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ui.R
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# setup ----
library(shinydashboard)
library(shinyTime)
library(lubridate)
library(shinythemes)
tags$head(
tags$link(rel = "stylesheet",
type = "text/css",
href = "bootstrap.css")
)
title_h5 <- function(chr="Predicted concentration"){
h5(chr, align='center', style="color:#dbdbdb; font-weight:bold")
}
# main ----
shiny::navbarPage(
title = "Cyclosporine TDM",
theme = shinytheme("paper"),
# Chapter 1. Patient Info `pinfo` ----
tabPanel(
#icon = icon("user-plus"),
icon = icon("address-card"),
title = "Patient Info",
tabName="pinfo",
h2("- Patient Information -",
align='center',
style="color:#dbdbdb; font-weight:bold"),
tags$hr(),
column(width=2),
column(
width=4,
box(title = "Patient ID",width = NULL,solidHeadner = TRUE,status = "primary",
textInput("pid","", value = "003866", width = NULL, placeholder = NULL)),
#tags$hr(),
box(title = "Information", status = "primary",width = NULL,solidHeader = TRUE,
numericInput("total_bilirubin", "Total Bilirubin (mg/dL)", 3.0, min = NA, max = NA, step = 0.1,
width = NULL),
numericInput("post_op_date", "POD, Post OP date (day)", 3, min = NA, max = NA,
step = 0.5,
width = NULL),
numericInput("age", "Age (year)", 50,min = NA, max = NA, step = 1),
numericInput("weight", "Weight (kg)", 60, min = NA, max = NA, step = 0.1)
)
),
column(width=4,
box(title = "Population PK parameters",
status = "primary", width = NULL,
solidHeader = TRUE,
tableOutput('typical_values')))
),
# Chapter 2. Dosage Regimen `dosa` ----
tabPanel(
icon = icon("eyedropper"),
title = "Dosage regimen",
tabName="dosa",
h2(" Dosage Regimen",align='center',style="color:#dbdbdb; font-weight:bold"),
tags$hr(),
column(width=2),
column(width=4,
box(width = NULL, status = "primary",
solidHeader = TRUE,
title="Upload Dosing History",
fileInput('file1', 'Choose File',
accept=c('text/csv',
'text/comma-separated-values,text/plain',
'.csv')),
tags$hr(),
selectInput("rt", "Administration Route", c("Oral administration"), selected = NULL, multiple = FALSE,
selectize = TRUE, width = NULL, size = NULL)
) ,
tags$hr(),
box(width=NULL,
background = "teal",
"Dosing History Template (CSV)",
tags$p(),
downloadButton('downloadData', 'Download')
)
),
column(width=4,
box( width=NULL, status = "primary", solidHeader = TRUE, title="Dosing History",
tableOutput('dosing_history_contents'))),
column(width=2)
),
# Chapter 3. Observations `obs` ----
tabPanel(
icon = icon("flask"),
title = "Obesrvations",
tabName="obs",
h2("Observations",align='center',style="color:#dbdbdb; font-weight:bold"),
tags$hr(),
column(width=2),
column(
width=4,
box(width = NULL,
status = "primary",
solidHeader = TRUE,
title="Number of Observations",
#textInput("1")
selectInput("Observations","",c("1" = "1","2" = "2")))
),
column(
width=4,
conditionalPanel(
condition = "input.Observations == 1",
box(width = NULL , solidHeader = TRUE, title="First Observation",
numericInput("obsc", "Observed Concentration (mg/L)", 100, min = NA, max = NA, step = NA,
width = NULL),
dateInput("obsDate", "Date", value = "2019-03-05", min = NULL, max = NULL,
format = "yyyy-mm-dd", startview = "month", weekstart = 1,
language = "en", width = NULL),
timeInput("obsTime", "Time", value = strptime("10:30", "%R"), seconds = FALSE)
)
),
conditionalPanel(
condition = "input.Observations == 2",
box(width = NULL ,solidHeader = TRUE, title="First Observation",
numericInput("obsc1", "Observed Concentration (mg/L)", 4.5,
min = NA, max = NA, step = NA,
width = NULL),
textInput("obsd1", "Time", value = "2017-05-06", width = NULL, placeholder = NULL),
timeInput("obst1", "Date", value = strptime("23:00", "%R"), seconds = FALSE)
),
tags$hr(),
box(width = NULL ,solidHeader = TRUE, title="Second Observation",
numericInput("obsc2", "Observed Concentration (mg/L)", 10,
min = NA, max = NA, step = NA,
width = NULL),
textInput("obsd2", "Time", value = "2017-01-01", width = NULL, placeholder = NULL),
timeInput("obst2", "Date", value = strptime("23:30", "%R"), seconds = FALSE)
)
)
),
column(width=2)
),
# Chapter 4. PK profile 1 `main` ----
tabPanel(
icon = icon("line-chart"),
title = "PK profile 1",
tabName="main",
column(
width=3,
title_h5('Predicted Concentration'),
box(width=NULL, status = "primary", solidHeader = TRUE, title="",
tableOutput('output_table1_time_predicted_concentration')),
tags$hr(),
title_h5('Individual PK Parameters'),
box(width=NULL, status = "primary", solidHeader = TRUE, title="",
tableOutput('outputtable2'))
),
column(width=9,
box(width = NULL, status = "primary", title="",
plotOutput("plotCONC",
width = '800px', height="500px")),
p('* Ctrough: 50 - 200 ng/mL is desired.'))
),
# Chapter 5. PK profile 2 `main2` ----
tabPanel(
icon = icon("line-chart"),
title = "PK profile 2",
tabName="main2",
column(
width=3,
box(width = NULL, status="warning", solidHeader = TRUE, title = "",
sliderInput("newdose", "Next dose (mg)", 50, min = 0, max = 1000, step = 50,ticks=TRUE,
width = NULL)),
box(width = NULL, status="warning", solidHeader = TRUE, title = "",
sliderInput("newtau", "New dosing interval (hours)", 24, min = 4, max = 48, step = 4,
width = NULL)),
tags$hr(),
box(width=NULL, solidHeader = TRUE, title='',status="primary",
sliderInput("ll", "trough levels (mg/L)", 50, min = 0, max = 500, step = 50,
width = NULL),
sliderInput("ul", "peak levels (mg/L)", 200, min = 0, max = 500, step = 50,
width = NULL))
),
column(width=9,
box(width = NULL, status = "primary", title="",
plotOutput("plotCONC2",
width = '800px', height="500px")),
p('* Ctrough : 50 - 200 ng/mL is desired. A solid blue line represents the starting time point with the new dosing regimen (tau and dose). '))
)
# End ----
)