diff --git a/app/scripts/controllers/app-state.js b/app/scripts/controllers/app-state.js
index 02bcf916939e..af9f410cd985 100644
--- a/app/scripts/controllers/app-state.js
+++ b/app/scripts/controllers/app-state.js
@@ -53,6 +53,7 @@ export default class AppStateController extends EventEmitter {
       showAccountBanner: true,
       trezorModel: null,
       currentPopupId: undefined,
+      currentExtensionPopupId: undefined,
       // This key is only used for checking if the user had set advancedGasFee
       // prior to Migration 92.3 where we split out the setting to support
       // multiple networks.
@@ -523,6 +524,10 @@ export default class AppStateController extends EventEmitter {
     });
   }
 
+  setCurrentExtensionPopupId(currentExtensionPopupId) {
+    this.store.updateState({ currentExtensionPopupId });
+  }
+
   /**
    * A getter to retrieve currentPopupId saved in the appState
    */
diff --git a/app/scripts/metamask-controller.js b/app/scripts/metamask-controller.js
index 84c20573479e..d47b49ba7d90 100644
--- a/app/scripts/metamask-controller.js
+++ b/app/scripts/metamask-controller.js
@@ -3105,6 +3105,8 @@ export default class MetamaskController extends EventEmitter {
       // AppStateController
       setLastActiveTime:
         appStateController.setLastActiveTime.bind(appStateController),
+      setCurrentExtensionPopupId:
+        appStateController.setCurrentExtensionPopupId.bind(appStateController),
       setDefaultHomeActiveTabName:
         appStateController.setDefaultHomeActiveTabName.bind(appStateController),
       setConnectedStatusPopoverHasBeenShown:
diff --git a/ui/index.js b/ui/index.js
index e1c01714ceab..99ba9980b9aa 100644
--- a/ui/index.js
+++ b/ui/index.js
@@ -23,6 +23,7 @@ import {
   getSelectedInternalAccount,
   getUnapprovedTransactions,
   getAutomaticSwitchNetwork,
+  getUseRequestQueue,
 } from './selectors';
 import { ALERT_STATE } from './ducks/alerts';
 import {
@@ -211,6 +212,18 @@ async function startApp(metamaskState, backgroundConnection, opts) {
     },
   };
 
+  // Register this window as the current popup
+  // and set in background state
+  if (
+    process.env.MULTICHAIN &&
+    getUseRequestQueue(state) &&
+    getEnvironmentType() === ENVIRONMENT_TYPE_POPUP
+  ) {
+    const thisPopupId = Date.now();
+    global.metamask.id = thisPopupId;
+    actions.setCurrentExtensionPopupId(thisPopupId);
+  }
+
   // start app
   render(<Root store={store} />, opts.container);
 
diff --git a/ui/pages/routes/routes.component.js b/ui/pages/routes/routes.component.js
index 6b9137b15d4d..7d3c51350fd1 100644
--- a/ui/pages/routes/routes.component.js
+++ b/ui/pages/routes/routes.component.js
@@ -198,6 +198,8 @@ export default class Routes extends Component {
     neverShowSwitchedNetworkMessage: PropTypes.bool.isRequired,
     autoSwitchNetwork: PropTypes.func.isRequired,
     unapprovedTransactions: PropTypes.number.isRequired,
+    currentExtensionPopupId: PropTypes.number,
+    useRequestQueue: PropTypes.bool,
     ///: BEGIN:ONLY_INCLUDE_IF(keyring-snaps)
     isShowKeyringSnapRemovalResultModal: PropTypes.bool.isRequired,
     hideShowKeyringSnapRemovalResultModal: PropTypes.func.isRequired,
@@ -254,9 +256,12 @@ export default class Routes extends Component {
       networkToAutomaticallySwitchTo,
       activeTabOrigin,
       unapprovedTransactions,
+      useRequestQueue,
+      currentExtensionPopupId,
       allNetworks,
       isUnlocked,
     } = this.props;
+
     if (theme !== prevProps.theme) {
       this.setTheme();
     }
@@ -283,6 +288,18 @@ export default class Routes extends Component {
         );
       }
     }
+
+    // Terminate the popup when another popup is opened
+    // if the user is using RPC queueing
+    if (
+      useRequestQueue &&
+      process.env.MULTICHAIN &&
+      currentExtensionPopupId !== undefined &&
+      global.metamask.id !== undefined &&
+      currentExtensionPopupId !== global.metamask.id
+    ) {
+      window.close();
+    }
   }
 
   UNSAFE_componentWillMount() {
diff --git a/ui/pages/routes/routes.container.js b/ui/pages/routes/routes.container.js
index 225b9e57a22f..2c3862b10a04 100644
--- a/ui/pages/routes/routes.container.js
+++ b/ui/pages/routes/routes.container.js
@@ -23,6 +23,7 @@ import {
   getNeverShowSwitchedNetworkMessage,
   getAutomaticSwitchNetwork,
   getNumberOfAllUnapprovedTransactions,
+  getUseRequestQueue,
 } from '../../selectors';
 import {
   lockMetamask,
@@ -114,6 +115,9 @@ function mapStateToProps(state) {
     unapprovedTransactions: getNumberOfAllUnapprovedTransactions(state),
     allNetworks: getAllNetworks(state),
     neverShowSwitchedNetworkMessage: getNeverShowSwitchedNetworkMessage(state),
+    currentExtensionPopupId: state.metamask.currentExtensionPopupId,
+    useRequestQueue: getUseRequestQueue(state),
+
     ///: BEGIN:ONLY_INCLUDE_IF(keyring-snaps)
     isShowKeyringSnapRemovalResultModal:
       state.appState.showKeyringRemovalSnapModal,
diff --git a/ui/store/actions.ts b/ui/store/actions.ts
index c0d0799ad161..2fa356a68d99 100644
--- a/ui/store/actions.ts
+++ b/ui/store/actions.ts
@@ -4950,6 +4950,16 @@ export function updateInterfaceState(
   }) as any;
 }
 
+/**
+ * Update the currentPopupid generated when the user opened the popup
+ *
+ * @param id - The Snap interface ID.
+ * @returns Promise Resolved on successfully submitted background request.
+ */
+export async function setCurrentExtensionPopupId(id: number) {
+  await submitRequestToBackground<void>('setCurrentExtensionPopupId', [id]);
+}
+
 /**
  * Delete the Snap interface from state.
  *