How does PharmCAT recommend related drug list per gene in report.json?

[Sillar-codes]

Hello everyone,
I want to know how PharmCAT recommends related drug list per gene in report.json.
Is it related to all info - position, chromosome, ref, alt and qual.

[whaleyr]

I'm not sure I understand your question completely but I'll give an answer to what I think you're asking.

In the report JSON file (for example, https://pharmcat.clinpgx.org/examples/pharmcat.example2.report.json), in the genes property is a map of gene symbol to information about that gene (for example, "CYP2C19"). If you look in that gene information you see a property called relatedDrugs.

That list of drugs is derived from all the annotations that are associated with the gene in question. Those annotations could be guidelines, drug labels, or FDA PGx associations. It is a unique list of all the drugs that appear in the annotations that the gene in question appears in.