diff --git a/packages/components/src/components/dropdown-select/dropdown-select.tsx b/packages/components/src/components/dropdown-select/dropdown-select.tsx
index f6fc19da59..1c7c06b6b8 100644
--- a/packages/components/src/components/dropdown-select/dropdown-select.tsx
+++ b/packages/components/src/components/dropdown-select/dropdown-select.tsx
@@ -498,7 +498,7 @@ export class DropdownSelect {
               id={this.comboboxId}
               part="combobox"
               role="combobox"
-              tabindex="0"
+              tabindex={this.disabled ? '-1' : '0'}
               onBlur={this.handleBlur}
               onFocus={this.handleFocus}
               onClick={this.handleClick}