The GSCID/BRC Project and Sample Application Standard is designed to capture standardized human pathogen and vector sequencing metadata to support epidemiologic and genotype-phenotype association studies for human infectious diseases. This standard was developed by representatives of the Genome Sequencing Centers for Infectious Diseases (GSCIDs), the Bioinformatics Resource Centers (BRCs), and NIAID and informed by discussions and input with numerous collaborating scientists. The standard includes data fields about the organism(s) in the specimen, environmental source of the specimen, spatial-temporal information about the specimen isolation event, phenotypic characteristics of the pathogen/vector isolated, sequencing and data processing methodologies used, quality and coverage of the resulting sequences, and project leadership and support.
##GSCID/BRC Project and Sample Application Standard
The specifications of the GSCID/BRC Project and Sample Application Standard version 1.3 can be found below:
- BRC Project and Sample Application Standard v1.3 – Core Project
- BRC Project and Sample Application Standard v1.3 – Core Sample
- BRC Project and Sample Application Standard v1.3 – Sequencing Assay
- BRC Project and Sample Application Standard v1.3 – Project Specific
- BRC Project and Sample Application Standard v1.3 – Bacterial Specific
- BRC_GSC_Metadata_Collection_Bacteria_Template_v1.35.xlsm - Example Bacteria Metadata Collection template
- BRC_GSC_Metadata_Collection_Viral_Template_v1.3 - Example Viral Metadata Collection Collection template
- Pl. see BRC_GSC_Metadata_Collection_Viral_Template_v1.3_ReadMe.txt files for details about usage and Excel dependencies.
The intent and scope of the GSCID/BRC Clinical Metadata Standard is to provide an extension to the GSCID/BRC Project and Sample Application Standard that adds data fields related to sequencing studies involving specimens isolated from human participants for which clinical and demographic data would be of interest.
The specifications of the GSCID/BRC Clinical Metadata Standard version 1.5 can be found below:
- NIAID Common Clinical Data Dictionary v1.5.xlsx
- NIAID Common Clinical Data Dictionary v1.5-Example.xlsx (Example data set)
The specifications of the GSCID/BRC Clinical Metadata Standard version 1.2 can be found below:
- GSCID/BRC Clinical Metadata standard v1.2
- GSCIB/BRC Clinical Metadata standard v1.2 - Appendix