diff --git a/pyproject.toml b/pyproject.toml
index 216defc..c2d49b9 100755
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,3 +1,3 @@
 [build-system]
-requires = ["setuptools", "wheel", "numpy>=1.19.0", "Cython>=0.29.21, <3.0"]
+requires = ["setuptools", "wheel", "numpy>=1.19.0", "Cython>=0.29.21"]
 build-backend = "setuptools.build_meta"
diff --git a/requirements.txt b/requirements.txt
index 19ece81..2383e0b 100755
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,5 +1,5 @@
-Cython<3.0
-numpy
+Cython>=3.0.10
+numpy>=2.0.0
 pandas
 scipy
 perturb-tools>=0.2.5