Issues

• How to generate cyclic backbone with rfdiffusion2

  RosettaCommons/RFdiffusion2#49 · Filter by author breadbread1984 opened on May 27, 2026
  2

• Specific value of sigma_perturb used in Stochastic Centering

  RosettaCommons/RFdiffusion2#47 · Filter by author Wangchentong opened on Dec 19, 2025

• Run the pipeline without container

  RosettaCommons/RFdiffusion2#46 · Filter by author giuliapeteani opened on Dec 10, 2025
  2

• Trying to run inference script

  RosettaCommons/RFdiffusion2#43 · Filter by author Valentin-Bio opened on Dec 1, 2025
  4

• Unexpected true atoms...

  RosettaCommons/RFdiffusion2#40 · Filter by author EvanKomp opened on Nov 14, 2025
  8

• Double Ligand Enzyme

  RosettaCommons/RFdiffusion2#38 · Filter by author alejandromontesa opened on Nov 13, 2025
  1

• AME Benchmark Clarification

  RosettaCommons/RFdiffusion2#33 · Filter by author ghost opened on Oct 22, 2025

• Chai prediction with ligands

  RosettaCommons/RFdiffusion2#29 · Filter by author BJHardy opened on Oct 16, 2025
  1

• The RFdiffusion2 paper claims that users can "specify the RASA of each atom" for fine control over ligand burial depth, but this feature is not implemented in the open source codebase? Only molecule-level RASA conditioning is available.

  RosettaCommons/RFdiffusion2#11 · Filter by author G-Armstrong opened on Sep 9, 2025