NaN | NaN |1\n", + "2023-02-17 16:05:43 fides(INFO) 1| +5.45E+04 | -2.4E+10 | +9.3E-02 | 1.0E+00 | 1.1E+11 | 2.8E+00 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 2| +8.86E+03 | -4.6E+04 | +9.0E-01 | 2.5E-01 | 2.5E+05 | 6.6E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 3| +1.61E+03 | -7.3E+03 | +9.0E-01 | 5.0E-01 | 3.9E+04 | 1.4E+00 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 4| +1.61E+03 | +4.5E+02 | -2.3E+00 | 1.0E+00 | 6.3E+03 | 2.4E+00 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 5| +4.66E+02 | -1.1E+03 | +9.0E-01 | 2.5E-01 | 6.3E+03 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 6| +2.88E+02 | -1.8E+02 | +9.0E-01 | 5.0E-01 | 1.0E+03 | 1.3E+00 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 7| +2.57E+02 | -3.2E+01 | +8.7E-01 | 1.0E+00 | 1.5E+02 | 2.4E+00 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 8| +2.57E+02 | +1.7E+02 | -1.3E+01 | 2.0E+00 | 3.2E+01 | 4.1E+00 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 9| +2.57E+02 | +1.4E+02 | -1.0E+01 | 5.0E-01 | 3.2E+01 | 1.2E+00 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 10| +2.50E+02 | -6.5E+00 | +7.3E-01 | 1.2E-01 | 3.2E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 11| +2.50E+02 | +9.7E-02 | -1.6E-01 | 1.2E-01 | 1.1E+01 | 2.7E-01 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 12| +2.50E+02 | -3.3E-01 | +6.1E-01 | 3.1E-02 | 1.1E+01 | 7.1E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 13| +2.50E+02 | -1.0E-02 | +2.0E-01 | 3.1E-02 | 2.9E+00 | 6.5E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 14| +2.50E+02 | -1.7E-02 | +5.1E-01 | 7.8E-03 | 2.5E+00 | 2.0E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 15| +2.50E+02 | -1.9E-03 | +3.6E-01 | 7.8E-03 | 8.3E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 16| +2.50E+02 | -1.6E-03 | +3.5E-01 | 7.8E-03 | 7.2E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 17| +2.50E+02 | -1.8E-03 | +4.2E-01 | 7.8E-03 | 7.1E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 18| +2.50E+02 | -1.6E-03 | +4.2E-01 | 7.8E-03 | 6.4E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 19| +2.50E+02 | -1.8E-03 | +4.7E-01 | 7.8E-03 | 6.4E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 20| +2.50E+02 | -1.7E-03 | +4.6E-01 | 7.8E-03 | 6.0E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 21| +2.50E+02 | -1.9E-03 | +5.0E-01 | 7.8E-03 | 6.1E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 22| +2.50E+02 | -1.7E-03 | +4.8E-01 | 7.8E-03 | 5.8E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 23| +2.50E+02 | -2.0E-03 | +5.2E-01 | 7.8E-03 | 6.0E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 24| +2.50E+02 | -1.8E-03 | +5.0E-01 | 7.8E-03 | 5.8E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 25| +2.50E+02 | -2.0E-03 | +5.3E-01 | 7.8E-03 | 6.0E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 26| +2.50E+02 | -1.9E-03 | +5.0E-01 | 7.8E-03 | 5.8E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 27| +2.50E+02 | -2.1E-03 | +5.3E-01 | 7.8E-03 | 6.1E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 28| +2.50E+02 | -2.0E-03 | +5.1E-01 | 7.8E-03 | 5.9E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 29| +2.50E+02 | -2.2E-03 | +5.4E-01 | 7.8E-03 | 6.2E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 30| +2.50E+02 | -2.1E-03 | +5.1E-01 | 7.8E-03 | 6.1E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 31| +2.50E+02 | -2.3E-03 | +5.4E-01 | 7.8E-03 | 6.4E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 32| +2.50E+02 | -2.1E-03 | +5.1E-01 | 7.8E-03 | 6.2E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 33| +2.50E+02 | -2.5E-03 | +5.4E-01 | 7.8E-03 | 6.5E-01 | 1.6E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 34| +2.50E+02 | -2.2E-03 | +5.1E-01 | 7.8E-03 | 6.3E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 35| +2.50E+02 | -4.6E-03 | +1.0E+00 | 7.8E-03 | 6.7E-01 | 1.7E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 36| +2.50E+02 | -7.5E-03 | +9.8E-01 | 1.6E-02 | 2.6E-01 | 3.4E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 37| +2.50E+02 | -1.7E-02 | +1.1E+00 | 3.1E-02 | 6.0E-01 | 6.8E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 38| +2.50E+02 | -4.1E-02 | +1.2E+00 | 6.2E-02 | 7.2E-01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 39| +2.49E+02 | -1.2E-01 | +1.4E+00 | 1.2E-01 | 1.2E+00 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 40| +2.49E+02 | -5.2E-01 | +1.8E+00 | 2.5E-01 | 2.3E+00 | 5.2E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 41| +2.45E+02 | -3.6E+00 | +2.2E+00 | 5.0E-01 | 4.7E+00 | 9.9E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 42| +2.33E+02 | -1.2E+01 | +1.5E+00 | 1.0E+00 | 1.5E+01 | 1.8E+00 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 43| +2.27E+02 | -6.1E+00 | +3.3E-01 | 2.0E+00 | 4.0E+01 | 1.9E+00 | trr |1\n", + "2023-02-17 16:05:43 fides(INFO) 44| +2.18E+02 | -9.2E+00 | +1.4E+00 | 2.0E+00 | 4.2E+01 | 5.7E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 45| +2.18E+02 | +8.7E+02 | -6.4E+01 | 2.0E+00 | 4.2E+01 | 3.6E+00 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 46| +2.13E+02 | -4.5E+00 | +3.2E-01 | 5.0E-01 | 4.2E+01 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 47| +2.13E+02 | +3.7E+00 | -7.4E-01 | 5.0E-01 | 3.7E+01 | 1.0E+00 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 48| +2.11E+02 | -2.5E+00 | +4.9E-01 | 1.2E-01 | 3.7E+01 | 2.7E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 49| +2.10E+02 | -3.4E-01 | +3.7E-01 | 1.2E-01 | 1.1E+01 | 3.2E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 50| +2.10E+02 | +7.4E-02 | -1.4E-01 | 1.2E-01 | 5.6E+00 | 2.2E-01 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 51| +2.10E+02 | -1.6E-01 | +6.6E-01 | 3.1E-02 | 5.6E+00 | 6.0E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 52| +2.10E+02 | -7.0E-02 | +8.0E-01 | 3.1E-02 | 2.8E+00 | 5.1E-02 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 53| +2.10E+02 | -2.7E-02 | +8.5E-01 | 6.2E-02 | 1.2E+00 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 54| +2.10E+02 | -2.2E-02 | +1.3E+00 | 1.2E-01 | 8.3E-01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 55| +2.10E+02 | -5.4E-02 | +1.8E+00 | 1.2E-01 | 6.3E-01 | 3.8E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 56| +2.10E+02 | -1.4E-01 | +1.9E+00 | 2.5E-01 | 1.7E+00 | 7.0E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 57| +2.10E+02 | +3.2E+00 | -3.0E+01 | 5.0E-01 | 3.1E+00 | 9.9E-01 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 58| +2.10E+02 | -9.1E-02 | +1.1E+00 | 8.6E-02 | 3.1E+00 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 59| +2.09E+02 | -3.9E-01 | +5.6E-01 | 1.7E-01 | 3.4E+00 | 3.7E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:43 fides(INFO) 60| +2.08E+02 | -1.0E+00 | +1.5E+00 | 1.7E-01 | 1.1E+01 | 4.8E-01 | 2d |1\n", + "2023-02-17 16:05:43 fides(INFO) 61| +2.08E+02 | +1.2E+01 | -1.1E+01 | 3.4E-01 | 8.2E+00 | 9.3E-01 | 2d |0\n", + "2023-02-17 16:05:43 fides(INFO) 62| +2.08E+02 | -5.2E-01 | +1.0E+00 | 8.6E-02 | 8.2E+00 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 63| +2.08E+02 | +3.6E+00 | -1.8E+00 | 1.7E-01 | 8.9E+00 | 4.4E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 64| +2.07E+02 | -3.3E-01 | +5.1E-01 | 4.3E-02 | 8.9E+00 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 65| +2.07E+02 | -6.0E-01 | +1.2E+00 | 4.3E-02 | 8.4E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 66| +2.06E+02 | -1.1E+00 | +1.0E+00 | 8.6E-02 | 5.5E+00 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 67| +2.05E+02 | -7.5E-01 | +3.2E-01 | 1.7E-01 | 8.6E+00 | 4.5E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 68| +2.02E+02 | -2.9E+00 | +1.4E+00 | 1.7E-01 | 2.4E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 69| +2.00E+02 | -2.6E+00 | +5.0E-01 | 3.4E-01 | 1.4E+01 | 9.4E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:44 fides(INFO) 70| +2.00E+02 | +3.8E+00 | -8.3E-01 | 3.4E-01 | 2.9E+01 | 6.8E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 71| +1.97E+02 | -2.7E+00 | +1.1E+00 | 8.6E-02 | 2.9E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 72| +1.96E+02 | -5.2E-01 | +1.4E-01 | 1.7E-01 | 1.8E+01 | 4.0E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 73| +1.95E+02 | -1.4E+00 | +9.5E-01 | 4.3E-02 | 2.5E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 74| +1.94E+02 | -8.7E-01 | +1.1E+00 | 8.6E-02 | 8.7E+00 | 2.3E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 75| +1.92E+02 | -2.3E+00 | +1.3E+00 | 1.7E-01 | 4.5E+00 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 76| +1.85E+02 | -6.7E+00 | +9.0E-01 | 3.4E-01 | 1.5E+01 | 8.9E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 77| +1.78E+02 | -7.2E+00 | +4.8E-01 | 6.9E-01 | 6.7E+01 | 4.7E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 78| +1.78E+02 | +1.2E+02 | -7.6E+00 | 6.9E-01 | 9.0E+01 | 1.1E+00 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 79| +1.67E+02 | -1.1E+01 | +9.0E-01 | 1.1E-01 | 9.0E+01 | 2.8E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:44 fides(INFO) 80| +1.64E+02 | -2.7E+00 | +3.1E-01 | 2.2E-01 | 6.3E+01 | 4.9E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 81| +1.64E+02 | +2.7E+01 | -1.8E+00 | 2.2E-01 | 1.2E+02 | 3.6E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 82| +1.62E+02 | -2.3E+00 | +2.4E-01 | 5.4E-02 | 1.2E+02 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 83| +1.60E+02 | -2.5E+00 | +9.9E-01 | 1.3E-02 | 1.1E+02 | 3.7E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 84| +1.58E+02 | -1.1E+00 | +9.2E-01 | 2.7E-02 | 3.6E+01 | 7.2E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 85| +1.57E+02 | -1.1E+00 | +6.7E-01 | 5.4E-02 | 2.4E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 86| +1.56E+02 | -8.8E-01 | +6.7E-01 | 5.4E-02 | 4.5E+01 | 1.3E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 87| +1.56E+02 | +1.1E-01 | -1.1E-01 | 5.4E-02 | 1.4E+01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 88| +1.56E+02 | -3.1E-01 | +7.8E-01 | 1.3E-02 | 1.4E+01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 89| +1.56E+02 | -4.0E-01 | +9.3E-01 | 2.7E-02 | 1.8E+01 | 5.4E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:44 fides(INFO) 90| +1.55E+02 | -6.1E-01 | +1.2E+00 | 5.4E-02 | 1.2E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 91| +1.54E+02 | -1.1E+00 | +1.2E+00 | 1.1E-01 | 1.1E+01 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 92| +1.52E+02 | -1.7E+00 | +7.5E-01 | 2.2E-01 | 2.0E+01 | 4.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 93| +1.52E+02 | +9.3E-01 | -6.7E-01 | 4.3E-01 | 4.5E+01 | 4.5E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 94| +1.51E+02 | -9.4E-01 | +9.2E-01 | 5.2E-02 | 4.5E+01 | 1.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 95| +1.50E+02 | -9.8E-01 | +9.8E-01 | 1.0E-01 | 1.5E+01 | 2.0E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 96| +1.50E+02 | +8.3E-01 | -5.9E-01 | 2.1E-01 | 3.5E+01 | 4.0E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 97| +1.50E+02 | -7.9E-01 | +9.1E-01 | 5.2E-02 | 3.5E+01 | 1.0E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 98| +1.49E+02 | -4.0E-01 | +3.9E-01 | 1.0E-01 | 1.2E+01 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 99| +1.49E+02 | -2.9E-01 | +3.3E-01 | 1.0E-01 | 4.3E+01 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:44 fides(INFO) 100| +1.49E+02 | +5.0E-02 | -6.4E-02 | 1.0E-01 | 4.6E+01 | 1.2E-01 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 101| +1.49E+02 | -4.0E-01 | +8.0E-01 | 1.2E-02 | 4.6E+01 | 3.1E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 102| +1.48E+02 | -2.5E-01 | +1.3E+00 | 2.3E-02 | 9.7E+00 | 4.2E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 103| +1.48E+02 | -3.6E-01 | +1.0E+00 | 4.7E-02 | 6.9E+00 | 8.0E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 104| +1.48E+02 | -2.6E-01 | +8.5E-01 | 9.3E-02 | 5.4E+00 | 1.5E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 105| +1.48E+02 | -8.8E-02 | +1.1E+00 | 1.9E-01 | 5.6E+00 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 106| +1.48E+02 | -5.0E-02 | +8.4E-01 | 1.9E-01 | 1.3E+01 | 1.2E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 107| +1.48E+02 | -3.8E-02 | +1.2E+00 | 1.9E-01 | 5.0E+00 | 8.1E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 108| +1.48E+02 | -7.9E-03 | +1.2E+00 | 1.9E-01 | 1.1E+00 | 5.8E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 109| +1.48E+02 | -3.1E-03 | +1.2E+00 | 1.9E-01 | 4.2E-01 | 5.5E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:44 fides(INFO) 110| +1.48E+02 | -7.6E-04 | +1.1E+00 | 1.9E-01 | 5.3E-01 | 3.2E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 111| +1.48E+02 | -4.2E-05 | +1.2E+00 | 1.9E-01 | 7.0E-02 | 9.0E-03 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 112| +1.48E+02 | -1.6E-06 | +8.5E-01 | 1.9E-01 | 2.7E-02 | 2.1E-03 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 113| +1.48E+02 | -2.4E-06 | +1.5E+00 | 1.9E-01 | 1.8E-02 | 3.4E-03 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 114| +1.48E+02 | -6.7E-06 | +1.6E+00 | 1.9E-01 | 1.2E-02 | 1.1E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 115| +1.48E+02 | -1.4E-05 | +1.5E+00 | 1.9E-01 | 5.9E-02 | 2.9E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 116| +1.48E+02 | -3.4E-05 | +1.5E+00 | 1.9E-01 | 1.3E-01 | 7.0E-02 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 117| +1.48E+02 | -7.2E-05 | +1.6E+00 | 1.9E-01 | 2.1E-01 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 118| +1.48E+02 | -1.1E-04 | +1.5E+00 | 1.9E-01 | 2.7E-01 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 119| +1.48E+02 | -8.0E-05 | +1.2E+00 | 1.9E-01 | 2.4E-01 | 2.5E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:44 fides(INFO) 120| +1.48E+02 | -4.5E-05 | +1.3E+00 | 3.7E-01 | 9.9E-02 | 2.6E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 121| +1.48E+02 | -1.8E-05 | +2.1E+00 | 3.7E-01 | 7.7E-03 | 1.8E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 122| +1.48E+02 | -8.9E-06 | +1.3E+00 | 3.7E-01 | 4.4E-02 | 2.1E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 123| +1.48E+02 | -8.8E-06 | +1.5E+00 | 3.7E-01 | 4.7E-02 | 2.4E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 124| +1.48E+02 | -4.1E-06 | +1.3E+00 | 3.7E-01 | 2.5E-02 | 2.2E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 125| +1.48E+02 | -1.9E-06 | +1.3E+00 | 3.7E-01 | 1.7E-03 | 1.7E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 126| +1.48E+02 | -3.0E-06 | +4.5E+00 | 3.7E-01 | 7.0E-03 | 1.4E-01 | 2d |1\n", + "2023-02-17 16:05:44 fides(INFO) 127| +1.48E+02 | +1.9E-06 | -6.9E+00 | 3.7E-01 | 6.7E-03 | 8.7E-02 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 128| +1.48E+02 | +2.9E-06 | -2.2E+01 | 6.4E-02 | 6.7E-03 | 2.2E-02 | 2d |0\n", + "2023-02-17 16:05:44 fides(INFO) 129| +1.48E+02 | +2.2E-06 | -5.4E+01 | 1.6E-02 | 6.7E-03 | 5.4E-03 | 2d |0\n", + "2023-02-17 16:05:45 fides(INFO) iter| fval | fdiff | tr ratio |tr radius| ||g|| | ||step||| step|acc\n", + "2023-02-17 16:05:45 fides(INFO) 130| +1.48E+02 | +3.1E-06 | -2.3E+02 | 4.0E-03 | 6.7E-03 | 1.4E-03 | 2d |0\n", + "2023-02-17 16:05:45 fides(INFO) 131| +1.48E+02 | +2.5E-06 | -3.6E+02 | 1.0E-03 | 6.7E-03 | 3.4E-04 | 2d |0\n", + "2023-02-17 16:05:45 fides(INFO) 132| +1.48E+02 | -9.0E-07 | +1.7E+02 | 2.5E-04 | 6.7E-03 | 8.5E-05 | 2d |1\n", + "2023-02-17 16:05:45 fides(WARNING) Stopping as function difference 8.99E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)\n", + "Performing parallel task execution on 8 processes.\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 5.44 s, sys: 2.02 s, total: 7.45 s\n", + "Wall time: 10min 31s\n" + ] + } + ], + "source": [ + "%%time\n", + "%%capture --no-display\n", + "n_starts = 100\n", + "\n", + "# Due to run time we already use parallelization. \n", + "# This will be introduced in more detail later.\n", + "engine = pypesto.engine.MultiProcessEngine()\n", + "history_options = pypesto.HistoryOptions(trace_record=True)\n", + "\n", + "# Scipy: L-BFGS-B\n", + "result_lbfgsb = optimize.minimize(problem=problem, \n", + " optimizer=optimizer_scipy_lbfgsb,\n", + " engine=engine,\n", + " history_options=history_options,\n", + " n_starts=n_starts)\n", + "\n", + "# Scipy: Powell\n", + "result_powell = optimize.minimize(problem=problem, \n", + " optimizer=optimizer_scipy_powell,\n", + " engine=engine,\n", + " history_options=history_options,\n", + " n_starts=n_starts)\n", + "\n", + "# Fides\n", + "result_fides = optimize.minimize(problem=problem, \n", + " optimizer=optimizer_fides,\n", + " engine=engine,\n", + " history_options=history_options,\n", + " n_starts=n_starts)\n", + "\n", + "\n", + "# PySwarm\n", + "result_pyswarm = optimize.minimize(problem=problem, \n", + " optimizer=optimizer_pyswarm,\n", + " engine=engine,\n", + " history_options=history_options,\n", + " n_starts=n_starts) " + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Optimizer Convergence\n", + "\n", + "\n", + "A common visualization of optimizer convergence are waterfall plots. Waterfall plots show the (ordered) results of the individual optimization runs. As we see below, Dlib and pyswarm, which are not gradient based, are not able to find the global optimum. \n", + "\n", + "Furthermore we hope to obtain clearly visible plateaus, as they indicate optimizer convergence to local minima. " + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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+ "text/plain": [ + "
" + ] + }, + "metadata": { + "needs_background": "light" + }, + "output_type": "display_data" + } + ], + "source": [ + "optimizer_results = [\n", + " result_lbfgsb,\n", + " result_powell,\n", + " result_fides,\n", + " result_pyswarm,\n", + "]\n", + "optimizer_names = ['Scipy: L-BFGS-B', 'Scipy: Powell', 'Fides', 'pyswarm']\n", + "\n", + "pypesto.visualize.waterfall(optimizer_results, legends=optimizer_names);" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Optimizer run time\n", + "\n", + "Optimizer run time vastly differs among the different optimizers, as can be seen below:" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Average Run time per start:\n", + "-------------------\n", + "Scipy: L-BFGS-B: 3.741806 s\n", + "Scipy: Powell: 9.719779 s\n", + "Fides: 2.701986 s\n", + "pyswarm: 25.507524 s\n" + ] + } + ], + "source": [ + "print('Average Run time per start:')\n", + "print('-------------------')\n", + "\n", + "for optimizer_name, optimizer_result in zip(\n", + " optimizer_names, optimizer_results\n", + "):\n", + " t = np.sum(optimizer_result.optimize_result.get_for_key('time')) / n_starts\n", + " print(f'{optimizer_name}: {t:f} s')" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Fitting of large scale models\n", + "\n", + "When fitting large scale models (i.e. with >100 parameters and accordingly also more data), two important issues are efficient gradient computation and parallelization.\n", + "\n", + "## Efficient gradient computation\n", + "\n", + "As seen in the example above and as can be confirmed from own experience: If fast and reliable gradients can be provided, gradients based optimizers are favourable with respect to omptimizer convergence and run time. \n", + "\n", + "It has been shown, that adjoint sensitivity analysis propose a fast and reliable method to compute gradients for large scale models, since their run time is (asymptotically) independent of the number of parameters ([Fröhlich et al. PlosCB 2017](https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005331&type=printable)).\n", + "\n", + "\"pyPESTO \n", + "\n", + "(Figure from Fröhlich et al. PlosCB 2017) Adjoint sensitivities are implemented in AMICI." + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "metadata": {}, + "outputs": [], + "source": [ + "# Set gradient computation method to adjoint\n", + "problem.objective.amici_solver.setSensitivityMethod(\n", + " amici.SensitivityMethod.adjoint\n", + ")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Parallelization\n", + "\n", + "Multi-start optimization can easily be parallelized by using `engines`." + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Engine set up to use up to 8 processes in total. The number was automatically determined and might not be appropriate on some systems.\n", + "Performing parallel task execution on 8 processes.\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 280 ms, sys: 148 ms, total: 427 ms\n", + "Wall time: 2min 1s\n" + ] + } + ], + "source": [ + "%%time\n", + "%%capture\n", + "\n", + "# Parallelize\n", + "engine = pypesto.engine.MultiProcessEngine()\n", + "\n", + "# Optimize\n", + "result = optimize.minimize(problem=problem, \n", + " optimizer=optimizer_scipy_lbfgsb,\n", + " engine=engine,\n", + " n_starts=100)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Uncertainty quantification\n", + "\n", + "PyPESTO focuses on two approaches to assess parameter uncertainties:\n", + "\n", + "* Profile likelihoods\n", + "* Sampling\n", + "\n", + "## Profile Likelihoods\n", + "\n", + "[Profile likelihoods](https://academic.oup.com/bioinformatics/article/25/15/1923/213246) compute confidence intervals via a [likelihood ratio test](https://en.wikipedia.org/wiki/Likelihood-ratio_test). Profile likelihoods perform a maximum-projection of the likelihood function on the parameter of interest. The likelihood ratio test then gives a cut off criterium via the $\\chi^2_1$ distribution.\n", + "\n", + "In pyPESTO, the maximum projection is solved as maximization problem and can be obtained via" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 1min 26s, sys: 5.81 s, total: 1min 32s\n", + "Wall time: 1min 32s\n" + ] + } + ], + "source": [ + "%%time\n", + "%%capture\n", + "\n", + "import pypesto.profile as profile\n", + "\n", + "result = profile.parameter_profile(problem=problem, \n", + " result=result, \n", + " optimizer=optimizer_scipy_lbfgsb)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "The maximum projections can now be inspected via:" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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\n", + "text/plain": [ + "
" + ] + }, + "metadata": { + "needs_background": "light" + }, + "output_type": "display_data" + } + ], + "source": [ + "# adapt x_labels..\n", + "x_labels = [f'Log10({name})' for name in problem.x_names]\n", + "\n", + "visualize.profiles(result, x_labels=x_labels, show_bounds=True);" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "The plot shows that seven parameters are identifiable, since the likelihood is tightly centered around the optimal parameter. Two parameters (`k_exp_hetero` and `k_imp_homo`) can not be constrained by the data.\n", + "\n", + "Furthermore pyPESTO allows to visualize confidence intervals directly via" + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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\n", + "text/plain": [ + "
" + ] + }, + "metadata": { + "needs_background": "light" + }, + "output_type": "display_data" + } + ], + "source": [ + "ax = pypesto.visualize.profile_cis(\n", + " result, confidence_level=0.95, show_bounds=True\n", + ")\n", + "\n", + "ax.set_xlabel('Log10(Parameter value)');" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Sampling\n", + "\n", + "In pyPESTO, sampling from the posterior distribution can be performed as " + ] + }, + { + "cell_type": "code", + "execution_count": 20, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "100%|████████████████████████████████████| 10000/10000 [00:27<00:00, 368.56it/s]\n", + "Elapsed time: 30.99180300000002\n" + ] + } + ], + "source": [ + "import pypesto.sample as sample\n", + "\n", + "n_samples = 10000\n", + "\n", + "sampler = sample.AdaptiveMetropolisSampler()\n", + "\n", + "result = sample.sample(\n", + " problem, n_samples=n_samples, sampler=sampler, result=result\n", + ")" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Sampling results are stored in `result.sample_result` and can be accessed e.g. via" + ] + }, + { + "cell_type": "code", + "execution_count": 21, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "array([[[-1.56903514, -5. , -2.20988782, ..., 0.58572263,\n", + " 0.81880994, 0.49856843],\n", + " [-1.56903514, -5. , -2.20988782, ..., 0.58572263,\n", + " 0.81880994, 0.49856843],\n", + " [-1.56903514, -5. , -2.20988782, ..., 0.58572263,\n", + " 0.81880994, 0.49856843],\n", + " ...,\n", + " [-1.42590748, -4.42706952, -2.00183415, ..., 0.73049356,\n", + " 0.85349596, 0.54844474],\n", + " [-1.48877016, -4.17264394, -2.22043926, ..., 0.61516694,\n", + " 0.93106418, 0.6043891 ],\n", + " [-1.48877016, -4.17264394, -2.22043926, ..., 0.61516694,\n", + " 0.93106418, 0.6043891 ]]])" + ] + }, + "execution_count": 21, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "result.sample_result['trace_x']" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Samlping Diagnostics\n", + "\n", + "Gewekes test accesses convergence of a sampling run and computes the burn in of a sampling result. The effective sample size indicates the strenght the correlation between different samples." + ] + }, + { + "cell_type": "code", + "execution_count": 22, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Geweke burn-in index: 3000\n" + ] + }, + { + "data": { + "text/plain": [ + "3000" + ] + }, + "execution_count": 22, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "sample.geweke_test(result=result)\n", + "result.sample_result['burn_in']" + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Estimated chain autocorrelation: 454.31751144999856\n", + "Estimated effective sample size: 15.376083335131788\n" + ] + }, + { + "data": { + "text/plain": [ + "15.376083335131788" + ] + }, + "execution_count": 23, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "sample.effective_sample_size(result=result)\n", + "result.sample_result['effective_sample_size']" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "### Visualization of Sampling Results" + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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PbG/+wizJcOW3B/W1Lnndzu7PG8o/b7dUJsdd0igZl8uhVMrUhDEVCvg9Gt9Utcc5bZz1/mzF4TBUX+PVyIYROnJ6Q35btPt32hlLK5M1dcOCY1QX5KIwyks8ntL6LZ1q6djzfDGXSev1DZ2qrHAr3pWVqktdLQ4kTXWV2ror0r3f7O38L+hSOJrWGxvbdPiUBs4DB4iGxhAKBbxy+0y9vnrPle1vu2KOvvOLf6mqwq3Dpo5gUVv0qbG2e8op4EAweVxAHeGsxo3y6O1NUS1e9kqPbeeNC47Rdxf/K/98r9spL1P2oQy1hhMaUVehGeNrdduVc7R5R2KPPM+cLg5kgWEqHk/p2deb1VjjU13Ip1gio+9fNltVFQ5t3N6lxcte6rE9+PHXj9fXfvQPSXq3ufEO7pJGKSWTWQWrHFrZzzltwO8udZkYgGQyq6qAs9ff6Y0LjpHT2f37zJnShh2d3HiJsrKhOarFy1bqR1cdpzUbI3scX594dJPC4YyyWVPZrCmXi4lqUHzZrKmtuzrl93slw9Hn+d+h00Mys4bW74jo0Mn1pS7bVvhLHkJur6m2tmz+IEHqvsNq8bKVymQd+s4lR8vjcao9klQdi9qiD9VVXiVSWUW7WEAew19HOKuOaFLxuNnrttPpdMvr7m5g7J7n1++lV4/yUxv0KWea8rqlTMbRa55b21hEFRiuNjRH9cLr29XSkdRN97yoH/7uZd306xeVShu9bg8ikazOOHGy/F6nPv+pQ3rs6646/yg11VeW8tvBAWzd9rDa2vs+p73mkqNZ38Vm1m0Pq7WP6xROp1s5M6fVG1vVHkmqlRsvUWbaI0mNGxlQNJbrNcOdnVl9/1cvaPOOqLbsYupuDI312ztlWU4lElnlMtk+z//a2rKKxNMsWj8IXPUZQrG4pfZIsvdh45GkaoM+STnVBn2aPLq6JDWi/DkMQ6MaAlq/tVOHT2sodTlAUe0ejtne2fu2syOa1PcunaW3Nrbr4Il1cjkNjarlIg/Kj8/rVCKZVSYrxRJ95xnA8NQeSerjx03STfe82ONktq9zg45oUg89vS6/MPgZJ06WwyEdMa1BB02o44IxSmb3TAL9ndO2hhOlKA2DlM3m1BnP9Lktqqny6b4n3tbC+bNLVCHQu2zWVF3Ip7knTe33Wtvui8fXkWEMkdbOhLJZU5JUE/T1e7zXUO1XNmcpnc7Jw2wTBWOExhBKJnOqC/nyd1jt5nU7VRv0qSOalMMwVF/nIsTo16j6Sr21ub3UZQBFV/fOXOK1fWw7a6p8cjgMfeCgBq3d3CbDkILM7YsyNCLkV2csrVgi02+eTdMqUYUAiqku5FO0a88Lhv1tD2676nidccIEtYa7mxuNNRWaOqaGZgZKqi7k2+s57bhRrO9iJ9XV3n63RelsVgvmzlQg4JIMs0RVAj1ls6aeXbld2UxWIxv63y5J3RePw9w8hCFSH/KrNuRTQ41f4Wiy/+sZTun5ldv01IqtSqdzfbwi3o+GxhAKx5Kqq3VpwdyZPYaNL5g7U1JWtUGfUmkpyXq22IsJTUH9ezULg2P4q6t1aeXqTtXW9L7trKlxaeEvn9f6rVHFExkWBEfZ2rwrplCVR3XVPsnK9prn+jqXdrTGS1wpgP0tmcyqwu/IX2ypr/bpnJOn6ZxTpqmywtHr9iCXy2jtxk4dd3iTbv3KsVo4f7YmjK7ipieUnN/nUijU/zltNMoUinYSjWb7vE5RV+tSbbVX6XRam7fHJItLSCgP67d3asvOmNZv71Q2k1NVoI/tkpXNf1xTxY1vGBqTRoXkdFjyerpzl8tm+jz/awuntGpjhxYvW6l128KlLdxGmHJqCNUEfWpty2rC6AotnD87PyQ3l8toR2tKk8b6tL0lJq+X6VLQvyljqrX0ybfV3BbXyDryguFr93y+C+cfo+kTQz22ncEqlx54dG1+CPHC+bOVznJHA8pTNJ5WTcgnl8uh9Vviaqzx9MhzfZ1LyaQUjSc0upE7W4HhwDQtbdsV09ZdUVX5PfrTk2v1lXMO166OhO5/Yo1SmZweemqdfnTV8T3PDbJpfXfxv+R1O/NTvOxojetgFuJFGdi6M6aA362Z00P9ntPCPmJdae0KJ/Y4NgkFXbp76Zs680NTNaoxKLfLqXgyU+pyAUndU/qYlqWp4+qVM6Wv/fgfWnjp0Xtsl97cFFFTXYXOPnmaJo6sKnXZOIDkTENdiaxyuZzCsaymjg/2yGdVwKWOcE5ej1NnnjRFP/zdy/lpHbF3NDSGUO6duSk37Yhq5dst+uQJk7V9V1x+n1NPvLBR51XPUE2VTx43w8jRP4/bqQ8dNUYL73peN33xuPwwSmA4SaffnfM0kTT1m7+8qk+eMFnJVPdck7/5yzrNnNIo6d35J+ur/SWuGuhdoMKjUNCh7c0pPfHCxneynJbf59Rv/vKGzjtthjwupxrq2J4Dw4FpWnpu5Q7dft8rSmVyuuKcI/TCqhYdOWOE7n9ijcaNDOjMk6Yomcpp8464aoIe/fB3L/d4jd1zfxuG1FRfqRG1FSX6boB31YW6p/vc3pzS/Y+/1ec5rWlaTI9mE4EKj2679/n8lHhTx4Y096SpaoskddIHxiqVziqRzsntSKuygmNtlIf6kF8btkXUHnl3XZ+NO+IKBXz588VlT76tzc0xLZw/W8EqlyorvSWuGgeK9ds7VRVwafO2mFwOQ3Uhv9ZuisjndepPT72ttVs65XU7dc3FH5Tf51J7Z1Jet1N1Ic4FC0VDY4iYpqWaaq8CAa9GNwZ02NR6tbR3ye9z6uGn1+nDHxwvpyEFAi5FY1lpRKkrRrk7/vDR6kpmdefS13TNxceUuhxgv1u3LayGGr+uPOdw5SxL55wyXb/800rtaOtSU12FLj1jpuKJtM45ZZqeWbFVNVU+VVQwFQfKU12tS61tWTkd0oc/OF5/fmZdvkH32Y8drKoql3buSqi6mkMzYDjY0RrPNzMkyed16vxTp2j8yKCuPO8IhSq9+t2jq/TmpnD3tANnzdRB46v15qZw/jXeO/f3wrue11XnH6U5M5u4SIySmjyqWuFkTJ4uQxecNkPRru479ne2d+ljx06U01B+CkVGHNpDVyqjY2eO0GlzJiqbsxRPpJXLSc2tcWVzlsaMqNTIukolUzmlM0wnhvIwaVRIzW1x1b5zAfj/++QMjair1JrNHTIt6ZkVW3X+R6arM55WZywlGZJZT6MVQ6O1M6FRngqNqKvQph1RLXvq7fy538WfOEQOhyXTMuR2SZFol+pCfn3lnMM1eXR1qUu3jZKdNa9atUrnnHOOXn/99VKVMKS27Iwoa0ktrXHFElk9uHyNTjhijBwO6TMnT9fjz2/Q3P83VRu3ReV0GIpGk6pifj/sxYeOGqNbf/eSwtGUqqu42wDDSySeViyR1p3LXlcqk5PX7dS5p07TqvWtOuWYCVq75d2D1bNPniav11AkmpUaS1050FM0mlRbe1btkaQaa/xKZ7L6+HGTtGVnTH97cZOi8YwWnDVTMyaGFA5nNYZZZQDba48klMrkNHVsSGeeNEX11V4lUwEtvOv5/D7t0jMOVaXfrUmja9TS3qXPfeIQ/eyBFdrR1pWfW9npMCXDUCqT0+33vaIJTR/iIjFKyudzSUlpx64uhSMpdcYzMi1LDsNQIpWT19PdwLeUIas2kM2aaqjx6wMHjdSbG9r1+AubdOqs8XrihU356xVup1OypEg8xRoEKBsul0Mj6irk8zlkmZYaaiu1ZnNYpiU5DEOfOXmqOqJp/f6vb+X3u9wYgKFSH/IrFu9uAL/w+nZ95uTp+esXDy5fo7NPnqYnXtioU2dN0MQxAf3yj6/ry+ccyVppA1CShkYikdD111+vTObAmX9xZ0eXKrxuZXPd4T111ng98M7cuV63U5efdZhiiYzqQ91DODe1xHQoBwvYC4/bqSljqvXyWzt18gfHlbocYL8KVnZPv7H77tZUJqcnXtikcz8yPX/X6+4mx4PL1+iKc49UOMqckyg/m1pi+WbG1pa4fvPIWz3y+8izG7R4afc6MB1kGBgWaoN+HTS+Wh/+4Hj99IF/a+H82Vq8bGWPfdrS/1urcz8yXb/4n9eUyuS07Ml1+vI5h8vvcarS71Gg0qW/Pb9Js2eOzn9Ne5R1dlB6rW1ZtbQnZJqWlj35dn6fdt6p05TK5NRQ75GVYcShHazf3ql0JqetLXEte/JtnXHiZD3xTlPjvdcrvviZw9RUX6loV7rUJQN5O9u6FKpyy+Nyqbm1q8f26NIzDtVjz23osd/lxgAMlVG1fr2ytlVej1OzZ47Wrb99aY/rF5/92EH5Y8Q3N4XVGU+VumxbcZTiTW+55RZdfPHFpXjrkqkJ+tQeSSqRyuqUY8blDw6k7g3rnUtfU6XPrbo6lwIBFxc0ULAJTUG9unZXqcsA9rvOeFozJ9fq+/Nn6+sXHKXvXzZbZ5w0OX/hR+refj7wxBqdcsw4daUyqg74lM2aJa4c6Kk9klRtyCeXS7pz6Z75/dicCfl1YLjzERgemuor9dmPH6xfPdQ9yjDWldYZJ07WOadM0zmnTFN9tU8nHDFmj33aoj+8qmg8rfZIUt/4yT80vqlasrrv8PO6naqtYv56lF57JKmm+sr84vZSd37vf2KNTEsKh7Nqqq8scZUoRGtn4p2bLny65uIPanxTVa/XK+74n9eUSmdVHfDINK0SVw10qwv55DScSqSye2yPfvXQ6zrlmHE65+Rp+X1vVaVb7dFEiavGgWDjzpgmjQ2o0ufu9fzvhCPGKJnO5c8BOcYbuCG/bWL58uVKJpP66Ec/2udzIpGIIpFIj8eam5uLXVpRpVI51YZ8Mk1TDofRYwh6MpWT3+dUPJmW2qRg0MUFDZspZWYnNAX1h7+tGZL3wvBgl21sddCjYw8brZvueVGpTE4Hja/WvI8drMvOnCm/z6llT3YvppXK5FQX9KuqwqM/Ll8jr2eGpo2rKXX52E/sktf+1IV82tkald/v7bEQ8O4c1wb9aqqrUG3Qp2CQO1rtbDjkFfuHw2Eo1pXRuJEBffr/TVU6a2rCqKCWPblWm5tjOvfUabIsK3+Cu1sqk1Og0qt0JqeF82fL7Tb1jf96Lj9Vxv68SExeMRimaampoVK72rt63ael0jk5DEupVFZ+v3u/vS95LY76kF8Oh7RhW0Q33fOiFsw9VNPH1/Z6vN2VzOmpl7foMyd7ucO9AGS2+CY1hfTSWzvl8Th7LGq/e7s0sq6ix3pV5506TXVBLhr3hrzuX263FO7MKp7M9JrNhhqf3C5DXrdTNVU+feWcw7kRYICKdtb86KOP6uabb+7x2KRJkxSLxXTPPff0+7VLlizRokWLilVaSbRHkho9IqBkMitZVo8h6LuHHS04a6bcToeiUam+zlPqkjEAfWXWXzep6O/dWFOhcDylzlhKoQDraGDv7LKNzWas/PQcU8eG9OEPjtcNd7/QYxixtFGbm2OyLFM509KEpiq1dSYk0dAYLuyS1/6MawjIsiQZlk6bNaHHvn/+GYcq4HPosrmHye1yqKuLEUZ2Nhzyin0XjiS1dVdMddU+nTZ7gm6/b0WPfdfjL2zUA0+s0fULZsvrdvZoanjdTlX63Ar43Vq9sVWTxtbqpi8eq9oqv5rqK/frvN/kFYOxozWudDonv9fV6z6trrp7tOy67Z06dHL9fntf8lock0aF9Namdi1etlLjRgZkyejzeLvC59KHjh7P1HcFIrPF5/e7VRvyyVL3/nPcyIA+8r7t0mVnHqqsaWntlk7d/8QazTq0qdRllyXyun9lMt3XgRtq/H1m8/KzZuon3zheqbTU6KxgbZcBMizLGrLxgg8++KAWL16sysrurtNbb72lGTNm6N5771Ug8O4Osa/O4Lx587R8+XKNGTNmqEreb97Y0KpMOiuXy6FoPKNApVfff2dRwN28bqduWDBbrZ1JNdZUaPr42hJWjIHoK7OXXnGtfvyjH6uhoaGo7//ff35D806boaMPGlHU98HwYJdt7DP/3qZbf/uSJOmbn/1Afue/m9ft1Pc+P0sOpyGZOclhaMeuhGZMCmlsQ3WJqsb+Zpe87s0z/96q+mqfrr1zz33/9y+bLafTUms4rWClR4dNKe4+A8UzXPKKwQtHknr17V1yGFJN0J9fBHw3r9upK849Qpt3hDXniDFKJLJqjyRVXeXV/724SVPG1qq+2q8//n2NTp01QVPHhzRhZHVRaiWvGIzX1u5SOJZSbdDXa76vu3SWqgJubWmO6YQj9l+GyGvxPL1iq374u5d161eO6/U4Zffxts/rUDKdVU1lBQ2NApDZ4kskMtreEdGutpTcTsnr9fS6XfrWhUfr+rtfkCTd9MVjNXMyx9rvR173r6dXbNWYEQHtbI3L53XK7XL1ms1rPz9LIxrcam1P69BJjSWs2H6GdF6Ds88+W2effXb+4+nTp+uhhx7a43nBYFDBYHAoSyu6qoBLsZghw5AcRkYdkWSvQ8zbOlOqqfJpV0dC08eXqFgMWKkzO6YhoLc2ttPQQEFKnddC1Ya8+TtXTbP3aTma27v0y2UrtWDuTE0aG9ILr69TU32lxnKMOmzYJa97UxP0qS2c6mPfn1R1lVsNNX6ZZq6PV4AdDJe8YvB2tMeVTOd0159e1xXnHtHr33wma2rmlHqt39KZH4nodTu1YO5MTR4bUlciqzc3hbV++0otnD+7aLWSVwyG1+PUtIkBvb0x3mu+w7GUPB7nfp9CmbwWT121T7+89iSt3RAr6HibaVEKQ2aLb932TpmWpfpavzZsjUjRTK8ZTqa7H2Odgr6R1/2rLuRTKp2TZKk1nJLU+3ngro4uOR2VKtES17bGT2yIJBKmWsNdSiSz8vs8MozuudLey+t2qi7kVVXApXGjOEhA4caNqNKqDW2lLgPYr6pDLi2YO1Net1P17wzVfC+v2ynfO/OlLl62UolEVh8/bpI6oskSVQz0wzIVrPT0mmNDhmQ5lE6byuUYagzYWSqd04tv7NA1F39Q1QFvr3/zI2or5HS68s0MSfl9WVciK7fbkX+MfRrKTbQrrY5wTtXB3vNdU9V9EWfyqFCJKsRAJJNZ1dW41NaWVU1V77/T9x9vMy0KykV7JKlwNKVksjufPq+z1wyHAh6dcvRofels1inA0JgwokqJZFaVFd5+s1lf7VdHNMnx3iCUtKGxevXqUr79kEqlcgr4HPm7VpY9uVaXnnFoPtC719BwOCylM5Yi0WyJK4adjBtZpbVbwsrlmHsdw0MsltSqtZ1yGJZu++rx8nqc+eaG1L3NnH/moar0ufSVs4/QlecdoXQmq2hXer/fEQjsHw5ta+nUgrP2zPGyp9YqHEspEk9xMAvYnMspHXPoKN10z4u65y9v6LK5ex7vR+MpmaalcSN7Ttmyu4Hx+tqW/PPZp6HcuJwOpTM5pVJZzT/z0D32aal0VpFYWk4n907awdbWqFau7tRPH1ih9khC899/jWLuTAX8Lk0dG6LJirJTF/Jp3KiA2t+ZAeXFN3bscc64YO5MVfpdOnhSg0Y1+GjIYUiE4xk5HVI42j0yY9mTb++xz7zszENlWaZG1ldyvDcIQzrl1IGsM55WTZVXgYChZMrU5uaYVq3fpe/+f7O0q6NLXo9Tf35mnU6dPUHjRlZxoIABqfB1L4b19tYwa69gWNi4M6bFy1bq6xccobWbOtXSkdCra3bqe5+fpUhXWgG/W4lkRjcveendqTrOmqkpY0MaEaoodfnAHuLJjCaNrVV7Z0JXnnukEums/B6XnA5LLoeh6oBXPq9D6cyQLW0GoCgc+uU7Iy9mjKtWld+tay7+oMKxlOpCft376Cq9uSmcX0BZ2qi1WzolvdvAuPW3L+cvwkwcWVXabwd4n8oKt2JdGQUqPUqls3vs0wKVHvm8ptZtC+ugiXWlLhd7kXjnzvZLTj9YP/vDaxo3MqDrLp2tjmhShgwte2qtNjfHdNncmaqt2s5FN5QVj8dQJmOpNuTTrIMbdeiURj3xwsbuKR/TOTXWVujJlzZpVEOlFi8r7jSOwHu1RxJyupyqrnJ0jxKq9ChY4e6xz3Q5u28SMCT5/S6ZpkXDbQBoaAyRupBXoZBLkUhOkqkFc2eqwufWjf/9Qo951NZvX6nrLp3FgQIGbOKokP69ZhcNDQwLu++yCVT69KPfP68zTpqsNzeF1RFJKpbIyDKl/3pgRc+pOpZ2H6RWNHlKXD2wp2ClR+l0Tj+6d0WP/f7uxeAsmcqZDtXXcWgG2FlH9N118o49fIwW3vW8zvvINE0eXa0b7n6hx37rrode15XnHqlbf/dSvoHh97t09ec+oJoqnyaOrFJlpbeU3w6wh1Qqp3QmK7fToR/f9+899mkL589WOpOVx8MIDTvYvc2qr/Yrlclp7ZZOmaalnz7Q83f7y2Urde3nZ8nptJRMZuXzcbyC0stmJJere6ri00+ckt/PvrnpZUnd26Qrzj1CbZ1JRhhhSDXU+LV2c1gvrtqhr5xzuIKVXv3nr/+1xz7zuktnKZHKKZXOyudyaXRjoJ9XxXtxlDFEEsmsOjqy2tWRkGE4NGlMUKbV+yK3nbE0d2NhwKaOqdaLq3aWugxgv6gL+eR1O9UReffCkNftVFXAo1//eZUSqWyv208OUlGuApVOhWPpXnMb7UrLcDjUGk6otY0pJwE7qw368tMJtEeSGjcyoGlja9QaTvT69y9DuvpzH9DC+bMViSW0vSWmE44Yo0Mn19PMQFnqjKVUF/L2aN7t1n0slpLb7ZIsLjXYQX119zp1lX53ftvVGe998dqW9i7lcoY2t0RKUSqwB6fT0MbtEcVj3fnsLbepdC6/b+bGYQyVzlhaNSGfnl25U+lMrs/jwM54WuFoUj6PS+3RRImqtSeOMoaIz+tSeySpkXUVSiYzkkzV9LGQWijg4QQGAzZxVEibdkbUGUuVuhRgn41vDOg/vzBLtSGfDhpfrYMm1OhLZx+uTDqj731+lkbWVfS5ECVQjjZsjammqvdFwUOVHqWSGTXWVtCUA2zO53Po9q8fr5u/eJxG1lXowo/NkMNhaERt7/utYKVHLoehPz25VhNH17AfQ9mrrvIqk1Wfi97XBL0KVLrYn9mE2+3oHh3mc+gr5xwur9spj8vR6+/W63GqK5VRMp3r49WAoZXJmtrVEdOOtq4+F7VvrK1QfZ1LC+bO1JgG7n7H0PB4HaqvdWnBWTPV0pHoc1HwmqBXjbUVymWzqq3yl6hae6KhMURG1wdUF/IpkzP14PK1crqcisZSeyy6ddncQ2U49/JiQC/cLoemjqnWC280l7oUYJ8FAj5lsobWbmrTqbMm6JYlL2nC6CpFunK6/u4XdM9f3thz0cKzZqqykuHvKE+1QZ+qAu5eFyoMVrn14PK1yuZMLmYCNmSalra1xPTKWztVWeHQW+s7tfCu5+VyO7QrnNLCu57vc78VqHSrvrZCL6xqUSyRkd/PfgzlLZPNaVdHQj6fa49F7+efcaiisZQsq3u/h/K3Y1dcY0ZUKpuVGmsrNPdDUxTwO3s9Xtm6s1Muh0ORWLrEVQPd2iMpHTZ1hJyGpUw2t8d+9vKzZqo65NbK1Z2aOT2karZLGCKGIaVSUpXfpYMm1Orhp9fpsjP33GdGoim5XQ41NvrUVF9Z4qrthSPmIbKtNaa6WpfWbIjpkydMViyW1Y9+v0LjRgZ0xblHKJnOye9xqbHOL6+XPhMGZ+aUBv3tX5v1kVnjS10KsE/CkaTaI0mNGRHSD37TvfB3PJ7V4ncWWu1eQHWjrjz3SBmGVBP0KpHMKJ1muh6UJ5/XqWgsm1+oMJnOyedx6s/PrFNT/SH65AmT1d6Z1NQJ3DkG2EE2a2r99k51xlOKdWX08wdfVSqT081fPC6/r+rq6n2/JaN7XZ0/PblWXrdTm3d0LxJeG/Sptb1Lk0dVl/rbA/pU4fPI5XIqmzU1vimYX+DU53HqT0+9rc3NMS2cP1tTRleXulQUoC7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\n", 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\n", + "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# scatter plots\n", + "ax = visualize.sampling_scatter(result)\n", + "\n", + "# marginals\n", + "ax = visualize.sampling_1d_marginals(result)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Sampler Choice:\n", + "\n", + "Similarly to parameter optimization, pyPESTO provides a unified interface to several sampler/sampling toolboxes, as well as own implementations of sampler:\n", + "\n", + "* Adaptive Metropolis: `sample.AdaptiveMetropolisSampler()`\n", + "* Adaptive parallel tempering: `sample.ParallelTemperingSampler()`\n", + "* Interface to `pymc3` via `sample.Pymc3Sampler()`" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Storage\n", + "\n", + "You can store and load the results the results of an analysis via the `pypesto.store` module to a `.hdf5` file.\n", + "\n", + "## Store result" + ] + }, + { + "cell_type": "code", + "execution_count": 25, + "metadata": {}, + "outputs": [], + "source": [ + "import tempfile\n", + "\n", + "import pypesto.store as store\n", + "\n", + "# create a temporary file, for demonstration purpose\n", + "result_file_name = tempfile.mktemp(\".hdf5\")\n", + "\n", + "# store the result\n", + "store.write_result(result, result_file_name)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Load result file\n", + "\n", + "You can re-load a result, e.g. for visualizations:" + ] + }, + { + "cell_type": "code", + "execution_count": 26, + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "WARNING: You are loading a problem.\n", + "This problem is not to be used without a separately created objective.\n" + ] + }, + { + "data": { + "text/plain": [ + "" + ] + }, + "execution_count": 26, + "metadata": {}, + "output_type": "execute_result" + }, + { + "data": { + "image/png": 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+ "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# read result\n", + "result_loaded = store.read_result(result_file_name)\n", + "\n", + "# e.g. do some visualisation\n", + "visualize.waterfall(result_loaded)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Software Development Standards:\n", + "\n", + "PyPESTO is developed with the following standards:\n", + "\n", + "* **Open source**, code on [GitHub](https://github.com/ICB-DCM/pyPESTO).\n", + "* [**Pip installable**](https://pypi.org/project/pypesto/) via: `pip install pypesto`.\n", + "* **Documentation** as [RDT](https://pypesto.readthedocs.io/en/stable/) and [example **jupyter notebooks**](https://github.com/ICB-DCM/pyPESTO/tree/master/doc/example) are available.\n", + "* Has **continous integration** & extensive automated **testing** via travis.\n", + "* **Code reviews** before merging into the develop/master branch.\n", + "\n", + "* Currently **5-10 people are using, extending** and (most importantly) **maintaining** pyPESTO in their \"daily business\"." + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Further topics\n", + "\n", + "Further features are available, among them:\n", + "\n", + "* Model Selection\n", + "* Hierarchical Optimization of scaling/noise parameters\n", + "* Categorial Data" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.4" + } + }, + "nbformat": 4, + "nbformat_minor": 4 +} diff --git a/doc/example/rosenbrock.ipynb b/doc/example/rosenbrock.ipynb index d4b01fde2..e7a211b76 100644 --- a/doc/example/rosenbrock.ipynb +++ b/doc/example/rosenbrock.ipynb @@ -61,6 +61,7 @@ " hess=sp.optimize.rosen_hess,\n", ")\n", "\n", + "\n", "# second type of objective\n", "def rosen2(x):\n", " return (\n",